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Blood pressure drugs may cause dangerous drops during spine surgery, new study warns

NCT ID NCT06649487

Knowledge-focused Sponsor: Tokat Gaziosmanpasa University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study looks at how high blood pressure and its medications affect blood flow and blood pressure when patients lie face-down for spinal surgery. Researchers will monitor 70 adults to see if those with hypertension have different changes in heart function compared to healthy patients. The goal is to help doctors prevent dangerous low blood pressure during surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

70 people

The number who actually took part.

Started

Sep 2024

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Prone position may cause some hemodynamic changes in patients with hypertension compared to those without comorbidities. Therefore, in this study, researchers planned to investigate the changes in some hemodynamic values in patients with hypertension and without comorbidities who were scheduled for vertebral surgery. When calculating the sample size; a previous study has shown that the cardiac index is 2.5±0.3 with a change in prone position under general anesthesia. By estimating a change of approximately 10% in this value in patients with hypertension, when the type 1 error value is accepted as 0.05 and the power is 0.90, it has been determined that the sample size for the study is sufficient with 64 patients. Considering the losses that may occur during follow-up, it is planned to conduct the study with 70 patients with a 10% increase.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with ASA scores between 1 and 3 who wish to participate in the study. * Patients between the ages of 18-75 who are scheduled for vertebral surgery Exclusion Criteria: * Heart failure * Severe arrhythmia * Severe respiratory failure * Renal failure * Chronic liver disease * Moderate and severe anemia * Severe fluid and electrolyte disturbances * Uncontrolled hypertension (systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg) * Severe thyroid dysfunction * Advanced psychiatric illness.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder Intervertebral Disc Displacement lumbar disk herniation, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Disk herniation Hypertension

Contacts and locations

Locations

  • Tokat Gaziosmanpasa University

    Tokat Province, Center, 600100, Turkey (Türkiye)

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