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Can Real-Time lung imaging Fine-Tune ventilator care for ARDS?

NCT ID NCT07793565

Disease control Sponsor: XIE MIN Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This trial tests whether using electrical impedance tomography (EIT) to guide ventilator pressure settings improves lung function in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) who are placed face down (prone positioning). Researchers will compare EIT-guided pressure adjustment against the standard ARDSNet table in 40 patients. The main goal is to see if EIT improves ventilation-perfusion matching, which reflects how efficiently the lungs exchange oxygen. The study also tracks breathing mechanics, heart function, and outcomes like survival and time on a ventilator.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
EIT-guided PEEP titration, a technique to adjust ventilator pressure using electrical impedance tomography imaging
What this could lead to
If it works, this approach could improve oxygen exchange and lung mechanics in ARDS patients, potentially reducing time on a ventilator and improving survival.
What could go wrong
This is a small, early physiological study with 40 patients, so results may not apply broadly. The technique may not improve outcomes, and adjusting ventilator settings carries risks like lung injury or heart strain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosis of moderate-to-severe ARDS according to the Berlin definition, with a PaO₂/FiO₂ ratio \< 150 mmHg on optimal mechanical ventilation. 2. Clinical decision has been made to place a central venous catheter (internal jugular or subclavian vein) for clinical management. Exclusion Criteria: 1. Pregnancy or postpartum state. 2. BMI \> 35 kg/m². 3. Duration of invasive mechanical ventilation \> 48 hours at enrollment. 4. Severe hemodynamic instability (mean arterial pressure \< 65 mmHg on norepinephrine ≥ 0.5 μg/kg/min). 5. Immediate need for veno-venous extracorporeal membrane oxygenation (VV-ECMO) at enrollment. 6. Contraindications to prone positioning or EIT monitoring, including but not limited to: facial or cervical trauma; unstable spinal, femoral, pelvic, or rib fractures; recent cardiac surgery; pneumothorax; elevated intracranial pressure; pacemaker or implantable cardioverter-defibrillator; severe chronic lung disease (e.g., severe COPD, asthma, interstitial lung disease); severe cardiac dysfunction (New York Heart Association Class III or IV, acute coronary syndrome, sustained ventricular tachyarrhythmia, or cardiogenic shock). 7. Lack of informed consent from legally authorized representative.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome (ARDS)

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430030, China

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