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Eye oxygen levels may hold key to childhood nearsightedness

NCT ID NCT07473401

Knowledge-focused Sponsor: Medical University of Vienna Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will compare 40 nearsighted children to 40 children with normal vision, all aged 8 to 13. Researchers will measure how much oxygen the retina uses and look at blood flow and eye structure. The goal is to learn whether low oxygen plays a role in causing myopia. No treatment is given; this is purely an observation study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study finds clear differences in retinal oxygen use, it could point toward new ways to prevent or slow myopia in children.
What could go wrong
This is an observational study, not a treatment trial. It will not directly test any therapy, and results may not lead to practical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

40 children with myopia and 40 healthy age- and sex-matched controls

Ages

8 to 13 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for children with myopia: * Children aged between 8 and 13 years (inclusive) * Signed informed consent of child and legal guardian * Normal ophthalmic findings except myopia * Cycloplegic spherical equivalent (SE) refraction ≤ -1.0dpt in both eyes * Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant Inclusion criteria for healthy age- and sex-matched controls: * Children aged between 8 and 13 years (inclusive) * Signed informed consent of child and legal guardian * Normal ophthalmic findings * Cycloplegic spherical equivalent (SE) refraction between +0.5dpt and -0.5dpt * Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant Exclusion Criteria: * Intake of stimulating beverages containing xanthine derivatives (tea, coffee, cola-like drinks) 12 hours before the study day * Previous eye abnormalities such as cataract, keratopathy, strabismus, amblyopia, ocular inflammation, trauma, or surgery * History of any disease or syndrome associated with severe myopia such as Marfan syndrome, Stickler syndrome, or retinopathy of prematurity * Non-axial cause of myopia * BCVA less than 20/25 * Intraocular pressure ≥ 21mmHg * Astigmatism ≤ -1.0dpt * Anisometropia ≥ 2dpt * Not able to read letters for visual acuity testing

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Conditions

The condition(s) this trial relates to.

myopia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myopia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Clinical Pharmacology, Medical University of Vienna, Austria

    Vienna, 1090, Austria

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