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Discarded eye tissue yields clues for better vision correction

NCT ID NCT04817592

Knowledge-focused Sponsor: University of Bern Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study will analyze corneal tissue that is normally thrown away during a common myopia surgery called CLEAR (or SMILE). Researchers will test the tissue's strength and structure to learn more about how the cornea behaves. The goal is to improve future eye surgeries by understanding the biomechanics of the cornea. The study involves 100 patients aged 20-50 scheduled for CLEAR surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could improve our understanding of corneal strength and shape, potentially leading to safer and more precise vision correction procedures.
What could go wrong
This is an early observational study on discarded tissue, not a treatment trial. The findings may not directly change clinical practice or benefit participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy subjects voluntarily undergoing routinely prescribed CLEAR /SMILE intervention

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for CLEAR procedures for myopia (range: \>-3D with an astigmatism \<0.25D) in the age group 20-50 years. * Willing and able to return for scheduled follow-up examinations * Able to provide written informed consent and follow study instructions in English or German Exclusion Criteria: * Irregular corneal topo-/tomography (Asymmetry \>1.0D within the inner 5mm) * Previous intraocular or corneal surgery of any kind in the eye to be treated, including any type of surgery for either refractive or therapeutic purposes. * History of steroid-responsive rise in intraocular pressure, glaucoma, or preoperative intraocular pressure (IOP) \> 21 mmHg in either eye. * History of diabetes, diagnosed autoimmune disease, connective tissue disease or clinically significant atopic syndrome.

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Conditions

The condition(s) this trial relates to.

corneal disorder myopia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myopia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • IROC AG

    Zurich, 8002, Switzerland

More trials for these conditions

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