Sound and light training may bring back sight after stroke
NCT ID NCT05894434
First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This study tests a training technique that uses repeated flashes of light and bursts of sound to help people who have lost part of their vision after a stroke. The goal is to see if this training can improve how much they can see and how their brain responds. The study will include 72 adults with vision loss from a stroke, some who have had it for a long time and some who recently had a stroke.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Multisensory training (repeated visual and auditory stimuli)
- What this could lead to
- If it works, this could offer a way to restore some vision in people who have lost sight after a stroke, improving daily life.
- What could go wrong
- This is an early-stage study with only 72 people. The training may not work for everyone, and results may not apply to all stroke survivors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 72 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age \>= 18 years old * Homonymous hemianopia diagnosed and referred by a neurologist, confirmed with Humphrey test (Goldmann size V) on first visit. Hemianopia must have been evident for at least 6 months for inclusion in the first experiment and \<1 month for inclusion in the second * Cognitively normal, defined as having normal activities of daily living OR has received a cognitive adjudication of normal through the Wake Forest University School of Medicine or equivalent within the past 12 months * MRI compatible * Has reliable transportation or is able to use transportation provided by the study * English speaking Exclusion Criteria: * Current major medical problems that might independently affect cognition, vision, or interfere with ability to attend study visits. This includes pathology of the retina or optic nerve explanatory of blindness * Unable or unwilling to attend scheduled testing and training sessions, including the 12 month follow up * Current diagnosis of a major neurological disorder that could interfere with the ability to follow task instructions (Dementia, Parkinson's disease, etc.) or that may interfere with the rehabilitation paradigm (uncorrected asymmetric hearing loss, deafness, hemineglect) * Unwilling or unable to provide consent for study participation * Current stroke symptoms deemed exclusionary by a study physician. This will be reviewed on a case-by-case basis by a study physician to determine whether factors may affect study outcomes, aims, or integrity * Taking medication that could negatively influence safety during the intervention * Enrolled in another interventional research study \<= 3 months prior to beginning this study * Self-reports regularly drinking \> 14 alcoholic beverages a week or current illicit drug use
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Wake Forest University School of Medicine
Winston-Salem, North Carolina, 27157, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can computer training rewire the brain to restore sight after stroke?
- Retraining the brain to see again: a new hope for Stroke-Related blindness
- Can home training restore lost vision? new study investigates
- Brain training game aims to restore sight after stroke
- VR driving test reveals how Stroke-Related blindness changes navigation
- Eye exercises may improve reading after stroke vision loss