Disorder of visual system

This trial tests a single injection of GEB-101, a gene-editing treatment, directly into the cornea of people with TGFBI-related corneal dystrophy, a hereditary condition that causes progressive vision loss. The study aims to see if the treatment is safe and whether it can slow or…

This trial tests a therapy called CTX112 in adults with severe neurologic autoimmune diseases, including progressive multiple sclerosis, neuromyelitis optica, and stiff-person syndrome. CTX112 uses donor T cells edited with CRISPR to target and deplete B cells, which are thought …

This phase 2 trial tests whether a single injection of EO2002, made from magnetic human corneal endothelial cells, can safely improve vision in people with corneal edema caused by endothelial dysfunction. Participants receive either a low or high dose of cells or a placebo inject…

This phase 1 trial is testing an experimental drug called ATG-201 in adults with systemic lupus erythematosus, systemic sclerosis, or Sjögren's disease. ATG-201 is designed to bind to specific proteins on immune cells, potentially quieting the overactive immune response that driv…

This trial tests a drug called ripertamab in people with neuromyelitis optica spectrum disorder (NMOSD), a rare condition where the immune system attacks the optic nerves and spinal cord. Participants receive the drug by IV infusion four times over 73 weeks and are monitored for …

This trial is testing an experimental eye gel called BETA-TT8 for people with wet age-related macular degeneration (AMD), a condition that causes rapid vision loss. The gel is applied to the eye up to three times daily for 12 weeks, and standard injections remain available if nee…

Researchers at Assiut University are studying whether combining cataract surgery with a procedure called goniotomy safely lowers eye pressure and reduces the need for glaucoma medications. The trial enrolls 70 adults with cataract plus either primary open-angle or primary angle-c…

This study tests a liquid form of the seizure drug zonisamide in children aged 1 month to 17 years who have partial-onset seizures. The goal is to find the right dose and check for side effects. About 40 children will take the medicine for up to 12 weeks, with a follow-up visit o…

Researchers are studying whether spectacle lenses designed to slow myopia progression affect astigmatism in children aged 6 to 13 who have both myopia and astigmatism. All participants wear the study lenses daily for one year and visit the Essilor R&D Centre for follow-up eye mea…

Researchers are testing an experimental antibody called JH013 in adults with primary Sjögren's syndrome, a condition where the immune system attacks moisture-producing glands and other tissues. The trial has two parts: one gives a single injection at increasing doses, and the oth…

Researchers are testing an experimental eye injection called GenSci148 in people with neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). GenSci148 is a fusion protein designed to block four proteins involved in blo…

Researchers are testing an experimental antibody called SZN-8141 in people with diabetic macular edema, a swelling of the retina that can blur vision. About nine participants will each receive a single injection of SZN-8141 into the eye, with small groups getting increasing doses…

This trial tests whether high-dose nicotinamide, a form of vitamin B3, can slow the loss of retinal nerve cells in adults with mild to moderate open-angle glaucoma. Participants already on standard glaucoma treatment will be randomly assigned to also take nicotinamide tablets or …

This study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…

Researchers are testing an experimental drug called OLN324 against ranibizumab, a standard treatment for wet age-related macular degeneration (nAMD). The trial enrolls about 400 adults aged 50 and older who have not yet received treatment for active wet AMD in the study eye. Part…

Researchers are testing an experimental drug called OLN324 against the standard treatment, aflibercept, in adults with wet age-related macular degeneration. About 500 people aged 50 and older who have not yet received treatment for this condition will take part. Both drugs are gi…

Researchers are studying how stable the RayOne RAO800S intraocular lens is after cataract surgery. The lens replaces the eye's cloudy natural lens and has marks to help surgeons position it. Adults scheduled for cataract surgery in both eyes receive the lens as part of routine ca…

This trial tests an experimental drug called VIS-101, given as an injection into the eye, for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. Researchers compare two doses of VIS-101 against aflibercept, a standard treatment, to see if VIS-…

Researchers are testing a treatment for melanoma that has spread to the liver. They collect tumor-infiltrating lymphocytes, a type of immune cell, from the patient's own tumor and grow them in the lab. Before returning the cells, they use a technique called percutaneous hepatic p…

This early-stage trial tests whether immune cells taken from a patient's own tumor (TIL) can be safely given directly into the liver or through a vein to fight metastatic melanoma. 18 adults with advanced uveal or cutaneous melanoma that has spread will receive TIL along with che…

Researchers are testing low-dose interleukin-2 (IL-2), an immune signaling protein, in adults with neuromyelitis optica spectrum disorder (NMOSD), a condition where the immune system attacks the optic nerves and spinal cord. The trial enrolls about 60 people aged 18 to 74 who rec…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests the long-term safety of vonaprument, an experimental drug given as an injection into the eye, for people with geographic atrophy, a severe form of dry age-related macular degeneration that causes blind spots. Researchers will monitor participants who completed an…

This trial tests whether special eyeglass lenses, called Stellest 2.0, can slow the progression of short-sightedness (myopia) in young adults compared with standard lenses. Participants will wear either the special lenses or standard ones for at least 12 hours a day for two years…

This study tests a non-invasive laser treatment called photobiomodulation for people with early age-related macular degeneration (AMD) who have a specific type of deposit in the eye called reticular pseudodrusen. The treatment uses low-energy light to stimulate cells and reduce i…

Researchers are testing whether MRI-guided high-intensity focused ultrasound can safely reduce seizures in adults with generalized epilepsy that does not respond to medication. The procedure uses sound waves to precisely target and ablate a small brain region involved in seizure …

This trial gives deucravacitinib, an oral drug that calms the immune system, to adults with lupus or Sjögren's disease and to children with psoriasis or psoriatic arthritis. Participants join after finishing an earlier study of the same drug, and the goal is to see how safe and t…

This study tests whether injecting stem cells into the eye can help people with severe dry eye caused by graft-versus-host disease (GVHD), a complication of bone marrow transplants. The trial will include 30 adults who have not improved with standard treatments. Participants will…

This trial tests a computer-based training method designed to improve stereo vision, or depth perception, in adults with conditions like amblyopia (lazy eye) or strabismus (misaligned eyes). Participants aged 18 to 39 with impaired depth perception will be randomly assigned to ei…

This study tests whether removing the ripcord from a glaucoma drainage device more than 3 months after placement lowers eye pressure. Adults with glaucoma who have had the ripcord in place for over 3 months will have it removed during a routine clinic visit. Researchers will meas…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This clinical trial tests a new type of immunotherapy called 4SCAR-T, which uses a patient's own immune cells engineered to recognize and attack three different markers (GD2, PSMA, and CD276) on neuroblastoma cancer cells. The study enrolls children and adults (ages 1 to 65) with…

This trial tests whether Lacrifill, a gel placed in the tear duct to block tear drainage, can reduce dry eye symptoms in people who have had cataract surgery. Participants receive either Lacrifill or standard saline eye drops, and researchers compare eye discomfort scores over th…

This trial tests the long-term safety of an experimental medicine called ultevursen, given as an injection into the eye, for people with retinitis pigmentosa caused by mutations in a gene called USH2A. The study enrolls about 81 adults and children who completed a previous 24-mon…

This early-stage trial tests giving a gene therapy to unborn babies diagnosed with GM1 gangliosidosis, a severe genetic disorder that damages the brain and body. The therapy uses a harmless virus to deliver a working copy of the missing enzyme gene. The main goal is to see if the…

This study compares five FDA-approved drugs—rituximab, ravulizumab, inebilizumab, satralizumab, and eculizumab—to see which best prevents relapses in people with neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune condition that can cause vision loss and paralysis. …

This trial tests a support program for adults with glaucoma who struggle to take their eye drops regularly or attend clinic visits. Participants identify their main barrier, such as forgetfulness or difficulty using drops, and receive matching help like education, reminders, or t…

This trial compares two daily disposable multifocal contact lenses to see which provides better vision at near, intermediate, and far distances, and which is safer for the eyes. About 150 adults aged 40 to 70 who need multifocal lenses will wear each type and have their vision te…

This trial tests whether an 8-week mindfulness course can shorten the duration of central serous chorioretinopathy (CSCR), an eye condition where fluid builds up under the retina, often linked to stress. Adults with active CSCR will either take the mindfulness course or receive n…

This study tests whether a training program that pairs sounds with visual cues can help people who have lost part of their vision due to brain damage (cortical blindness). Participants will do 12 sessions where they see and hear stimuli in their blind area, plus virtual reality t…

Researchers are testing a new type of implantable lens, called a diffractive trifocal phakic ICL, in adults aged 21 to 60 with myopia (nearsightedness) with or without astigmatism. The lens is surgically placed inside the eye to correct distance vision while also aiming to improv…

Researchers are testing a new type of implantable lens, called an aspheric ICL, to correct or reduce nearsightedness (myopia) with or without astigmatism. The lens is placed inside the eye during surgery and is designed to improve vision. This small study will include 10 people a…

This trial tests the TECNIS PureSee, an extended depth of focus lens implanted during cataract surgery, in 50 adults with cataracts in both eyes. The goal is to see how well the lens restores vision at distance, intermediate, and near ranges, and whether it allows people to go wi…

This trial tests whether eyedrops made from a patient's own blood plasma, rich in growth factors (PRGF), can reduce symptoms of severe dry eye disease. About 100 adults with severe dry eye will use either PRGF or a placebo solution alongside their standard treatment for one month…

This study tests whether omega-3 supplements or a special anti-demodex eyelid cleanser can help treat and prevent chalazia (styes) in children aged 4 to 17. All 168 participants will use warm compresses, and they will be split into three groups: one adds omega-3 fish oil and stan…

This trial tests a single injection of a gene therapy called ZVS101e for people with Bietti crystalline dystrophy, a rare inherited eye disease that leads to progressive vision loss. The therapy uses a harmless virus to deliver a working copy of the CYP4V2 gene to cells in the ey…

This trial tests whether injecting natural killer (NK) cells into the eye can help people with refractory Mooren's ulcer, a painful and recurring corneal condition. Six participants will receive the cell injection and be followed for 48 weeks to see if it improves corneal thickne…

This trial tests whether adding a preventive step during orbital fracture surgery can reduce the chance of the lower eyelid turning outward (ectropion), a common complication. Adults with orbital floor fractures will be randomly assigned to receive the standard subciliary approac…

This phase 1 trial tests whether an intravenous nanoparticle formulation of pitavastatin, called ULREA-PVS-NP, is safe in adults with retinitis pigmentosa, a rare inherited disease that causes progressive vision loss. The study aims to see if the treatment can reduce retinal infl…

This study tests whether a low-intensity laser applied to the diseased area just before an anti-VEGF injection helps the drug work better in people with wet age-related macular degeneration (AMD). Wet AMD causes abnormal blood vessels to leak fluid under the retina, and current t…

This trial tests a new surgical technique for people with an epiretinal membrane, a condition where abnormal tissue grows on the retina and blurs or distorts vision. The standard treatment is to peel off this membrane, but the retina may not fully heal. The new approach uses a sm…

This trial tests a new device called VividFlo, a small implant placed under the eye's surface to help drain fluid and lower pressure in people with glaucoma. The study involves 10 adults with glaucoma in one eye, who will receive the implant during surgery. Researchers will track…

This study tests whether a light-activated treatment called Rose Bengal photodynamic therapy can help people with a severe fungal eye infection called Fusarium keratitis. The infection can cause vision loss, and standard treatments may not always work. Participants receive either…

This study looks at whether switching to a higher-dose eye injection called aflibercept 8 mg can allow people with neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME) to go longer between treatments. It follows adults in Portugal who have already …

This trial tests whether an experimental drug called efgartigimod can reduce nerve damage and pain in adults with Sjogren's disease. Participants will receive either the drug or a placebo as a subcutaneous injection. The study measures changes in neuropathy symptoms and quality o…

This study tests whether oral valganciclovir or ganciclovir eye drops can reduce the virus causing eye inflammation and prevent flare-ups. About 117 adults with CMV anterior uveitis will receive either antiviral treatment or placebo for 7 days, then some continue for 12 months. T…

This trial evaluates Paragon CRT contact lenses with a 5mm optic zone diameter, worn overnight to temporarily reshape the cornea and correct myopia and astigmatism. Participants aged 6 to 35 will wear the lenses daily for a short period, and their comfort and visual performance w…

This early-stage trial is evaluating an investigational drug called QLS2404, given as an injection, to see if it is safe and tolerable. The study first tests single doses in healthy volunteers, then moves to multiple doses in people with systemic lupus erythematosus or primary Sj…

This trial tests whether faricimab, an eye injection, can improve vision and reduce swelling in South Asian patients with diabetic macular edema (DMO), a complication of diabetes that can lead to blindness. Previous studies mostly included Caucasian or East Asian participants, le…

This study tests a new type of artificial lens for cataract surgery that may adjust focus like a natural lens. About 100 adults needing cataract surgery will get this lens in one eye and a standard lens in the other. Researchers will check for complications and measure vision imp…

This early-phase trial is testing an investigational drug called RBP-01 (sotrastaurin), given as an injection into the eye, for people with primary uveal melanoma—a rare cancer of the eye. The study aims to see if the drug is safe and whether it can shrink the tumor enough to avo…

This trial tests whether dual-focus contact lenses, which have special rings to slow eye growth, can reduce the progression of myopia (nearsightedness) in young adults aged 18 to 30. Participants will wear either these lenses or standard single-vision lenses for 24 months. The st…

This trial studies children aged 8 to 16 who have used repeated low-level red light (RLRL) therapy for one year to control nearsightedness (myopia). Participants are randomly assigned to either continue the therapy, stop it completely, or gradually reduce it. The goal is to see h…

This trial is testing whether giving two drugs—sintilimab and disitamab vedotin—before surgery can shrink tumors in people with a rare type of eyelid cancer called sebaceous gland carcinoma. Participants receive two cycles of the combination, then undergo surgery to remove the tu…

This trial compares two surgical implants—the Baerveldt Glaucoma Implant and the Paul Glaucoma Implant—in people with glaucoma that is not well controlled by eye drops. Both devices are tiny tubes placed in the eye to drain fluid and lower pressure. The study will track which imp…

This trial compares two prostate medications, tamsulosin and silodosin, to see how each affects the iris—the colored part of the eye—in men with benign prostatic hyperplasia (BPH). Both drugs can make the iris floppy and the pupil small, which complicates cataract surgery. The st…

This clinical trial is testing whether an experimental eye drop called OT202 can improve symptoms and repair the eye surface in people with moderate to severe dry eye. About 842 adults aged 30 to 75 with a history of dry eye will receive either OT202 or a placebo drop three times…

This early-stage trial is testing whether adding the drug sivelestat to standard steroid therapy is safe and may help people during an acute attack of neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune condition that can cause vision loss and paralysis. Seven parti…

This early-stage trial tests a gene therapy called AGX-08 for geographic atrophy, an advanced form of age-related macular degeneration that causes vision loss. The study will involve 24 people aged 50 and older, each receiving a single injection into one eye. The main goal is to …

This phase 2 trial is testing an oral drug called PLX-200 (gemfibrozil) in children aged 2 to 15 with certain lysosomal storage disorders (LSDs), including CLN2, CLN3, Sandhoff disease, and Krabbe disease. The study aims to see if the drug is safe, tolerable, and may slow the pro…

This trial investigates whether a 12-week home-based circuit training program can reduce intraocular pressure and improve retinal health in people with glaucoma. Participants are randomly assigned to either the exercise program plus standard care or standard care alone. The study…

This trial is investigating whether a higher 8 mg dose of aflibercept, given every three months, can effectively control wet age-related macular degeneration (nAMD) in people who have not been treated before. The study will measure changes in eye fluid biomarkers, vision, and saf…

This phase 2 trial is testing whether an oral drug called ICP-488 can reduce disease activity in people with primary Sjögren's syndrome, an autoimmune condition that causes dry eyes, dry mouth, and fatigue. About 240 adults aged 18 to 70 with moderate-to-active disease will recei…

This study tests whether oral dietary supplements can improve the health of the back of the eye in children with nearsightedness (myopia). About 156 children aged 8-13 will take either a supplement or a placebo for a period, and researchers will measure changes in the thickness a…

This trial tests whether adding an oral Chinese herbal formula called Tongluo Huayu to standard care (eye injections and laser therapy) can improve vision and reduce retinal swelling in people with retinal vein occlusion. Eighty participants will receive either standard treatment…

This study tests a caregiver-led digital program called VIPPSTAR designed to improve vision and brain development in infants at risk of or with visual impairment. The program provides personalized activities integrated into daily routines, supported by remote coaching. Researcher…

This trial compares two types of artificial lens implants used during cataract surgery: enhanced monofocal lenses and extended depth-of-field lenses. The goal is to see which one provides better vision at far, intermediate, and near distances, and whether one causes fewer visual …

This study tests an experimental drug called nizubaglustat (AZ-3102) in people aged 4 to 30 with Gaucher disease type 3, a rare genetic condition that can cause anemia, low platelets, an enlarged spleen, and neurological problems. Participants take the drug daily as a dissolvable…

This trial compares a new autostereoscopic 3D vision training system to standard eye patching for children aged 7 to 12 with amblyopia (lazy eye). Participants use the 3D system for 20 minutes daily or wear an eye patch for 2 hours daily over 6 months. The study measures improvem…

This phase 3 trial tests whether an experimental drug called NPI-001 can slow the loss of light-sensing cells in the eyes of adults with Usher syndrome, a genetic condition that causes both hearing and vision loss. About 80 participants take either NPI-001 or a placebo twice dail…

This early-phase trial tests whether a new CAR T cell therapy called CC-97540 is safe for people with a rare autoimmune disease called neuromyelitis optica (NMOSD). The study will enroll 5 adults who are stable on current treatments. Researchers will check for side effects and wh…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This trial tests a gene therapy called PST-611 in people aged 65 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes blind spots. PST-611 is a DNA plasmid injected into the eye muscle that instructs cells to produce human transferri…

This study tests a gene therapy called OPGx-RDH12 for people with Leber Congenital Amaurosis (LCA) caused by mutations in the RDH12 gene, a rare condition that leads to severe vision loss from a young age. The treatment is given as a single injection under the retina in the worse…

This trial tests whether a device called OcuLign, which automatically adjusts for eye rotation during SMILE surgery, corrects astigmatism better than the standard manual marking method. Adults aged 18 to 40 with stable myopia and astigmatism will have one eye treated with each me…

This phase 3 trial compares an experimental drug, MK-8748, to the standard treatment aflibercept for diabetic macular edema (DME), a condition where fluid buildup in the retina blurs vision. About 1,100 adults with diabetes and vision loss from DME receive either MK-8748 or aflib…

This study tests whether two dietary supplements—tauroursodeoxycholate (a bile acid) and a traditional Chinese medicine formula—can help people with diabetic macular edema, a vision-threatening complication of diabetes. The 69 participants will take the supplements or a placebo f…

This trial investigates whether children and young adults with juvenile idiopathic arthritis (JIA)-related uveitis can safely take adalimumab injections less frequently without their eye or joint inflammation returning. Participants are assigned to receive injections every 2, 4, …

This trial investigates whether a personal-use electric stimulator, worn at home for 30 minutes daily, can improve vision in people with early to intermediate dry age-related macular degeneration (AMD). Participants are randomly assigned to receive either real or sham stimulation…

This trial investigates whether people with chronic non-infectious uveitis—an eye condition that can cause blindness—can safely reduce their dose of adalimumab (a drug that calms the immune system) by using regular blood tests to monitor drug levels. Participants whose uveitis ha…

This study tests whether augmented reality (AR) training can help children aged 5 to 12 who have lazy eye (amblyopia) after congenital cataract surgery. Participants use an AR headset for 2 hours daily for 4 months, playing visual games designed to strengthen the weaker eye. The …

This trial compares two surgical techniques for treating corneal basement membrane dystrophy, a condition that causes blurred vision and painful eye erosions. One method is manual scraping of the damaged corneal layer; the other uses a laser to remove it. The study aims to find w…

This study tests a new trifocal intraocular lens (IOL) for people having cataract surgery. The lens is designed to help see clearly at near, intermediate, and far distances. Researchers will compare the new lens to a commercially available one in 66 participants, measuring distan…

This study tests whether special glasses called Kubota Glass can temporarily change the length of the eye, which is key to controlling nearsightedness (myopia). Participants aged 8 to 24 with mild to moderate myopia will try five different lens settings in a randomized, double-ma…

This study compares two types of artificial lenses used during cataract surgery, both designed to provide clear vision at far and intermediate distances. Adults having cataract surgery in both eyes are randomly assigned to receive either the Tecnis PureSee or the 1stQ Comfort Z-E…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This study compares two types of spectacle lenses designed to slow the progression of myopia (nearsightedness) in children aged 6 to 10. The goal is to see if the new test lenses are as comfortable and easy to adapt to as the control lenses during the first two weeks of wear. Chi…

This trial investigates whether faricimab, an eye injection, can help people with chronic central serous chorioretinopathy (CSCR), a condition where fluid builds up under the retina and can cause vision loss. The study includes 50 adults with persistent fluid for at least three m…

This study tests an oral drug, AV078, in people aged 12 and older with tuberous sclerosis complex (TSC) whose seizures are not controlled by standard medications. Participants are randomly assigned to receive AV078 or a placebo for 12 weeks. The goal is to see if AV078 safely red…

This study tests an experimental drug called REGN22530 in people with primary open angle glaucoma or ocular hypertension. The drug is designed to block a protein in the eye that causes fluid buildup and high pressure. Researchers are checking for side effects, how the drug moves …

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This phase 2 trial tests whether eye drops containing infliximab, a drug that blocks a key inflammatory protein, can safely improve severe dry eye in people with Sjögren's syndrome. 38 adults will receive either the active drops or a steroid drop for 6 weeks. The study measures s…

This study will follow 100 adults with non-infectious posterior uveitis, a chronic inflammatory eye disease, who have received a fluocinolone acetonide implant. Researchers will analyze medical records over three years to see how well the implant reduces the frequency and severit…

This study compares two surgical techniques for removing very hard cataracts, which are tough to break apart and can lead to complications like corneal swelling or lens rupture. The new method, called 'divide and conquer with debulking,' aims to make the procedure safer. Research…

This study tests a new artificial lens, called an intraocular lens (IOL), placed in the eye during cataract surgery. The lens is designed to replace the eye's natural lens and help restore vision. Researchers will measure how clearly participants see one year after surgery and ch…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This study compares three different devices used to perform a glaucoma surgery called goniotomy at the same time as cataract surgery. The goal is to see which device best lowers eye pressure and reduces the need for glaucoma medications over six months. About 132 adults with open…

This study will test a special gel that can be injected into the eye to seal wounds on the cornea (the clear front part of the eye) without needing stitches. The gel turns from liquid to solid inside the eye and helps the cornea heal naturally. About 30 adults with certain types …

This early study tests a small ring placed in the eye that slowly releases the drug bimatoprost to lower eye pressure in people with glaucoma or ocular hypertension. The ring is implanted during a quick surgery and may work for up to 3 years. The trial includes 24 adults and comp…

This study tests whether using cord blood, rich in fetal hemoglobin, for transfusions in preterm infants can reduce serious complications like blindness, lung disease, and gut problems. Researchers will compare outcomes in 200 very low birth weight babies who receive either cord …

This study compares two types of special glasses (DIMS and DOT) to control nearsightedness in children aged 6 to 12 who also have intermittent exotropia (a type of eye misalignment). Researchers want to see which lens works better and whether the glasses affect eye coordination. …

This early-stage study tests a new injection called CM336 in 30 adults with active Sjogren's syndrome. The main goal is to check safety and how the body handles the drug. Researchers will also look for signs that it helps control the disease. This is a Phase 1 trial, so it's one …

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This study compares two approved cyclosporine eye drops—Vevye (0.1%) and a generic (0.05%)—in 60 adults with dry eye disease. Over 8 weeks, researchers will measure changes in goblet cells, which produce mucus to keep eyes moist. Participants use drops daily and visit the clinic …

This study tests whether insulin eye drops can protect the optic nerve in people with open-angle glaucoma. Researchers will give 90 participants either insulin drops or placebo daily for up to 12 months. The main goal is to check safety, but they will also measure vision changes …

This Phase 3 trial tests a new eye drop, DNN.31.19.026, against a standard treatment (Cosopt) for people with high eye pressure or open-angle glaucoma. About 336 adults will use the drops twice daily for 56 days. The main goal is to see if the new drop lowers eye pressure better …

This study tests whether a treat-and-extend schedule for aflibercept eye injections works better than the standard as-needed approach for people with diabetic macular edema who have not had prior treatment. About 186 participants will receive three monthly injections, then either…

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This study tests whether a remote dietary program can help people with early to intermediate age-related macular degeneration (AMD) lower their blood sugar and increase protective nutrients called carotenoids. About 32 participants will receive coaching to improve their eating ha…

This trial tests a new device called the enVVe system, a catheter-based artificial valve placed in leg veins to treat chronic venous insufficiency. The study will enroll 220 people with severe symptoms like skin changes or leg ulcers. Participants are randomly assigned to receive…

This study tests a special hydrogel that acts like a glue to hold eye tissues together during surgery, avoiding the need for stitches. Stitches can cause pain, swelling, and scarring, but this gel uses light to bond quickly and gently. The trial will include 20 people with cornea…

This Phase 2a trial tests SCAI-005 eye drops in 50 adults with wet age-related macular degeneration (AMD). Participants will receive either a low dose, high dose, or placebo drops three times daily. The study aims to see if the drops can reduce retinal swelling and control the di…

This early-stage trial tests a new gene therapy called VGN-R08b for children with type III Gaucher disease, a rare genetic disorder affecting the brain and body. The treatment is given as a single injection into the brain's fluid spaces. The study will monitor safety and measure …

This study compares two treatments given after emergency eye surgery for people with thyroid eye disease who have vision loss. One group gets teprotumumab, a newer drug that blocks a growth factor, and the other gets high-dose steroids. The goal is to see which one better improve…

This early-phase trial tests whether injecting stem cells from a relative's bone marrow into the spine is safe for people with a severe relapse of neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune disease that attacks the optic nerves and spinal cord. Only 6 adult…

This study looks at 50 infants born with a blocked tear duct (a common condition causing watery eyes). It compares two treatments: early probing (a quick procedure to open the duct) and tear duct massage. The goal is to find which approach works best and when to do it, to help ba…

This early-phase trial tests a new treatment called KSVCBD, a type of CAR-T cell therapy, for people with a severe autoimmune disease called neuromyelitis optica spectrum disorder (NMOSD) that has not responded to standard treatments. The study will include 18 adults who test pos…

This study is for people with Bietti's crystalline dystrophy, a rare genetic eye disease that causes vision loss. They have already received the gene therapy VGR-R01 in one eye. Now, researchers want to test if giving the same treatment to the other eye is safe and can improve vi…

This study tests a new laser treatment called DSLT for people with high eye pressure or open-angle glaucoma who have already had a similar laser (SLT). The DSLT laser does not touch the eye, which may make it faster and more comfortable. Researchers want to see how well it lowers…

This study tests a combination of two drugs, nemtabrutinib and rituximab, in about 35 adults with marginal zone lymphoma, a slow-growing blood cancer. The goal is to see if the combo is safe and can shrink or eliminate tumors. Participants will receive the drugs by mouth and thro…

This study will test the drug faricimab, given as eye injections, in 50 people with wet age-related macular degeneration (nAMD). The goal is to see if it improves vision and eye health. Participants will receive 4 initial doses, then more as needed. The study is observational, me…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study looks at whether a home monitoring app can help people with wet age-related macular degeneration (eAMD) safely extend the time between Aflibercept injections. About 80 adults already receiving this treatment will use the app and have regular eye exams over one to two y…

This early study tests whether stimulating a nerve cluster behind the cheekbone (the pterygopalatine ganglion) is safe and doable for people with geographic atrophy, a severe form of age-related macular degeneration that causes blind spots. Sixty-two adults will receive either re…

This study tests whether adding echothiophate iodide eye drops to standard atropine therapy can improve vision in children aged 3 to 18 with refractory amblyopia (lazy eye that hasn't improved with standard treatment). Twenty participants will use atropine nightly for 12 weeks, a…

This phase 2 trial tests a combination of seven drugs (CL-Pola-R-CHP) in 28 adults aged 65 and older with double or triple-hit diffuse large B-cell lymphoma who are not eligible for transplant. The goal is to see how many patients achieve complete remission after six cycles of tr…

This study tests a new medicine called AIV007 for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. About 35 participants will receive either AIV007 or the standard treatment Eylea. The goal is to see if AIV007 can improve vision and reduce t…

This study looks at children with a rare, severe eye disease called primary congenital glaucoma. It compares three different amounts of a surgery called goniotomy (120°, 240°, or 360°) to see which works best and is safest. The goal is to lower eye pressure and protect vision, bu…

This study tests whether placing a temporary stitch inside a tiny drainage device (Preserflo) can reduce the risk of dangerously low eye pressure after glaucoma surgery. The device is already used in France to lower eye pressure, but low pressure can still happen. About 192 adult…

This study tests an investigational drug called OCUL101 for people with wet age-related macular degeneration (AMD), a condition that causes blurry vision and can lead to blindness. OCUL101 targets two proteins involved in the disease to reduce abnormal blood vessel growth and inf…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This early-stage trial tests a single injection of ZM-02, a gene therapy, in 21 people aged 6 to 60 with advanced retinitis pigmentosa, a genetic condition that causes progressive vision loss. Participants are randomly assigned to receive either a low or high dose of ZM-02 or a s…

This study tests whether treating donor corneal tissue with a cross-linking procedure before transplant can improve vision and reduce astigmatism in people with keratoconus. About 216 adults aged 18–50 who need a corneal transplant will receive either cross-linked or standard don…

This study tests two new types of multifocal glasses designed to manage myopia (nearsightedness) in children aged 8 to 15. Twenty kids who already wear myopia-control glasses will try each new design for a short time to see how well they see and how comfortable they feel. The goa…

This study compares transfusions using red blood cells from umbilical cord blood versus standard adult donor blood in extremely premature infants. About 176 babies born before 28 weeks or weighing under 1000 grams will be enrolled. The goal is to see if cord blood reduces the ris…

This study compares two treatments used during tear duct surgery for blocked tear ducts: hyaluronic acid gel versus the chemotherapy drug mitomycin-C. The goal is to see if the gel works as well or better at keeping the new tear duct open, with fewer side effects. Thirty-six adul…

This study will enroll about 3,890 children aged 8-12 who still have rapidly worsening nearsightedness (myopia) even after using orthokeratology (Ortho-K) lenses. Researchers will compare four approaches: continuing Ortho-K alone, adding low-dose atropine eye drops, using lenses …

This phase 3 trial tests whether a new drug, QL1207H, works as well as the standard treatment Eylea for wet age-related macular degeneration, a leading cause of vision loss. About 356 adults aged 50 and older with active disease will receive injections every 4 weeks for 3 doses, …

This study tests whether a structured glaucoma awareness program helps patients in Nepal follow their treatment better. Glaucoma requires lifelong care to prevent blindness, but many patients struggle with adherence. Researchers will measure changes in adherence using a questionn…

This Phase 1 trial will test the safety of PRO-169, a form of bevacizumab injected into the eye, in 60 adults with diabetic macular edema. The study checks for immune reactions and side effects. It is not yet recruiting and focuses on safety, not whether it improves vision.

This study tests an oral medication, CU06-1004, for people with diabetic macular edema (DME), a condition that causes vision loss. About 156 participants will take either a low dose, high dose, or placebo pill daily for 24 weeks. The goal is to see if the drug improves vision and…

This study tests whether special spectacle lenses can slow the progression of myopia (nearsightedness) in European children aged 6 to 12. A total of 180 kids will wear one of three lens designs for two years. The main goal is to measure changes in eye length and prescription stre…

This study tests a new gene therapy for GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff diseases. Researchers will take blood cells from 6 patients, fix the genetic defect in the lab, and then see if these cells can help brain cells work better. The goal is to show the …

This trial tests two different needle insertion spots during YAMANE surgery, a procedure to fix a lens in the eye for children with congenital ectopia lentis (a condition where the eye's lens is out of place). Researchers will compare how accurate the lens placement is and how we…

This study will test whether adding a salt water (sodium chloride 5%) eye drop to standard antibiotic treatment helps heal bacterial eye infections faster. About 40 adults with bacterial keratitis will receive either antibiotics plus the salt drop or antibiotics alone. The goal i…

This early study tests a 3D-printed human collagen implant in 4 people with severe corneal melting, a condition where the eye's clear front layer thins and can perforate. The implant is placed on the eye to reinforce the cornea and prevent vision loss. The main goal is to check i…

This early-stage trial will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus or scleroderma that have not responded to standard treatments. The children will receive a single infusion of these cells, and researchers will…

This study compares a combination of a steroid implant (dexamethasone) plus an anti-VEGF injection (aflibercept) against aflibercept alone for diabetic macular edema. Researchers will enroll 114 people with diabetes who have not had prior treatment. The goal is to see if the comb…

This study follows up 18 people who received umbilical cord stem cells or conditioned medium for retinitis pigmentosa, a rare eye disease that causes vision loss. Researchers will check vision, eye structure, and safety five years after the injection. The goal is to see if the tr…

This early-stage study tests a one-time cell therapy called TRX103 for people with active non-infectious uveitis, a condition causing inflammation inside the eye. Up to 18 adults aged 18 to 70 will receive the treatment by IV and be monitored for a year. The main goal is to check…

This study tests whether stem cells from umbilical cord tissue can safely slow vision loss in people with retinitis pigmentosa, an inherited eye disease. Thirty participants will receive one of two doses injected around the eye and be monitored for six months. The main goals are …

This study tests whether using EPD-09-25 eyelid wipes before and after cataract surgery can reduce bacteria on the eyelid and improve dry eye symptoms. One hundred adults scheduled for cataract surgery will either use the wipes twice daily for five weeks or receive no special eye…

This study tests if intense pulsed light (IPL) is a safe and effective way to treat chalazion, a common eyelid lump. About 40 adults with an inflamed chalazion will receive IPL or a control treatment. The main goal is to see if the lump shrinks by at least 80% four weeks after th…

This study tests if low-intensity red light therapy can slow or stop the worsening of high and extreme myopia (severe nearsightedness) in adults aged 18 to 45. The treatment has shown promise in children, but its effects in adults are unknown. The goal is to prevent vision loss a…

This early-stage trial tests whether transplanting lab-grown retinal cells (made from stem cells) into the eye is safe for people with late-stage age-related macular degeneration. Nine participants will receive the cell transplant and be monitored for side effects and any improve…

This early study tests a drug called piclidenoson in 5 adult men with Lowe syndrome, a rare genetic disorder that harms the kidneys. The goal is to see if the drug can improve how the kidneys reabsorb important small proteins over 6 months. Researchers will also check safety and …

This early-stage trial tests a new drug called GB10, given as an eye injection, for people with wet age-related macular degeneration (AMD). The study will include 48 participants and aims to check safety and find the right dose. It is not yet recruiting and is too early to know i…

This study tests a new, non-invasive treatment for dry age-related macular degeneration (AMD), a common cause of vision loss in older adults. About 94 people aged 50 and older with dry AMD will use a red-light device at home twice daily for three months. Researchers will check if…

This early-phase trial will test a new treatment called QT-019C in up to 15 adults with relapsed or refractory neurological autoimmune diseases, including multiple sclerosis, neuromyelitis optica, and myasthenia gravis. The treatment uses donor-derived CAR T-cells that target two…

This study tests a non-invasive laser procedure called direct selective laser trabeculoplasty (DSLT) in 40 adults with pseudoexfoliation glaucoma. The goal is to see if the laser can safely lower eye pressure by at least 20% at 6 and 12 months. Participants will have their eye pr…

This study tests whether glucose-lowering medications (semaglutide and possibly dapagliflozin) can reverse prediabetes and prevent complications like eye, kidney, and nerve damage in people with heart disease. About 158 participants with prediabetes and coronary artery disease wi…

This study tests whether the drug upadacitinib can reduce how often people with axial spondyloarthritis (a type of arthritis affecting the spine) get sudden eye inflammation (acute anterior uveitis). About 200 adults who have had at least one eye flare in the past year will take …

This study tests whether silver diamine fluoride or silver fluoride, sometimes with a special LED light, can stop early cavities in the back teeth of young adults. About 366 high-risk dental students will receive one of these treatments. The goal is to see which approach works be…

This phase 3 trial tests whether taking serine, a natural amino acid, twice a day can slow vision loss in people with MacTel type 2, a rare eye disease. About 120 participants will receive either serine or a placebo for 24 months, with regular eye exams and imaging. The study aim…

This study tests whether using sterile air during eye surgery for a detached retina works as well as the standard gas bubble. About 150 patients from 10 UK centers will be randomly assigned to receive either air or a fluorinated gas. The main goal is to see if the retina stays re…

This study tests whether two doses of stem cells, given four months apart, can improve saliva production and reduce dry mouth in people who had radiation for head and neck cancer or have Sjögren's disease. One hundred participants will receive either stem cells or a placebo. The …

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This early study tests whether high-dose vitamin B3 (nicotinamide) can help preserve or improve vision in people with Leber's hereditary optic neuropathy (LHON), a rare genetic disease that causes sudden vision loss. Researchers will give 13 participants 2 grams of vitamin B3 dai…

This large study in Fiji tests whether a new combination of drugs (moxidectin plus two others) can safely treat three common parasitic infections: lymphatic filariasis, scabies, and strongyloidiasis. About 5,100 people will receive either the new combo or the standard treatment o…

This early-stage trial will test an oral probiotic called R-2487 in 36 adults with Sjogren's syndrome. The main goal is to see if the probiotic is safe and tolerable. Researchers will also check for changes in disease activity and inflammation using blood and stool samples. The s…

This study checks if a special thinking test (MoCA Blind) can find memory or thinking problems after cornea surgery. It includes 200 adults with cornea disease who will take the test before and 90 days after surgery. The goal is to give doctors a better way to spot these issues i…

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Researchers are testing a new way to measure how much sweat the body produces during controlled heat exposure. About 20 healthy volunteers and up to 10 people with ROSAH syndrome, a rare genetic condition that can cause reduced sweating, will sit in a temperature-controlled sauna…

This trial tests whether the Tomey FT-1000, a non-contact tonometer that measures eye pressure with a puff of air, agrees with the standard Goldmann applanation tonometer, which touches the eye. Researchers will enroll 30 adults with glaucoma and measure eye pressure with both de…

This study tests an artificial intelligence (AI) system called GlaukomAI that analyzes standard eye photos to detect glaucoma, a leading cause of blindness. Researchers will enroll 1,200 participants to see how accurately the AI identifies glaucoma compared to expert doctors. If …

Researchers are testing a new device called SmartEyes that measures refractive errors, which are vision problems like nearsightedness. The study involves 200 children and teens aged 6 to 17 who need eye exams. The trial compares SmartEyes with standard equipment and subjective re…

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study explores whether a novel computer-based visual task can detect early glaucoma by measuring how well people perceive contrast-modulated motion. Glaucoma often goes unnoticed because it starts in peripheral vision, and current tests may miss early damage. The researchers…

This study tests whether two advanced MRI techniques, called Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI), can improve the assessment of optic neuritis—inflammation of the optic nerve that can affect vision. Researchers will compare MRI measurements of the a…

This study tests whether an artificial intelligence (AI) system can help eye doctors identify urgent retinal conditions—like retinal detachment or bleeding—more accurately from wide-field eye images. Eight ophthalmologists will review images with and without AI assistance to see …

This study will check if an AI system can accurately measure eye movements from smartphone videos. About 1,000 adults with suspected eye movement issues will record a short video while following a moving target. The AI's measurements will be compared to expert ratings to see if i…

This study aims to create an artificial intelligence system that can automatically analyze confocal microscopy images of the cornea to diagnose dry eye disease. Researchers will collect eye scans from 75 adults (healthy and with dry eye) to train and test the AI. The goal is to r…

This study looks at how quickly the optic nerve sheath shrinks after starting steroids in people with giant cell arteritis, a condition that can cause blindness. Researchers will use eye ultrasounds and blood tests over two months in 60 newly diagnosed patients. The goal is to fi…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study will develop and test an artificial intelligence system to detect common eye diseases like glaucoma, cataracts, and diabetic retinopathy using 15,000 existing eye images from Costa Rican patients. The goal is to create a tool that works accurately for local populations…

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study will test a software that uses artificial intelligence to analyze photos of the retina and detect diabetic retinopathy, a common eye problem in people with diabetes. About 198 adults with diabetes will have their retinal images analyzed by the AI tool, and the results …

This study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …

This study tests a new device designed to measure nearsightedness and astigmatism. Researchers will compare its accuracy to standard tools used by eye doctors. Thirty adults aged 18-39 who wear glasses will participate. The goal is to see if the new device works as well as curren…

This study looks at 60 adults with high eye pressure or early open-angle glaucoma to see if combining advanced eye scans and vision tests can detect damage sooner. Participants will have standard eye exams plus special imaging of the optic nerve. The goal is to improve how doctor…

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

This trial tests whether Epidiolex, a prescription CBD medication, can delay or prevent the first seizure in infants with Sturge-Weber syndrome, a rare condition that often leads to seizures and developmental challenges. The study enrolls babies aged 1 to 18 months who have brain…

Researchers are testing whether an artificial intelligence tool can sort children by their risk of nearsightedness and guide personalized prevention, such as more outdoor time and special glasses. The trial enrolls about 1,600 students in grades 1 through 3 from public primary sc…

This study will test whether a single antibiotic injection given during cataract surgery can prevent endophthalmitis, a rare but severe eye infection. About 60,000 people with cataracts will receive either the antibiotic or a placebo. The goal is to see if the antibiotic reduces …

People with multiple sclerosis or neuromyelitis optica spectrum disorder who take anti-CD20 drugs have a higher risk of shingles. The shingles vaccine is recommended for them, but the drug may weaken its effect. This trial compares two dosing schedules: one gives the second shot …

This phase 2 trial tests whether a low dose of the steroid dexamethasone, given before the first four infusions of tebentafusp, can prevent cytokine release syndrome in people with advanced uveal melanoma. Tebentafusp is a standard first-line treatment for this eye cancer, but it…

This study looks at whether long-acting HIV prevention shots and opioid use disorder medications can help people in prison who are about to be released. Researchers will enroll 450 adults at participating prisons and follow them to see if they stick with treatment and avoid HIV, …

This study tests whether ZEISS MyoActive lenses, designed to send a specific optical signal to the eye, can prevent or delay the onset of short-sightedness (myopia) in children who are not yet myopic but are at risk. Children aged 6 to 12 with mild farsightedness will be randomly…

This trial tests whether special glasses with defocus lenses, aided by artificial intelligence, can prevent myopia in children aged 3 to 6 who are at high risk. The glasses are worn for at least 10 hours a day, and a smartwatch reminds kids to spend time outdoors. The study measu…

This trial tests whether combining a daily 18-minute virtual reality training session with low-dose atropine eye drops can slow the worsening of nearsightedness in children aged 6 to 12. Participants will also wear special glasses that provide defocus to the peripheral vision. Th…

This trial investigates whether a new type of eyeglass lens, called a With-the-Rule Astigmatic Defocus Lens, can prevent the development of myopia (nearsightedness) in children aged 6 to 9 who have low hyperopia (farsightedness). The lens creates a 'defocus' signal around the ret…

This study tests whether a structured referral tracking program helps adults in Pakistan complete follow-up eye care after community screenings. 500 participants will receive either standard referral or extra support like counseling and weekly reminders. The goal is to prevent bl…

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This study tests whether special glasses lenses can prevent nearsightedness (myopia) in children aged 6 to 8 who are not yet nearsighted. About 255 children will wear either a new type of lens or a standard lens for at least 8 hours a day for one year. Researchers will check thei…

This study tests whether pressing tiny pellets on ear points can delay or prevent nearsightedness (myopia) in children aged 4 to 14 who are at high risk. It compares ear acupressure, low-dose atropine eye drops, and a combination of both. The goal is to find a safe, non-drug way …

This study tests whether low-dose atropine eye drops can prevent nearsightedness (myopia) in children aged 6 to 9 who are at risk. Over 12 months, children receive daily drops, with the dose adjusted based on how fast their eyes change. The goal is to find the best dose to keep t…

This study tests a special optical film called S.T.O.P®KIT that attaches to eyeglasses. The goal is to slow down the growth of the eye in children aged 6 to 10 with mild farsightedness, which may help prevent nearsightedness later. 180 children will be split into two groups: one …

This study tests whether levetiracetam, a seizure medication, works as well as magnesium sulfate to prevent seizures in pregnant people with severe preeclampsia. About 1,240 participants at 32 weeks or more will be randomly assigned to one of the two drugs. The goal is to see if …

Researchers compare two monthly replacement silicone hydrogel multifocal toric contact lenses in people over 40 who already wear soft contacts. The study measures how easy the lenses are to handle, especially removal, and other performance factors. About 60 participants with asti…

This study tests whether a full-spectrum screen bar light can reduce eye fatigue and dry eye symptoms after two hours of computer work. Healthy adults aged 18 to 35 who use screens at least four hours daily will be randomly assigned to use the light or a standard screen without i…

Researchers are testing an experimental drug called ONO-4915 in adults with primary Sjogren's disease, a condition that causes dryness, fatigue, and pain. The trial enrolls about 60 people who have moderate to severe symptoms and a positive anti-SS-A/Ro antibody. Participants rec…

Progressive supranuclear palsy (PSP) causes problems with movement, thinking, and behavior, including impulsivity that can lead to falls. Researchers are testing a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) aimed at the right in…

Researchers compare two approved soft contact lenses to see which provides better distance vision in low-light conditions. The study enrolls 150 adults aged 18 to 39 who already wear reusable spherical silicone hydrogel lenses. Participants wear each lens for two weeks in a rando…

Researchers are testing whether very low-dose atropine eye drops reduce excessive tearing in adults who wipe their eyes at least twice a day. Each participant uses two drops, one at a time: atropine 0.005% and an identical-looking drop with no active ingredient. They use each dro…

This trial investigates whether a home-based self-management program called HOBSCOTCH can improve thinking, memory, and quality of life in young adults (ages 18–29) and youth (ages 13–17) with epilepsy. Participants attend nine weekly one-on-one coaching sessions by phone or comp…

Dry eye can appear or worsen after cataract surgery, causing discomfort and blurry vision. Researchers at the Medical University of Vienna are testing whether a hyaluronic acid gel placed into the tear drainage duct of one eye can help retain tears and reduce dry eye. Each partic…

This study tests if using a cotton-tipped applicator to hold the eyelid open during eye injections is less painful and faster than the standard metal speculum. About 120 adults with certain eye conditions will take part. The goal is to improve comfort and satisfaction without com…

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers will compare 4 nights of real stimulation to 4 nights of sham (fake) stimulation in up to 16 patients. The goal is to see if better sleep ca…

This study tests a training technique that uses repeated flashes of light and bursts of sound to help people who have lost part of their vision after a stroke. The goal is to see if this training can improve how much they can see and how their brain responds. The study will inclu…

This study tests an investigational eye drop (FID 123472) to see how well and how safely it reduces eye redness from minor irritations in adults. About 178 participants will receive either the active drop or a placebo (vehicle). The main goal is to measure redness reduction 15 mi…

This Phase 3 trial tests an investigational eye drop (FID123472) containing apraclonidine to reduce redness in adults with minor eye irritation. About 230 participants will receive either the active drop or a placebo (vehicle). The main goals are to see if redness improves within…

This trial tests whether an extended depth of focus (EDOF) lens, which aims to improve vision at multiple distances, works better than a standard monofocal lens in people who need both cataract and epiretinal membrane surgery. The study enrolls 100 adults with an epiretinal membr…

This study will test a new type of artificial lens, called the PureSee IOL, in 10 people who need surgery for both cataracts and a cornea condition called Fuchs dystrophy. The goal is to see if this lens helps patients see well at different distances and reduces their need for gl…

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This trial tests different concentrations of an experimental eye drop called BL1107 to find the lowest dose that completely clears eye redness (conjunctival hyperemia) in people with dry eye disease. About 20 participants with dry eye and redness in both eyes will receive the eye…

This study tests whether an online meditation program can reduce stress and improve quality of life in people with glaucoma. Participants aged 65 and older will be randomly assigned to either meditation plus usual care or usual care alone. They will fill out questionnaires about …

This study compares three commonly used instruments for scleral depression, a routine eye exam technique that presses on the eye to view the retina. The goal is to see which tool causes the least pain and is easiest for doctors to use. Adults with symptoms of posterior vitreous d…

This pilot study tests a new preservative-free eye drop called NOX-01 in people with mild to moderate dry eye who are having cataract surgery. The drop is designed to lubricate and protect the eye surface, potentially reducing the dry eye symptoms that often occur after surgery. …

This trial tests whether a structured reading rehabilitation module can improve reading speed and reduce errors in people with glaucoma, a condition that often impairs vision. Participants will practice the module for 20-30 minutes daily, at least 3 days a week, for 6 months. The…

This trial tests whether warming lidocaine or adding sodium bicarbonate, hyaluronidase, or tranexamic acid can make the numbing injection less painful and reduce bleeding during upper eyelid surgery. About 80 adults having bilateral blepharoplasty will receive different mixtures …

This study tests a 3-week digital program delivered through the VIPPSTAR app, designed to help children and adolescents with visual impairment build a healthier body image and become more critical of social media content. Participants aged 10-18 will complete daily exercises and …

This trial tests whether two specific probiotics—Bifidobacterium longum BL531 and Lactobacillus reuteri LR1349—can reduce eye fatigue caused by blue light and long screen time. Middle-aged adults with digital eye strain take daily probiotic supplements or a placebo for several we…

This trial compares pain relief from bandage contact lenses soaked in the anti-inflammatory drug ketorolac versus plain lenses after photorefractive keratectomy (PRK), a type of laser eye surgery. PRK often causes significant pain in the first few days as the cornea heals. The st…

This study tests a 12-week adapted physical activity program for children and adolescents aged 10-17 with visual impairment. The program includes supervised school-based exercise sessions and home-based activities, along with peer-group meetings to promote social inclusion. Resea…

This trial investigates whether the drug crisugabalin can reduce neuropathic pain in people with neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune condition affecting the nerves. Participants will receive either crisugabalin or a placebo, and their pain levels wil…

This early study tests a special contact lens that has a tiny pinhole built in. The idea is that the pinhole helps focus light better, improving vision for people with presbyopia (age-related blurry near vision) or keratoconus (a cone-shaped cornea). Sixteen adults will try the l…

This study compares a new eye drop (perfluorohexyloctane) with a standard one (sodium hyaluronate) for people whose eyes get dry from using screens for more than 6 hours a day. Participants aged 18 to 70 with mild to moderate dry eye will use the drops four times daily for 8 week…

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests a 3D-printed 'oxygen support cage' placed over the patient's head during cataract surgery. The cage lifts surgical drapes off the face, which may reduce feelings of suffocation and anxiety. Researchers will measure changes in blood pressure, heart rate, breathing…

This study tests a smart cap called iD2 that fits on eye drop bottles. It tracks when you remove the cap and sends reminders to your phone if you forget a dose. The goal is to help people with glaucoma take their drops more regularly, which can prevent vision loss. About 100 adul…

This study compares two types of artificial tears for dry eye disease: one with preservatives and one without. Researchers want to see which is safer and more effective over 8 weeks. About 80 adults with dry eye will take part, and neither they nor their doctors will know which t…

This Phase 3 trial tests whether CAM-101 eye drops can reduce eye discomfort and corneal damage in people with moderate to severe dry eye. About 475 adults will receive either CAM-101 or a placebo for 9 weeks, then all participants can switch to CAM-101 for a year. The study aims…

This study compares a new eyelid support plate to a standard glass rod for eyelid massage in people with dry eye from meibomian gland dysfunction. 142 adults will receive either the new device or standard massage, plus eye drops, over 8 weeks. The goal is to see which method bett…

This study tests an experimental eye drop called RCI001 in 200 adults with dry eye disease. Participants will use the drops or a placebo for 4 weeks. The goal is to see if RCI001 reduces eye discomfort and damage to the eye's surface better than placebo. The study is not yet recr…

This study tests whether adding low-level laser therapy to a minor bone-poking procedure (micro-osteoperforations) can speed up tooth movement in people with braces. About 33 patients aged 12-30 will have their canine teeth retracted after premolar extraction. The goal is to shor…

This study tests if a special augmented reality (AR) training program can improve vision in people aged 12 to 55 with lazy eye (amblyopia). It compares the AR method to the standard treatment of patching the stronger eye. The goal is to see if the AR approach is safer and more ef…

This study tests two different manual therapy techniques—Active Release Technique and Myofascial Release—each paired with eye exercises, to see which better reduces eye strain, improves sleep quality, and lowers stress in people with neck pain. 44 adults aged 18-40 with neck pain…

This study tests whether placing surgical cuts in specific parts of the cornea during cataract surgery can reduce astigmatism (blurry vision from an irregularly shaped cornea) and lower the need for glasses afterward. About 100 people with cataracts and astigmatism will be random…

This study tests whether playing recordings of family members' or nurses' voices, along with a gentle gloved hand technique called the 'love glove', can improve vital signs like blood pressure and oxygen levels in unconscious patients in the ICU. About 100 adults in a coma will t…

This study will test a new fitting experience for multifocal contact lenses in 25 people with presbyopia (age-related blurry near vision). Participants, who already wear certain contact lenses, will use an at-home trial kit with the new lens for 15 minutes daily. The goal is to s…

This study tests a 14-day home program called BraW-Day™ that combines brain exercises (like counting backwards) with walking, delivered via a smartphone app. Researchers want to see if doing both tasks together improves thinking, balance, and mood in athletes aged 18-40 who had a…

This study tests a device called TearCare that warms the eyelids and manually clears blocked oil glands in young adults (ages 18-29) with dry eye disease. 45 participants will receive one treatment and be checked after 4 weeks to see if symptoms and tear film stability improve. T…

This small study tests whether a special VR headset, called Lacrima VR, can improve dry eye symptoms in people with dry eye disease and meibomian gland dysfunction. Twenty adults will either get the active treatment (light pulses through the headset) or a sham version with dimmer…

This study will observe 300 adults who have cataract surgery to see which of three tear substitute eye drops works best for reducing dry eye and discomfort. The drops contain different combinations of sodium hyaluronate, dexpanthenol, trehalose, and amino acids. Researchers will …

This study tests whether simply taping the eyelids shut during general anesthesia is enough to protect the cornea, or if adding lubricant eye drops is better. Two hundred adults having non-eye surgery will be randomly assigned to one of the two methods. The main goal is to see ho…

This study tests whether watching 3D movies, combined with standard patching therapy, improves depth perception and vision in children aged 4 to 14 with amblyopia (lazy eye). Half the children will receive patching alone, while the other half will also attend weekly 3D movie sess…

This study tests whether a structured blinking exercise can improve dry eye symptoms in adults with glaucoma who use eye drops. 45 participants will perform 15 close-squeeze-open blinks three times daily for two weeks. Researchers will measure symptom changes and tear film stabil…

This study tests whether Xdemvy eye drops can reduce eyelash mite irritation and improve comfort for people who wear special scleral lenses. Five adult lens users with moderate to severe Demodex blepharitis will use the drops and report changes in symptoms like dryness, itching, …

This study tests lifitegrast eye drops (Xiidra) in 30 adults with dry eye disease. Researchers will use a special microscope to see if the drops reduce immune cells on the eye surface. The goal is to ease dry eye symptoms and understand how the treatment works.

This study will follow 100 people with keratoconus or corneal ectasia who undergo CTAK surgery. Researchers will use a questionnaire before and after surgery to measure changes in vision quality and overall quality of life. The goal is to see if this surgical approach helps patie…

This early-stage study tests whether a new eye ointment called RC017 is safe and tolerable in 24 healthy adults aged 18 to 55. The ointment is being developed to treat dry eye disease. Participants will receive either the ointment or a placebo, and researchers will monitor for si…

This study compares two behavioral interventions—Baduanjin (a gentle 10-15 minute exercise) or laughter exercises using a smartphone app—plus artificial tears, against artificial tears alone for treating dry eye disease. About 540 adults aged 18-45 with moderate dry eye will part…

This study tests whether a 10-week camp program can help children and teens (ages 7-14) reduce binge eating. Some parents will also receive special training to see if it adds extra benefit. Researchers will follow participants for up to 5 years to track lasting effects.

This study tests a new eye drop called IRX-101 to see if it reduces pain and surface damage after anti-VEGF injections for retinal disease. About 240 adults who get these injections will receive either IRX-101 or standard povidone-iodine. The goal is to make the procedure more co…

This study compares two ways to manage pain and swelling after cataract surgery. One uses a single injection and two types of eye drops, the other uses three different drops multiple times a day. 40 adults having surgery on both eyes will try each method and say which they prefer…

This study looks at whether adding osteopathic manual therapy (a type of hands-on body treatment) to standard vision therapy can help people with eye coordination problems that cause eyestrain, blurred vision, and headaches. The trial will involve 100 adults who work on screens a…

This study tests whether a combination of gentle brain stimulation and visual exercises can improve vision and daily function in people with glaucoma who have lost some side vision. About 56 adults with open-angle glaucoma will receive both real and sham treatments in a crossover…

This study tests whether daily SMS or WhatsApp reminders can help people with primary open-angle glaucoma stick to their eye-drop schedule. About 84 adults will be split into two groups: one gets the reminders plus weekly educational messages for 3 months, the other gets standard…

This study will test perfluorohexyloctane eye drops, the only approved drug in China for dry eye disease related to meibomian gland dysfunction. Researchers plan to enroll 2000 adults and track their symptoms, eye health, and any side effects over 12 weeks. The goal is to see how…

This study tests a special laser to help people who had cataract surgery with a standard lens implant see better up close or correct remaining blurry vision. About 12 participants will receive the laser treatment, and doctors will check if it safely improves near or distance visi…

This study explores how visual impairment affects movement and daily activities, and tests a wearable system called VIS4ION that provides audio and touch cues to help users navigate. Researchers will enroll 150 adults with visual impairment and healthy controls to see if the devi…

This study will test whether a special type of lens implant (extended depth-of-focus, or EDOF) can give better vision and more satisfaction than standard monofocal lenses for people with both glaucoma and cataracts. About 74 adults with early-to-moderate open-angle glaucoma will …

This study tests a blink reminder program called 'BlinkEasy' in 28 adults aged 18–40 who use screens at least 4 hours a day and have dry eye symptoms. Over three months, researchers will measure if the app slows the loss of oil glands in the eyelids and improves eye comfort. Part…

This clinical trial tests whether transcranial magnetic stimulation (TMS) can restore vision in adults with severe retinal degeneration. Over 100 participants will receive either real TMS or a sham (fake) treatment for five days, and their eyesight will be checked up to a year la…

This study tests a program called COMA-F, designed to help caregivers of patients with severe acute brain injury manage emotional distress. The program teaches skills to cope with uncertainty and long-term caregiving challenges. Researchers will compare it to a basic education pr…

This study compares two ways of doing cataract surgery to find out which one helps people see better the day after the operation. The researchers will test a newer method that keeps the surgery inside the lens capsule, hoping it causes less damage to the eye's inner lining. About…

This study tests a new method called Zero CDE for cataract surgery. It uses a special laser to break up the cloudy lens into tiny pieces that can be removed without using much energy. The goal is to see if this technique leads to fewer side effects and quicker recovery. About 90 …

This study compares two common eye drops—rebamipide and diquafosol—for managing dry eye in people having cataract surgery. Sixty adults with mild to moderate dry eye will use one of the drops four times a day, starting one month before surgery and continuing for three months afte…

This study looks at whether giving sedation (medication to help you relax) during cataract surgery improves patient comfort and satisfaction. About 120 adults having cataract surgery under numbing eye drops will be randomly placed into one of three groups: no sedation, mild sedat…

This study tests whether watching 3D movies can improve depth perception and vision in children aged 4 to 12 who still have some vision loss from lazy eye (amblyopia) despite prior treatment. Forty children will be randomly assigned to watch three movies in either 3D or 2D, then …

This study tests acoltremon eye drops in 60 adults with dry eye disease to see if they improve symptoms like discomfort and blurry vision. Participants will complete surveys over three months to track changes. The goal is to understand how well the drops work in everyday life for…

This study tests a new surgical gel, IXIUM TWIN, designed to protect the eye during cataract surgery. About 180 adults having cataract surgery will receive either the new gel or an approved one to see if it causes less damage to the eye's inner lining. The goal is to offer surgeo…

This study looks at whether a common procedure for varicose veins—called endovenous ablation—can also reduce knee pain in people aged 80 and older. The researchers will follow 50 participants for one year after treatment, measuring pain and knee function. The goal is to see if im…

This study tests a miniaturized smart contact lens in 32 people—some healthy, some with Stargardt's disease—to see if it is comfortable and easy to use. The lens tracks eye movements to help with vision tasks. Researchers will check for side effects and ask participants how they …

Researchers want to understand the different ways pain works in people with rheumatic diseases such as lupus, rheumatoid arthritis, and Sjogren's syndrome. The study enrolls up to 225 people aged 9 to 85 who have or may have a rheumatic disease, plus healthy volunteers matched by…

Researchers are studying whether navigational memory fades before other spatial memory in people with Parkinson's disease and related conditions. The pilot includes 80 participants: those with mild or advanced Parkinson's, those with parkinsonism, and healthy volunteers. Particip…

Researchers at Shanghai General Hospital are studying whether exercise relates to visual function in people with glaucoma. About 100 patients aged 18 to 100 answer a questionnaire about their physical activity. The team then measures central visual field, retinal nerve fiber laye…

Anti-VEGF injections treat conditions like diabetic macular edema, age-related macular degeneration, and retinal vein occlusion by adding fluid inside the eye, which can briefly raise eye pressure. This observational study at Assiut University follows 50 adults receiving these ro…

Doctors use anti-VEGF injections to treat retinal diseases such as age-related macular degeneration and diabetic macular edema, and patients often need these shots for years. During each injection, a small tool holds the eyelids open, stretching the upper lid. Researchers want to…

This project at King's College London asks how hospital outpatient departments can work better for people with neurofibromatosis who also have sensory challenges. About 30 patients, carers, and staff from Guy's and St Thomas' NHS Foundation Trust take part in interviews, observat…

Researchers at Assiut University are studying whether rheumatic diseases such as rheumatoid arthritis, lupus, and Sjogren's syndrome harm the meibomian glands, the tiny eyelid glands that keep tears from evaporating. The study compares 120 people with these conditions to 30 healt…

Researchers are observing patients in China who have both a tumor in the sellar region of the brain and an unruptured intracranial aneurysm. The study compares three approaches: removing the tumor before treating the aneurysm, treating the aneurysm before removing the tumor, or r…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study follows adults having cataract surgery to see how their fear of falling, vision-related quality of life, and ability to follow post-surgery care instructions change over three months. Researchers will measure these factors before surgery and again at one and three mont…

This observational study will use advanced imaging techniques to measure changes in the retina and choroid (the layer beneath the retina) in people with eye diseases and healthy volunteers. Over 5 years, researchers will track thickness and blood vessel density to better understa…

After cataract surgery, the membrane holding the artificial lens can turn cloudy, blurring vision. The standard fix is a quick laser procedure called Nd:YAG capsulotomy, but doctors disagree on whether it shifts the lens. This study measures the lens position in 80 people using t…

This trial tests whether eplerenone, a drug already approved for other conditions, lowers eye pressure in healthy adults. Researchers will compare eplerenone with a placebo in a crossover design, where each participant takes both treatments at different times. Eye pressure is mea…

This study investigates whether the speed at which blood sugar falls after starting a new diabetes medicine affects small blood vessels in the eye. Adults with type 2 diabetes who are beginning a GLP-1 receptor agonist or an SGLT2 inhibitor will undergo advanced eye scans and blo…

This study will measure how healthy volunteers move their eyes and head when searching for a tank in simulated night vision goggle images. Ten participants will complete four sessions with different viewing conditions, including fog and restricted views. The goal is to understand…

This study will test whether using virtual reality headsets raises the risk of seizures in adolescents and adults with epilepsy. Forty participants will wear a VR headset while their brain activity is recorded with EEG, comparing periods with the display off, on, and with hand co…

This study investigates whether a protein called FCRL5, found on certain immune cells, can serve as a marker for multiple sclerosis (MS) activity and treatment response. Researchers will track MS patients with blood tests every six months for two years, and compare their results …

This study investigates whether computerized cognitive training can change brain metabolism and excitatory/inhibitory balance in adults with schizophrenia. Participants will undergo brain imaging and EEG before and after about 10 hours of either perceptual discrimination or cogni…

This study looks at whether older adults experience a drop in thinking skills after outpatient cataract surgery done under sedation. Researchers will test participants' memory and attention before surgery and again at 3 weeks and 3 months afterward using a phone or video call. Th…

This study will screen over 7,000 adults aged 40+ living in affordable housing in New York City for undiagnosed high blood pressure and glaucoma. Participants who need follow-up care will be randomly assigned to receive text message reminders or usual care. The goal is to see if …

This study follows children aged 7-18 who have nearsightedness (myopia) in only one eye and are being treated with MiSight 1 Day contact lenses in that eye. The other, non-myopic eye is simply observed to see if and when it becomes nearsighted. If it does, standard myopia control…

This study evaluates whether an investigational eye imaging device, UNITY DX, can measure the thickness of the cornea and its epithelial layer as accurately and consistently as a commercially available device. About 110 participants with normal or abnormal corneas will undergo mu…

This early-stage trial is evaluating the safety, tolerability, and how the body absorbs PAN-90806, an experimental eye drop being developed for wet age-related macular degeneration (AMD), a leading cause of vision loss. Healthy adults aged 18 to 50 will receive either PAN-90806 o…

This observational study compares corneal thickness six weeks after routine cataract surgery in people with Fuchs endothelial corneal dystrophy (FECD) versus those without the condition. Researchers aim to see whether FECD eyes swell more or recover differently after surgery. Par…

This study follows adults having cataract surgery who choose either a trifocal or monofocal intraocular lens implant. It asks whether one type leads to more difficulty or visual disturbances, like glare or halos, when driving at night. Participants must be licensed drivers with r…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This study compares two common prostate medications, tamsulosin and silodosin, to see how they affect pupil size and the thickness of a layer at the back of the eye called the choroid. Men aged 50 and older with benign prostatic hyperplasia (BPH) who have not used these drugs bef…

This observational study tests whether wearable sensors and digital health tools can reliably measure falls, movement, speech, and thinking skills in people with progressive supranuclear palsy, Parkinson's disease, or multiple system atrophy. Participants wear a pendant sensor an…

This study uses a novel ingestible mini-pill to collect bacteria samples from different parts of the gut in people with Sjögren's disease and healthy volunteers. By comparing these samples with mouth and stool bacteria, researchers hope to understand how the microbiome relates to…

This study is testing a new, investigational eye scanner that uses light waves to measure the eye before cataract surgery. Researchers want to see if its measurements match those of a standard device, and whether an artificial intelligence model can better predict the correct len…

This study is testing whether a specialized eye scanner called the MONA IV can capture clear, detailed images of the retina's tiny cells and blood vessels. Researchers will use it in people with conditions like glaucoma or age-related macular degeneration, as well as in healthy v…

This study uses a special eye scan called OCTA to examine how blood sugar control relates to tiny blood vessel changes in the retinas of people with diabetic retinopathy. Researchers will compare patients with well-controlled and poorly controlled blood sugar levels. The goal is …

This study checks how accurately eight different formulas predict the lens power needed for people with very short or very long eyes after cataract surgery. Researchers will measure the actual vision result and compare it to what each formula predicted. The goal is to find which …

This study follows 70 adults aged 50 and older who are having routine cataract surgery. Half have pseudoexfoliation syndrome, a condition that can weaken eye tissues, and half do not. Researchers measure corneal stiffness before surgery and at several points afterward to see whet…

This study investigates how a drug called Cobenfy KarXT, which affects the brain's cholinergic (acetylcholine) system, alters brain activity during memory and thinking tasks. About 30 people with essential tremor or epilepsy who are already scheduled for deep brain stimulation (D…

This study tests whether showing patients with diabetes short animated videos (in English or Spanish) about diabetic eye disease can improve their understanding and increase how often they return for follow-up eye exams. About 150 patients at Zuckerberg San Francisco General Hosp…

This trial tests whether an artificial intelligence model called OCT-PRO can predict how well a person will see after cataract surgery more accurately than standard doctor predictions. The AI analyzes eye scans and other clinical data to forecast visual recovery. About 534 adults…

This study compares two methods for aligning toric intraocular lenses during cataract surgery: a digital image-guided navigation system (Verion) and the traditional manual corneal marking technique. Researchers measure how closely the manual mark matches the digital reference in …

This study aims to identify and describe people with allergic conjunctivitis (eye allergies) caused by cats or birch tree pollen, with or without accompanying allergic rhinitis (hay fever). Researchers will collect information and perform allergy tests to see who qualifies for fu…

This study investigates whether people with central or peripheral vision loss develop heightened senses of taste and smell. Researchers will measure brain responses to sweet and vanilla flavors in 50 visually impaired adults and compare them to sighted controls. The goal is to un…

This observational study looks at whether combining genetic information with standard clinical data can better predict who will develop multiple sclerosis after a first episode of optic neuritis (inflammation of the optic nerve). Researchers will follow 180 people aged 16 and old…

This study follows 1,000 preschool children (ages 0-6) with refractive errors like nearsightedness, farsightedness, or astigmatism. Researchers aim to map how these conditions progress, identify related health issues, and find the best ways to correct vision early. The goal is to…

This study aims to find which eye tests best predict vision in people with surface eye diseases like neurotrophic keratopathy and limbal stem cell deficiency. Researchers will collect data from standard exams and patient questionnaires from 1,000 adults. The goal is to identify k…

This study surveys about 2,800 adults aged 65 and older in Xinxing County, China, to measure how many have untreated vision or hearing problems. Participants receive eye exams, hearing tests, and questionnaires. The goal is to provide local health services with data to improve ca…

This study tests whether a video-based eye exam can help more people in rural Nepal get the cataract surgery they need. Currently, only about 3% of patients referred from local clinics actually make it to the hospital for surgery. The study will compare a new tele-ophthalmology s…

This study compares how various myopia control methods—like special glasses, contact lenses, eye drops, and light therapy—affect eye strain in children and adolescents aged 6 to 18. Researchers will survey 600 participants to see which approaches cause the least visual fatigue. T…

This observational study will compare dental caries (tooth decay) experiences and quality of life between visually impaired and sighted children aged 6 to 14. Researchers will use a special questionnaire to measure how cavities affect daily life, and will also count decayed, miss…

This trial aims to see if educational videos or audio messages can improve parents' knowledge and practices about retinopathy of prematurity (ROP) screening. About 99 parents of premature infants in Karachi will receive either a video, audio, or standard pamphlet. Their understan…

This study aims to develop new methods to help veterans with vision loss caused by age-related macular degeneration. About 20 veterans aged 50 and older with reduced vision will take part. Researchers will measure how well they recognize objects and how their brains respond befor…

This study will use a special imaging device (AS-OCT) to measure the thickness of the cornea's outer layer in 360 adults with nearsightedness, farsightedness, astigmatism, or normal vision. The goal is to see if different vision problems have unique thickness patterns. Participan…

This study will test a new, noninvasive camera called XyCAM CRE that measures blood flow in the back of the eye. Researchers will compare its images with standard eye tests in 350 adults with retinal disorders. The goal is to see if this camera can provide extra information to he…

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…

This study will see if outdoor activities like rafting, canyoning, and kayaking can help teens with and without disabilities feel more included and connected. About 35 teens aged 12–16 will take part, with some doing the activities and others not. Researchers will measure changes…

This study will measure eye pressure in one person with mild keratoconus before and one month after corneal cross linking. The goal is to see how the treatment changes eye pressure using a special device called Corvis CT. This is an observational study, not a treatment trial.

This study tests whether a personalized care approach helps patients with chronic macular diseases (like wet age-related macular degeneration and diabetic macular edema) attend their regular eye injection appointments. Many patients skip these vital treatments, risking further vi…

This study looks at whether a new, objective way to fit toric contact lenses (for astigmatism) gives the same results as the traditional subjective method. About 45 adults with astigmatism will have their lens prescription checked both ways. The goal is to see if the new method c…

This study looks at whether a common type of glaucoma eye drop (prostaglandin analogues) can protect the eye's nerve cells directly, not just by lowering eye pressure. Researchers will review medical records from 1500 adults with glaucoma over 3 years, comparing those on prostagl…

This study will enroll 50 adults with a specific type of retinal detachment to look for clues in eye fluid and images that might predict a complication called PVR. Participants will receive standard surgery plus extra non-invasive eye scans and a sample of their eye fluid taken d…

This study will follow 421 people with keratoconus, a condition that thins and bulges the cornea, to learn how it progresses and what factors increase risk. Researchers will use eye exams and imaging to track changes over time. The goal is to improve how doctors manage the diseas…

This study will measure how eye pressure changes after common laser vision correction surgeries like PRK, LASIK, and femtosecond laser. Researchers will compare two measurement methods—Corvis CT and the standard applanation tonometer—in 50 people aged 19 to 35 with mild to modera…

This study looks at people with primary angle-closure glaucoma who need a specific type of eye surgery. The goal is to find out which patients are at higher risk for a rare but serious complication called ciliary block, where fluid builds up in the wrong part of the eye. Research…

This study will test a wearable device called Syde® in 30 people with progressive supranuclear palsy (PSP-R). The device tracks movement and activity during daily life. Researchers want to see if patients find it easy to use and if the data matches standard clinic tests. The goal…

This study will analyze eye and brain scans from over 200,000 people to see if eye images can predict brain diseases like small vessel disease and other health problems. Researchers will build computer models to map eye features to brain structure and disease diagnoses. No treatm…

This study tests whether asking people to write down their personal reasons for or against cataract surgery helps them make a clearer decision. About 268 adults with cataracts will be randomly assigned to either do this writing exercise or not. Researchers will then track how man…

This study will look at what happens when a standalone eye center becomes part of a government hospital in Kalaiya, Nepal. Researchers will track changes in how many patients visit, follow up, and get referrals, and ask patients and staff what they think. The goal is to learn if …

This study tests a computer program that learns from patient data to predict how the body will respond during anesthesia. Researchers will check if the AI can accurately forecast changes in brain activity and vital signs. 115 adults having planned surgery will take part. The goal…

This study will look back at the medical records of 150 children with retinoblastoma who received additional eye treatments after initial chemotherapy. The treatments include radioactive plaque therapy, freezing therapy, or laser therapy. The goal is to see how often each treatme…

This study looks at 50 people with neuromyelitis optica spectrum disorder (NMOSD) who seem stable on rituximab treatment. Researchers want to see if hidden damage to brain cells, measured by a protein called GFAP and special MRI scans, can predict future relapses or worsening dis…

This study looks at whether dry eye disease makes it harder to calculate the right lens power for cataract surgery. Researchers will compare 100 patients with and without dry eye to see if those with dry eye have less accurate lens measurements. The goal is to find out if treatin…

This study will measure how pupil size and eye shape affect visual quality in 300 people with normal eyes or after refractive surgery. Researchers will use questionnaires and special instruments to track symptoms and eye measurements. The goal is to better understand what influen…

This study looks at why some eye centers in rural India have better rates of follow-up after cataract surgery than others. Researchers will study 150 patients and staff at about 120 vision centers to find what works. Then they will test a package of improvements—like reminders, c…

This survey will ask about 60 people—patients with Gaucher disease, their caregivers, and home infusion nurses—how well they understand and use educational materials for at-home VPRIV infusions. The materials include an infusion diary, a guide, and an emergency plan. The goal is …

This study looks at how blinking behavior is linked to the stability of the tear film in adults aged 18 to 65, both with and without dry eye symptoms. Participants will answer a questionnaire, have their vision checked, and undergo non-invasive tear film measurements using an ima…

This study looks at how different ways of managing a child's airway during anesthesia affect eye pressure and heart rate in children having surgery for congenital glaucoma. 75 children will be split into three groups, each receiving a different airway device. The goal is to find …

This study will compare two common anesthesia methods—propofol and sevoflurane—in 40 people having cataract surgery. The goal is to see which one keeps eye pressure more stable and causes fewer heart-related side effects. Researchers will measure eye pressure repeatedly during th…

This study will measure changes in tear fluid proteins in 36 adults with dry eye disease who are already using lifitegrast (Xiidra) eye drops. Researchers want to see how the drug affects these biomarkers over 84 days. The goal is to better understand dry eye and how the treatmen…

Standard eye tests often miss the real-world vision problems people face, like trouble recognizing faces or navigating in low light. This study will test new tablet and virtual reality tools in 50 adults with neurodegenerative eye diseases to see if they better capture how vision…

This study looks at the blood immune cells of 10 adults with a rare inherited skin condition called NIPAL4 ichthyosis. Researchers want to understand why three patients with this skin disease also developed a very rare lymphoma (Sezary syndrome). By describing the normal immune c…

This study will compare 40 nearsighted children to 40 children with normal vision, all aged 8 to 13. Researchers will measure how much oxygen the retina uses and look at blood flow and eye structure. The goal is to learn whether low oxygen plays a role in causing myopia. No treat…

This study will test a new type of eye imaging called OCT in 24 adults who have had a cornea transplant. The goal is to see if the new method can take clearer pictures of the eye to help doctors better detect eye diseases. Participants will have their eyes scanned with the new de…

This study looks at why some children are born with droopy eyelids (congenital ptosis). Researchers will examine the eyelid muscle during surgery and under a microscope to understand what goes wrong. The goal is to learn more about the muscle's development to help guide better su…

This study at Stanford University will test how the brain responds when visual information is turned into patterns of sound or touch. Two hundred blind and sighted participants will use special devices (BrainPort and AI Sight) for 5 weeks. Researchers will use brain scans and per…

This study follows up with 220 people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect tears, saliva, blood, and other samples, along with eye and mouth exams, to trac…

This study tests an AI tool called EyeAgent that helps eye doctors make decisions. About 300 people visiting eye clinics in Hong Kong and mainland China will take part. The AI reviews patient images and history to suggest diagnoses and treatments. The goal is to see if using the …

This study aims to see if virtual reality tests can better measure how age-related macular degeneration affects daily life compared to standard eye exams. Researchers will enroll 60 participants, including healthy adults and those with the eye condition. The goal is to develop a …

This study looks at children born prematurely who had retinopathy of prematurity (ROP), a disease that can cause blindness. Some were treated with laser, others with injections, and some had ROP but no treatment. Researchers will compare their vision and retina structure to see w…

This study looks at whether measuring a specific antibody, anti-Ro52, in the blood of people with Sjögren's syndrome can help predict who will develop serious problems like lymphoma or organ damage. Researchers will follow 150 patients over time to see if higher antibody levels a…

This study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…

This study will follow 110 people with myopic choroidal neovascularization (mCNV), a complication of severe nearsightedness that can cause vision loss. Researchers will use deep learning to analyze eye scan images and build a model that predicts how well patients respond to anti-…

This study will use a non-invasive eye scan called OCTA to look for tiny blood vessel changes in the retina of 90 adults who have taken hydroxychloroquine for at least a year. Hydroxychloroquine, used for autoimmune diseases, can sometimes harm the retina with long-term use. The …

This study checks if a small patch placed on the neck can accurately track body temperature during surgery. About 30 adults having planned surgery will wear the patch while standard temperature probes are also used. The goal is to see if the patch matches the accuracy of current …

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This study aims to see if elderly patients with age-related macular degeneration (AMD) find a new web-based eye-tracking system easy and acceptable to use at home. The system is designed to help patients monitor their vision without frequent clinic visits. Thirty patients aged 55…

This study tests a special program designed to improve critical thinking, reflective thinking, and motivation to learn in nursing students. About 243 students will take part in the program, which focuses on building skills like problem-solving and open-mindedness. Researchers wil…

This study will measure sex hormone levels in 4000 people with NMOSD, a rare autoimmune disease affecting the nerves. Researchers want to see if hormone changes are linked to the disease. Participants will give blood samples for hormone testing. The study does not test any new dr…

This study will compare how often autonomic nervous system problems occur in people with neuromyelitis optica spectrum disorder (NMOSD) versus multiple sclerosis (MS). Researchers will use questionnaires and bedside heart tests to measure symptoms like dizziness, bladder issues, …

This study looks back at medical records of 200 people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Researchers will analyze vision tests and eye scans to see how these diseases progress and how genetics affect symptoms. The goal is to find be…

This study will test a new way to care for people in Ghana who have both a neglected tropical skin disease (like leprosy or Buruli ulcer) and mental health challenges like depression or anxiety. Researchers will work with 200 affected adults and local health workers to create a G…

This study will use a special eye scan called OCT to look for early signs of retinal damage in people with diabetes who have no vision problems. Researchers want to see if these scans can detect changes before symptoms appear. About 112 participants will get a detailed eye exam, …

This study looks at how diabetes affects small blood vessels and nerves in the eyes and brain. Researchers will use advanced imaging to detect damage and test a traditional Chinese herbal medicine called Tangshen'an Granules to see if it can help. 160 adults with diabetes will ta…

This study looks at how working night shifts changes eye movements, attention, and the ability to spot blood clots in lung scans. Forty emergency radiologists will be tested after a night shift and after a good night's rest. They will do eye-tracking tasks, read CT scans, and wea…

This study will analyze corneal tissue that is normally thrown away during a common myopia surgery called CLEAR (or SMILE). Researchers will test the tissue's strength and structure to learn more about how the cornea behaves. The goal is to improve future eye surgeries by underst…

This study examines immune cells in 60 people with allergic conjunctivitis, both those receiving desensitization therapy and those not, plus healthy controls. Researchers will analyze blood and tear samples to measure specific immune markers and cell activity. The goal is to find…

This study compares a standard high-field MRI with a portable low-field MRI to see if the portable version can detect brain damage in people in a coma after cardiac arrest. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two …

This study will follow 50 adults with varicose veins and chronic knee pain who are scheduled for standard vein treatment (laser or radiofrequency ablation). Researchers will measure changes in knee pain, stiffness, and function before and after the procedure. The goal is to see i…