New lens option may reduce need for glasses after cataract surgery in glaucoma patients
NCT ID NCT07436871
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will test whether a special type of lens implant (extended depth-of-focus, or EDOF) can give better vision and more satisfaction than standard monofocal lenses for people with both glaucoma and cataracts. About 74 adults with early-to-moderate open-angle glaucoma will receive the same type of lens in both eyes during cataract surgery. The main goal is to see if the EDOF lens improves intermediate vision (like computer distance) without causing more visual disturbances.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Extended depth-of-focus (EDOF) intraocular lens
- What this could lead to
- If successful, this could show that EDOF lenses are a safe option for glaucoma patients, offering better intermediate vision and less need for glasses after cataract surgery.
- What could go wrong
- This is a small, early-stage trial (74 people) that hasn't started yet. Results may not apply to all glaucoma patients, and EDOF lenses might cause more glare or halos than monofocal lenses.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 74 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: * Patients of any sex aged 18 years or older willing to participate and sign the informed consent form. * Clinically significant cataracts in both eyes. * Patients clinically diagnosed of primary open angle glaucoma (POAG) in both eyes. * Early to moderate POAG, as defined by a mean deviation in the Humphrey Visual Field Analyzer (HFA) no worse than ≤ -12 dB and worse ≥ -2 dB at least in one eye, using a 24-2 SITA standard strategy * Two visual field tests without progression and stability of RNFL in Optical Coherence Tomography (OCT) thickness remaining same or less than 10 um in the previous 6 months, with pharmacologically controlled IOP in both eyes \<21mmHg. * Potential for post-surgery monocular distance corrected visual acuity of ≤ 0.10 LogMAR. * Normal corneal topography. * Able to attend all study visits. Exclusion criteria: * Patients with uncontrolled glaucoma, defined as those with an IOP ≥21 mm Hg despite maximal medical therapy, requiring glaucoma surgery and/or laser in either eye in the next year. * Pre-surgery refractive error requiring IOL implantation beyond the commercially available range. * Patients with a not reliable visual field, a VFI ≤ 60% or defects of ≤ 10 dB in the 4 central points of the visual field. Any other form of glaucoma (pseudoexfoliative, severe forms of pigmentary, primary angle closure glaucoma, etc.), ocular hypertension, zonular instability or possible intuitive lens decentration after surgery. * Patients with any previous glaucoma surgery or any other ocular surgery that can affect the results, or any ocular surgery in the previous six months. * Any other ocular pathology that can affect the results. * Use of topic or systemic medication that may affect vision * Unable to cooperate to obtain consistent testing results. * Participation in any other trial during or within 30 days of the screening visit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new lens make glasses obsolete after cataract surgery?