Can a flash of light beat a blinding eye infection?
NCT ID NCT07743489
First seen Aug 04, 2026 · Last updated Aug 18, 2026 · Updated 3 times
Summary
This study tests whether a light-activated treatment called Rose Bengal photodynamic therapy can help people with a severe fungal eye infection called Fusarium keratitis. The infection can cause vision loss, and standard treatments may not always work. Participants receive either the active light therapy or a sham procedure, and their vision is checked after three months. The goal is to see if this approach can clear the infection and improve visual outcomes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Rose Bengal photodynamic therapy (RB-PDT), a light-activated treatment applied to the cornea
- What this could lead to
- If effective, this could offer a new way to treat Fusarium keratitis, potentially saving vision and reducing the need for more invasive procedures.
- What could go wrong
- The trial is still in progress, and results may not confirm benefit. Risks include possible discomfort, corneal damage, or lack of improvement over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 434 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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Jan 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Presence of culture positive fusarium fungal keratitis * Age over 18 years * Moderate to severe vision loss, defined as Snellen visual acuity of 20/40 (6/12) to 20/400 (6/120) * Corneal thickness ≥350 µm, as measured on AS-OCT * Basic understanding of the study as determined by the physician * Commitment to return for follow up visits Exclusion Criteria: * History of hypersensitivity to Rose Bengal * Evidence of concomitant infection on exam, gram stain, or confocal microscopy (i.e. herpes, both bacteria and acanthamoeba on gram stain) * History of intraocular surgery within the last three months\* * Impending or frank perforation at recruitment * Involvement of sclera at presentation * Presence of desmestocele at recruitment * Non-infectious or autoimmune keratitis * History of corneal transplantation * Pinhole visual acuity worse than 20/200 in the unaffected eye * Participants who are decisionally and/or cognitively impaired
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
4 sites in 3 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Aravind Eye Care System
Madurai, Tamil Nadu, 625 020, India
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Federal University of São Paulo
São Paulo, 04023-062, Brazil
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Stanford University
Palo Alto, California, 94303, United States
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University of Miami - Bascom Palmer Eye Institute
Miami, Florida, 33136, United States