HYPERTENSION

This study tests whether royal jelly, a substance made by bees, can lower inflammation and oxidative stress in people with high blood pressure. Researchers will give 34 participants royal jelly or a placebo for 8 weeks and measure changes in blood markers. The goal is to see if t…

This study tests whether a natural supplement called inorganic nitrate can safely lower blood pressure in pregnant women with chronic hypertension. About 144 women will receive either the supplement or a placebo from the second trimester onward. The goal is to see if it reduces t…

This study tests whether a mobile health program that helps children sleep longer can lower their blood pressure. Ten children recently diagnosed with essential hypertension and who sleep 7.5 hours or less on school nights will use a sleep tracker and receive coaching. The goal i…

This study tests a new treatment for high blood pressure called renal denervation, which uses ultrasound to calm overactive nerves in the kidneys. About 261 adults with high blood pressure will be randomly assigned to receive either the real ultrasound procedure or a sham (fake) …

This study tests whether a smartphone app can help African-American adults with uncontrolled high blood pressure lower their numbers and adopt healthier habits. About 100 participants will use the app or receive standard care, and their blood pressure will be tracked for up to 6 …

This study tests whether providing healthy groceries and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to healthy food. About 80 participants from Baltimore will be randomly assigned to receive either standar…

This study tests a drug called engagliflozin (an SGLT2 inhibitor) in 120 people with high blood pressure who show early signs of heart strain but do not have diabetes or full heart failure. Participants will take either the drug or a placebo daily for 6 months. The goal is to see…

This study tests a once-daily pill called orforglipron in people who have both high blood pressure and obesity or overweight. The goal is to see if it can lower blood pressure and help with weight loss. About 487 adults will take either the study drug or a placebo for several mon…

This study aims to see if giving people healthy prepared meals and education helps them eat better compared to just physical activity coaching. It involves 120 adults in Anson County who have or are at risk for chronic conditions like obesity, diabetes, or heart disease. Particip…

This study in Pokhara, Nepal, will test if female community health volunteers visiting homes and sending regular SMS messages can help people better manage high blood pressure, type 2 diabetes, and quit smoking. About 2,070 adults with these conditions will be split into two grou…

This study aims to see if prescribing a specific number of daily steps based on a person's weight and body fat can help overweight or obese adults lose weight and improve heart health. Researchers will first develop a formula to predict weight loss from step counts, then test it …

This study tests whether trained community health workers can help refugees with high blood pressure stick to their medication and lower their numbers. About 250 adult refugees will either get extra support sessions or just standard information and a home blood pressure monitor. …

This study compares two medicines, dotinurad and febuxostat, to see which one better improves heart health in people with both high uric acid (hyperuricemia) and high blood pressure. About 360 adults will take one of the drugs for 24 weeks. The main goal is to measure changes in …

This study aims to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity by promoting traditional diets and cooking skills. About 210 adults from Hawaiian homesteads will take part in a program that includes dietary guidance, cooking demonstrations, and g…

This study tests if nurse home visits help people with high blood pressure and type 2 diabetes manage their conditions better than standard clinic visits. Researchers will track blood pressure and blood sugar changes over 6 months in 100 adults aged 18-60. The goal is to see if h…

This study tests whether a community-based lifestyle program can help adults with or at risk for high blood pressure lower their numbers. Participants receive coaching on diet, exercise, and self-management from experts. The program is added to usual medical care, and blood press…

This large study will test if a mobile digital health platform helps people better control high blood pressure, blood sugar, and cholesterol—known as the 'three highs'—to prevent heart and kidney disease. About 4,162 adults in New Taipei City will use the platform to track their …

This study looks at how well a procedure called ultrasound renal denervation works over time to lower blood pressure in people 65 and older whose blood pressure is not well controlled with medication. Researchers will review medical records from 1,000 Medicare patients to see if …

This study looks at whether a procedure called renal denervation (RDN) helps lower blood pressure over two years in Medicare patients with uncontrolled hypertension. Researchers will compare patients who received RDN plus standard care to those who received standard care alone, u…

This early-phase study at Vanderbilt University is testing whether a natural substance called angiotensin-(1-7) can improve how the body uses insulin in people with obesity, insulin resistance, and high blood pressure. About 26 adults aged 18-60 will receive the peptide or a plac…

This study tests a team of pharmacists and community health workers who work together to help African-American and Latino adults with high blood pressure take their medications as prescribed. The goal is to improve medication adherence and lower blood pressure. Participants must …

This study tests whether delivering healthy food and teaching kitchen skills at home can improve blood pressure and nutrition in adults who have high blood pressure and struggle to afford food. About 200 participants will either receive the food and skills program or standard car…

This study tests whether combining pharmacist counseling with community health worker support helps older African American adults (55+) better control their high blood pressure. Participants receive guidance on medication, diet, and physical activity over 24 months. The goal is t…

This study looks at whether empagliflozin, a drug originally for diabetes, can improve heart function in 80 older adults with high blood pressure and obesity who are at risk for heart failure. Participants will take either the drug or a placebo daily for 9 months. The goal is to …

This study tests a program that combines home blood pressure monitors, a mobile app, community health workers, and pharmacist support to help adults with uncontrolled high blood pressure plus diabetes or kidney disease. About 425 participants from 16 clinics will either get usual…

This study tests whether a mobile health app can help people who have had a bleeding stroke (intracerebral hemorrhage) better control their blood pressure. High blood pressure is a major risk factor for another stroke. The study will enroll 140 participants and track blood pressu…

This study tests whether a non-drug method called remote ischemic preconditioning (RIPC) — brief cycles of inflating and deflating a blood pressure cuff on the arm — combined with mindfulness training can lower blood pressure in people with mild hypertension. Researchers will enr…

This study tests whether community health workers, guided by a mobile app and remote doctor oversight, can manage high blood pressure as effectively as a physician. Researchers will enroll 460 adults with hypertension in rural Guatemala and compare blood pressure changes over 12-…

This study tests whether coaching from community health workers through telehealth can help people with dangerously high blood pressure avoid major heart problems like heart attacks and strokes. About 3,620 adults with severe hypertension will either get this coaching or standard…

This study tests whether training religious leaders to measure and educate about blood pressure can lower average blood pressure in their communities. About 24,000 adults aged 35 and older from 20 Tanzanian villages will take part. The goal is to see if this community-based appro…

This study tests a special setting in a pacemaker that may help lower blood pressure. About 500 people who already have or need a pacemaker and have high blood pressure will take part. The setting adjusts the timing between heartbeats to improve blood pressure control. Participan…

This study tests a new treatment that uses focused ultrasound to modify fat around the kidney, aiming to lower blood pressure in people with essential hypertension. About 30 adults whose blood pressure remains high despite medication will be randomly assigned to receive the ultra…

This study looks at whether community health workers can help people in Nepal manage high blood pressure. About 3,572 participants with high blood pressure will receive regular home visits or group meetings from a health worker over one year. The goal is to see if this approach i…

This study tests an experimental drug called tonlamarsen in 100 adults recently hospitalized for dangerously high blood pressure. The goal is to see if it can lower blood pressure and reduce a protein linked to hypertension. Participants will receive either the drug or a placebo,…

This study is for adults with high blood pressure that stays high even with lifestyle changes and medication. It tests a device called the Paradise System, which uses ultrasound to calm overactive kidney nerves. Researchers will check if the treatment safely lowers blood pressure…

This study is testing an investigational drug called angiotensin-(1-7) to see if it can improve cardiovascular health in people who have both obesity and high blood pressure. Researchers will measure nerve activity and artery function during a short infusion of the drug compared …

This study aims to help 2,000 adults in Chicago's South Side better control their high blood pressure. The program adapts proven clinic-based methods for use in local churches and community clinics, led by health workers and church volunteers. The goal is to make blood pressure m…

This study tests whether the drug iloperidone can lower blood pressure in people whose hypertension remains uncontrolled despite taking one or more standard medications. About 240 adults with systolic blood pressure of 130 mmHg or higher will receive either iloperidone or a place…

This study tests whether taking low-dose aspirin for six months after childbirth can help women who had preeclampsia recover their blood vessel health and lower their blood pressure. About 60 new mothers will be randomly assigned to receive aspirin or a placebo. The goal is to se…

This study tests a 12-month church-based program to help African Americans with uncontrolled high blood pressure lower their numbers. Participants will have their blood pressure checked and learn about healthy eating and taking medications as prescribed. The goal is to see if a c…

This study tests a new digital tool that helps doctors create personalized exercise plans for people with heart disease risk factors like high blood pressure, diabetes, and obesity. About 72 patients and 24 doctors will take part. The goal is to see if the tool is easy to use and…

This study is testing a smartphone mini-program that gives personalized exercise plans to people with high blood pressure, high blood sugar, high cholesterol, and high uric acid (the 'Four Highs'). Researchers want to see if using the app for six months helps people become more a…

This study tests if a device called the Gemini System can safely lower blood pressure by disrupting certain nerves in the kidney and liver. It includes 175 adults with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The main goal…

This study tests whether a drug called clevidipine can lower blood pressure quickly and keep it stable in people having a bleeding stroke. About 1,000 adults with high blood pressure and stroke symptoms will receive either clevidipine or another IV blood pressure medicine. The go…

This study tests a pharmacy-led program to help low-income patients with chronic conditions like diabetes and heart disease take their medications after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to help with follow-up care. …

This Phase 3 study tests a once-daily pill called orforglipron to see if it can safely lower blood pressure in people who are overweight or have obesity. About 974 adults with high blood pressure will receive either the study drug or a placebo. The goal is to find a new treatment…

This study looks at whether a 12-week exercise program with support from a peer is something women with HIV and high blood pressure can stick with and enjoy. About 50 women aged 40 and older will take part. The goal is to see if the program is acceptable and helps with blood pres…

This study tests whether a church-based program led by community health workers can help Black adults in New Orleans lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 806 adults aged 40 and older with at least three heart disease risk f…

This study tests whether a dietary supplement made from omega-3s (called SPM) can reduce blood vessel inflammation and improve artery function in 60 adults with obesity and high blood pressure. Participants will take the supplement or a placebo for 12 weeks. The goal is to see if…

This early-stage study tests a new tablet called VB19055 in 86 healthy Chinese adults to see if it is safe and how the body processes it. The drug is being developed to treat high blood pressure. Participants will receive either the drug or a placebo, and researchers will monitor…

This study looks at whether taking ketone supplements can prevent the negative effects of eating too much salt, like high blood pressure and kidney problems. Researchers will give 35 healthy young adults a high-salt diet with or without ketone supplements and measure changes in b…

This study looks at whether adding stair climbing to daily routines can lower blood pressure more than brisk walking alone. About 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk wa…

This study compares different approaches to help nearly 17,000 adults with uncontrolled high blood pressure get it under control. Participants receive care at safety-net clinics serving diverse, underserved populations. The goal is to find which strategies—like better monitoring,…

This study tests a program called PILI 'Āina to help Native Hawaiians better manage common health problems like type 2 diabetes, high blood pressure, and obesity. About 1,780 adults who are overweight and have at least one of these conditions will take part. The program focuses o…

This study looks at whether a new educational tool can help adults with high blood pressure eat less salt and more potassium. About 190 participants from two clinics in Singapore will either get the tool or standard care. The goal is to see if the tool helps lower sodium and rais…

This study tests whether a digital diet program, combined with extra vegetables and soy foods, can lower blood pressure in adults with hypertension, obesity, and type 2 diabetes. 300 participants will be split into three groups: one gets highly processed soy foods, another gets m…

This study looks at whether eating only during the early part of the day (early time-restricted eating) can improve heart health and daily body rhythms in older adults with high blood pressure. Researchers will track blood sugar, heart rate variability, and blood pressure in 30 p…

This study tests whether extra support from a community pharmacist can help people with type 2 diabetes better manage their blood sugar levels. About 600 adults with uncontrolled diabetes will either receive pharmacist-led care or continue with their usual doctor visits. The goal…

This study is testing whether a combination of green propolis extract and royal jelly can lower inflammation and oxidative stress in people with chronic kidney disease or high blood pressure. About 153 participants will take the supplement or a placebo for two months. Researchers…

This study tests an experimental drug called zilebesiran in 11,000 adults whose high blood pressure is not well controlled despite taking at least two standard medications. The goal is to see if adding zilebesiran can lower the risk of major heart problems like heart attack, stro…

This study compares a team-based program that combines medical care and social support to standard care for controlling high blood pressure. It will enroll 200 African American and Latinx adults with uncontrolled hypertension. The main goal is to see if more participants lower th…

This study tests whether SGLT2 inhibitors, a type of diabetes drug, can improve the heart's upper chamber function in people with intermittent atrial fibrillation, high blood pressure, and abnormal blood sugar. The goal is to prevent heart failure. About 66 adults will receive ei…

This study tests a wearable cuffless blood pressure monitor (CART BP Pro) in 400 Korean adults with uncontrolled high blood pressure. Participants are randomly assigned to use the device to guide their treatment or receive usual care. The goal is to see if the device helps lower …

This study tests whether dietary nitrate from beetroot juice can lower blood pressure and improve kidney function in people with hypertension and early-stage chronic kidney disease. About 14 to 20 adults will receive either nitrate-rich or placebo beetroot juice for two weeks, th…

This study tests a new medicine called QCZ484, given as a shot under the skin every 6 months, to see if it safely lowers blood pressure in adults with mild to moderate hypertension. About 380 participants will receive either QCZ484 or a placebo for 12 months. The main goal is to …

This study tests a health coaching program called STAR-MAP to help older adults (age 40+) with high blood pressure take their medication as prescribed. About 402 participants will either get coaching sessions plus reminder tools, or just the tools. Researchers will check if coach…

This study tests whether powerful weight loss drugs can lower blood pressure in young adults (ages 18-40) who are overweight or obese and have early-stage hypertension. Participants will either receive standard care (medication and lifestyle advice) or a weight loss drug. The goa…

This study tests whether having a peer deliver blood pressure medication directly to patients' homes, combined with health technology, helps people take their pills regularly and lowers their blood pressure. About 1,140 adults with uncontrolled high blood pressure in western Keny…

This study tests whether smartphone apps and text messages can help African American adults aged 50 and older better manage their blood pressure and stick to their medications. High blood pressure is a major health issue for this group, and the goal is to see if technology can ma…

This study tests whether a computer program that learns from patient data can help doctors choose the most effective blood pressure medication for each individual. About 2,160 adults with high blood pressure will be enrolled across 51 clinics in China. Some clinics will use the c…

This study tests whether doing wall-squat exercises can lower blood pressure in people with hypertension. About 390 adults who do not exercise regularly will be randomly assigned to either a wall-squat group or a stretching group for 24 weeks. Their blood pressure will be tracked…

This study tests a new medicine called ALN-AGT01 RVR in adults with mild to moderate high blood pressure who have already been treated with another drug, zilebesiran. The goal is to see if it safely helps lower blood pressure. About 93 participants will receive either the study d…

This study is testing whether a smartphone app powered by artificial intelligence can help people who have had heart bypass surgery or a stent procedure better control their blood pressure, diabetes, and cholesterol. About 536 adults who already have these conditions will use the…

This study tests whether a type of water pill (thiazide diuretic) can lower blood pressure in people on peritoneal dialysis who have high blood pressure. About 40 participants will take the medication and have their blood pressure, weight, and body fluid levels monitored. The goa…

This study tests a 24-week program called Black Impact to improve heart health and reduce stress in Black men. About 340 Black men with below-ideal heart health will either join the program right away or be placed on a waitlist. The program includes weekly exercise, health educat…

This study is testing a new way to program pacemakers to help lower blood pressure in people who have both high blood pressure and a slow heart rate. About 30 adults who already have or need a special pacemaker will try two different setup sessions for the new programming. Resear…

This study tests a new wearable device that uses light to measure blood pressure continuously, comparing it to standard home cuffs. About 35 adults with high blood pressure (stage 1 or 2) will wear the device while starting or adjusting their blood pressure medications. The goal …

This study tests whether older adults (65+) with high blood pressure and other chronic conditions can better control their blood pressure by measuring it at home. Some participants will get standard clinic support, while others will also work with a clinical pharmacist. The goal …

This study tests a smartphone app that gives daily rewards and helps plan when to take blood pressure medication. Researchers want to see if it helps people take their pills regularly, lowers blood pressure, and reduces healthcare costs. About 600 adults with high blood pressure …

This study tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps…

This study tests whether a simple, 5-minute daily breathing exercise (inspiratory muscle strength training) can lower blood pressure and improve blood vessel health in postmenopausal women aged 50 and older with high blood pressure. It compares this quick exercise to the standard…

This study tests whether a smartphone app with reminders and education can help older adults (60+) with mild memory problems stick to their blood pressure medication routine. About 100 participants will use the app or receive standard education for 16 weeks. The goal is to see if…

This study looks at whether eating baked potatoes with the skin, along with a Mediterranean-style diet, can improve blood sugar, cholesterol, and blood pressure in adults with pre-diabetes. About 60 people aged 45-80 will either follow the Mediterranean diet alone or add baked po…

This study looks at whether adding Pilates breathing or diaphragmatic breathing to moderate cycling can improve blood pressure, chest expansion, lung function, and quality of life in people with high blood pressure. About 45 adults aged 20–55 with stage 1 or 2 hypertension will b…

This pilot study is testing whether providing free produce boxes can improve health outcomes for Veterans with kidney disease who also face food or nutrition insecurity. The study will track changes in blood pressure and kidney function, and also interview participants about thei…

This study tests a new method for removing fluid during dialysis in people with kidney failure. Instead of standard care, doctors will use each patient's recent blood pressure patterns to decide how much fluid to remove. The goal is to lower the risk of dangerously low blood pres…

This study looks at whether continuing GLP-1 agonist drugs (like Ozempic or Wegovy) after weight-loss surgery helps people lose more weight and control blood sugar better than stopping them. About 150 adults with severe obesity will be randomly assigned to either keep taking the …

This study looks at whether a type of blood pressure medication called a mineralocorticoid receptor antagonist can improve blood flow in the small vessels of the heart and make the heart pump more efficiently. Researchers will compare it to a standard diuretic in 75 adults with h…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic health issues. The program offers health education, physical activity, and social support to help lower heart disease risk. Researchers will see if the program is practical …

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve heart health. Participants will either receive peer support and help finding community resources, or just basic health in…

This study tests whether a ketone supplement can reduce the harmful effects of a high-salt diet in adults aged 60-85. Researchers will measure changes in blood pressure, blood vessel function, and kidney health. The goal is to find a simple way to protect older adults from salt-r…

This study tests a 12-week program for Black women who have had breast cancer and also have high blood pressure or obesity. The program includes grocery delivery, cooking classes, and nutrition education to help them eat better and control blood pressure. The goal is to see if th…

This study tests whether a nose spray medication (dexmedetomidine) can help control blood pressure in elderly patients with high blood pressure who are having cataract surgery. About 126 people aged 65 and older will be randomly assigned to receive either the drug or a placebo be…

This study tests whether adding vicadrostat to the standard drug empagliflozin can lower the chance of heart problems or death in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo plus empa…

This study tests whether a telemedicine system can safely replace regular doctor visits for people whose high blood pressure is already well-controlled. About 364 participants will either use the telemedicine system or continue seeing their doctor every 16-18 weeks. The goal is t…

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe …

This study looks at whether taking blood pressure medication in the morning or evening can help restore the natural nighttime drop in blood pressure in people with obesity. Obese individuals often have high nighttime blood pressure, which raises their risk for heart problems. Res…

This study compares two different programs designed to reduce heart disease risk factors in Black women after pregnancy. Researchers will track changes in blood pressure and body weight at 6 weeks and 12 months after delivery. The goal is to find the best way to support heart hea…

This phase 3 study tests a once-daily pill called orforglipron in about 487 adults who have both high blood pressure and obesity or overweight. The goal is to see if the drug safely lowers blood pressure and helps with weight loss compared to a placebo. Participants will take the…

This study is testing whether getting healthy, DASH-diet groceries delivered to your home, along with help from a dietitian, can lower blood pressure in adults with hypertension. Researchers in Florida, Georgia, and Tennessee are looking for 150 participants with high blood press…

This study tests whether adding a specially trained doula to standard care helps new mothers with pregnancy-related high blood pressure improve their blood pressure one year after giving birth. About 454 women who had preeclampsia or similar conditions will be randomly assigned t…

This study looks at whether a structured clinical and medication management plan can improve heart health in adults with risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will track 220 patients in a regular cardiology clinic to see if this approa…

This study tests a program to help 800 adults in Africa control their high blood pressure. The program includes support for patients, healthcare providers, and the health system. The goal is to lower blood pressure and reduce the risk of heart disease, stroke, and kidney disease.

This study looks at how long new mothers with high blood pressure should monitor their blood pressure from home after giving birth. Researchers will compare a 2-week program with a 6-week program to see which leads to better blood pressure control at the 6-week checkup. About 400…

This study tests whether a single pill containing three blood pressure medications can quickly control resistant hypertension better than taking several separate pills. About 142 adults with hard-to-treat high blood pressure will be randomly assigned to either the triple-combinat…

This study tests a streamlined version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. The goal is to see if a faster approach works just as well as the standard method. About 130 adults with uncontrolle…

This study tests whether patiromer, a drug that lowers potassium, allows people with chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this reduces protein in the urine and lowers blood pressure, which c…

This study tests a program to help people with high blood pressure and high cholesterol lower their risk of heart disease. About 1,980 adults from Penn Medicine primary care will be assigned to either the program or usual care. The program uses tools and behavior change support t…

This study tests whether a combination of three drugs (THP-00101, THP-00102, and THP-00103) works better than taking just one or two of them for people with both type 2 diabetes and high blood pressure. About 221 adults will take the pills daily for 12 weeks. The goal is to see i…

This study looks at whether taking melatonin for 12 weeks can improve blood pressure in women going through menopause who also have high blood pressure. Researchers will measure nighttime blood pressure and markers of oxidative stress. The goal is to find a simple way to help con…

This early-stage study tests a new drug, KN060, for people with high blood pressure (hypertension). About 60 adults will receive either KN060 or a placebo by IV every two weeks for 12 weeks. The goal is to see if KN060 safely lowers blood pressure compared to placebo.

This study tests whether an upgraded smartphone app helps people follow their bariatric surgery plan better than the standard app. About 200 adults having weight-loss surgery will use either the regular or an enhanced version of the "Get Ready" app. Researchers will track weight …

This study looks at two ways to help people who have had a stroke lower their blood pressure. One way is checking blood pressure at home. The other adds group medical visits where people learn together. The goal is to see if combining both methods works better to prevent another …

This study looks at whether the drug eplerenone can improve blood flow to the heart better than another drug (chlorthalidone) in women who had preeclampsia during pregnancy and now have high blood pressure. About 90 women will take one of the two medications daily for 48 weeks. R…

This study tests a pharmacist-led program to help adults with uncontrolled high blood pressure in underserved Chicago communities. Over 3 months, a mobile team provides blood pressure checks, medication management, and health education. The goal is to lower blood pressure and imp…

This study tests whether combining remote blood pressure monitoring with support from community health workers helps Latinx patients better control their hypertension. About 300 adults with uncontrolled high blood pressure will be enrolled. The goal is to see if this approach low…

This study tests whether taking two medications together (JW0104 and C2402) is safe and effective for people with both high blood pressure and high cholesterol. About 162 adults will receive either the combo or a placebo. The goal is to see if the combo lowers blood pressure and …

This study is observing how well the drug dapagliflozin works and how safe it is for people with type 2 diabetes who also have high blood pressure. Researchers will track blood sugar and blood pressure control in 9,000 participants over time. The goal is to see if this medication…

This study tests whether taking one of two new single drugs (HL1113R1 or HL1113R2) works as well as a combination pill for people with both high blood pressure and type 2 diabetes. About 228 adults will join this Phase 3 trial to compare blood pressure and blood sugar control ove…

This study tests whether gentle shockwave therapy to the kidneys can help lower blood pressure and improve kidney function in people with chronic kidney disease and high blood pressure. 30 adults will receive either real or sham treatments over three weeks. The goal is to see if …

This study is tracking about 5000 people with high blood pressure who have a procedure called renal denervation, which uses energy to calm overactive kidney nerves. The goal is to see how safe and effective the procedure is over 1 to 5 years in real-world settings. Participants m…

This study checks how well the Withings BPM Pro 2, an automatic blood pressure monitor, works in pregnant women, including those with high blood pressure or pre-eclampsia. About 45 participants in their second or third trimester will have their readings compared to a standard dev…

This study looks at whether a new steroid-based blood test can more accurately identify a curable form of high blood pressure called primary aldosteronism. About 406 adults with high blood pressure will have their blood tested while continuing their usual medications. The goal is…

This study is testing whether using a smartwatch along with personalized digital health coaching can help people at risk for or with early-stage chronic conditions (like high blood pressure, prediabetes, or obesity) become more active and improve their health. About 1,700 adults …

This study looks at whether combining the MIND diet (a mix of the Mediterranean and DASH diets) with aerobic exercise can help prevent thinking and memory problems in Black adults ages 35-75 who have high blood pressure. Participants will either receive food delivery, cooking les…

This study tests whether combining graphic health warnings with personalized counseling from community pharmacists helps adults in Bangladesh and Pakistan quit smoking and prevent non-communicable diseases like high blood pressure. About 3,400 adult smokers will be randomly assig…

This study is testing whether helping older adults (70+) keep their blood pressure under control can prevent memory loss and dementia. Researchers will compare a special care program (with decision support and team-based care) to usual care in 4,000 participants. The goal is to s…

This study aims to reduce heart-related health problems in Detroit and Cleveland by using community health workers to help people manage high blood pressure and prevent heart failure. About 364 adults with high blood pressure or other heart risks will receive coaching and support…

This study tests whether applying gentle heat to the abdomen overnight can safely lower high blood pressure that occurs when lying down in people with autonomic failure. About 20 adults with conditions like Parkinson's or Multiple System Atrophy who have this nighttime blood pres…

This study tests whether a smartphone game that responds to physical activity can help Native American adults with high blood pressure move more and improve their health. About 220 participants will either get the game plus activity sensors or just the sensors alone. Researchers …

This study looks at whether exercising in the morning or early evening is better for lowering blood pressure and improving blood vessel health in postmenopausal women with high blood pressure. Researchers will measure changes in blood pressure and artery function over time. The g…

This study tests whether an 8-week program of supervised physical and mental exercises can improve daily function, thinking, and quality of life in adults with Long COVID who also have high blood pressure or diabetes. About 374 participants will be randomly assigned to either the…

This study looks at how a 20-week exercise program combining endurance and resistance training affects heart health, body composition, menopause symptoms, and quality of life in 60 physically active postmenopausal women. Participants will be assigned different exercise routines t…

This study looks at whether a beetroot supplement can help older women (ages 60-70) with high blood pressure during exercise. Researchers will measure blood pressure, muscle oxygen, and stress markers after taking the extract and doing aerobic exercise. The goal is to see if beet…

This study tests an 8-week mindfulness program designed for African American adults who have both high blood pressure and depression. Participants will learn stress management techniques like deep breathing and meditation in a group setting. Researchers want to see if the program…

This study tests if a telephone-based mindfulness program can help Black women with high blood pressure lower their numbers. Researchers will compare the mindfulness program to a support group. The goal is to see if learning to manage stress through mindfulness leads to better bl…

This early-stage study tests an experimental injection called LY3971297 in healthy volunteers and people with obesity and high blood pressure. The main goal is to check for side effects and see how the drug moves through the body. About 225 participants will be involved, with stu…

This study will use wearable digital patches to collect heart data from 5,000 adults with conditions like heart failure, high blood pressure, and heart valve disease. The goal is to observe how these conditions change over time for research purposes. Participants wear a sensor pa…

This study will measure blood pressure in over 22,000 children aged 5 to 18 across South Africa. The goal is to create the country's own normal blood pressure charts, since current guidelines are based on children from the US and Europe. This will help doctors correctly diagnose …

This study is testing a simple food questionnaire called EvalSel to see how well it measures salt intake in hospitalized patients with high blood pressure or kidney disease. Researchers will compare the questionnaire results with a 24-hour urine test, which is the standard way to…

This study is creating a biobank—a collection of DNA samples and health information—from 500 adults. Researchers will use this resource to study genetic links to heart disease, high blood pressure, diabetes, and obesity. The goal is to provide a valuable tool for future medical d…

This study looks at how blood flow to muscles changes as people age or have conditions like COPD, pulmonary hypertension, heart failure, or high blood pressure. Researchers will measure blood flow and blood pressure before and after exercise in healthy volunteers and patients. Th…

This study looks at whether pregnant women with high-risk conditions like diabetes or high blood pressure can use a home device to monitor their baby's health instead of going to the clinic. Fifty participants will try the device for 30 minutes, three times a week, starting at 32…

This early-phase study tests a new radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol in the adrenal glands using PET scans. It includes healthy volunteers whose hormones are temporarily changed, as well as people with known adrenal problem…

This study looks at sleep issues in healthy Somali Americans and how they might affect blood pressure. Researchers will measure sleep quality and blood pressure in 240 adults. The goal is to find hidden sleep problems that could raise hypertension risk.

This study looks at why people with rheumatoid arthritis (RA) often have trouble controlling high blood pressure, which raises their risk for heart disease. Researchers will work with 25 adults who have both conditions to test a program that helps them monitor their blood pressur…

This study looks at why some children with high blood pressure develop heart or kidney damage. Researchers will measure certain chemicals in the blood and urine of 125 children aged 7-18 with a new diagnosis of high blood pressure, as well as healthy children. The goal is to bett…

This study aims to find the genetic causes of primary aldosteronism—a condition where an adrenal gland tumor causes high blood pressure—in Black individuals. Researchers will study up to 1,150 participants, including those with hard-to-control blood pressure and their relatives. …

This study watches 220 adults aged 75 and older who have high blood pressure to see if brief drops in daytime blood pressure (below 90 mmHg) raise the risk of falls, hospital stays, heart problems, or death. Participants wear a 24-hour blood pressure monitor and are followed over…

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some people's blood pressure doesn't drop enough at night. The goal is to uncover mechanisms behind th…

This study looks at how high blood pressure, diabetes, and high cholesterol change the tiny blood vessels in the retina (the back of the eye). Researchers will use a special, non-invasive scan called OCTA to measure these changes over five years. The goal is to see if eye vessel …

This study looks at how a park-based afterschool program called Fit2Play affects children's physical fitness and mental health. Researchers will analyze data from about 5,000 kids to see changes in weight, blood pressure, fitness tests, and feelings of anxiety or depression. The …

This study aims to find the genes that cause high blood pressure in children and teens. Researchers will collect blood, urine, and other samples from 2300 people with or without the condition over up to 10 years. No treatments are tested; the goal is to understand the genetic cau…

This study follows 300 people having weight-loss (metabolic) surgery to see how their gut bacteria change and how that affects heart health and diabetes. Researchers collect stool, blood, and tissue samples before and up to 3 years after surgery. The goal is to learn which gut mi…

This study looks at whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cylindrical cuff on the upper arm in pregnant women. The goal is to improve diagnosis and management of high blood pressure during pregnancy, especia…

This study looks at why people with chronic conditions like high blood pressure, diabetes, and high cholesterol often struggle to adopt healthy behaviors, even when they know it's important. Researchers will test a program designed to boost motivation and help patients take charg…

This study aims to find out which hospitalized patients are more likely to experience side effects from a specific eye drop combination (tropicamide/phenylephrine) used to dilate the pupil before eye surgery. Researchers will monitor 1,000 patients before and after receiving the …

This study is enrolling 8,000 adults who are already getting a routine physical exam. Researchers will look at how a person's environment, genes, and proteins interact to find early clues for diseases like diabetes and high blood pressure. The goal is to create a better early war…

This study looks at how different blood pressure treatment targets (intensive vs. standard) affect artery stiffness in veterans over 60 with high blood pressure. Researchers will use a new, non-invasive method to measure artery stiffness and also analyze genetic factors. The goal…

This study tests a new radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol in the adrenal glands using PET scans. Six healthy adults will receive a tiny, non-treatment dose of the tracer and then be scanned. The goal is to improve imaging fo…

This study is testing a new MRI technique that uses a special substance called hyperpolarized pyruvate to take pictures of the heart's energy use. Researchers want to see if this method can show how the heart is working in people with high blood pressure, heart thickening, or hea…

This study looks at how early menopause (before age 45) affects the body's ability to control blood pressure. Researchers will measure nerve activity, heart rate, and blood pressure in 160 women aged 35-70. The goal is to understand why some women develop high blood pressure afte…

This study follows over 4,000 adults from Shanghai communities to track how heart, kidney, and metabolic diseases develop and change over time. Participants were first checked between 2016-2017 and will be re-assessed through 2035. The goal is to understand risk factors and impro…

This study will test if the Oura Ring's new algorithm can accurately identify signs of high blood pressure. Up to 2 million adults in the US who already use an Oura Ring will participate by sharing their health data. The goal is to see how well the ring can detect hypertension, n…

This study aims to uncover the genetic and lifestyle factors that contribute to type 2 diabetes in African populations, particularly the Yoruba people in Nigeria. Researchers will compare 300 people with diabetes to 300 without, using blood samples and health questionnaires. The …

This study looks at whether tailoring digital reminders and messages to each person can help them better manage their high blood pressure. Researchers will track 12,000 adults with uncontrolled hypertension to see if personalized outreach improves doctor visits, medication use, a…

This study looks at the diet, heart health, body composition, and mental well-being of 600 U.S. Army soldiers. Researchers will collect information through surveys, physical tests, and blood samples. The goal is to understand how nutrition and health affect soldier performance an…

This study looks at how blocking certain nerve signals for two weeks changes the way the body produces sugar in people with obesity and high blood pressure. Researchers will compare three treatments: a placebo, a blood pressure drug (amlodipine), and a nerve-blocking drug (moxoni…

This study looks at the connection between high blood pressure and obstructive sleep apnea (OSA) using heart rate variability (HRV), a simple measure of how your heart responds to stress. Researchers will monitor 100 adults with high blood pressure who are at risk for OSA using a…

This study tests whether a training session for hospital doctors can help them feel more confident when prescribing medications for older adults with diabetes and high blood pressure. About 150 doctors will attend a one-time educational session and complete surveys before and aft…

This study is enrolling 20,000 adults in Taining County, China, to better understand chronic diseases like high blood pressure, diabetes, and frailty. Researchers will collect health data and samples over three years to find patterns and risk factors. The goal is to create a bett…

This study observes 1,000 teens aged 12-17 in Miami-Dade County who join a park-based afterschool program. Researchers will track changes in mental health, physical fitness, and resilience over time. The goal is to understand if community park programs can improve overall well-be…

This study tests whether nurses using an AI tool can plan care as effectively as doctors for adults with high blood pressure, diabetes, fever, breathlessness, or muscle pain. About 672 patients in rural and semi-urban India will each see both a nurse with AI and a doctor, in rand…

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) to better serve Black women and birthing persons. Researchers will work with community groups and staff to identify barriers and helpful factors, and then test small changes. The goal is to improve …

This study looks at whether giving older adults (65+) with diabetes or high blood pressure written notes from their doctor visits, plus audio recordings, can improve their quality of life. About 1,022 participants will be randomly assigned to receive only written notes through a …

This study looks at whether adding a heart ultrasound to routine check-ups can help doctors better manage high blood pressure in young adults aged 18 to 40. Researchers will collect data from 750 participants during their regular clinic visits and follow them for up to 10 years. …

This study looks at how the body regulates blood pressure and heart rate in healthy adults and older adults with high blood pressure. Participants will undergo tests like standing up and exercising on a stationary bike while their heart activity and artery stiffness are measured.…

This study looks at whether telling people their genetic risk for high blood pressure helps them make healthier choices and lower their blood pressure. Researchers will give some participants their genetic risk score along with counseling, while others get standard care. The goal…

This study aims to improve health research participation among Black, Latino, and Native American communities in Colorado. Researchers will work with local organizations to address health issues like mental health, high blood pressure, and diabetes. About 1,500 adults aged 18-90 …

This study follows 1,000 adults aged 50 and older who take part in a park-based fitness program in Miami-Dade County. Researchers will measure changes in weight, blood pressure, arm and leg strength, and mobility over time. The goal is to see if community exercise programs can im…

This study will follow 30,000 people aged 60 and older in Qujiang, China, who have chronic heart conditions like high blood pressure, heart failure, or atrial fibrillation. Researchers want to see if a program combining medication, lifestyle advice, education, and regular check-u…

This study looks at whether a 12-week education and support program can help African American patients with advanced chronic kidney disease learn more about their condition and how to manage it. About 180 hospitalized adults will either receive the program or standard care. The g…

This study looks at whether obesity raises heart disease risk in African American men and women. Researchers will measure body fat, blood fats, and how well insulin works in 2000 healthy non-diabetic adults. The goal is to understand why heart disease risk factors may differ betw…

This study uses special high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand eye diseases. About 1,200 people with various eye conditions or healthy …

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. …

This study is following 2,500 adults in Puerto Rico, ages 30 to 75, to learn how stress, diet, and living environment affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years. The goal is to gui…

This study looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel problems later in life. Researchers will use MRI scans to measure heart structure in 200 women who gave birth 10 to 25 years ago. The goal is to better und…

This study aims to learn how the body responds to kidney nerve stimulation in people with high blood pressure. Researchers will measure these responses before and after a procedure that quiets certain kidney nerves. About 19 adults with hypertension will take part. The goal is to…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This study looks at whether taking a single 1 mg dose of dexamethasone at bedtime can make screening for primary aldosteronism more accurate in people already taking blood pressure medications. Primary aldosteronism is a condition where the adrenal gland makes too much aldosteron…

This study looks at whether screening for social needs (like housing or food) with a focus on antiracism can help reduce chronic diseases such as high blood pressure, diabetes, and asthma. About 68,000 adults and children in primary care will take part. The goal is to see if this…

This study compares a new cuff-less wrist wearable (ViTrack) to standard blood pressure cuffs in 91 healthy adults with normal or high blood pressure. The goal is to see if the wrist device measures blood pressure accurately. Researchers will also check for skin irritation from t…

This study follows 50 people who have had a stroke and at least one risk factor like high blood pressure or diabetes. Researchers use repeated MRI scans over 15 months to watch how small blood vessel damage in the brain gets worse. The goal is to learn more about how this damage …

This study looks at whether two types of strength training can help older adults (60+) with high blood pressure improve their heart health, mental well-being, and physical fitness. Sixty participants will be randomly assigned to either dynamic or isometric strength training for s…

This study will collect information from HeartMate 3 heart pumps in 150 adults to see if pump data can predict problems like bleeding, infection, or frailty. Researchers want to understand how pump readings relate to patients' quality of life and health outcomes. The goal is to h…

This study will look at health records from 15,000 adults with high blood pressure in Brazil's public health system. The goal is to understand how doctors treat the condition and whether they adjust medications when blood pressure stays high. No new treatments are being tested; i…

This study looks at 500 women who recently gave birth—250 with preeclampsia and 250 without—to see if exercise stress tests can spot early signs of heart failure with preserved ejection fraction (HFpEF). Researchers will track heart function and blood markers over a year. The goa…

This study looks at 100 living kidney donors to see if the amount of fat around the kidney (called PRAT) is linked to worse blood pressure and kidney function after donation. Researchers will compare donors with high and low PRAT by testing blood, urine, and fat samples. The goal…

This study looks at how three common blood pressure medications (beta-blockers, ACE inhibitors, and calcium channel blockers) affect balance and fall risk in adults newly diagnosed with high blood pressure. About 186 participants will be randomly assigned to one of the three drug…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…