Breakfast or fast? a trial puts Prifetrastat's absorption to the test
NCT ID NCT07731100
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This phase 1 trial in 12 healthy adults tests whether eating a high-fat, high-calorie meal changes how much of the experimental drug prifetrastat enters the bloodstream. Each participant receives a single dose of prifetrastat once after a meal and once on an empty stomach, with a two-week break in between. The goal is to determine whether food affects drug levels, which could guide how prifetrastat is taken in future studies and by patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental drug called prifetrastat (PF-07248144)
- What this could lead to
- If successful, this study could provide guidance on whether prifetrastat should be taken with or without food in future trials and for patients.
- What could go wrong
- This is a very early, small phase 1 study in just 12 healthy people, so results may not predict effects in patients or account for individual differences.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Pfizer Clinical Research Unit - New Haven
New Haven, Connecticut, 06511, United States
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