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Magnetic pulses to the brain may help the blind see again

NCT ID NCT07425717

Symptom relief Sponsor: Shanghai High Myopia Study Group Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This clinical trial tests whether transcranial magnetic stimulation (TMS) can restore vision in adults with severe retinal degeneration. Over 100 participants will receive either real TMS or a sham (fake) treatment for five days, and their eyesight will be checked up to a year later. The goal is to see if this non-invasive brain stimulation can improve visual function safely.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial magnetic stimulation (TMS)
What this could lead to
If it works, this could point toward a non-invasive treatment to improve vision in people with severe retinal degeneration.
What could go wrong
This is an early-stage trial with only 136 participants, and the treatment is very short (5 days). It may not produce lasting or meaningful vision improvement, and the sham group helps control for placebo effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 136 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * between 45 and 70 years old * bilateral severe MMD (META-PM grades ≥ 3) * no prior TMS history or contraindications to TMS Exclusion Criteria: * other significant ocular diseases, such as refractive media opacity, glaucoma, uveitis, ocular trauma, untreated retinal detachment, or lens dislocation * received anti-vascular endothelial growth factor treatment or other ocular surgeries within 3 months * history of epilepsy or family history of epilepsy, intracranial metal implants, or severe cerebrovascular diseases * mental illness, cognitive impairment (MMSE score \< 24), unable to communicate effectively * severe heart disease, liver or kidney dysfunction, or coagulation disorders * pregnant or lactating women * currently participating in other clinical trials.

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Conditions

The condition(s) this trial relates to.

blindness (disorder) retinal degeneration vision disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Retinal degeneration Vision impairment and blindness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Eye and Ear, Nose, Throat Hospital of Fudan University

    Shanghai, 200031, China

  • Hong Kong Polytechnic University

    Hong Kong, China

  • Huadong Hospital of Fudan University

    Shanghai, China

  • Shanghai Ninth People's Hospital

    Shanghai, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.