Can a daily pill bring back skin color? new trial tests ritlecitinib for vitiligo

NCT ID NCT05583526

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 study tested ritlecitinib, an oral drug, in 607 adults and adolescents with nonsegmental vitiligo (a type of white patches on the skin). Participants took either the drug or a placebo daily for 52 weeks. The main goals were to see if the drug could improve skin color on the face and body, and to check for side effects. The trial is complete, and results will show if ritlecitinib is a safe and effective treatment for vitiligo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Ritlecitinib (oral capsule)

What this could lead to

If successful, ritlecitinib could become a new treatment option to restore skin color in people with nonsegmental vitiligo.

What could go wrong

This is a Phase 3 trial, but results are not yet published. The drug may not work for everyone, and side effects are possible. It is not a cure, as ongoing treatment may be needed.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

vitiligo

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACTIVE NONSEGMENTAL VITILIGO STABLE NONSEGMENTAL VITILIGO

Contacts and locations

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Locations

AUDIKA

Córdoba, 14001, Spain
Accellacare

Wilmington, North Carolina, 28411, United States
Accellacare - Wilmington

Wilmington, North Carolina, 28411, United States
Advanced Medical Research, PC.

Sandy Springs, Georgia, 30328, United States
Ajou University Hospital

Suwon, Kyǒnggi-do, 16499, South Korea
Alpesh D. Desai, DO PLLC - Research

Houston, Texas, 77008, United States
Arké SMO S.A de C.V

Veracruz, 91910, Mexico
Audiology

Washington D.C., District of Columbia, 20007, United States
Austin Institute for Clinical Research

Houston, Texas, 77056, United States
Bellaire Dermatology Associates

Bellaire, Texas, 77401, United States
Botho Ke Bontle Health Services

Pretoria, Gauteng, 0184, South Africa
CaRe Clinic

Red Deer, Alberta, T4P 1K4, Canada
California Dermatology & Clinical Research Institute

Encinitas, California, 92024, United States
Celal Bayar Universitesi Hafta Sultan Hastanesi

Manisa, 45030, Turkey (Türkiye)
Center for Dermatology and Dermatologic Surgery

Washington D.C., District of Columbia, 20037, United States
Centre de Recherche Dermatologique du Quebec metropolitain

Québec, G1V 4X7, Canada
Centre de Recherche Saint-Louis inc.

Québec, G1W 4R4, Canada
Centro de Dermatologia de Monterrey

Monterrey, Nuevo León, 64460, Mexico
Clever Medical Research

Miami, Florida, 33126, United States
Clinical & Translational Research Center (CTRC)

Chapel Hill, North Carolina, 27599, United States
Clinresco Centres

Kempton Park, Gauteng, 1619, South Africa
DCC Aleksandrovska EOOD

Sofia, 1431, Bulgaria
Dawes Fretzin Clinical Research Group, LLC

Indianapolis, Indiana, 46250, United States
DelRicht Research

Baton Rouge, Louisiana, 70809, United States
DelRicht Research

New Orleans, Louisiana, 70115, United States
DermEdge Research

Mississauga, Ontario, L4Y 4C5, Canada
Dermatology Clinical Research Center of San Antonio

San Antonio, Texas, 78229, United States
Dermatology Hospital of Southern Medical University

Guangzhou, Guangdong, 510091, China
Dermatology Research Institute

Calgary, Alberta, T2J 7E1, Canada
Dermatology and Ophthalmology Kume Clinic

Sakai, Osaka, 593-8324, Japan
Dermedic Jacek Zdybski

Ostrowiec Witokrzyski, Świętokrzyskie Voivodeship, 27-400, Poland
DermoDent Centrum Medyczne Aldona Czajkowska Rafał Czajkowski s.c.

Osielsko, Kuyavian-Pomeranian Voivodeship, 86-031, Poland
Dermoklinika - Centrum Medyczne spółka cywilna M. Kierstan, J. Narbutt, A. Lesiak

Lodz, Łódź Voivodeship, 90-436, Poland
Dongguk University Ilsan Hospital

Goyang-si, Kyǒnggi-do, 10326, South Korea
Dr Rodney Sinclair Pty Ltd

East Melbourne, Victoria, 3002, Australia
Encore Medical Research of Boynton Beach

Boynton Beach, Florida, 33436, United States
Erciyes Universitesi Tıp Fakultesi Hastaneleri

Kayseri, 38039, Turkey (Türkiye)
Fachklinik Bad Bentheim

Bad Bentheim, Lower Saxony, 48455, Germany
First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, 650032, China
ForCare Clinical Research

Tampa, Florida, 33613, United States
Fujian Medical University Affiliated First Hospital

Fuzhou, Fujian, 350005, China
Guangzhou First People's Hospital

Guangzhou, Guangdong, 510180, China
Guy's & St Thomas' NHS Foundation Trust

London, SE1 9RT, United Kingdom
Hamzavi Dermatology - Canton

Canton, Michigan, 48187, United States
Hospital Clinic de Barcelona

Barcelona, 08036, Spain
Hospital Infantil de Mexico Federico Gomez

Mexico City, Mexico City, 06720, Mexico
Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain
Hospital Universitario Reina Sofia

Córdoba, Andalusia, 14004, Spain
Hospital Universitario de Gran Canaria Doctor Negrín

Las Palmas de Gran Canaria, Canary Islands, 35010, Spain
Huashan Hospital Fudan University

Shanghai, Shanghai Municipality, 200040, China
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Istanbul Universitesi- Cerrahpasa, Cerrahpasa Tip Fakultesi

Istanbul, 34098, Turkey (Türkiye)
Istituti Fisioterapici Ospitalieri (IFO)

Roma, RM, 00144, Italy
Istituto Clinico Humanitas, IRCCS

Rozzano, Milano, 20089, Italy
Lawrence J Green, MD LLC

Rockville, Maryland, 20850, United States
Lynderm Research Inc.

Markham, Ontario, L3P 1X3, Canada
MC "Asklepiy" OOD

Dupnitsa, 2600, Bulgaria
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi

Istanbul, 34890, Turkey (Türkiye)
Marvel Clinical Research

Huntington Beach, California, 92647, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Modern Research Associates, PLLC

Dallas, Texas, 75231, United States
Nagoya City University Hospital

Nagoya, Aichi-ken, 467-8602, Japan
Nippon Medical School Hospital

Tokyo, 113-8603, Japan
North Eastern Health Specialists

Campbelltown, South Australia, 5074, Australia
North York Research Inc

Toronto, Ontario, M2N3A6, Canada
Olympian Clinical Research

St. Petersburg, Florida, 33709, United States
PMG Research of Wilmington, LLC

Wilmington, North Carolina, 28411, United States
Phoenix Pharma

Port Elizabeth, Eastern Cape, 6001, South Africa
Policlinico S. Orsola- Malpighi

Bologna, 40138, Italy
Prairieville Family Hospital (XRay)

Prairieville, Louisiana, 70769, United States
Praxis Leitz und Kollegen

Stuttgart, Baden-Wurttemberg, 70178, Germany
Progressive Clinical Research

San Antonio, Texas, 78213, United States
Remington Davis Clinical Research

Columbus, Ohio, 43215, United States
Remington-Davis, Inc

Columbus, Ohio, 43215, United States
Royalderm Agnieszka Nawrocka

Warsaw, Masovian Voivodeship, 02-962, Poland
SUNY Downstate Health Sciences University

Brooklyn, New York, 11203, United States
Severance Hospital, Yonsei University Health System

Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, 310016, China
Skin Care Research

Hollywood, Florida, 33021, United States
Skin Health Institute Inc.

Carlton, Victoria, 3053, Australia
Skin Specialists, PC

Omaha, Nebraska, 68144, United States
Sociedad de Metabolismo Y Corazon Sc

Veracruz, 91900, Mexico
Sociedad de Metabolismo y Corazon S.C.

Veracruz, 91900, Mexico
Sugamo Kobayashi Derma Clinic

Toshima-Ku, Tokyo, 170-0002, Japan
Task Central

Cape Town, Western Cape, 7530, South Africa
Texas Dermatology and Laser Specialists

San Antonio, Texas, 78218, United States
The Alfred Hospital

Melbourne, Victoria, 3004, Australia
The Catholic University Of Korea St. Vincent's Hospital

Suwon, Kyǒnggi-do, 16247, South Korea
The First Hospital of China Medical University/Dermatology and STD Department

Shenyang, Liaoning, 110001, China
The First Hospital of Wuhan

Wuhan, Hubei, 430022, China
The NeuroMedical Center (XRay)

Baton Rouge, Louisiana, 70810, United States
The Skin Hospital

Darlinghurst, New South Wales, 2010, Australia
The first Affiliated hospital of Wenzhou medical University

Wenzhou, Zhejiang, 325000, China
Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, 300052, China
Tohoku University Hospital

Sendai, Miyagi, 980-8574, Japan
Tokyo Medical University Hospital

Shinjuku-ku, Tokyo, 160-0023, Japan
Twoja Przychodnia SCM

Szczecin, West Pomeranian Voivodeship, 71-500, Poland
UMHAT "Prof. dr. Stoyan Kirkovich" AD

Stara Zagora, 6000, Bulgaria
Universitaetsklinikum Erlangen

Erlangen, Bavaria, 91054, Germany
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
University of Alabama at Birmingham Faculty Office Towers (Regulatory

Birmingham, Alabama, 35294, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of New Mexico Health Sciences Center

Albuquerque, New Mexico, 87102, United States
University of North Carolina Medical Center

Chapel Hill, North Carolina, 27516, United States
Universitätsklinikum Münster

Münster, North Rhine-Westphalia, 48149, Germany
Velocity Clinical Research at The Dermatology Clinic, Baton Rouge

Baton Rouge, Louisiana, 70808, United States
Visage Dermatology and Aesthetic Center

Bowie, Maryland, 20716, United States
Wallace Medical Group, Inc

Los Angeles, California, 90056, United States
Whitby Health Centre Dermatology trials

Whitby, Ontario, L1P 0p9, Canada
Yamanashi Prefectural Central Hospital

Kofu, Yamanashi, 400-8506, Japan
Zhejiang Provincial People's Hospital/Dermatology Department

Hangzhou, Zhejiang, 310014, China
Ziaderm Research LLC

North Miami Beach, Florida, 33162, United States