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Laugh your way to better eyes? trial tests fun fixes for dry eye

NCT ID NCT07524725

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two behavioral interventions—Baduanjin (a gentle 10-15 minute exercise) or laughter exercises using a smartphone app—plus artificial tears, against artificial tears alone for treating dry eye disease. About 540 adults aged 18-45 with moderate dry eye will participate for 12 weeks, with follow-ups up to 48 weeks. The main goal is to see if these activities improve eye discomfort and vision-related quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Baduanjin (a gentle exercise routine) and laughter exercise (facial movements guided by a smartphone app), plus artificial tears
What this could lead to
If it works, this could offer simple, drug-free ways to ease dry eye symptoms.
What could go wrong
This is an early-stage trial with no phase, and the benefits may be small or not last long. The exercises require regular commitment, which may be hard for some people to maintain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 540 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Dec 2033

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥18 TO ≤45 years of age, any sex. * Meet the dry eye diagnostic criteria of the DEWS international consensus, and show both of the following two conditions: OSDI score between 18 and 80; NIBUT (Non-invasive tear break-up time) \< 8 seconds * Best corrected visual acuity ≥ 0.5(10/20) (in each eye). * Intraocular pressure between 5 and 21 mmHg (in each eye). * Women of childbearing potential must agree to use safe contraception during the study. * Willingness/ability to return for all study visits and to follow instructions from the study investigator and their staff. * Voluntary participation and signing of the informed consent form approved by the Ethics Committee. Exclusion Criteria: * NEI corneal fluorescein staining score \> 5 (in either eye). * Wore contact lenses within the past 14 days and cannot commit to not wearing them during the study period (3 months) (in either eye). * Received refractive surgery (LASIK, SMILE) or other ocular surgery, or had ocular trauma within the past 12 months (in either eye). * Had acute allergic conjunctivitis, infection, or ocular surface inflammation within the past 3 months (in either eye). * Eyelid abnormalities that affect eyelid function, such as nystagmus, blepharospasm, ectropion, entropion, or severe trichiasis (in either eye). * Previously diagnosed with glaucoma and received medical or surgical treatment (in either eye). * Currently receiving other ophthalmic or systemic treatments that may affect the tear film. * Allergy to fluorescein sodium. * Have a serious health condition that may limit their ability to participate. * Pregnant, breastfeeding, or planning to become pregnant. * Diagnosed with neurological or psychiatric disorders (e.g., severe anxiety, depression, or severe sleep disorder). * Have difficulty with physical movement. * Previous experience with traditional exercise such as Baduanjin. * Previous experience with laughter exercise.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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