A new lens design might stop adult nearsightedness from worsening
NCT ID NCT07747311
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial tests whether dual-focus contact lenses, which have special rings to slow eye growth, can reduce the progression of myopia (nearsightedness) in young adults aged 18 to 30. Participants will wear either these lenses or standard single-vision lenses for 24 months. The study measures changes in eye length and prescription to see if the dual-focus design helps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dual-focus soft contact lenses (MiSight 1 day)
- What this could lead to
- If effective, these lenses could offer a simple way to slow worsening nearsightedness in adults, reducing future risks of serious eye conditions.
- What could go wrong
- This is a relatively small trial, and results in children may not translate to adults. The lenses may not slow progression as hoped, and contact lens wear carries risks like eye infections or discomfort.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 152 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 30 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Any gender, aged 18-30 years, inclusive. * Successful previous contact lens wearer * Documented ongoing myopia progression (at least 0.50D over past 2 years) * Refractive error meeting the following by cycloplegic autorefraction: * Myopia -0.50D to -5.00D SER in both eyes * Astigmatism (absolute value) ≤ 1.50 D in both eyes * Anisometropia \< 1.50 D SER. Best-corrected distance visual acuity (BCDVA) in current correction as follows: * 0.1 logMAR or better * Interocular difference ≤ 0.1 log MAR Exclusion Criteria: * Current or previous use of pharmacologic or optical myopia control treatment within the past 2 years. * Any ocular disease or abnormality affecting the cornea, lens, retina, iris, ciliary body, choroid, or sclera. * History of manifest strabismus, amblyopia, or nystagmus. * Previous eyelid, strabismus, intraocular, or refractive surgery. I- ntraocular pressure \>26 mmHg. * of premature birth (≥6 weeks before the due date). * Neurological disorders, genetic syndromes, or other conditions that would interfere with completion of study procedures. * Known allergy or hypersensitivity to fluorescein, proparacaine, or tropicamide. * Conditions associated with degenerative myopia or abnormal ocular anatomy (e.g., Marfan syndrome, Stickler syndrome, retinopathy of prematurity, keratoconus, lenticonus, or spherophakia). * Regular use of ocular medications, artificial tears, or wetting agents. * Current use of systemic medications that may affect contact lens wear, tear film, pupil size, accommodation, electrophysiology, or refractive state. * Diagnosis of or treatment for attention-deficit/hyperactivity disorder (ADHD) or a learning disability. * Systemic disease that may affect visual function (e.g., diabetes mellitus). * Ocular inflammation within 30 days before screening. * Slit-lamp findings that contraindicate contact lens wear (e.g., corneal scars, corneal neovascularization, giant papillary conjunctivitis). * Blepharospasm or other eyelid abnormalities that interfere with contact lens wear. * Any severe ocular or systemic condition that, in the investigator's judgment, would interfere with study participation or follow-up.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University Of California, Berkeley Myopia Research Group
Berkeley, California, 94720, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can AI protect Kids' eyesight where eye doctors are scarce?
- Two toric lenses go head to head in vision test
- Eye scans as a window to the body: study probes retinal imaging across diseases
- Lens showdown: which contact lens wins in dim light?
- Myopia glasses may keep working even after kids take them off