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Gut bacteria may soothe tired Eyes—A trial puts it to the test

NCT ID NCT07737938

Symptom relief Sponsor: Synbio Tech Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether two specific probiotics—Bifidobacterium longum BL531 and Lactobacillus reuteri LR1349—can reduce eye fatigue caused by blue light and long screen time. Middle-aged adults with digital eye strain take daily probiotic supplements or a placebo for several weeks. Researchers measure changes in eye discomfort and dry eye symptoms using standard questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
probiotic supplements containing Bifidobacterium longum BL531 and Lactobacillus reuteri LR1349
What this could lead to
If effective, these probiotics could offer a simple, non-drug way to reduce eye discomfort from prolonged screen time.
What could go wrong
This is an early-stage trial with a moderate number of participants. The effect may be small or no better than placebo, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women aged 20-65 years * Daily digital screen use \>6 hours for at least 1 year * Mild to severe digital eye strain (CVS-Q score ≥ 6) * Mild to moderate dry eye symptoms (OSDI ≥ 13) Exclusion Criteria: * Amblyopia or strabismus * Severe eye diseases (e.g., glaucoma , cataract , retinal disorders, severe corneal disease) * Ocular surgery within the past 12 months * Chronic systemic diseases (e.g., uncontrolled diabetes, autoimmune disease, severe liver/kidney impairment, cancer) * Recent use (\<1 months) of steroids, antibiotics, immunosuppressants, probiotics, prebiotics, or eye-health supplements * Pregnant or breastfeeding * Allergy to probiotics or study product ingredients * Eating disorders, psychiatric illness, or cognitive impairment affecting compliance * Any condition judged unsuitable by the investigator

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Conditions

The condition(s) this trial relates to.

asthenopia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Digital eye strain (DES)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Taiwan Normal University

    Taipei, 106, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.