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Eye scans may predict brain disease in massive new study

NCT ID NCT07541651

Knowledge-focused Sponsor: Beijing Friendship Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will analyze eye and brain scans from over 200,000 people to see if eye images can predict brain diseases like small vessel disease and other health problems. Researchers will build computer models to map eye features to brain structure and disease diagnoses. No treatments or procedures are tested—this is purely an observation and data analysis study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a way to screen for brain diseases and other health problems using simple eye scans.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear links, and any future tests would need years of additional research.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 208,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

(1) Ophthalmic Data Cohort: Patients and health check-up participants who underwent CFP , OCT or OCTA examinations at Beijing Friendship Hospital, Capital Medical University, from January 2009 to September 2025.(2) Cerebral Data Cohort: Patients and health check-up participants who underwent cerebral MR (Magnetic Resonance) examinations at the same hospital during the corresponding period.(3) Oculo-Cerebral Matched Cohort: Individuals from Beijing Friendship Hospital, Capital Medical University and the UK Biobank (UKB) database who had any of the above ophthalmic imaging examinations, plus cerebral MR scans, and could be matched with complete clinical information.(4) Clinical Correlation Cohort: Individuals from the above cohorts who had complete ICD (International Classification of Diseases) diagnoses, laboratory test results (including blood glucose, blood lipids, uric acid, etc.) and medical order records at Beijing Friendship Hospital, Capital Medical University.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Eye data: Images must meet quality standards (no significant artifacts, key structures clearly visible), with complete examination records (including examination date and device model). * Brain data: MR images must be free of motion artifacts, with complete sequences (at least including T1-weighted imaging and MRA), and reports must confirm no technical issues. * Eye-brain paired cohort: Must contain at least one type of eye image (including CFP, OCT, or OCTA) along with brain MR data, and be linkable to a unique identifier and clinical information in the database * Clinical data: Clinical information (such as core biochemical indicators, demographic information, and necessary questionnaire items) must have a missing rate ≤30%, with standardized and clear ICD diagnostic codes, complete laboratory test data, and medical order information (including medication or follow-up recommendations) * Prior to initial inclusion in the study, participants must have no history of severe organic diseases (including non-curable or end-stage malignancies, severe heart failure (NYHA Class III-IV), end-stage renal disease (CKD Stage 5), decompensated cirrhosis, or significant functional impairment due to severe cerebrovascular disease sequelae, etc.). Exclusion Criteria: * Ocular examinations in which key features cannot be identified due to conditions such as cataracts or vitreous hemorrhage brain MR images deemed unacceptable in quality due to factors such as metal implants * Clinical information (including core biochemical indicators, demographic details, essential questionnaire items, etc.) with a missing rate exceeding 30% * Individuals who are pregnant or lactating, those with ocular trauma, congenital ocular malformations, or severe organic diseases.

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Conditions

The condition(s) this trial relates to.

cataract cerebral artery stenosis Cerebral Small Vessel Diseases diabetic retinopathy Vitreous Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cataract Cerebral small vessel disease Cerebrovascular stenosis Diabetic eye diseases Vitreous hemorrhage

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.