HYPERTENSION

This study tests a system where doctors get easy-to-read reports from patients' wearable fitness trackers. The goal is to help doctors counsel patients with high blood pressure to increase their physical activity. About 330 patients and their doctors will take part. The study wil…

This study tests a new way to help Black and Hispanic women control high blood pressure by bringing health services right into beauty salons. Hair stylists will be trained to check blood pressure, and participants will get home monitoring, coaching, and pharmacist support. The go…

This early-stage study tests a single injection of a new drug, IBI3016, in 30 Chinese adults with mild to moderate hypertension. The main goal is to check safety and how the drug moves through the body, while also watching for any changes in blood pressure. Participants must not …

This study tests whether providing healthy foods and cooking lessons can help adults with high blood pressure and obesity lower their blood pressure and lose weight. About 150 participants will either receive the food program or standard care for 24 weeks. The goal is to see if t…

This study looks at whether a special clinic with heart, kidney, diabetes, and liver doctors working together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either us…

This study tests a drug called osilodrostat in 63 adults with Cushing's syndrome who also have high blood pressure. The goal is to see if the drug can safely lower both cortisol levels and blood pressure over 30 weeks. Participants will receive either the drug or a placebo, and b…

This study tests whether a pharmacist can help patients and their doctors switch to a single pill that combines multiple blood pressure medicines. The goal is to make it easier for people to take their medication and lower their blood pressure. About 720 adults with high blood pr…

This study tests a community-based program to help adults with high blood pressure in rural Bangladesh. About 480 people will take part in group classes, one-on-one counseling, and regular check-ins led by health workers. The goal is to see if this approach can lower blood pressu…

This study tests two types of progestin-only birth control pills (drospirenone and norethindrone) to see which one helps control high blood pressure better in women who had preeclampsia during pregnancy. About 50 participants will take one of the pills for 6 weeks after leaving t…

This study tests a new way to manage care for older adults (ages 60-74) who have both high blood pressure and type 2 diabetes in rural China. About 960 people from community health centers will either receive the new integrated care package or continue with standard care. The goa…

This study tests whether regular phone counseling can help adults with high blood pressure improve their self-care, such as taking medication correctly, eating well, and staying active. About 320 patients in Ethiopia will either receive usual care or get 10-15 minute phone sessio…

This study tests whether Songling Xuemaikang capsules can help control cerebral small vessel disease (CSVD), a condition where tiny blood vessels in the brain get damaged over time, often linked to high blood pressure. Researchers will enroll 90 adults aged 55-75 with high blood …

This study tests if a smartphone-based stress management program can help Black men with high blood pressure lower their numbers. About 135 men will use either a special text-and-video program or a standard online course for 3 months. Researchers will check blood pressure and str…

This pilot study tests a new, non-invasive brain stimulation technique called temporal interference stimulation to see if it can safely help regulate blood pressure. Researchers will enroll 25 adults with either mild untreated hypertension or hard-to-control hypertension. The goa…

This study tests whether a special tool in the electronic medical record helps doctors make better treatment decisions for patients with uncontrolled high blood pressure. About 168 adults with high blood pressure who are already on medication will take part. Their blood pressure …

This study tests a procedure called renal denervation (RDN) that uses energy to calm overactive kidney nerves, which can raise blood pressure. Researchers want to see if it safely lowers diastolic blood pressure (the bottom number) in people with isolated diastolic hypertension w…

This study tests if a non-invasive light treatment called vascular photobiomodulation can improve blood pressure and blood vessel health in people with hypertension who are already taking the medication losartan. Eighty adults aged 18-65 will receive either the active light treat…

This study looks at whether giving blood pressure medicine (enalapril) to women who had preeclampsia or high blood pressure during pregnancy can help their heart health after childbirth. Researchers will enroll 60 postpartum women to see if they are willing to take the medicine a…

This study will give 150 children with high blood pressure, high cholesterol, or obesity a prepaid card to buy fruits and vegetables, plus virtual nutrition classes. The goal is to see if this program improves their eating habits and heart health over 6 to 12 months. Participants…

This study tests whether choosing blood pressure medication based on a person's unique heart function (called hemodynamic phenotyping) works better than the usual guideline-based approach. About 240 adults with mild to moderate high blood pressure who have never taken medication …

This study tests if a short digital education program (videos, brochures, podcasts) can help 166 adults aged 50+ with high blood pressure improve their self-care and health literacy. Participants will attend two sessions over two weeks. The goal is to see if using digital tools h…

This study tests whether giving people with high blood pressure personalized advice based on their daily habits helps lower blood pressure more than standard guidance. About 64 adults aged 18-65 with high blood pressure will be split into two groups: one gets routine advice, the …

This study tests a device that uses radiofrequency energy to calm overactive nerves in the lung arteries of people with heart failure and a specific type of high blood pressure in the lungs. About 750 adults who are stable on heart failure medications will either get the procedur…

This study tests whether a simple, non-invasive treatment called remote ischemic conditioning (RIC) can help lower blood pressure in people who moved to high-altitude areas. 184 adults with hypertension who have lived above 2500 meters for over 6 months will either take standard …

This study will test if a program called 'Eat Well' helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will check if their blood pres…

This study tests a digital tool called "Smart family doctor" that uses artificial intelligence to help patients manage their blood pressure, blood sugar, and cholesterol after heart surgery or stent placement. About 951 adults who have had bypass surgery or a stent and also have …

This study tests whether an AI-powered tool can help community doctors improve control of high blood pressure, diabetes, and high cholesterol in 6,800 adults. Participants will be randomly assigned to either AI-assisted care or usual care. The goal is to see if the AI helps more …

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The program includes digital tools, personalized guidance, and ongoing support. Researchers will compare it…

This study will give 4,450 low-income adults with diabetes or hypertension a monthly food card benefit of either $80 or $120. Researchers want to see if the extra grocery support helps reduce food insecurity and improves key health measures like blood sugar and blood pressure. Pa…

This study tests whether a mobile app that tracks blood pressure readings and provides feedback can help people with hypertension better control their condition. About 40 adults with high blood pressure will either use the app or standard monitoring for 3 months. The goal is to s…

This study tests if a personalized blood test can help doctors pick the best blood pressure medication for each patient. About 400 adults with high blood pressure will join. The test measures natural chemicals in the blood and uses a computer program to guide treatment choices, a…

This study tests a technology-based program to help women with high blood pressure get their numbers under control before pregnancy. About 350 women aged 18-44 who get care at community health centers will use remote blood pressure monitoring and medication support. The goal is t…

This study will test a community-based program that combines exercise training and lifestyle changes to help people with high blood pressure, high blood sugar, or high cholesterol. About 1000 adults will take part to see if the program can improve heart and lung function and musc…

This study tests a new medicine called TCA108 for people whose high blood pressure is not controlled by current treatments. About 400 adults aged 18 and older will take the drug or a placebo for 10 weeks to see if it safely lowers blood pressure. The goal is to help more people r…

This study tests a 12-month app-based program with a health coach and wearable device to see if it can reduce scarring in the heart muscle caused by long-term high blood pressure. Researchers will enroll 200 adults aged 40-70 who have an enlarged heart but no history of heart att…

This study tests whether a supplement called Nigella sativa (Nisatol®) can lower blood pressure in women with borderline high readings or a specific nighttime blood pressure pattern. About 106 women will take either the supplement or a placebo for 12 weeks, with follow-up diet ch…

This study tests a workplace-based program to help adults aged 18-60 with newly diagnosed high blood pressure. About 512 participants will either get the special program or standard workplace health management. The goal is to see if the program improves blood pressure and healthy…

This study tests a program called iTHRIVE for 100 Black and Hispanic adults with high blood pressure and related conditions like diabetes. Participants get access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor. The goal is to see if these too…

This study will test a new way to manage heart disease risk using a digital, nurse-led remote monitoring program. About 750 adults with heart disease or related conditions will use the program as part of their regular care. Researchers will check if more patients reach healthy ch…

This study looks at whether using a low sodium salt substitute is safe for adults with high blood pressure who are already on medication. About 607 people in Bangladesh will replace regular salt with the substitute and be monitored for changes in potassium levels and blood pressu…

This early-stage study tests whether a daily probiotic (Bifidobacterium) can reduce blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 12 weeks and have their blood pressure measured at the clinic. The goal is to …

This study tests whether covered stents work better than bare metal stents for people with narrowed kidney arteries caused by plaque buildup. About 150 participants will be randomly assigned to receive one of the two stents and will be followed for 12 months. The goal is to see w…

This study tests a new medicine called VCT220 for people with high blood pressure who are also overweight or obese. About 160 adults will take either the drug or a placebo for 20 weeks to see if it safely lowers blood pressure. The goal is to find a better treatment option for th…

This study tests whether group care—where patients meet together with a healthcare provider for education and check-ups—can help control high blood pressure and diabetes better than standard one-on-one visits. About 1,110 adults in Nepal will take part, with some receiving group …

This study will test whether a combination of nifedipine and enalapril controls high blood pressure after childbirth better than nifedipine and labetalol. About 200 women with persistent postpartum hypertension will be enrolled. The goal is to see which combo reduces complication…

This study tests whether a combination drug (sacubitril/allisartan) works better than the standard medicine amlodipine for lowering blood pressure in overweight or obese adults with high blood pressure. About 104 participants will take one of the two medicines for 8 weeks, and do…

This study tests an investigational drug called IBI3016 for people with mild to moderate high blood pressure. The drug is given as an injection under the skin every 3 or 6 months, aiming to lower blood pressure more conveniently than daily pills. The trial will compare different …

This study tests a program called Primary Care Connect (PC2) for cancer survivors who also have heart-related conditions like high blood pressure, diabetes, or high cholesterol. The goal is to see if the program helps them stay connected to their primary care doctor and better ma…

This study will check if a newer blood pressure medicine called ARNi works better than standard treatments in adults with high blood pressure living in the United Arab Emirates. About 500 people will take either ARNi or a standard drug for up to 12 weeks. The main goal is to see …

This study tests a community-based exercise program for adults aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, or arthritis. The goal is to see if personalized exercise can improve heart and muscle fitness, mobility, and overall well-b…

This small pilot study will test whether a pharmacist-led program to manage high blood pressure and high cholesterol can help protect brain health in 10 people aged 50-75 who carry the APOE ε4 gene, a known risk factor for dementia. Participants will take standard medications (AR…

This study will test if a 1-3 minute facial scan using artificial intelligence can accurately measure health indicators like heart rate, blood pressure, blood sugar, and even stress levels. Researchers will compare the scan results with standard medical tests in 1000 adults livin…

This study tests a wrist-worn device that measures blood pressure and pulse over a week. About 200 adults aged 22 to 59 will wear the device and have their readings compared to standard arm-cuff measurements. The goal is to see how accurate and safe the device is for everyday use…

This study tests whether a powder containing potassium, magnesium, and citrate (taken in water) can help prevent or treat high blood pressure in African Americans. About 45 African American adults with slightly elevated blood pressure will take the supplement or a placebo for sev…

This study looks at whether a single dose of beetroot juice can improve how the heart and blood vessels respond to and recover from exercise in adults with type 2 diabetes. About 20 people aged 40–65 will drink either beetroot juice or a placebo before light cycling. Researchers …

This study looks at whether combining the Mediterranean diet with intermittent fasting can lower blood pressure in people newly diagnosed with hypertension. About 48 adults aged 40-65 with high blood pressure and a healthy weight will be assigned to different diet plans. Research…

This study explores whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Researchers will measure blood pressure changes in 60 adults aged 18 to 65. The goal is to see if this gentle, non-invasive treatment can hel…

This study tests whether laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic problems. 35 adults with at least two related conditions (like high blood pressure, diabetes, or chroni…

This early-stage study looks at how three experimental drugs (AD-231A, AD-231B, and AD-231C) interact in the body. It involves 55 healthy adults aged 19 to 64. The goal is to measure drug levels and check safety, not to treat any disease.

This study collects basic health information like blood pressure, heart rhythm, and heart rate from 50 adults aged 18 to 64. The goal is to use this data to create a device that can monitor blood pressure continuously without needles or cuffs. Participants will have their vitals …

This study aims to collect health information and blood samples from 15,000 adults aged 40-70 over time. Researchers will use artificial intelligence to analyze molecular patterns in the blood to find early signs of diseases like heart disease, diabetes, cancer, and lung disease.…

This study looks at how changes in blood pressure during sleep (called dipping) relate to heart electrical activity in 140 adults with high blood pressure. Researchers will compare people whose blood pressure drops normally at night to those whose does not, to see if non-dippers …

This study looks at how to help VA medical centers better serve women Veterans, especially those in midlife. Researchers will test two different strategies to get more women involved in programs for heart health, weight management, and stress. The study involves 18 VA sites and f…

This study looks at how drinking coffee versus hibiscus tea affects blood pressure and heart rate in people who sit for long periods. Thirty healthy adults (15 men, 15 women) will try both drinks on different days. The goal is to learn which beverage may be better for heart healt…

This study looks at how metabolic health, artery stiffness, and daily blood pressure changes are connected in adults. Researchers will measure artery stiffness and use routine blood tests to calculate a simple score that reflects insulin resistance. The goal is to find better way…

This study tests a new tool that helps doctors and cancer survivors decide together on the best heart-protecting medications and heart scans. About 60 adult cancer survivors who have not yet seen a heart specialist will take part. The goal is to see if the tool is easy to use and…

This study looks at whether different types of exercise (like walking or strength training) done at different times of day can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure an…

This pilot study tests whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation. The study will enroll 60 people, including those with hard-to-control blood pressure, t…

This study looks at how clinics can better identify physically inactive patients and refer them to community-based exercise programs. Researchers will track how many patients get referred and whether a 12-week program improves their activity levels and health. The goal is to make…

This study will test a new device called the Hilo band, which uses light to measure blood pressure continuously over 24 hours. About 330 adults with high blood pressure will wear the Hilo band along with a standard arm cuff monitor. The goal is to see if the new band is comfortab…

This study compares three methods of measuring pulse wave velocity, a key indicator of artery stiffness and heart risk. Researchers will enroll 350 adults with high or suspected high blood pressure. Participants will have measurements taken with a neck/groin sensor, a blood-press…

This early-stage study will test a new experimental drug called AD-231 in 60 healthy adults aged 19 to 64. The goal is to see how the body processes the drug and whether it is safe when taken as a single pill versus taking its components separately. Participants will receive a si…

This study looks at how everyday mouthwashes change the natural balance of bacteria in your mouth and whether that affects your heart health. Researchers will test several over-the-counter mouthwashes in 200 adults, some with gum disease and some without. The goal is to find out …

This study tests a method called 'audit and feedback' to help primary care providers follow best practices for high blood pressure and diabetes. Researchers will give some providers reports on how well they are doing and compare their care to providers who get no feedback. The go…

This large observational study will follow 100,000 elderly Chinese adults to see how conditions like diabetes, high blood pressure, and high cholesterol impact kidney disease and overall health. Participants will provide blood and urine samples and be tracked over time through cl…

This study looks at how two different exercise programs—moderate steady walking versus short bursts of brisk walking—affect heart health and inflammation in women with obesity and high blood pressure. Researchers will measure a protein called Sestrin-2, which may help control inf…

This early-stage study tests whether a new tablet that combines two medicines (for type 2 diabetes and high blood pressure) works as well as taking the two medicines separately. Healthy adult volunteers will receive single doses of each version in a random order, and researchers …

This study tests a new camera technology that measures heart rate and blood pressure from a short video of your face. Researchers will compare these readings to standard medical tests in 300 adults in Jakarta. If accurate, this could make heart disease screening easier and more a…

This study aims to find better ways to help people living with HIV who also have high blood pressure take their blood pressure medications regularly. Researchers will interview patients and providers to identify barriers, then test a nurse-supported program. The goal is to improv…

This study looks at how a 12-week cardiac rehabilitation exercise program affects the hearts of 42 adults with high blood pressure who don't currently exercise. Participants will have heart scans, fitness tests, and blood draws before and after the program. The goal is to find pr…

This study looks at people whose high blood pressure remains high despite taking at least two medications. Over three months, researchers will track changes in blood pressure and other health markers. The goal is to find which patients are most likely to benefit from newer, fourt…

This study looks at 40 mothers and their babies to see if mindfulness training during pregnancy helps them handle stress better together. Researchers will measure heart rate and breathing patterns during a lab stress task when babies are 6 months old. They want to know if better …

This study tests whether community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. CHWs will work one-on-one with participants to create personalized health plans and teach …

This study will screen over 7,000 adults aged 40 and older living in affordable housing in New York City for undiagnosed or uncontrolled high blood pressure and glaucoma. Participants will receive free screenings and be referred to follow-up care. The goal is to see if a virtual …

This early-stage study will test two experimental drugs, AD-2321 and AD-2322, in 41 healthy adults aged 19 to 64. The goal is to see how the drugs interact in the body and whether they are safe. Participants will take both drugs in a set order, and researchers will measure drug l…

This study will examine 100 adults on hemodialysis to see how traditional heart risk factors (like high blood pressure and diabetes) and dialysis-specific factors (like treatment length) relate to the thickness of the carotid artery wall. The goal is to better understand why hear…

This project, based on King's Goal Achievement Theory, aims to develop a mobile application for individuals over 18 years of age diagnosed with hypertension. The project comprises the stages of educational content creation, mobile application design, implementation, and effective…