HYPERTENSION

This study tests whether gamification—using game-like elements and social rewards—can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their d…

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study tests a program to help adults aged 35 and older in rural Pakistan better control their high blood pressure. Participants receive home health education, regular blood pressure checks, and referrals to doctors if needed. The goal is to see if this approach works when us…

This study looks at whether eating wild blueberries can lower blood pressure and improve blood vessel health in men and postmenopausal women aged 45-70 who have slightly high blood pressure. Researchers will measure changes in artery function and stiffness. The goal is to find a …

This study tests a new device that uses radiofrequency energy to calm overactive nerves in the kidneys, which may help lower blood pressure. It is for adults aged 18-65 with uncontrolled high blood pressure and chronic kidney disease who are already on at least two blood pressure…

This study aims to improve blood pressure control among a diverse group of patients in Los Angeles County. Researchers will compare three approaches: training healthcare providers, educating patients with culturally tailored materials, and usual care. About 540 adults with high b…

This study looks at whether exercise, cognitive training, or both can improve the physical and mental abilities of adults aged 60 and older who have had a stroke and also have high blood pressure or diabetes. About 444 participants from community health centers in five Chinese ci…

This study tests a program that combines home blood pressure monitoring with support from community health workers to help adults at risk for high blood pressure. About 600 adults with slightly elevated blood pressure will either get a home monitor and usual care, or the full pro…

This study compares two ways to lose weight and reduce liver damage in people with cardiometabolic risks like type 2 diabetes or obesity. One group will follow a Mediterranean diet with intermittent fasting, while the other group takes a weight-loss medication (naltrexone/bupropi…

This study tests whether delivering DASH-diet groceries to the homes of Black adults with high blood pressure can help lower their blood pressure. Participants live in Boston-area neighborhoods with limited access to healthy food. The goal is to see if better food access can impr…

This study looks at whether using a cuffless blood pressure monitor (CART BP Pro) can help manage high blood pressure better than usual care in Korean adults whose blood pressure is not well controlled. About 288 participants will either use the device to guide their treatment or…

This early-stage study tests a new medicine called ADX-850 in 28 adults with mild to moderate high blood pressure. The main goal is to check if the drug is safe and how the body processes it. Researchers will also measure changes in blood pressure over time.

This study tests a program where HIV nurses are trained to also manage high blood pressure in their patients. About 830 adults with HIV and uncontrolled high blood pressure from 30 clinics in Lagos, Nigeria will take part. The goal is to see if this approach helps lower blood pre…

This study looks at whether having a cancer survivor's regular doctor work closely with their cancer team can better manage heart-related conditions like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers (like breast, prostate, or lung) an…

This study looks at different ways to help people from racially and ethnically diverse groups monitor their blood pressure at home. The goal is to see which methods work best to safely and fairly improve blood pressure control. About 330 adults with high blood pressure who get ca…

This study looks at whether a smartphone app called OptiZ can help people with high blood pressure get better control of their condition. The app helps patients track their blood pressure, remember to take their medication, and report side effects to their doctor, who can then ad…

This study looks at the long-term safety and effectiveness of a drug called lorundrostat for people with high blood pressure. About 1,076 adults who completed a previous lorundrostat study will take the drug for up to 36 weeks. The goal is to see if it keeps blood pressure under …

This study tests a digital app called COACH that helps patients with high blood pressure track their readings at home and share them with their doctor. The goal is to see if using the app leads to better blood pressure control compared to usual care. About 550 adults from primary…

This study tests whether a home blood pressure monitoring program helps people with high blood pressure get it under control. About 24,000 adults from primary care clinics will use home monitors and receive support. The goal is to see if this approach lowers blood pressure over 1…

This study looks at whether treating people with conditions like heart failure, infections, or diabetes at home (instead of in the hospital) can lead to better health and happier patients. About 9,600 adults will take part, receiving hospital-level care in their own homes. Resear…

This study tests a procedure called renal denervation, where a small amount of alcohol is injected into the nerves around the kidneys to lower blood pressure. About 142 adults with high blood pressure will stop their usual medications and receive either the real procedure or a fa…

This study tests a community program to help 700 adults in a large Vietnamese city better control their high blood pressure. Participants will receive support from community health workers and watch storytelling videos about managing hypertension. The goal is to see if these tool…

This study tests whether giving stroke patients a more thorough exam—looking at hidden causes like artery stiffness, 24-hour blood pressure, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people admitted to a Swedish hospital for st…

This study tests a smartphone app called MED-AD to see if it helps people with heart disease take their medications as prescribed. About 1000 adults in Oman will either use the app, get daily text reminders, or receive standard care. The goal is to improve medication adherence an…

This study tests whether a nurse-led program can help women aged 45-64 in Hong Kong better manage their health and use medical resources wisely. Over 1,700 participants will either receive personalized nurse guidance or general health advice. The goal is to improve health confide…

This study looks at how exercise affects blood pressure and gut bacteria in African Americans, who often have high blood pressure and poor gut health. Researchers will measure changes in blood pressure and gut microbes in 36 sedentary adults aged 30-50. The goal is to see if exer…

This study looks at whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) who also have high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The main goal…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. About 25 participants, at least 3 months post-transplant, will follow a plant-based diet for 16 weeks. Researchers will track c…

This study tests whether a simple treatment program led by village doctors can help control high blood pressure in rural China. Over 34,000 adults aged 40 and older with high blood pressure are taking part. The program focuses on lowering blood pressure to reduce the risk of hear…

This study tests whether checking blood pressure at home and talking to a pharmacist by phone each week can help manage high blood pressure after an ER visit. Twenty-four adults will take part, with half using the telehealth program and half getting usual care. The program lasts …

This study looks at whether sending doctors monthly feedback comparing their performance to peers can improve how they manage patients with high blood pressure. About 93 primary care providers and their patients are involved. The goal is to see if this feedback leads to more pres…

This study tests two programs—mindfulness exercises and a heart-healthy diet plan—to help Black women aged 40+ who care for a family member with Alzheimer's. Participants will learn stress-reduction techniques and healthy eating to lower blood pressure. The goal is to improve bot…

This study tests whether women with high blood pressure can better control it by checking their BP at home and sharing readings with a pharmacist every 4 weeks. About 368 women will either receive a home monitor plus pharmacist follow-up or usual pharmacy care. The goal is to see…

This study tests whether virtual group visits can help adults with type 2 diabetes and related heart conditions better manage their health. About 720 participants will join online group sessions led by healthcare providers. The main goal is to see if these visits lower blood suga…

This study tests a digital care program for adults aged 50 and older with type 2 diabetes and at least one other chronic condition like high blood pressure or kidney disease. The program combines online tools, in-person classes, phone support, and home visits to help people bette…

This study looks at how well the drug benidipine controls blood pressure and reduces chest pain in 800 adults (ages 18-80) with high blood pressure or chronic coronary syndrome. Participants are already taking benidipine and will continue under their doctor's care. The goal is to…

This study looks at whether helping adults with type 2 diabetes and high blood pressure or high cholesterol meet their social needs (like food, housing, or transportation) can improve their health. About 4,800 participants will be screened during clinic visits and offered support…

This study tests whether a time-efficient breathing exercise program can help lower blood pressure in adults aged 50 and older who have moderate to severe sleep apnea but cannot use standard CPAP therapy. Researchers will measure blood pressure changes over 36 weeks. The goal is …

This study tests whether a telehealth coaching program led by community health workers can help South Asian patients better control their diabetes and high blood pressure. About 450 adults with both conditions will either receive the coaching or usual care. The main goal is to se…

This study looks at whether a treatment tailored to a specific gene (LSD1) can better control blood pressure and protect the kidneys in Black adults with hypertension. About 300 participants who carry a certain gene variant will follow a controlled diet and receive therapy for 4 …

This study looks at the long-term safety of a drug called ralinepag for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug is …

This study tests whether a time-saving, joint-friendly training method called whole-body electromyostimulation (WB-EMS) can lower resting blood pressure and improve other heart-related risk factors in people with mild hypertension who are overweight. About 28 participants will un…

This study looks at a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys, to help lower blood pressure in people whose hypertension is not controlled by medication. About 1,900 adults with high blood pressure are taking part. The goal i…

This study looks at whether helping people with high blood pressure or prehypertension sleep longer (at least 7 hours a night) can lower their blood pressure. About 110 adults who currently sleep 6.5 hours or less will either receive sleep coaching or general health education for…

This study tests a personalized mobile health program (iTAB-CV + Self-Monitoring) to help people with bipolar disorder or major depression stick to their blood pressure medications. 176 participants will be randomly assigned to use the app plus self-monitoring, or self-monitoring…

This study compares different strategies to help people with high blood pressure get their numbers under control. Researchers will test patient-focused and clinic-focused approaches using remote monitoring. About 2,500 English- and Spanish-speaking adults with hypertension will t…

This study tests a mobile health system called mGlide to help people with uncontrolled high blood pressure. About 395 stroke survivors and others at high risk for heart disease will use a wireless blood pressure monitor and smartphone to send daily readings to their healthcare te…

This study tests a device that uses ultrasound to calm overactive nerves in the kidneys, which can help lower blood pressure. About 282 adults with high blood pressure took part. The goal was to see if the device works better than a fake procedure (sham) to safely reduce blood pr…

This study looks at how the timing of meals and sleep patterns impact blood sugar control, heart disease risk, and weight loss in adults with type 2 diabetes, high blood pressure, or obesity. Researchers will provide nutritional guidance and track changes in weight, blood tests, …

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits. About 49 adults who had a kidney transplant in the past year and have high blood pressure, hi…

This study tests whether providing home-delivered DASH diet groceries (low salt, rich in fruits and veggies) can lower blood pressure in Black adults who live in Boston-area food deserts and have mildly elevated blood pressure but are not on medication. About 150 participants wil…

This study tests whether colchicine, a common anti-inflammatory drug, can improve blood vessel stiffness and heart function in 150 adults with high blood pressure who also have diabetes, high cholesterol, or take multiple blood pressure medications. Participants take colchicine o…

This study looks at two ways of doing peritoneal dialysis (a treatment for kidney failure) in 100 new patients. One method uses a standard full dose, while the other uses a smaller, tailored dose based on how much kidney function remains. The goal is to see which approach better …

This study tests whether a smartphone app called Elfie can help people with high blood pressure lower their numbers better than standard care. About 930 adults with uncontrolled hypertension who already take at least one blood pressure pill will use the app to improve medication …

This study is tracking 1,000 people with high blood pressure that is hard to control with medication or who cannot tolerate blood pressure drugs. The treatment uses a special catheter to deliver radiofrequency energy to nerves in the kidney arteries, which can help lower blood pr…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, diabetes, or high blood pressure. Participants use a tablet and fitness tracker at home, and some get extra support from a coach by video or …

This study tests a device that uses ultrasound to calm overactive kidney nerves, which can help lower blood pressure. About 154 adults with high blood pressure who are already taking two medications will receive either the ultrasound treatment or a fake procedure. The goal is to …

This study aimed to see if telling surgery patients about their high blood pressure would lead to a formal diagnosis of hypertension. Researchers planned to follow up with 108 adults who had elevated blood pressure but no prior diagnosis. However, the study was withdrawn before e…

This study tests if portable devices like handheld ultrasound and blood glucose monitors can find chronic diseases such as diabetes, heart disease, and kidney disease earlier than standard care. About 200 adults aged 18 to 75 will use these devices or receive usual care for 6 mon…

This study looks at whether helping families switch to cleaner cookstoves can reduce indoor air pollution and prevent high blood pressure. About 1,280 households in Nigeria will either receive community support to adopt the stoves or just get information on their own. Researchers…

This study looks at whether taking vitamin D and omega-3 (fish oil) supplements can prevent high blood pressure in healthy adults. Over 25,000 men and women without prior high blood pressure are taking daily supplements or placebos for several years. Researchers will measure chan…

This study tests whether personalized counseling can help prevent high blood pressure in adults living in Dhaka slums. About 1700 healthy participants will receive 20 counseling sessions focused on exercise, diet, and avoiding tobacco and alcohol. The goal is to see if these talk…

This study tests a culturally tailored program to help Latinx and Vietnamese families in Santa Ana, CA, improve their heart health and prevent high blood pressure. About 483 participants will work with community health workers to set healthy goals, improve communication with doct…

This study tests whether berberine, a natural compound, can prevent heart disease and diabetes in over 2000 adults with high cardiometabolic risk (prediabetes, obesity, high blood pressure, or existing heart disease). Participants take berberine or a placebo for one year, and res…

This study tests whether a mobile health unit program can help Black adults in Detroit lower their blood pressure and prevent stage 2 hypertension. Participants receive personalized lifestyle coaching from community health workers. The goal is to address social barriers like food…

This study tests a program to prevent high blood pressure in 528 rural Black adults in Alabama who have higher-than-normal blood pressure but not yet high enough for medication. Participants from 30 churches will either get group health education and online resources, or the same…

This study looks at whether a powder made from haskap berries can help lower blood pressure and improve alertness in women aged 35 and older. Thirty-two women with slightly high blood pressure will take either the berry powder or a placebo for six weeks, then switch after a break…

This study tests two local anesthetics (articaine with epinephrine vs. mepivacaine without epinephrine) in 60 adults with controlled high blood pressure who need a single upper tooth pulled. The goal is to see which drug provides better pain control and causes fewer changes in bl…

This study tests whether using game-like rewards and personal coaching can help older adults (50+) become more active after leaving the hospital. About 350 participants with conditions like high blood pressure or heart failure will wear a Fitbit to track steps. The goal is to see…

This study tests whether a virtual reality (VR) program can help Black women cope with stress and improve heart health. About 60 Black women with high blood pressure will use VR and report changes in stress, sleep, and blood pressure. The goal is to see if VR is a practical and h…

This study tests whether a non-invasive brain stimulation technique called TMS can help lower blood pressure and reduce PTSD symptoms in women aged 18-44 who have both conditions. Thirty participants will receive TMS and have their blood pressure monitored for 24 hours. The goal …

This study looks at whether a medication used for heart failure can also help people with type 2 diabetes or pre-diabetes. The drug blocks an enzyme that breaks down hormones, possibly increasing a hormone called GLP-1 that helps release insulin after meals. Researchers will meas…

This study looks at how sleep and your body's internal clock affect your blood pressure at night. Researchers will measure melatonin, body temperature, and blood pressure in 1,427 adults. No treatment is given—the goal is simply to learn more about these connections.

This study checks blood pressure in 60 children and teens (ages 6-18) with type 1 diabetes to see how many have pre-hypertension and what factors might be involved. Researchers will measure blood pressure carefully on multiple visits. The goal is to better understand this early w…

This study looks at people with high blood pressure whose levels don't naturally dip during sleep, a condition linked to worse health outcomes. Researchers will use wearable devices and smartphone apps to track blood pressure patterns over time. The goal is to better understand t…

This study follows over 31,000 adults aged 45 and older to understand how being overweight or having high blood pressure increases the risk of heart problems like heart attacks and strokes. Researchers will track participants until 2026, recording major heart events. No treatment…

This study looks at a specific genetic variant found in about 6% of people that may raise the risk of high blood pressure, especially in men. Researchers will test 76 people with this variant and high blood pressure to see if they have a treatable condition called primary aldoste…

This study collects blood, urine, and tissue samples from 500 adults with obesity to help researchers learn why people gain or lose weight, and why some regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up t…

This study aimed to see if using wearable devices and game-like features could encourage hospital patients with heart conditions to walk more. It was designed for adults aged 50 and older admitted to medicine or cardiology floors. However, the study was withdrawn before any parti…

This study reviews over 2,500 medical records to understand why some people with treated and controlled high blood pressure still die from heart attacks, strokes, kidney failure, or sudden death. Researchers are looking for overlooked factors beyond blood pressure numbers. The go…

This study looks at 10,000 people with both sleep apnea and high blood pressure to see how well their treatments work together to prevent major heart problems or death. Researchers will track whether using a breathing machine at night (PAP) and taking blood pressure medicine lowe…

This study looks at how a gene called Caveolin-1 affects blood vessel function in people with high blood pressure. Researchers will measure heart and artery health after low-salt and high-salt diets. About 120 adults with mild to moderate hypertension will participate. The goal i…

This study looks at how a special heart device (Moderato IPG) affects nerve activity and blood pressure in 15 people with high blood pressure who already have the device. Researchers will measure nerve signals in the leg muscle and compare them with and without the device's thera…

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other problems. Participants give blood, stool, a…

This study tests a program called CONNECT that helps women and Black/Latino adults learn about and join heart health research. About 1,000 adults with heart disease or risk factors like high blood pressure or diabetes will receive text messages with health info and study opportun…

This study looks at how often kidney injury happens in newborns in intensive care units around the world. Researchers will review medical records from about 4,000 babies to find risk factors and improve future care. No new treatments or medications are given—this is an observatio…

This study looks at whether a personalized brain-training program can help older adults (60+) with high blood pressure who are at risk for memory loss. About 120 people will be split into two groups: one gets the real brain training, the other gets a placebo version. The training…

This study looks at how serious combat injuries impact the long-term health of US military members. Researchers will measure heart activity, blood pressure, sleep patterns, and mental health in 200 injured service members. The goal is to understand links between injury severity, …

This study uses advanced heart MRI scans to better understand early-stage heart failure in 3000 people with diabetes, high blood pressure, or obesity. Participants will get detailed imaging and check-ups, then be followed over time to see who develops serious heart problems. The …

This study aimed to see if holistic education could help people manage stress and related conditions like anxiety, fatigue, and PTSD. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who agreed to a smoke-free, drug-free, and alcohol-free lifestyle. The …

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyle and health changes affect heart disease risk later in life. Researchers measure things like blood pressure, weight, and cholesterol over time. The goal is to understand what…

This study aimed to see if data from Withings devices (like smart scales and blood pressure monitors) could predict uncontrolled high blood pressure. It planned to enroll adults in the US who had used Withings devices for at least two years. However, the study was withdrawn befor…

This long-term study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers used medical records and exams to identify risks and triggers. The goal was to better understand how to prevent these con…

This study looks at how having high blood pressure changes the body's response during spine surgery when patients lie face down. Researchers will measure heart function and blood pressure in 70 adults with and without hypertension. The goal is to better predict and prevent danger…

This study will give 300 new mothers a medical-grade smartwatch to continuously monitor their blood pressure for 6 weeks after delivery. Researchers want to see how blood pressure changes differ between low-risk, intermediate-risk, and high-risk women. The goal is to learn how to…

This study looks at whether moving combination blood pressure pills to the top of the electronic prescribing list—and adding the word "(PREFERRED)"—makes doctors prescribe them more often. Combination pills can help patients take fewer pills each day and follow guidelines for val…

This study aims to reduce health gaps in Black and Latino communities by connecting people with health and social services. Researchers will track how many participants use these services and how satisfied they are. The goal is to build trust and improve health for those with dia…

This study looks at the best ways to help primary care clinics set up team-based home blood pressure monitoring. About 5,760 patients and their care teams will take part. The goal is to see which strategies improve blood pressure control and reduce differences between Black and W…

This study looks at how blood pressure affects chronic pain in people who already have a spinal cord stimulator. About 36 adults with chronic low back pain and high blood pressure will take a standard blood pressure drug for 2 weeks and a placebo for 2 weeks (in random order) to …

This study is a review of many smaller trials that looked at what happens when people replace animal proteins (like meat, dairy, eggs) with plant proteins (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weigh…

This study re-examines 317 adults with type 2 diabetes who were first checked between 2019 and 2023. Researchers use advanced scans and blood tests to see how many have fatty liver disease (MASLD) and whether it has gotten better or worse over time. The goal is to learn what fact…

This study tests a new way of organizing care for chronic diseases like high blood pressure, diabetes, and kidney disease in Thailand. Researchers will work with 16 primary care clinics to see if using patient data in real time helps doctors and nurses provide better care. The go…

This study looks at how the kidneys use oxygen and process nutrients in people whose blood pressure is sensitive to salt. Researchers will compare 70 adults with and without salt sensitivity using MRI scans and lab tests. The goal is to better understand what causes salt-sensitiv…

This study looks at over 1,000 South African children ages 5 to 9 to understand why some develop early signs of high blood pressure and heart disease. Researchers will measure fitness, body composition, and blood markers. The goal is to find early clues that could lead to better …

This study watches 50 adults with chronic lymphocytic leukemia who are starting certain drugs (acalabrutinib or zanabrutinib). These drugs can cause high blood pressure and irregular heartbeats. Participants will use wearable devices at home to track their heart rhythm and blood …

This study looks at how vitamin D levels might influence blood pressure in people with type 2 diabetes. Researchers will collect blood samples from 40 participants to see if certain immune cells (monocytes) trigger a hormone that raises blood pressure. The goal is to better under…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, testing two different support strategies. The goal is to see which approach gets more women …

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study looks at 100 adults with sleep bruxism (teeth grinding during sleep) to understand how it relates to sleep quality, heart health, thyroid function, and mental well-being. Participants will undergo sleep monitoring and fill out questionnaires. No treatment is given; the…

This study planned to see if training residents of Boston housing developments as Community Health Ambassadors could help more people get regular doctor visits and screenings for high blood pressure and diabetes. The ambassadors would lead workshops and connect neighbors to clini…

This study follows 500 adults aged 50 and older in the Washington, D.C. area for up to 5 years. Participants receive a personalized 'Health Passport' with tips to manage risks for Alzheimer's, heart disease, and frailty. The goal is to see how these recommendations affect health …

This study looks at whether training and coaching for clinic staff can improve how they measure blood pressure and educate patients about hypertension during and after pregnancy. About 4,000 providers and staff from prenatal clinics in North Carolina will take part. The goal is t…

This study looks at whether giving extra support to care teams at community health centers helps them better screen patients for non-medical needs—like food, housing, or transportation—and connect them to community services. About 20 health centers will take part. The goal is to …

This study tests a new MRI method to see if it can measure scarring in narrowed kidneys. Researchers will scan 24 people with high blood pressure and narrowed kidney arteries. The goal is to see if this MRI technique is reliable and can predict kidney recovery.