High altitude pulmonary edema
MONDO:0031257A rare pulmonary condition characterized by non-cardiogenic pulmonary edema occurring in otherwise healthy individuals within days of an ascent above 2500-3000 m. Early symptoms include exertional dyspnea, non-productive cough, chest tightness, and reduced exercise performance, followed by dyspnea at rest and possibly orthopnea, as well as gurgling in the chest and pink frothy sputum in advanced cases. Clinical signs are cyanosis, tachypnea, tachycardia, crackles or wheezing, and elevated body temperature (generally not exceeding 38.5°C). Signs of concomitant high-altitude cerebral edema may also be observed. Chest x-rays typically show patchy opacities predominantly in the right middle lobe.
37 clinical trials for this condition and its sub-types.
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New breathing vest could reduce need for Re-Intubation in ICU patients
Disease control Not yet recruitingThis study compares a new type of breathing device (biphasic cuirass ventilator) to standard non-invasive ventilation in 50 high-risk patients who are about to have their breathing tube removed. The goal is to see if the new device can reduce the number of patients who need to be…
Phase: NA • Sponsor: University of Missouri-Columbia • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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New hope for high altitude emergencies: study tests Life-Saving treatments
Disease control Not yet recruitingThis study aims to improve treatment for severe high altitude pulmonary edema (fluid in the lungs) and cerebral edema (brain swelling). Researchers will test breathing support devices and inhaled nitric oxide gas in over 3,000 patients in Tibet. The goal is to speed up recovery, …
Phase: NA • Sponsor: Tibet Autonomous Region People's Hospital • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New ECMO device tested for safe transport of critically ill patients
Disease control Not yet recruitingThis study will test a new medical device kit (Novalung ultimate kit with Xenios 2.0) in 20 adult patients with severe heart-lung failure who need ECMO life support. The goal is to see if the device safely and effectively maintains blood oxygen levels during hospital use and grou…
Sponsor: Xenios AG • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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New combo therapy aims to speed up breathing tube removal in ICU
Symptom relief Not yet recruitingThis study looks at whether adding a type of stretching called proprioceptive neuromuscular facilitation (PNF) to standard breathing exercises helps patients get off a breathing machine faster. About 93 adults in the ICU who are stable and awake will be split into three groups: o…
Phase: NA • Sponsor: Beni-Suef University • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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New mask aims to reduce breathing effort in ventilation patients
Symptom relief Not yet recruitingThis study tests a redesigned non-invasive ventilation mask that may help people with respiratory insufficiency breathe more easily. Sixty adults who are stable on NIV will wear their usual mask for one hour and then the new mask for one hour. Researchers will measure breathing r…
Phase: NA • Sponsor: Fisher and Paykel Healthcare • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Could a tiny heart hole worsen altitude sickness?
Knowledge-focused Not yet recruitingThis study looks at how a small opening in the heart, called a patent foramen ovale (PFO), affects blood flow and oxygen levels during exercise and simulated high altitude. About a third of people have this opening, which may allow oxygen-poor blood to mix with oxygen-rich blood,…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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Tweaking ventilator settings could ease breathlessness and cut PTSD risk in ICU survivors
Knowledge-focused Not yet recruitingThis pilot study investigates how standard changes to mechanical ventilator settings—such as breath size, flow rate, and pressure—affect shortness of breath in awake patients on ventilators. Many ICU patients experience breathlessness despite sedation, which may contribute to PTS…
Phase: NA • Sponsor: Beth Israel Deaconess Medical Center • Aim: Knowledge-focused
Last updated Jul 16, 2026 00:00 UTC
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Ventilator pressure showdown: which setting saves lungs best?
Knowledge-focused Not yet recruitingThis study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…
Phase: NA • Sponsor: Vastra Gotaland Region • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC