New dosing strategy for myeloma drug shows promise in early trial

NCT ID NCT05014412

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new way of giving the drug elranatamab to people with multiple myeloma that came back or didn't respond to treatment. The drug was given as a shot under the skin, starting with low doses and then increasing, with longer breaks between doses over time. The goal was to see if this approach is safe and works well. 86 people took part in the study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Elranatamab

What this could lead to

If successful, this could provide a new treatment option for patients with multiple myeloma that has returned or not responded to prior therapies.

What could go wrong

This is an early-phase study with only 86 participants, so results may not apply to all patients. Side effects like cytokine release syndrome are a known risk.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

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Locations

Blood Cancer and Stem Cell Transplant Clinic

San Antonio, Texas, 78229, United States
Cancer Care & Hematology - Fort Collins

Fort Collins, Colorado, 80528, United States
China Medical University Hospital

Taichung, 40447, Taiwan
Cleveland Clinic Taussig Cancer Institute

Cleveland, Ohio, 44195, United States
East Jefferson General Hospital

Metairie, Louisiana, 70006, United States
East Jefferson General Hospital Bone Marrow Transplant Clinic

Metairie, Louisiana, 70006, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Guy's and St Thomas' NHS Foundation Trust

London, SE1 9RT, United Kingdom
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Huntsman Cancer Institute, University of Utah

Salt Lake City, Utah, 84112, United States
Japanese Red Cross Medical Center

Shibuya-ku, Tokyo, 150-8935, Japan
King's College Hospital NHS Foundation Trust

London, SE5 9RS, United Kingdom
Kobe City Medical Center General Hospital

Kobe, Hyōgo, 650-0047, Japan
MSK Basking Ridge

Basking Ridge, New Jersey, 07920, United States
MSK Bergen

Montvale, New Jersey, 07645, United States
MSK Commack

Commack, New York, 11725, United States
MSK Monmouth

Middletown, New Jersey, 07748, United States
MSK Nassau

Uniondale, New York, 11553, United States
MSK Westchester

Harrison, New York, 10604, United States
Mayo Clinic

Scottsdale, Arizona, 85259, United States
Mayo Clinic Hospital

Phoenix, Arizona, 85054, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).

New York, New York, 10021, United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy

Long Island City, New York, 11101, United States
Methodist Healthcare System of San Antonio dba Methodist Hospital

San Antonio, Texas, 78229, United States
Methodist Hospital Investigational Pharmacy

San Antonio, Texas, 78229, United States
Methodist Plaza Clinical Trials Office

San Antonio, Texas, 78229, United States
Nagoya City University Hospital

Nagoya, Aichi-ken, 467-8602, Japan
National Cancer Center Hospital

Chuo-ku, Tokyo, 104-0045, Japan
National Taiwan University Hospital

Taipei, 10002, Taiwan
Poudre Valley Health System (PVHS)

Fort Collins, Colorado, 80528, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
St. David's South Austin Medical Center

Austin, Texas, 78704, United States
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Texas Oncology-South Austin

Austin, Texas, 78745, United States
The Regents of the University of Michigan

Ann Arbor, Michigan, 48109, United States
The Royal Marsden NHS Foundation Trust

London, SW3 6JJ, United Kingdom
The Royal Marsden NHS Foundation Trust

Surrey, SM2 5PT, United Kingdom
Tulane University

New Orleans, Louisiana, 70112, United States
UCHealth Cancer Care & Hematology - Greeley

Greeley, Colorado, 80634, United States
UCHealth Cancer Care & Hematology - Loveland

Loveland, Colorado, 80538, United States
UF Health Shands Cancer Hospital

Gainesville, Florida, 32608, United States
UF Health Shands Hospital

Gainesville, Florida, 32610, United States
UF Health Shands Hospital Pharmacy Investigational Drug Service - Main

Gainesville, Florida, 32610, United States
University College London Hospitals NHS Foundation Trust

London, NW1 2PG, United Kingdom
University College London Hospitals NHS Foundation Trust NIHR

London, W1T 7HA, United Kingdom
University Hospital,Kyoto Prefectural University of Medicine

Kyoto, 602-8566, Japan
University Hospitals Birmingham NHS Foundation Trust

Birmingham, B15 2TH, United Kingdom
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Utah

Salt Lake City, Utah, 84112, United States