Can AI protect Kids' eyesight where eye doctors are scarce?
NCT ID NCT07825428
First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time
Summary
Researchers are testing whether an artificial intelligence tool can sort children by their risk of nearsightedness and guide personalized prevention, such as more outdoor time and special glasses. The trial enrolls about 1,600 students in grades 1 through 3 from public primary schools in remote counties of Guizhou and Yunnan, China. Schools are randomly assigned to either the AI-guided approach or the usual screening and referral. Over 12 months, the study tracks changes in eye length and vision to see if the AI strategy works better and is worth the cost.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- an AI-based risk-stratified intervention strategy that combines outdoor activity guidance and defocus spectacle lenses
- What this could lead to
- If it works, this approach could give schools in remote areas a practical way to identify children at risk of myopia and slow its progression without needing specialized eye exams.
- What could go wrong
- The trial relies on AI risk predictions and behavior changes, which may not translate into meaningful protection for every child. Results from rural China may not apply to other settings, and the 12-month follow-up is too short to show long-term effects on vision.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 1,600 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 to 9 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
1. School level: Inclusion Criteria: * The school is a regular public primary school located within a project county in Guizhou Province or Yunnan Province. * The school has the organizational capacity to conduct myopia screening and follow-up studies in children and adolescents, including the ability to coordinate screening organization, parent communication, informed consent collection, result feedback, and follow-up coordination. * The number of students in grades 1-3 in study school is sufficient to meet the requirements for conducting a cluster randomized study. Exclusion Criteria: * The school has implemented a similar systematic myopia intervention program within the past year that may affect the evaluation of study outcomes. * Student mobility is high, with a predicted high risk of transfer, missed visits, or loss to follow-up within 12 months. * There is a lack of accessible medical institutions near the school to support necessary cycloplegic examinations and related services. 2. Participant level: Inclusion Criteria: * Age of participants is 6-9 years (equivalent to grades 1-3 of primary school). * Participants can be able to complete baseline and follow-up examinations including visual acuity, non-cycloplegic autorefraction, and axial length measurements. * For participants who have previously received myopia control interventions such as low-dose atropine eye drops, defocus spectacle lenses, or red-light therapy, a washout period of at least 1 month is required prior to enrollment. Exclusion Criteria: * Baseline spherical equivalent refraction (SER) ≤ -10.00 D. * Presence of ocular or systemic diseases (including infections) that may affect visual acuity or refraction, or use of systemic or topical medications that may alter ocular status or affect ocular health. * Presence of any ocular conditions that preclude suitability for the interventions in this study, including but not limited to amblyopia, manifest strabismus, or current use of orthokeratology lenses. * Presence of any other condition that, in the investigator's judgment, makes the participant unsuitable for enrollment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Shanghai Eye Disease Prevention & Treatment Center
Shanghai, Shanghai Municipality, 200041, China
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The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, 550000, China
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The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Two toric lenses go head to head in vision test
- Eye scans as a window to the body: study probes retinal imaging across diseases
- Lens showdown: which contact lens wins in dim light?
- Myopia glasses may keep working even after kids take them off
- Can glasses that slow nearsightedness also reshape a Child's astigmatism?
- Can a lens put the brakes on worsening Short-Sightedness?