High altitude pulmonary edema
MONDO:0031257A rare pulmonary condition characterized by non-cardiogenic pulmonary edema occurring in otherwise healthy individuals within days of an ascent above 2500-3000 m. Early symptoms include exertional dyspnea, non-productive cough, chest tightness, and reduced exercise performance, followed by dyspnea at rest and possibly orthopnea, as well as gurgling in the chest and pink frothy sputum in advanced cases. Clinical signs are cyanosis, tachypnea, tachycardia, crackles or wheezing, and elevated body temperature (generally not exceeding 38.5°C). Signs of concomitant high-altitude cerebral edema may also be observed. Chest x-rays typically show patchy opacities predominantly in the right middle lobe.
37 clinical trials for this condition and its sub-types.
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A painless, contact-free vibration sensor may detect hidden heart and lung problems
Diagnosis CompletedThis study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …
Phase: NA • Sponsor: University Hospital, Caen • Aim: Diagnosis
Last updated Jul 31, 2026 00:00 UTC
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Can a computer speed up breathing recovery in kids?
Symptom relief CompletedThis study tested whether a computer-driven system called Smartcare/PS could help children with respiratory failure come off a breathing machine faster than usual care. Thirty children were enrolled, and the system automatically adjusted breathing support based on each child's ne…
Phase: NA • Sponsor: St. Justine's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Patients take control: Self-Sedation may ease anxiety in the ICU
Symptom relief CompletedThis study tested whether critically ill patients on breathing machines could safely manage their own sedation using a button-controlled device. 161 adults in the ICU were randomly assigned to either self-manage their sedation or have it managed by a nurse. The goal was to see if…
Phase: PHASE2, PHASE3 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Baby breathing machine under the microscope: new study watches how it works
Knowledge-focused CompletedThis study watches how a high-frequency ventilator (Servo-n HFOV) works in real hospital use for babies with severe breathing failure. About 75 infants will be observed to see if the machine safely helps them get enough oxygen and remove carbon dioxide. The goal is to gather info…
Sponsor: Maquet Critical Care AB • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Breathing machine may harm diaphragm: new study investigates
Knowledge-focused CompletedThis study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…
Sponsor: University Health Network, Toronto • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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What's it like to live with a home breathing machine? new study asks patients and families
Knowledge-focused CompletedThis study looked at the experiences of 126 people in Denmark who rely on a breathing machine at home, along with their families and the trained caregivers who help them. The goal was to understand the challenges and successes of this life-sustaining care. No new treatments were …
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Tiny pressure difference could save lungs on ventilators
Knowledge-focused CompletedThis study looked at 500 adults on breathing machines to see if measuring airway pressure at a specific moment (P1) versus a later moment (P2) better predicts lung damage. The goal is to find which measurement helps doctors set safer ventilator settings. No new treatment was test…
Sponsor: University of Padova • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Massive study reveals Real-World impact of respiratory failure in china
Knowledge-focused CompletedThis study observed over 4,000 patients in Chinese ICUs who needed breathing support for acute respiratory failure. Researchers tracked treatments, outcomes, and costs to better understand the disease burden. The goal is to improve care and identify risk factors, not to test a ne…
Sponsor: Southeast University, China • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Which ventilator mode is best? new study aims to find out
Knowledge-focused CompletedThis pilot study tested three common ventilator modes—volume control, pressure control, and adaptive pressure control—in 566 ICU adults with respiratory failure. The goal was to see which mode leads to more days alive and off the ventilator. The study is a first step to guide fut…
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Oxford researchers seek better way to open collapsed lungs in ICU
Knowledge-focused CompletedThis University of Oxford study looked at 48 ICU patients on ventilators for respiratory failure. Doctors sometimes inflate the lungs briefly (a recruitment manoeuvre) to reopen collapsed areas, but it's unclear when this helps. Researchers used a device to measure lung volume an…
Sponsor: University of Oxford • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Brain waves may predict ventilator weaning success
Knowledge-focused CompletedThis study looked at whether measuring tiny brain signals during a breathing test can help predict if a patient on a ventilator will successfully breathe on their own. Researchers monitored 70 intubated adults as they tried breathing without the machine. The goal is to find a sim…
Phase: NA • Sponsor: Poitiers University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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Doctors' humidification habits during breathing support revealed in global survey
Knowledge-focused CompletedThis study surveyed 534 physicians worldwide to understand how they use humidification (adding moisture to air) when treating hospitalized adults with non-invasive ventilation (breathing support through a mask). The goal was to find out how often humidification is used, what type…
Sponsor: Dr. Ram Manohar Lohia Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Small study tests best ventilator settings for ICU breathing measurements
Knowledge-focused CompletedThis study looked at 24 critically ill patients on breathing machines to see how changing the machine's settings affects measurements of breathing effort. Researchers compared a simple bedside measurement with a more invasive gold-standard technique. The goal was to find the best…
Phase: NA • Sponsor: Fondazione IRCCS San Gerardo dei Tintori • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:16 UTC