Pfizer

This study is testing a 5th booster dose of the VLA15 Lyme disease vaccine. It aims to see if the extra dose is safe and helps maintain strong protection against Lyme disease. The study will include about 1,700 healthy people aged 7 and older who have already received 4 doses of …

This study is testing a new medicine called PF-08634404 for adults with early-stage or locally advanced non-small cell lung cancer. Researchers want to see if the drug works better when given alone or with chemotherapy, either before surgery or after other treatments. The trial w…

This study is testing a new medicine, PF-08634404, for adults with advanced bladder cancer that has spread. It will see if the drug is safe, how well it works to control the cancer, and how the body processes it. One group will get the new drug alone, and another group will get i…

This study is testing whether a new drug called PF-08634404 works better when combined with standard chemotherapy for people with advanced stomach, esophageal, or gastroesophageal cancers. The trial has two parts: first checking safety and early effectiveness, then directly compa…

This study is testing a daily oral medication called etrasimod in children aged 2 to 12 who have moderately to severely active ulcerative colitis, a chronic inflammatory bowel disease. The main goal is to see if the drug is safe, effective at controlling the disease, and how it b…

This study aims to monitor the safety and effectiveness of the breast cancer drug TUKYSA in real-world medical practice in Korea. It will enroll 600 adults with advanced HER2-positive breast cancer who are starting TUKYSA treatment as prescribed by their doctor. The main goal is …

This study will monitor the safety and effectiveness of Velsipity tablets over one year in patients with moderate to severe ulcerative colitis. Researchers will track 553 patients taking the medication in real-world medical settings to identify any long-term side effects. The mai…

This study is testing whether a new medicine called PF-08634404 works better when given with standard chemotherapy for a rare, aggressive form of lung cancer called transformed small cell lung cancer. The trial will enroll 40 adults who haven't received treatment for this specifi…

This study aims to monitor the safety and real-world effectiveness of the antibiotic Zavicefta in Japan. It will include about 59 patients who have severe bloodstream infections (sepsis) or reduced kidney function and are receiving Zavicefta for the first time. Researchers will t…

This study aims to see how well the approved drug ritlecitinib works for people with severe alopecia areata (an autoimmune condition causing hair loss) in real-world settings. It will look back at the medical records of about 300 people in the U.S. who started the treatment to un…

This is the first study in people for a new drug called PF-07994525, developed by Pfizer. It aims to find a safe dose and see if the drug shows early signs of fighting cancer in adults with advanced multiple myeloma that has stopped responding to other treatments. The study will …

This study aims to see how well the drug elranatamab works for patients in Taiwan with multiple myeloma that has come back or stopped responding to other treatments. It will follow about 30 adults who have already tried at least four other therapies. The goal is to understand how…

This study aims to see how well a pneumonia vaccine (PCV20) prevents lung infections in adults at higher risk. It will use existing health records from over 800,000 Kaiser Permanente members in Southern California, comparing infection rates between those who received the vaccine …

This study will analyze treatment patterns and outcomes for 4,000 people with ulcerative colitis using existing medical records. Researchers want to understand how patients respond to different medications over time and whether switching treatments earlier leads to better long-te…

This study looks back at existing German health insurance records to better understand ATTR-CM, a rare and serious heart condition. Researchers will analyze data from people diagnosed between 2020 and 2022 to learn about their survival rates, hospital visits, and how common the d…

This study aims to see if a new tablet form of the drug tafamidis gets into the bloodstream the same way as the currently available capsule. It will involve 24 healthy adult volunteers who will take both forms after eating a meal. The main goal is to check if the two forms are eq…

This study will use existing Scottish national health records to see if babies born to mothers who received the RSV vaccine (ABRYSVO) are less likely to be hospitalized with severe RSV infections in their first year of life. It will compare these infants to those whose mothers di…

This study examines how the body processes an experimental cancer medicine called vepdegestrant in people with liver problems compared to those with normal liver function. Researchers will give a single oral dose to 24 participants and measure how the medicine moves through their…

This study aims to observe how the breast cancer drug Talzenna performs in real-world clinical practice in Korea after its approval. It will follow 600 patients already scheduled to receive Talzenna to monitor its safety and effectiveness. This is an observational study, meaning …

This study aims to understand how well current treatments work for advanced bladder cancer in everyday medical practice. Researchers will review existing health records of 3,000 U.S. patients who started treatment after April 2023. The study will track how long treatments keep th…

This is an early safety study to test a new medicine called PF-08065010, which is being developed for rheumatoid arthritis and lupus. The study will involve 100 healthy adults who will receive either the study medicine or a placebo injection or infusion. Researchers will monitor …