New pill combo shows promise in shrinking breast tumors before surgery
NCT ID NCT06465368
First seen Jun 24, 2026 · Last updated Jul 16, 2026 · Updated 3 times
Summary
This phase 2 trial tested whether adding the experimental drug PF-07220060 to the standard hormone therapy letrozole works better than letrozole alone in postmenopausal women with a common type of breast cancer (HR+/HER2-). The 121 participants took the pills for 14 days before their planned surgery. Researchers measured tumor cell changes through biopsies to see if the combination slows cancer growth more effectively.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PF-07220060 plus letrozole
- What this could lead to
- If successful, this combination could shrink tumors before surgery, potentially improving outcomes for women with HR+/HER2- breast cancer.
- What could go wrong
- This is a small, early-phase trial with only 121 participants and a short 14-day treatment period. Results may not lead to a new standard of care, and side effects are still being evaluated.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AIDPORT Sp. z o.o.
Skórzewo, Greater Poland Voivodeship, 60-185, Poland
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AMG -Crystal Lake
Crystal Lake, Illinois, 60014, United States
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Advocate Good Shepherd Hospital
Barrington, Illinois, 60010, United States
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Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068, United States
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Advocate Medical Group
Park Ridge, Illinois, 60068, United States
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Akademiska sjukhuset
Uppsala, Uppsala LÄN [se-03], 751 85, Sweden
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Azienda Ospedaliero Universitaria Maggiore della Carità
Novara, 28100, Italy
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Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno
Livorno, Tuscany, 57124, Italy
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Baylor College of Medicine Medical Center
Houston, Texas, 77030, United States
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Baylor St. Luke's Medical Center
Houston, Texas, 77030, United States
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Ben Taub General Hospital
Houston, Texas, 77030, United States
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CHU de Saint-Etienne
Saint Priest En Jarez, Pays de la Loire Region, 42271, France
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CaritasKlinikum Saarbrücken St. Theresia
Saarbrücken, Saarland, 66113, Germany
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Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer
Rennes, Ille-et-vilaine, 35042, France
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Centre Hospitalier Lyon Sud
Pierre-Bénite, Rhône, 69310, France
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Centre de Cancérologie du Grand Montpellier
Montpellier, Languedoc-roussillon, 34070, France
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Fondazione IRCCS San Gerardo dei Tintori
Monza, Lombardy, 20900, Italy
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Gustave Roussy
Villejuif, Val-de-marne, 94800, France
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HCL, Centre Hospitalier Lyon Sud
Saint-Genis-Laval, Rhône, 69230, France
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Harris Health System - Smith Clinic
Houston, Texas, 77054, United States
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Hospital Clínico Universitario Virgen de la Arrixaca
El Palmar, Murcia, Región de, 30120, Spain
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Hospital General Universitario Gregorio Marañon
Madrid, Madrid, Comunidad de, 28009, Spain
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Hospital General Universitario de Elche
Elche, Alicante, 03203, Spain
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Hospital Jerez de la Frontera
Jerez de la Frontera, Cádiz, 11407, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [barcelona], 08035, Spain
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Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, 28041, Spain
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Hospital Universitario HM Sanchinarro
Madrid, 28050, Spain
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Hospital Universitario San Cecilio
Granada, 18016, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, Málaga, 29010, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, Catalunya [cataluña], 08041, Spain
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola, Emilia-Romagna, 47014, Italy
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Institut Jules Bordet
Anderlecht, Bruxelles-capitale, Région de, 1070, Belgium
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Institut de Cancérologie de l'Ouest
Saint-Herblain, Loire-atlantique, 44805, France
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Kantonsspital Baden
Baden, 5404, Switzerland
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Mackay Memorial Hospital
Taipei, 10449, Taiwan
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Narodny onkologicky ustav
Bratislava, 833 10, Slovakia
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
Warsaw, Masovian Voivodeship, 02-781, Poland
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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Nemocnica AGEL Komarno
Komárno, Nitra Region, 945 05, Slovakia
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O'Quinn Medical Tower - McNair Campus
Houston, Texas, 77054, United States
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Ospedale Antonio Perrino
Brindisi, 72100, Italy
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Peter MacCallum Cancer Centre
Melbourne, Victoria, 3000, Australia
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Pratia MCM Krakow
Krakow, Lesser Poland Voivodeship, 30-727, Poland
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Royal Melbourne Hospital
Parkville, Victoria, 3052, Australia
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START San Antonio
San Antonio, Texas, 78229, United States
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Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
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Sjukhuset I Gävle
Gävle, Gävleborgs LÄN [se-21], 80187, Sweden
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Tumor Zentrum Aarau
Aarau, Canton of Aargau, 5000, Switzerland
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UZ Leuven
Leuven, Vlaams-brabant, 3000, Belgium
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University Hospital Basel
Basel, Canton of Basel-City, 4031, Switzerland
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Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
Przemyśl, Podkarpackie Voivodeship, 37-700, Poland
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