Pfizer

This study tested a new vaccine (20vPnC) that protects against 20 types of pneumonia-causing bacteria. About 541 healthy infants in India and Taiwan received either the new vaccine or an existing one over 4 doses. Researchers checked for side effects and measured immune responses…

This study checked how well the Prevnar 13 (PCV13) vaccine works to prevent pneumonia and related infections in adults with HIV. Researchers looked at health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The goal was to see i…

This study tested whether new modified RNA (modRNA) flu vaccines are safe and help the body build protection against the flu. About 1,200 generally healthy adults aged 18 and older took part. Each person received one dose of either an experimental modRNA vaccine or a licensed flu…

This study tested an RSV vaccine in 378 older adults (age 60+) in Korea to see if it is safe and helps the body fight the virus. Participants received either the vaccine or a placebo and were monitored for side effects and immune response. The results will help determine if the v…

This study tested a new type of flu vaccine called a self-amplifying RNA (saRNA) vaccine in 440 healthy adults aged 18 to 49. The goal was to see if it is safe and how the body responds compared to a licensed flu shot or a placebo. Participants received one injection and were fol…

This study tested whether a single injection combining a licensed COVID-19 vaccine and a licensed flu vaccine is safe and triggers a strong immune response. It involved 644 healthy adults aged 50 and older. The main goal was to check for side effects and measure antibody levels a…

This study tested an RSV vaccine in 453 healthy women aged 18-49. It compared a single-dose vial to a multidose vial that includes a preservative to prevent germ growth. The goal was to see if both versions are safe and produce a similar immune response. Participants received one…

This study looked at the safety of the Abrysvo RSV vaccine in pregnant women and their infants in Japan. About 500 pregnant women received the vaccine, and researchers tracked any side effects for 28 days after vaccination and after birth. The goal was to confirm the vaccine is s…

This study tested a new vaccine called VLA15 to see if it is safe and creates a strong immune response against Lyme disease. It included 625 healthy people aged 5 to 65, some with and some without a history of Lyme. Researchers compared two different vaccination schedules to find…

This study tested a new 20-valent pneumococcal vaccine (20vPnC) in 400 Chinese adults aged 50 and older who had never received a pneumonia vaccine. The goal was to see if it is safe and triggers a strong immune response compared to the current 13-valent vaccine. Participants were…

This study tested whether a new Lyme disease vaccine (VLA15) is safe for healthy children aged 5 to 17. Over 3,500 children received either the vaccine or a placebo (saltwater shot) and were monitored for about 2 years. The goal was to see if the vaccine causes any side effects, …

This study tested a new vaccine called MenABCWY that protects against five types of meningococcal bacteria, which can cause serious infections like meningitis. About 309 healthy teens aged 11 to 14 received two doses either 12 or 36 months apart. Researchers checked how well the …

This study looked at whether giving the RSV vaccine and the shingles vaccine at the same time is safe and works well in adults aged 50 and older. About 526 healthy or stable participants received either both vaccines together or one alone. Researchers measured immune responses an…

This study tested a new mRNA vaccine designed to protect against a future flu pandemic. 157 healthy adults received either the experimental vaccine, a licensed flu shot, or a placebo. Researchers monitored side effects and immune responses for 13 months to see if the vaccine is s…

This study tested a new pneumococcal vaccine in 225 healthy toddlers aged 12 to 15 months. The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either one or two doses and were monitored for side effects like redness, fever, and …

This study looked at the safety and side effects of the drug BESPONSA in 421 adults whose acute lymphocytic leukemia had come back or stopped responding to treatment. All participants received BESPONSA as prescribed by their doctor. The main goal was to track serious side effects…

This study looked at how well the drug tafamidis works for Korean patients with a rare heart condition called ATTR-CM. Researchers tracked 13 patients who were already taking the drug to see if it improved their heart function, symptoms, and quality of life. The goal was to under…

This study tested a combination of two targeted drugs, encorafenib and binimetinib, in 98 people with a specific type of advanced lung cancer (BRAFV600-mutant non-small cell lung cancer). The goal was to see if the drugs could shrink tumors. Participants had either not received p…

This study followed 596 adults in France with advanced or metastatic urothelial carcinoma (a type of bladder cancer) who were given avelumab as a maintenance treatment after initial chemotherapy. The goal was to see how long patients lived and how the drug performed in everyday m…

This study tested a drug called inclacumab in 241 people with sickle cell disease aged 12 and older. The goal was to see if it could reduce the number of painful vaso-occlusive crises (VOCs) over 48 weeks compared to a placebo. Participants received either the drug or a placebo, …

This study tested a new way of giving the drug elranatamab to people with multiple myeloma that returned or didn't respond to other treatments. The approach starts with very low doses and gradually increases them to reduce side effects. 86 participants received injections under t…

This study looked at over 9,000 people with rheumatoid arthritis to compare how well different treatments work in everyday life. Researchers compared drugs like TNF inhibitors and tofacitinib, taken alone or with methotrexate. The goal was to find which approach controls disease …

This study tested a drug called somatropin (a growth hormone) in 33 Japanese people with Prader-Willi syndrome, a genetic condition that causes weak muscles, slow growth, and constant hunger. The goal was to see if the drug safely improves body composition by increasing lean musc…

This study tested a drug called lorlatinib in 109 Chinese patients with advanced ALK-positive non-small cell lung cancer whose disease had worsened after previous ALK inhibitor treatment. The goal was to see how many patients' tumors shrank or disappeared. Results help doctors un…

This study tested a gene therapy called SB-525 in 13 adults with severe hemophilia A. The goal was to see if a single infusion could help their bodies produce the missing clotting factor, reducing or eliminating the need for regular factor injections. Participants were followed f…

This study checked how safe and effective the COVID-19 medicine PAXLOVID is in real-world use. Over 3,300 people aged 12 and older who took PAXLOVID were watched for 28 days. Researchers tracked side effects and whether the infection got worse. The goal was to make sure the drug …

This study tested a new medicine called PF-07976016 in 263 adults with obesity to see if it is safe and helps with weight loss. Participants received either the study drug or a placebo (fake pill) for a period of time. The main goal was to measure changes in body weight and any s…

This study looked at the safety of taking rimegepant every day to prevent episodic migraines. 441 adults with a history of migraines took the pill daily and were monitored for side effects. The main goal was to see how well people tolerated the medication over time, not to measur…

This study looked at the long-term safety of the drug tofacitinib in children with juvenile idiopathic arthritis (JIA). It included 302 children who had already taken tofacitinib in earlier studies. Researchers monitored lab tests, side effects, and growth to see how well the dru…

This study looked at how well the drug tofacitinib works for people with psoriatic arthritis in everyday medical practice. 116 adults with moderate to severe disease were observed for 12 months after starting the medication. The goal was to see if the drug could reduce disease ac…

This study tested a daily oral medication called ritlecitinib in 607 adults and teenagers with nonsegmental vitiligo, a condition that causes white patches on the skin. The goal was to see if the drug could bring back at least 75% of color on the face and 50% on the whole body ov…

This study tested whether adding the experimental drug PF-07220060 to the standard hormone therapy letrozole works better than letrozole alone for postmenopausal women with a common type of breast cancer (HR-positive, HER2-negative). About 121 women who had not yet received treat…

This study tested whether adding enzalutamide to the hormone therapy exemestane helps control advanced breast cancer that is hormone receptor-positive and HER2-normal. About 247 postmenopausal women who had already tried up to one prior hormone or chemotherapy took part. The main…

This study tested a new medicine, elranatamab, in 39 Chinese adults with multiple myeloma that stopped responding to several standard treatments. The drug works by helping the body's immune system attack the cancer cells. The goal was to see if the drug is safe and can shrink or …

This study tested a drug called enzalutamide in men with a type of prostate cancer that has stopped responding to hormone therapy but hasn't spread yet. The goal was to see if the drug could delay the cancer from spreading to other parts of the body. About 1,400 men took part, an…

This study looked at 108 people in Korea with a type of blood cancer (B-cell ALL) that had come back or stopped responding to treatment. Researchers tracked side effects and how well the drug Besponsa worked in everyday hospital use. The goal was to make sure the drug is safe and…

This study tested whether taking rimegepant daily or every other day can prevent migraines in people with episodic migraine (4-14 migraine days per month). Over 1400 adults participated, and researchers measured how much migraine days decreased over 12 weeks compared to a placebo…

This study looked at the safety of a medicine called VyndaMx (tafamidis) for people with a rare heart condition called transthyretin amyloid cardiomyopathy (ATTR-CM). Six adults in India took the medicine by mouth, and doctors tracked any side effects for 6 months. The goal was t…

This study looked at a biosimilar version of trastuzumab (a targeted cancer drug) in 8 people with advanced or recurrent HER2-positive stomach cancer. The goal was to confirm the drug's safety and how well it worked in real-world use. Researchers tracked side effects and tumor re…

This study tested whether adding the drug palbociclib to standard hormone therapy (letrozole) helps slow the growth of advanced breast cancer in Asian women who have gone through menopause and have not had prior treatment for their advanced disease. About 340 women took part. The…

This study looked at the long-term safety and effectiveness of an experimental drug (PF-06651600) for adults and teens aged 12 and older with alopecia areata, a condition that causes patchy or total hair loss. Over 1,000 participants received the drug for up to several years, and…

This study followed 152 adults with moderate to severe ulcerative colitis for two years to see if tofacitinib helps control symptoms in real-life settings. Researchers measured symptom relief, like stopping rectal bleeding and normalizing bowel movements, one and two years after …

This study tested whether a combination of two targeted drugs (LGX818 and MEK162) works better than single drugs for people with advanced melanoma that has a BRAF V600 mutation. About 900 patients took part. The combination helped delay cancer growth longer than the single drugs.…

This study looked at how safe and effective the drug Cresemba is for adults with serious fungal infections like invasive aspergillosis or mucormycosis. It involved 94 people in Korea who were already prescribed the drug. The main goal was to track any side effects and see if the …

This study tested a daily pill called abrocitinib for people aged 12 and older with moderate to severe eczema. It looked at how well the drug controls symptoms and its safety over a long period, up to 92 weeks or more. Participants had already completed an earlier study. The goal…

This study looked at how safe and effective Infliximab BS (a biosimilar of Remicade) is for people with rheumatoid arthritis in everyday medical practice. 77 adults who were starting this drug for the first time took part. Researchers tracked side effects and measured changes in …

This study looked at how well the drug lorlatinib works for people with advanced non-small cell lung cancer that has a specific gene change (ALK). All 73 participants had already tried other treatments and their cancer was no longer controlled. The study found that lorlatinib hel…

This study tested a drug called inotuzumab ozogamicin in 44 adults from China whose acute lymphoblastic leukemia (ALL) had come back or stopped responding to other treatments. The goal was to see if the drug could make the cancer disappear or reduce it significantly. The drug wor…

This study looked at medical records of 50 adults with a specific type of heart disease (mixed-phenotype ATTR-CM) to see how well high-dose tafamidis (61 mg daily) works in everyday life. The main goal was to compare how fast nerve damage progressed before and after starting the …

This study tested whether a pill called rimegepant can help prevent migraines in Chinese adults. About 787 people with a history of migraines took the medicine every other day for 12 weeks. The main goal was to see if it reduced the number of migraine days per month compared to a…

This study tested whether the drug rimegepant can help prevent migraines in Japanese adults. About 496 people with a history of migraines took either the drug or a placebo for 12 weeks. The main goal was to see if the drug reduced the number of migraine days per month compared to…

This study tested a drug called rimegepant for quickly treating migraine headaches in adults who cannot use triptans (common migraine drugs) due to side effects, lack of effectiveness, or heart risks. Over 800 participants took either rimegepant or a placebo and reported their pa…

This early-stage study tested a new topical medicine (PF-07905428) for acne. It included 52 healthy volunteers and people with moderate to severe acne, aged 18 to 40. The medicine was applied daily for 2 to 4 weeks. The main goal was to check safety and how the body processes the…

This study tested whether a wearable device called ActiGraph can accurately record walking patterns and physical activity in healthy children ages 3 to 17. Kids wore the device like a watch and belt while doing simple tasks in a lab and then went home to wear it for two weeks. Th…

This study used health records from over 8 million COVID-19 patients in Taiwan to understand the disease's impact and how well the oral antiviral nirmatrelvir/ritonavir works in real-world settings. Researchers compared patients who did and did not receive the treatment to see wh…

This study looked at how much of the COVID-19 treatment nirmatrelvir (Paxlovid) passes into breast milk. Eight healthy breastfeeding women took the medicine three times over two days. Researchers collected breast milk samples to measure drug levels and safety.

This study looked at 185 people with a common type of advanced breast cancer (HR+/HER2-) who were starting treatment with palbociclib combined with other drugs. Researchers observed how long the treatment kept the cancer from growing and how patients' quality of life changed in e…

This study looked at how healthy men absorb, process, and eliminate a drug called PF-07220060. Twelve men took the drug by mouth or by mouth plus an injection. Researchers measured the drug in blood, urine, and stool to understand how it travels through the body. This study did n…

This study tested a new medicine called PF-06414300 in 63 healthy adults aged 18-65. The goal was to see how safe it is and how the body processes it, not to treat any disease. Participants received either the drug or a placebo in single or multiple doses, and researchers monitor…

This study watched 188 adults with advanced lung cancer who were prescribed Vizimpro as their first treatment. Researchers recorded any side effects and how well the drug shrank tumors during routine doctor visits. The goal was to confirm the drug works safely in everyday practic…

This study analyzed data from 123 adults with severe alopecia areata to understand their experiences with the drug ritlecitinib and traditional treatments. Researchers looked at how satisfied doctors were with the treatment and how the disease changed over time. The goal is to ga…

This study looked at how safe and effective IBRANCE® is when used in everyday medical practice. It involved 552 women in Korea with advanced or metastatic breast cancer. Researchers tracked side effects during the first 3 months of treatment. The goal was to gather more informati…

This study reviewed medical records of 693 Japanese patients with a certain type of advanced breast cancer (HR+/HER2-) who received palbociclib plus hormone therapy as their first or second treatment. Researchers wanted to see how long patients lived without the cancer getting wo…

This study gathered information on how often adults with moderate to severe hemophilia A or B experience bleeding while on their usual clotting factor treatment. The goal was to create a baseline to compare against future gene therapy results. About 212 participants took part, an…

This study looked at how two different versions of an experimental drug, PF-07976016, are absorbed into the blood after a single dose. It involved 12 healthy adults and was completed by Pfizer. The goal was to compare the drug levels, not to treat any disease.

This study checks whether prazosin capsules made in Barceloneta (Puerto Rico) work the same in the body as those made in Ascoli (Italy). About 69 healthy adults aged 18 and older will take the capsules and have blood samples taken to measure drug levels. The goal is to confirm th…

This study looked at nearly 20 million health records to see how well different versions of the Pfizer-BioNTech COVID-19 vaccine prevent severe illness, hospital visits, and death. Researchers used existing data from state vaccine registries and insurance claims, so no new partic…

This study tested whether different versions of a CGRP receptor antagonist (a type of migraine medicine) are absorbed and processed by the body in the same way. It involved 64 healthy adults aged 18 and older who received a single dose of each formulation. The goal was to see if …

This study analyzed medical records from 779 Medicare patients aged 65 and older with a specific type of advanced breast cancer (HR+/HER2-). It compared survival between those who received a combination of palbociclib and an aromatase inhibitor (AI) versus those who received an A…

This study looked at medical records from over 2,700 people in Japan with a type of lymphoma (CD20-positive B-cell non-Hodgkin's lymphoma) who were treated with Rituximab Pfizer or Rituxan. The goal was to compare how often serious infections and low blood cell counts happened. T…

This study looked at medical records from 494 adults with advanced kidney cancer to see how well first-line immunotherapy combinations work and what happens when patients switch to other treatments. Researchers tracked how long patients stayed on treatment, their response to ther…

This study reviewed medical records of women with advanced or metastatic HR+/HER2- breast cancer who were treated with palbociclib plus an aromatase inhibitor or fulvestrant in community clinics. The goal was to understand real-world treatment patterns, how long patients stayed o…

This study looked at how two common drugs—cyclosporine (an immune suppressant) and clarithromycin (an antibiotic)—change the way the body processes a new medicine called PF-07328948. 26 healthy adults took part. The goal was to gather safety and drug-level information, not to tre…

This study reviewed medical records from over 1,300 men with metastatic castration-sensitive prostate cancer to see how long they actually take the drugs apalutamide or enzalutamide. It is not a clinical trial but an observation of real-world treatment patterns. The goal is to un…

This study looked at how healthy adults process and eliminate the experimental drug PF-07304814. Five participants received a single dose with a tiny radioactive tag, and researchers measured how much of the drug left the body in urine and stool over time. The goal was to underst…

This study collected information from over 1,000 men in Finland with metastatic prostate cancer that has spread. Researchers looked at patient details, what treatments they received, and how well those treatments worked. The goal was to better understand the disease and its impac…

This study looked at how the experimental drug PF-07054894 moves through the body in healthy adult men. Ten participants received a radioactive-labeled version of the drug so researchers could measure how much is absorbed, how it is broken down, and how quickly it leaves the body…

This study looked at how a new medicine called PF-07328948 is handled by the body and whether it is safe in healthy Chinese adults. Ten participants took the drug daily for 7 days. The goal was to gather early safety information for a possible future heart failure treatment.

This study looked at how an experimental medicine for atopic dermatitis (eczema) behaves in the body when made in different versions. Twelve healthy adults each took five different pill forms—some fast-acting, some slow-release—both on an empty stomach and after a high-fat meal. …

This study looked back at medical records of 42 Japanese patients with a type of advanced breast cancer (HR+/HER2-). All patients had previously taken the drugs palbociclib and letrozole in an earlier study. The goal was to see how long they lived overall, without giving any new …

This study examined the safety and side effects of the drug Ibrance (palbociclib) in women with advanced or metastatic breast cancer. Researchers used a large database of real-world patient records rather than conducting a new clinical trial. The goal was to understand how often …

This study looked at how healthy men absorb, distribute, and eliminate the experimental drug PF-07976016. Eight participants took the drug by mouth, and researchers measured how much of it was processed and left the body. The goal was purely to understand the drug's behavior, not…

This study looked at medical records of over 2,700 men with advanced prostate cancer that no longer responds to hormone therapy. Researchers compared two common treatments, enzalutamide and abiraterone, to see which one helped men live longer and stay on treatment longer. The goa…

This study looks at how the drug carbamazepine changes the way the body handles another drug, PF-07248144. It involves 12 healthy adults who will take PF-07248144 alone and then with carbamazepine. Researchers will measure drug levels in the blood to understand the interaction an…

This study looked at health records of over 2 million people in France with atrial fibrillation (an irregular heartbeat) to compare those who took blood thinners and those who did not. Researchers tracked strokes, major bleeding, and deaths between 2016 and 2020. The goal was to …

This early-stage study tested a new medicine called PF-07264660 in 12 healthy Chinese adults to see if it is safe and how the body processes it. Participants received a single IV dose, and three-quarters got the real medicine while the rest got a placebo. The study lasted up to 1…

This study looked at insurance records of over 3,000 men aged 65+ with metastatic prostate cancer that still responds to hormone therapy. Researchers wanted to see how long patients stayed on newer hormone drugs like abiraterone, apalutamide, or enzalutamide as part of their usua…

This study reviewed medical records of over 1,100 people with advanced breast cancer in Japan to see how they were treated with the drug palbociclib. Researchers looked at how often patients had blood tests and how long they stayed on the drug. The goal was to understand real-wor…

This study looked at survey data from over 1,300 people with migraine to compare how satisfied they were with two types of acute treatments: rimegepant (Nurtec) and triptans. Researchers measured quality of life, work productivity, and disability. The goal was to see if one treat…

This early-stage study tested a new medicine called PF-07940369 in 30 healthy adults to see if it is safe and how the body processes it. Participants took the drug or a placebo by mouth for 14 days while staying at a clinic. The study is complete and will help decide if further t…

This study looked at medical records of 507 veterans with prostate cancer who started taking relugolix between 2020 and 2023. Researchers wanted to understand who these patients were, what other treatments they had received, and where they lived. The goal was to describe real-wor…

This study looked at how two other drugs (itraconazole and probenecid) change the way a new medicine (PF-07220060) works in the body. It involved 25 healthy adults who took the new medicine alone and then with the other drugs. The goal was to understand any interactions to help d…

This study looked at medical records of 86 people with HER2+ metastatic breast cancer to see how well a three-drug combination (tucatinib, trastuzumab, and capecitabine) worked after they had already received a treatment called T-DXd. The goal was to measure things like time unti…

This study looked at how healthy men process the experimental drug PF-07104091. Nine participants took the drug by mouth and later received a tiny radioactive version by IV. Researchers measured how much of the drug entered the blood and how it was removed in urine and stool. The…

This study looks at how the drug carbamazepine changes the way the body handles a new medicine called PF-07220060. It involves 14 healthy adults aged 18 to 65. Participants take PF-07220060 once alone and once after several days of carbamazepine, with blood samples collected to m…

This study looked at whether a small device placed on the skin can collect blood samples as well as standard needle draws for the drug zavegepant. Fourteen healthy adults took the drug as a nasal spray, and their blood was tested using both methods. The goal was to see if the sim…

This study looked at insurance records from over 7,300 cancer patients who had a blood clot (VTE) and were treated with either apixaban or low molecular weight heparin (LMWH). The goal was to compare total healthcare costs, including hospital stays, outpatient visits, and pharmac…

This study tested whether a new, higher-dose tablet of the experimental drug atirmociclib works the same in the body as the current tablet. Thirty-five healthy adults each took a single dose of both tablet types after a meal, in random order. The goal was to see how the medicine …

This study looked at how well the drug axitinib works in real-world settings for people with advanced kidney cancer who had already taken sunitinib. Researchers tracked 554 patients to see how long the cancer stayed under control and how long patients stayed on treatment. No new …

This completed Phase 1 study by Pfizer involved 24 healthy adults to compare how the body absorbs two different pill forms of an experimental drug called PF-07248144. Participants received a single dose of each form in a crossover design, and researchers measured drug levels in t…

This study looked at over 131,000 high-risk people in the US who had mild-to-moderate COVID-19 during the Omicron period. It compared those who took the antiviral Paxlovid with those who didn't, to see how much work they missed and the costs of that lost work. The goal was to und…

This study reviewed medical charts of 307 adults in five European countries who were treated with isavuconazole for invasive aspergillosis or mucormycosis. Researchers tracked how well the drug worked, its safety, and how it was used in routine care. The goal was to understand re…

This study tracked 559 adults in Israel with metastatic breast cancer who were prescribed palbociclib (a targeted therapy) as part of their treatment. Researchers wanted to see how the drug was actually used in real life, including which other medicines were combined with it, how…

This study looked at how the experimental drug Ibuzatrelvir is absorbed into the blood in 12 healthy Chinese adults. Participants received a single dose, and researchers measured drug levels and safety. The goal was to understand the drug's behavior, not to treat any disease.

This study looked at over 12,500 people in Korea with atrial fibrillation (an irregular heartbeat) to see how their condition and health outcomes changed over time. Researchers used existing hospital and national insurance records, so no new patients were enrolled. The goal was t…

This study looked at how doctors in Poland treat a common type of advanced breast cancer (HR+/HER2-). Researchers tracked 440 patients to see which treatments were used and how they changed over a year. The goal was to understand real-world care, not to test a new drug.

This study tracked 1,290 people with non-small cell lung cancer who were already taking the drug Lorbrena. The goal was to learn more about side effects, especially brain and liver problems. Researchers wanted to see what factors might increase these risks. The study did not test…

This study looked at how the drug palbociclib works in Chinese women with a certain type of advanced breast cancer. 26 postmenopausal women took the drug, and researchers measured its levels in the body and checked for side effects. The goal was to gather information for Chinese …

This early-stage study aims to understand how the body absorbs and eliminates an experimental Pfizer drug called PF-07248144. Eight healthy adult volunteers will receive the drug both orally and through an IV, with a tiny radioactive marker added to track its movement. Researcher…