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Can a simple salt solution boost antibiotics for eye infections?
NCT ID NCT07452588
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will test whether adding a salt water (sodium chloride 5%) eye drop to standard antibiotic treatment helps heal bacterial eye infections faster. About 40 adults with bacterial keratitis will receive either antibiotics plus the salt drop or antibiotics alone. The goal is to see if the salt solution speeds up healing, clears the infection better, and improves vision.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sodium chloride 5% solution (salt water eye drop)
- What this could lead to
- If it works, this could provide a simple, low-cost way to speed up healing and improve outcomes for bacterial eye infections.
- What could go wrong
- This is a very small, early-stage trial with only 40 people, and it has not started yet. The salt solution may not provide any extra benefit over standard antibiotics alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
IncluInclusion Criteria * Age ≥ 18 years. * Clinically diagnosed bacterial infectious keratitis * Positive corneal scraping or strong clinical suspicion of bacterial cause. * Ability to provide informed consent and attend follow-up visits Exclusion Criteria: * • Fungal, viral, or acanthamoeba keratitis. * Recent (\<7 days) topical corticosteroid use. * Corneal perforation or impending perforation. * History of hypersensitivity to study agents. * Systemic immunocompromised state (uncontrolled diabetes, Human immune defecinicy virus). * Poor compliance expected with follow-up.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.