University Hospital, Bordeaux

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested the drug lenalidomide (Revlimid) in 19 people with a rare type of skin lymphoma called leg-type large B-cell lymphoma that had come back or not responded to initial chemotherapy. Participants took lenalidomide pills daily for 21 days, then rested for 7 days, rep…

This large, completed phase 3 trial tested whether giving tranexamic acid (TXA) right after a C-section can prevent postpartum hemorrhage (dangerous heavy bleeding). Over 4,500 women received either TXA or a placebo. The study measured blood loss and need for transfusions. Result…

This phase 2 trial tested whether adding methotrexate (a drug used for arthritis) to standard light therapy helps people with active vitiligo regain skin color. Thirty-two adults with symmetrical vitiligo covering at least 10% of their body took part. Half received methotrexate p…

This early-phase study tested a daily combination of two oral drugs, axitinib and everolimus, in 19 people with advanced solid tumors, particularly kidney cancer. The main goal was to find the safest dose by monitoring side effects in the first month. Researchers also tracked how…

This phase 2 trial tested whether adding the oral drug baricitinib to phototherapy (light treatment) helps restore skin color in adults with progressive vitiligo. 49 participants received either baricitinib plus phototherapy or a placebo plus phototherapy for 36 weeks. The main g…

This study compared two surgical techniques for covering deep leg wounds: the newer Integra dermal substitute (a synthetic skin) versus traditional flap surgery (moving skin from another body part). Researchers tracked complications, scarring, and recovery in 72 patients with tra…

This study looked at 222 adults with Hodgkin lymphoma that had returned or not responded to first treatment. Researchers wanted to see how well the combination of brentuximab vedotin and bendamustine worked in everyday medical practice. They measured how long patients stayed free…

This study looked at whether people with mechanical heart valves can safely check their own blood thinning levels at home instead of going to a lab. Over 900 adults who recently had valve surgery used a device to measure their INR (a clotting test) and had monthly lab checks. The…

This pilot study tested a standardized 5-step weaning procedure to safely remove tracheostomy tubes in 30 brain-injury patients. The procedure involves steps like deflating the tube cuff and using a speaking valve, with a team of doctors and nurses monitoring stability. The goal …

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This study looked at 220 adults with chronic myeloid leukemia who had been in deep remission for at least two years while taking imatinib. Researchers wanted to see if stopping the drug would cause the cancer to come back. They found that many patients stayed in remission after s…

This small pilot study tested whether beta-blockers, a type of heart medication, could shrink or stabilize kidney tumors (angiomyolipomas) in people with tuberous sclerosis. Only 2 participants were enrolled, and the goal was to see if the tumors got smaller or stopped growing af…

This study tested a stem cell transplant approach for adults with relapsed follicular lymphoma, a type of blood cancer. The treatment included the drug rituximab to help control the disease and prevent complications. The goal was to see if this strategy could improve survival and…

This lab study tested whether concizumab, a drug that blocks a natural clotting inhibitor, can improve blood clotting in people with Glanzmann thrombasthenia (GT), a rare genetic bleeding disorder. Blood samples from 20 adults with GT and healthy donors were mixed with concizumab…

This study tested two different methods of pacing the left side of the heart in people with severe heart failure. The goal was to see if pacing from inside the heart (endocardial) works better than the usual method from outside (epicardial). Only 6 adults took part, and the main …

This study tested whether giving oxytocin (a drug that helps the uterus contract) after a second-trimester medical pregnancy termination reduces the chance of retained placenta. 27 women participated. The goal was to see if this simple step could lower the need for additional pro…

This study tested whether a mouthrinse made with red grape seed extract and a fluoride compound can reduce dental plaque. Fifty healthy volunteers used the rinse three times a day for four days without brushing. The trial was double-blind and cross-over, meaning each person tried…

This phase 3 trial tested whether adding two months of Folfirinox chemotherapy before standard radiation and chemo could help more patients with early-stage rectal cancer avoid major surgery. 218 adults with small, low-lying tumors were enrolled. The goal was to see if more patie…

This phase 2 trial tested sodium valproate, a drug used for seizures, in 41 children with Rubinstein-Taybi syndrome (RTS), a rare genetic condition causing intellectual disability. Participants aged 6 to 21 received either the drug or a placebo for one year. Researchers measured …

This study tested whether using a CT scan before heart ablation can make the procedure faster and safer for people with ventricular tachycardia, a fast heart rhythm that can be life-threatening. 119 adults who had a prior heart attack and an implanted defibrillator were randomly …

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study tested a new way to place electrodes in the brain for deep brain stimulation (DBS) in people with Parkinson's disease. Instead of using awake brain recordings to guide placement, the new method uses a special MRI-based target calculated by a computer model. The trial i…

This study tested whether imatinib, a drug used for certain cancers, can reduce skin hardening in people with severe scleroderma. 28 adults received either imatinib or a placebo for 6 months. The main goal was to see if the drug improved skin thickness and quality of life.

This study tested a man-made bone material (HAP/TCP) to repair the nasal septum in 26 adults with severe nose injuries. The goal was to see if it is safe and works as well as using the patient's own bone, while avoiding extra surgery to take a bone graft. Results focused on compl…

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This study looked at whether taking non-steroidal anti-inflammatory drugs (NSAIDs) every day, along with anti-TNF biologic therapy, can prevent new bone growth in the spine of people with ankylosing spondylitis. 188 adults were split into two groups: one took NSAIDs continuously,…

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and c…

This study tested the drug pravastatin in 21 HIV-positive people with high cholesterol who were already on HIV medications. The goal was to see if pravastatin could safely lower their cholesterol without affecting their HIV treatment. Participants received either pravastatin or a…

This study tested a new way to treat paroxysmal atrial fibrillation (a type of irregular heartbeat) using pulsed field energy instead of standard radiofrequency. 292 adults with drug-resistant AF took part. The goal was to see if the new method is faster, safer, and more effectiv…

This study tested whether giving early treatment to adults with COVID-19 who have risk factors (like age over 60 or high blood pressure) could prevent them from needing oxygen, hospitalization, or dying. About 412 people took part. The goal was to see if these treatments are safe…

This study tested a special stent called MEMOKATH 051 in 13 adults with long-term ureter blockages who usually need a standard double J stent. The goal was to see how long the new stent lasts and how well it is tolerated over 3 years. Participants had the new stent placed during …

This study looked at 60 adults with a slipped vertebra in the lower back (degenerative spondylolisthesis) who needed surgery. It compared two types of spine fusion: one that only fuses the back of the spine (GPLI) and one that also fuses the front (TLIF). The goal was to see whic…

This study tested whether using sevoflurane (a gas for anesthesia) during kidney transplant surgery helps the new kidney start working faster compared to the standard drug propofol. About 120 adults receiving a kidney transplant took part. The goal was to see if sevoflurane could…

This study tested a new way to treat blood cancers like leukemia in 16 adults who did not have a standard bone marrow donor. Doctors used a single unit of cord blood that was grown in a lab to increase the number of stem cells before transplant. The goal was to see if this method…

This study looked at 31 adults with chronic myeloid leukemia (CML) whose cancer came back after they stopped taking imatinib. They were given nilotinib, a more powerful targeted therapy, to see if it could make their cancer undetectable again and allow them to stop treatment once…

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study tested whether exenatide, a diabetes drug, plus lifestyle changes helps adults with severe weight gain after treatment for a rare brain tumor (craniopharyngioma). 42 adults aged 18-75 took either exenatide or a placebo for 6 months. The main goal was to see if they los…

This study looked at whether a common antibiotic (piperacillin-tazobactam) could effectively treat ventilator-associated pneumonia in ICU patients who carry resistant bacteria in their gut. The goal was to see if this approach could reduce the need for stronger, last-resort antib…

This study tested the drug sunitinib (Sutent) in 71 people with advanced thyroid cancer that had spread or could not be removed by surgery. The goal was to see if the drug could shrink tumors when standard treatments like radioactive iodine no longer work. Participants took sunit…

This study tested three non-drug approaches—cognitive training, reminiscence therapy, and a personalized program—in 640 people with mild-to-moderate Alzheimer's. The goal was to see if these therapies could delay progression to severe dementia. Participants were followed for chan…

This study looked at 222 people whose leg artery stents had become blocked again. It compared three treatments: standard balloon angioplasty, a drug-coated balloon, and using a laser plus a drug-coated balloon. The goal was to see which option is most cost-effective and improves …

This study tested a combination of two drugs, peginterferon alfa2a and ribavirin, in 17 adults with both HIV and chronic hepatitis C who had not responded to a previous hepatitis C treatment. The goal was to see if this second-line treatment could clear the hepatitis C virus from…

This study looked at whether a therapeutic education program, added to standard medical care, helps people who have had a heart attack or stroke better control their risk factors over one year. About 202 adults aged 18-75 took part. The goal was to see if the program improves phy…

This study tested whether giving personalized physical activity advice to older cancer patients (70+) could help them stay independent during treatment. 302 patients with various cancers receiving curative care were randomly assigned to general health advice or a tailored exercis…

This study looked at 38 kidney transplant patients who had CMV infection. Researchers wanted to see if measuring a type of immune cell (γδ T cells) could help decide who needs extra medication to prevent the virus from coming back. The goal is to avoid unnecessary drugs while sti…

This study tested a non-invasive mapping system (Cardioinsight®) to help doctors treat heart rhythm disorders. It included 492 patients who needed ablation, pacemaker implantation, or risk assessment for sudden death. The goal was to see if the mapping system improves outcomes co…

This study looked at whether women would be willing to collect their own urine sample for cervical cancer screening instead of a traditional swab. 173 women aged 31-49 at a French hospital tried it and answered questions about their experience. The goal was to see how acceptable …

This study tested a new MRI method that measures temperature changes in the prostate. The goal is to help doctors find cancer more accurately and guide laser treatments. The study involved 70 adults who were already scheduled for a prostate MRI. The temperature mapping was added …

This study tested a virtual reality application to help diagnose ADHD in children aged 8 to 12. Thirty children with ADHD participated, using a VR task that measures attention and movement in a lifelike setting. The goal was to find key signs of ADHD that could make diagnosis mor…

This study tested whether MRI can accurately detect lung abnormalities caused by allergic bronchopulmonary aspergillosis (ABPA), a fungal allergy. Researchers compared MRI results to standard CT scans in 25 adults with ABPA or severe asthma. If MRI works well, it could provide a …

This study looked at whether a detailed MRI scan (multiparametric MRI) can accurately tell the difference between benign (non-cancerous) and malignant (cancerous) small kidney tumors. About 387 adults with small kidney masses (1.5 to 4 cm) were scanned before surgery or biopsy. T…

This study tested whether a special light (autofluorescence) can help doctors spot early signs of mouth cancer in people who smoke and drink heavily. 180 adults hospitalized for alcohol withdrawal took part. The goal was to see if the light technique is more reliable than a stand…

This study tested whether a high-detail eye scan called SD-OCT can tell the difference between people with glaucoma and healthy individuals. Glaucoma is a leading cause of blindness, and current tests often miss early signs. Researchers measured eye structures in 109 participants…

This study tested a new rapid test (OCEAN Dx) to identify bacteria in the blood of 110 ICU patients with suspected sepsis. The goal was to see if it works as well as standard blood cultures, which take 48-72 hours. A faster result could help doctors choose the right antibiotics s…

This study tested whether a noninvasive device that measures oxygen levels in the brain can detect dangerous blood vessel spasms after a severe brain bleed. 50 adults with severe aneurysmal subarachnoid hemorrhage were monitored. The goal was to see if this method works as well a…

This study compares two types of PET/CT scans—one using a standard tracer (FDG) and another using a newer tracer (18F-choline)—to see which detects more bone lesions in people newly diagnosed with multiple myeloma. Twenty participants will receive both scans and an MRI within thr…

This study tested whether a special PET-CT scan using a radioactive tracer (18F-FDG) can improve diagnosis of infectious endocarditis on natural heart valves. Researchers scanned 31 adults with suspected endocarditis within 5 days of starting care. The goal was to see how well th…

This study looked at whether a special MRI scan can accurately measure how well a transplanted kidney is working. Researchers compared the MRI results to the standard method (Cr51-EDTA) in 71 kidney transplant patients. The goal was to find a simpler, non-invasive way to monitor …

This early-phase study tested a new way to make a radioactive tracer called 68Ga-DOTATOC for PET-CT scans in 20 adults with suspected or known neuroendocrine tumors. The goal was to see if this new method could find tumors more accurately than the current standard scan (OctreoSca…

This study tested a new genetic screening approach to find cases of a rare inherited nerve disease called TTR-FAP in 130 patients with chronic neuropathy of unknown cause. The goal was to see how many of these patients actually have TTR-FAP, which is often missed due to varied sy…

This study looked at whether a special lung MRI can diagnose bronchiolitis obliterans syndrome (BOS), a serious lung complication after stem cell transplant, as well as the standard CT scan. Sixteen adults who had a stem cell transplant and showed signs of lung problems took part…

This study looked at whether a portable sleep monitor used during a short hospital stay can accurately diagnose sleep apnea in people with multiple system atrophy (MSA), compared to the standard overnight lab test. Thirty adults with probable MSA took part. The goal was to see if…

This study looked at whether a detailed heart ultrasound can find early signs of heart damage in people with leukemia who are receiving a type of chemotherapy called anthracycline. About 100 adults aged 18 to 65 took part. The goal was to catch heart problems sooner, so doctors c…

This study looked at whether analyzing proteins in kidney biopsy samples can better detect early signs of rejection after a transplant. Researchers studied 141 kidney transplant recipients to see if a protein signature could identify microvascular inflammation, a key sign of anti…

This study tested a new MRI method to detect endolymphatic hydrops (fluid buildup) in the inner ear of people with Meniere's disease. The new method does not require a contrast injection, unlike the standard approach. Researchers compared the new scan to the standard contrast-enh…

This study tested an artificial intelligence (AI) system called CAD EYE to see if it could accurately predict whether colon polyps are cancerous during a colonoscopy. Researchers compared the AI's predictions to those of doctors and the final lab results. The goal was to improve …

This study tested whether using a mobile app to track daily moods could help prevent depression in people who recently had a stroke. About 400 adults who had a stroke or mini-stroke used the app for 3 months to report their feelings in real time. The goal was to catch early signs…

This study tested a new way to prevent CMV infection in 42 CMV-positive kidney transplant patients. Researchers combined an antibody infusion with a specific type of immune cell (gamma delta T cells) to see if it could stop the virus from reactivating. The goal was to find a safe…

This study tested whether giving breathing support early (non-invasive ventilation and high-flow nasal oxygen) to people with chest injuries and low oxygen levels could prevent them from needing a breathing tube. 144 patients in the ICU took part. The goal was to see if this earl…

This study tested a new way to position the weak arm in stroke patients to prevent shoulder pain, a common problem that can slow recovery. 76 people who had a stroke within the last 48 hours took part. The program used special supports and slings, along with training for patients…

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…

This study tested whether physiotherapy (special breathing exercises and early movement) could prevent acute respiratory failure within 7 days after a breathing tube is removed in ICU patients at high risk. 245 patients took part. The goal was to see if physiotherapy reduces the …

This study tested whether adding sodium bicarbonate (baking soda) to the standard epidural painkiller (lidocaine with epinephrine) could provide better pain relief for women needing an extremely urgent C-section during labor. 65 women were randomly assigned to receive either the …

This study looked at whether a structured 8-week mindfulness-based stress reduction (MBSR) program is practical for people with Parkinson's disease. Thirty-one participants were enrolled to see how many could complete the program, including weekly group sessions and a full medita…

This study tested whether propranolol, a beta-blocker usually used for heart conditions, can reduce nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT), a genetic disorder that causes abnormal blood vessels. Fifteen adults with HHT took either propranolol or a p…

This study tested whether giving propofol sedation during a lung exam (bronchoscopy) under noninvasive ventilation helps patients with severe breathing failure stay more comfortable and maintain oxygen levels. Forty-six adults with acute respiratory failure needing a diagnostic l…

This study tested whether training in a virtual supermarket could help stroke survivors improve their ability to shop and perform daily tasks. 29 participants either received standard rehabilitation or virtual reality training on a computer for 45 minutes, 5 times a week, over 2 …

This study tested whether a brain-training technique called neurofeedback can help healthy young adults stay awake and think clearly after a full night of sleep deprivation. Twenty-two participants completed eight neurofeedback sessions. The goal was to see if this training could…

This early-phase study tested a freezing technique called cryoablation on 14 adults with painful venous malformations that had come back after standard treatments like surgery or sclerotherapy. The main goal was to check safety and see if it could ease pain and discomfort. Result…

This study tested whether using a computer navigation system with special pre-surgery X-rays (EOS imaging) helps surgeons place a new hip joint more accurately. 78 adults with hip osteoarthritis who needed a total hip replacement took part. The goal was to see if this technology …

This study tested a drug called BX1514M in 38 people with hypertrophic cardiomyopathy, a genetic heart condition that can cause shortness of breath, chest pain, and dizziness. The drug works by tightening veins to reduce a blockage in the heart's main pumping chamber. Researchers…

This study tested whether a simple internet-based self-help program could help people with long-term insomnia stop using sleeping pills like benzodiazepines or Z-drugs. The program used sleep restriction and stimulus control techniques. 62 adults who had been taking sleep medicat…

This study tested a personalized counseling and support program for 130 people with multiple system atrophy (MSA) and their caregivers. The program aimed to identify individual needs and improve daily life management. Researchers measured quality of life and depression symptoms t…

This study looked at whether a one-hour hypnosis session, done 5 to 15 days before a hysterectomy for pelvic gynecologic cancer, could reduce anxiety around the time of surgery. Twenty-nine women participated, and the researchers measured their anxiety, pain, nausea, and use of a…

This study looked at whether metoclopramide, a common anti-nausea drug, works as well when injected under the skin (subcutaneous) as when given through a vein (IV). Five patients in a palliative care unit received the drug both ways to compare absorption. The goal is to offer a m…

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study looked at whether a single educational phone call from a nurse, before a doctor's appointment, could help people with medication overuse headaches. 88 adults with frequent migraines took part. The goal was to see if the call reduced the number of headache days in the m…

This study tested a new way to guide deep brain stimulation (DBS) surgery for essential tremor. Normally, patients must be awake during surgery to help doctors find the right spot in the brain. The new method uses a computer model to target the area while the patient is asleep. T…

This study tested whether a numbing injection (TAP block) given before a tummy tuck can reduce pain and the need for strong painkillers after surgery. 52 adults having abdominoplasty received either the nerve block or a placebo. The main goal was to measure how much opioid pain m…

This study tested whether a botulinum toxin injection (like Botox) can reduce pain in people with tennis elbow that hasn't improved after 6 months of standard care. 61 adults received either the injection or a placebo (fake injection). The main goal was to measure pain levels 3 m…

This study tested whether L-carnitine, a natural supplement, can reduce fatigue in people with multiple sclerosis (MS). About 60 adults with MS who had significant fatigue took either L-carnitine or a placebo, then switched. The goal was to see if L-carnitine improved fatigue sco…

This study tested whether a continuous drip of numbing medicine into the surgical wound for two days after back fusion surgery could reduce pain and speed recovery better than a placebo. Fifty adults having lumbar fusion for degenerative spine disease took part. The goal was to i…

This study tested whether a high-flow oxygen system (Optiflow) works better than a standard oxygen mask for patients with breathing failure. About 100 adults in intensive care who needed non-invasive ventilation (NIV) took part. The goal was to see if Optiflow keeps oxygen levels…

This study tested a special diet (low-FODMAP) in 31 adults with GERD (chronic heartburn) that didn't improve with standard acid-reducing medication. The goal was to see if changing what they eat could ease their symptoms. Results focused on symptom scores and quality of life.

This study tested whether plasma exchange (a blood-filtering treatment) helps people with multiple sclerosis who have severe flare-ups that don't get better with steroids. Thirty-eight adults took part, and researchers compared real plasma exchange to a sham procedure. The main g…

This study tested whether a drug called Polaramine can prevent dangerous drops in blood pressure when patients come off a heart-lung machine during aortic valve replacement. 18 adults took part. The goal was to see if the drug helps the body keep a stable blood pressure after sur…

This study tested three ways to help children with ADHD: a computer-based attention training program using a virtual classroom, the medication methylphenidate, and supportive talk therapy. Fifty-one children aged 7 to 11 took part. The goal was to see if the virtual classroom tra…

This study looked at whether giving a special therapy called EMDR to people in the emergency room right after a traumatic event could help prevent post-traumatic stress disorder (PTSD). About 110 adults who were at high risk for PTSD took part. The therapy uses eye movements to h…

This study tested whether a newer breathing machine method (NAVA) helps patients with respiratory failure come off the ventilator faster than the usual method (PSV). The study included 47 adults who had trouble weaning from the ventilator. Researchers measured how long it took to…

This study looked at two ways to do bunion (hallux valgus) surgery. In one method, a small screw is used to hold the bone in place; in the other, no screw is used. The goal was to see which approach leads to better toe movement one year after surgery. 58 adults who needed bunion …

This study looked at two different breathing machines used to help newborn babies with breathing trouble. The goal was to see if a newer device called nasal high frequency percussive ventilation (nHFPV) is as well-tolerated as the standard nasal CPAP machine. The study included 4…

This study tested whether botulinum toxin type A (like Botox) can ease symptoms of restless legs syndrome (RLS) in 27 adults who did not get enough relief from standard treatments. Participants received one injection, and researchers checked if leg discomfort and urge to move imp…

This study looked at whether hypnosis sessions led by a nurse over video calls are possible for people with chronic nerve pain. Thirty adults with nerve pain lasting over a year took part. The main goal was to see if they could complete five sessions, either in person or by video…

This study tested whether a shared decision-making tool could help women with uncomplicated cystitis (bladder infection) and their doctors decide together about antibiotic use. 169 women aged 18-65 participated. The goal was to see if the tool reduced antibiotic use without harmi…

This study collected blood, hair, and urine samples from 25 people treated at festival medical tents for possible drug poisoning. Researchers aimed to identify which psychoactive substances were actually used, so they can better warn the public and prevent harm. The focus was on …

This study looked at tiny particles called microparticles in the blood and urine of people with lupus or scleroderma. Researchers wanted to see if these particles could help explain how these diseases work and possibly lead to better diagnosis or treatment. Over 200 adults partic…

This study looked at how well people with COPD can learn to use three different inhaler devices: Diskus, Breezhaler, and Respimat. Twenty-four participants were taught to use each device and then checked for mistakes. The goal is to find better ways to train patients so they get …

This completed study looked at 75 people with relapsing-remitting multiple sclerosis (RRMS) who were taking the medication Aubagio. The goal was to see if virtual reality tests and real-world tasks could better detect cognitive (thinking) problems in everyday life compared to sta…

This completed study looked at 304 retired farmers aged 65 and older living in rural France. The goal was to find very early brain scan markers for Alzheimer's disease in people who had no memory complaints. Researchers used MRI and PET scans to measure brain volume and other cha…

This study looked at 28 people with Glanzmann thrombasthenia, a rare bleeding disorder, to understand why some develop harmful antibodies after blood transfusions or pregnancy. Researchers checked for antibodies every six months and after each transfusion over 18 months. The goal…

This study looked at how getting older and missing sleep affect thinking skills like attention and impulse control. 28 healthy volunteers stayed awake for 40 hours or took short naps in a controlled lab setting. Researchers tested their mental performance every few hours to see h…

This completed study from France looked at how often patients and their relatives develop post-traumatic stress disorder (PTSD) after a sudden cardiac arrest. Researchers interviewed 45 people—20 survivors and 20 relatives—within a week of the event and again at 3 months using st…

This completed study in France looked at 248 people taking PrEP (a daily pill to prevent HIV) to see if long-term use changes risky sexual behaviors or increases sexually transmitted infections (STIs). Participants filled out a questionnaire about their sexual practices and recen…

This completed study looked at whether stomach emptying is slower during a heart attack, which could delay the absorption of crucial antiplatelet drugs. Researchers measured paracetamol levels in the blood every 15 minutes in 23 participants to track stomach emptying. The goal wa…

This study looks at how stress and insomnia are connected. Researchers used driving simulations with stressful events to measure emotional reactions and sleep patterns in women with and without insomnia. The goal is to understand how short-term sleep problems might turn into long…

This study checked how often nerve damage (neuropathy) occurs in people with a rare heart condition called wild-type TTR cardiac amyloidosis. Researchers examined 65 patients using interviews, physical exams, and nerve tests (electromyograms). The goal was to find out if nerve pr…

This study combined brain imaging with real-world data from mobile devices to explore how addiction affects the brain. Researchers scanned the brains of 107 people with alcohol, cannabis, or nicotine dependence, along with healthy controls. They also tracked cravings and daily fu…

This study used special brain scans (SPECT imaging) to look at two key brain chemicals—acetylcholine and dopamine—in people with dementia with Lewy bodies. Researchers aimed to see if differences in these chemicals could help diagnose the disease and identify subtypes. The study …

This study tested a computer system called PRoSIT that automatically checks hospital discharge prescriptions for dangerous drug interactions. Researchers looked at nearly 5,800 prescriptions for patients aged 65 and older from three French hospitals. The goal was to see how well …

This study looked at how the body's natural endocannabinoids (similar to cannabis compounds) interact with the stress hormone cortisol in people with Cushing's syndrome, a condition of high cortisol. Researchers measured blood levels of these compounds in 40 participants, includi…

This study tested 137 people with chronic pain of unknown cause to see if they had Fabry disease, a rare genetic disorder. Researchers used blood tests to check for the condition. The goal was to find out how common Fabry disease is in this group and help diagnose it earlier.

This study tested whether giving nursing mothers omega-3 supplements (from rapeseed oil and special margarine) changes the fat composition of their breast milk compared to standard olive oil. 82 women who were 1-4 months into breastfeeding took part. The goal was to measure key f…

This study looked at 22 men with prostate cancer who were scheduled for surgery. Each man received two different PET/CT scans to see which one better detects cancer spread. The goal was to compare the two imaging methods, not to treat the disease. Results may help doctors choose …

This study looked at how multiple sclerosis (MS) affects social thinking, like understanding others' feelings. Researchers used MRI scans to compare brain activity in 35 people with MS and healthy volunteers. The goal was to find which brain changes cause social difficulties, not…

This study tested a special PET scan to measure oxygen levels inside glioblastoma brain tumors. Low oxygen (hypoxia) can make tumors harder to treat. The goal was to find the best way to use this scan to guide treatment. 14 adults with newly diagnosed glioblastoma took part.

This study looked at 22 ICU patients who had difficulty being taken off a breathing machine (ventilator). The goal was to measure two key aspects of their breathing muscles: strength and endurance. By tracking these over time, researchers hope to understand which problem is more …

This study looked at how the brain chemical serotonin works in people with multiple system atrophy (MSA), a rare and serious nerve disease. Researchers used special PET scans to measure serotonin receptors in the brains of 53 adults with MSA or Parkinson's disease. The goal was t…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study looked at 200 adults who had a cardiac arrest outside the hospital and needed emergency medical care. Researchers measured how long it took to get a working IV or IO line and what factors made it harder or slower. The goal is to improve emergency procedures and save mo…

This study looked at whether certain blood markers at diagnosis can predict if immune thrombocytopenic purpura (ITP) will become a chronic condition. Researchers followed 70 children and adults for 12 months to see who achieved complete remission. The goal is to better understand…

This study looked at 31 full-term newborns with brain injury from lack of oxygen (hypoxic-ischemic encephalopathy). Researchers used a special MRI technique called arterial spin labeling to measure blood flow in the brain during the first week of life. The goal was to see if this…

This study looked at whether neck muscle activity during sleep affects breathing recovery in 17 COVID-19 patients who were on ventilators in the ICU. Researchers used sleep tests and activity monitors to track sleep quality and breathing patterns. The goal was to understand why s…

This study looked at 21 soccer players to see how heading a ball 10 times affects the brain. Players were tested with and without a mouthguard. Researchers measured head movement, brain scans, and thinking skills before and after heading. The goal is to understand if a mouthguard…

This completed study tested a new biosensor designed to measure blood glucose every 10 minutes in people with type 1 diabetes who use an insulin pump. The sensor uses microdialysis to sample interstitial fluid and was compared to standard continuous glucose monitors (CGM) during …

This pilot study tested two different techniques for applying an alcoholic antiseptic to healthy skin before inserting a device into a vein. Researchers measured how many germs were on the skin before and after each method. The goal was to gather initial data to plan a larger, mo…

This study tests whether a very small dose of fentanyl can reveal how sensitive a person is to pain and whether they might develop worse pain after surgery. Researchers will give healthy volunteers either fentanyl or a placebo and measure their pain threshold using a mechanical s…

This study looked at how much blood sugar levels go up and down during the day in frail or disabled patients over 75 with diabetes who use basal insulin. Researchers used a continuous glucose monitor for 5 days to compare two types of insulin: human NPH and long-acting analogues.…

This study looked at brain activity in the frontal cortex of 14 people with Tourette syndrome using a 24-hour portable EEG. Participants pressed a button each time they had a tic, so researchers could compare brain signals with and without tics. The goal was to identify which bra…

This study uses a powerful 3-Tesla MRI to compare the visual pathways in the brains of 114 people with glaucoma against healthy volunteers of the same age and sex. The goal is to see if glaucoma causes damage beyond the eye, in the brain's visual processing areas. Researchers hop…

This study tested a new, powerful MRI scan on 56 stroke patients to see if it could detect subtle brain damage not visible on standard scans. The goal was to better understand how much brain tissue is truly saved after treatment. The findings could help doctors predict recovery m…

This completed study looked at 216 women to see how certain enzymes (matrix metalloproteinases) and their inhibitors relate to the severity of cervical lesions caused by HPV. Researchers compared tissue and cell samples from women with normal cervices, dysplasia, or cervical canc…

This study looked at 40 women with symptomatic uterine fibroids to understand why MR-guided focused ultrasound (HIFU) works better for some than others. Researchers measured fibroid blood flow, stiffness, and other features before treatment to see which factors affect how much fi…

This study tracked 582 children aged 6 to 18 who had surgery to see how many still had pain 3 months later. Researchers used a pain questionnaire to measure pain levels and identify risk factors. The goal was to better understand chronic post-operative pain in kids, not to test a…

This study compared two devices used to help patients breathe during surgery: the LMA ProSeal and the I-Gel. Researchers enrolled 700 adults and looked at how easily each device could be inserted, how well it sealed the airway, and any side effects. The goal was to see if one dev…

This study looked at whether a special pH-impedance test placed in the throat and esophagus can better detect laryngopharyngeal reflux (LPR) in people with chronic throat symptoms like hoarseness, lump sensation, or cough. Thirty adults with suspected LPR and healthy volunteers u…

This study looked at whether a quick, painless eye scan can detect early signs of Alzheimer's disease. Researchers measured the thickness of the retina's nerve layer in 200 older adults, some with Alzheimer's and some without. The goal was to see if these eye changes could serve …

This study tested whether using a pulse oximeter (a small sensor on the foot or hand) to measure oxygen levels in all seemingly healthy newborns can help find hidden, life-threatening heart defects early. Over 44,000 babies took part. The goal was to see if this screening reduces…

This study looked at whether lung MRI could be used instead of CT scans to diagnose idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring. Researchers compared MRI images to standard CT scans in 60 adults to see if MRI could spot the same key signs of IPF. The …

This study examined 90 children with obesity and additional features like intellectual disability or birth defects, whose genetic cause was unknown. Researchers used a special DNA test to look for tiny missing or extra pieces of chromosomes. The goal was to find new genes that ma…

This study looked at 14 men with intermediate-risk prostate cancer who were scheduled for prostate removal surgery. Each man received two different types of PET scans to see which one better highlights cancer cells. The goal was to compare the scans' ability to detect and measure…

This study looked at how getting only 4 hours of sleep for 5 days, or no sleep at all, affects driving ability and thinking skills in healthy young and older adults, as well as snorers. Participants took driving simulator tests and sleepiness assessments. The goal was to understa…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study examined how the drug tranexamic acid (TXA) affects blood clotting in women having planned C-sections. Researchers measured clot breakdown times in 34 participants to see if TXA could help prevent heavy bleeding after delivery. The goal was to better understand how TXA…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looked at why people with Parkinson's disease often gain weight after getting deep brain stimulation (a treatment that uses electrical pulses in the brain). Researchers measured energy use and calorie intake in 20 patients to see if weight gain is linked to changes in …

This study tested a new MRI method that measures temperature inside the heart in real time. Researchers want to see if it works well in people, including those with irregular heartbeats or larger body sizes. 61 patients had special MRI scans, and the data will help improve future…

This study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or lupus). Researchers measured stress, depression, and anxiety levels over 6 months. The goal was to unde…

This study tested whether a special ultrasound technique (dynamic contrast-enhanced ultrasound) can predict how well rectal cancer responds to chemotherapy and radiation. Only 2 participants were enrolled. The goal was to see if this imaging method could help doctors decide which…

This study looked at whether a special type of MRI (called SWI-MRI) can find endometriosis spots more accurately before surgery. Endometriosis lesions contain old blood, and SWI-MRI is very good at detecting blood byproducts. Researchers compared the MRI results with what surgeon…

This study looked at 47 older adults without major memory problems to see if changes in their sleep/wake cycles are linked to early brain changes that might increase Alzheimer's risk. Researchers used wrist-worn activity monitors and brain scans to measure sleep patterns and brai…

This study looked at whether a special PET scan called FMISO can help predict how well head and neck cancer patients respond to treatment. Sixteen adults with this cancer received the scan before starting radiation therapy. The goal was to see if the scan's results matched their …

This study tested a 4-hour head ultrasound (transcranial-holter) to detect tiny blood clots in people who recently had a stroke. The goal was to see if this test could help doctors find the exact cause of the stroke, which is important for choosing the right treatment to prevent …

This study looked at whether placing a drain in the pelvis after rectal cancer surgery reduces the risk of serious infections. About 494 adults with rectal cancer were randomly assigned to get a drain or not. The main goal was to see how many people developed pelvic infections wi…

This study looked at how a specific brain chemical system (cholinergic) might be involved in dystonia, a condition causing muscle spasms and abnormal postures. Researchers used PET scans to measure chemical activity in the brains of 40 adults with a genetic form of dystonia (DYT1…

This study looked at a program to make sure patients at Bordeaux University Hospital get the right care for their needs. Researchers checked if the program helped improve how well care matched what patients actually needed. The study involved 63 hospital services and their staff,…

This study looked back at 46 cases of periventricular pseudocysts (small fluid-filled sacs in the brain) found during pregnancy ultrasounds at a French hospital over 5 years. Researchers wanted to see how these children developed after birth, tracking milestones like sitting, wal…

This study tested whether a special type of CT scan (dual energy CT) can help doctors better understand and predict the severity of pulmonary hypertension, a condition of high blood pressure in the lungs. Researchers looked at lung images from 60 adults already diagnosed with the…

This study looked at whether a special type of scan called 4D PET-CT can help doctors plan radiation therapy better for people with non-small cell lung cancer. Seven patients had both a standard CT scan and a 4D PET-CT scan, and researchers compared the radiation target areas fro…

This study looked for a new gene that causes hereditary lipodystrophy, a rare disease where people lose body fat and often develop diabetes and heart problems. Researchers studied DNA and cells from 2 patients who had the disease but no known genetic cause. The goal was to find t…

This study looked at 50 people with and without COPD to understand how fibrocytes—a type of cell—might be involved in airway damage. Researchers measured fibrocytes in the blood and around the airways of patients at different COPD stages and compared them to healthy controls. The…

This study looked at whether saliva can be used to measure endocannabinoids—natural chemicals linked to appetite and weight—instead of taking blood. Researchers compared 12 obese and 12 normal-weight adults after fasting. The goal was to see if saliva levels differ between the gr…

This study looked at how to best set a breathing machine during lung surgery when only one lung is being used. The goal was to see if using smaller breaths with higher pressure could keep oxygen levels stable. 88 adults having lung surgery took part. The study measured oxygen in …

This study tested a new catheter designed to measure the heart's electrical signals in people with irregular heartbeats (atrial fibrillation, ventricular fibrillation, or junctional tachycardia). Researchers enrolled 42 adults to see if the device could better identify abnormal e…

This study looked at whether specific cells from the blood, called fibrocytes, are involved in muscle wasting (sarcopenia) in people with COPD. Researchers compared thigh muscle samples from 22 COPD patients with and without muscle loss. The goal was to understand why muscle loss…

This study looked at how modafinil, a drug that promotes wakefulness, affects driving ability in 27 people with narcolepsy or hypersomnia. Participants took driving tests in a simulator to measure lane control and sleepiness. The goal was to understand if the treatment reduces dr…

This study looked at whether measuring the stiffness of uterine fibroids can help predict how well they respond to a non-invasive treatment called MR-HIFU. Forty women with symptomatic fibroids were enrolled. The goal was to improve patient selection so that only those likely to …

This completed study looked at whether natural plant estrogens (phytoestrogens) in food might be a risk factor for lupus flares. Researchers measured phytoestrogen levels in blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or healthy control…

This study tested whether a CT scan before a heart procedure could help doctors better target the source of a dangerous heart rhythm called ventricular tachycardia. 23 people who had a prior heart attack and needed catheter ablation took part. The approach aimed to see if using C…

This study tested a new ultrasound technique (ARFI) to measure muscle stiffness in 65 volunteers: young adults (18-30), healthy older adults (70+), and older adults undergoing cancer treatment. The goal was to see if this method could help screen for sarcopenia (age-related muscl…

This study looked at 46 infants under 2 years old in the pediatric ICU with severe bronchiolitis. Researchers used a heart ultrasound measure called TAPSE to see if it could predict how long babies needed intensive care. The goal was to find a simple test that helps doctors plan …

This study used a special MRI technique to create detailed maps of the Achilles tendon in 121 adults. Researchers compared healthy volunteers to people with a type of arthritis called spondyloarthropathy, both with and without tendon pain. The goal was to better understand tendon…

This study looked at whether immune cells from the intestine play a role in Sjogren's syndrome, an autoimmune disease that causes dry eyes and mouth. Researchers examined saliva gland samples from 57 adults suspected of having Sjogren's. The goal was to better understand the dise…

This study looked at health records from over 36,000 people in France to create better ways to measure the quality of care for stroke and chronic heart disease. The goal was to develop tools that can be used nationwide to track and improve patient care pathways. No new treatments…

This study tested a short, computerized thinking and memory test for people with multiple sclerosis (MS). The goal was to see if it could quickly spot early cognitive problems, like slower thinking or memory trouble. Over 400 French-speaking adults with MS and healthy volunteers …

This small pilot study looked at whether clopidogrel, a drug that stops blood clots, could lower a substance called sCD40L in people with lupus. Lupus is an autoimmune disease where the body attacks itself. The study involved 18 adults with lupus and measured sCD40L levels in the…

This study looked at how blood vessel function relates to heart blockage in people with a genetic heart condition called hypertrophic cardiomyopathy. Researchers measured blood flow and vessel flexibility in 40 adults. The goal was to understand the connection, not to test a trea…

This study tested a special MRI technique called magnetic resonance elastography (MRE) to see if it can detect scarring in transplanted kidneys. Researchers compared MRE results with traditional biopsy samples from 73 kidney transplant patients. The goal was to find a non-invasiv…

This study looked at how blood vessel cells and immune cells talk to each other in people with systemic sclerosis, a rare autoimmune disease that causes skin hardening. Researchers collected skin samples from 350 adults aged 18 to 75 to measure a specific protein (OX40L) on blood…

This study looked at whether people with essential tremor have trouble making decisions or recognizing facial emotions. Researchers compared 39 patients with healthy volunteers using special tests. The goal was to understand how the condition might affect daily social life.

This study followed 40 women with cervical, uterine, or ovarian cancer to understand how their couple relationship and sexual communication changed from diagnosis to 3 months after treatment. Researchers used questionnaires to track sexual activity, pleasure, and discomfort. The …

This study aimed to collect detailed measurements of the spine and pelvis in 161 healthy adults using a special low-dose X-ray technology called EOS. By understanding what a normal, pain-free spine looks like, doctors hope to better diagnose and treat people with lower back pain.…

This study tested whether a video call between paramedics and a stroke specialist can help decide the right treatment—like clot-busting drugs or clot removal—before the patient arrives at the hospital. About 215 adults with suspected stroke took part. The goal was to see if remot…

This study tested whether a special heart ultrasound (speckle tracking strain echocardiography) can detect early heart muscle changes in 61 adults with type 1 diabetes, before symptoms appear. Researchers looked for links between these changes and small blood vessel damage (micro…

This study tested whether doctors can safely check and adjust pacemakers and defibrillators from a remote location, instead of requiring patients to come into the clinic. 110 adults with these heart devices took part. The goal was to see if remote programming works as well as in-…

This study looked at the oral health of 88 people with chronic kidney disease (stages 2 to 5) to see how dental problems relate to kidney health. Researchers checked teeth, gums, saliva, and breath, and tracked nutrition and inflammation over 12 months. The goal was to understand…

This study tested a new questionnaire to better understand eye rubbing habits in people with or suspected keratoconus, a condition where the cornea thins and bulges. Researchers enrolled 292 participants to see if the questionnaire is reliable and useful. The goal is to improve h…

This study looked at 33 patients who had both cancer and a bleeding disorder called immune thrombocytopenia (ITP). The goal was to see if cancer cells trick the immune system into attacking the body's own platelets. Researchers found that treating the cancer often helped the ITP …

This study followed 516 elderly French people for up to 8 years to see how many develop age-related macular degeneration (AMD), a leading cause of blindness. Researchers looked at genetic, clinical, and lifestyle factors that might increase risk. The goal is to better understand …

This study looked at 100 adults having heart surgery who needed a central line placed in the subclavian vein (under the collarbone). Doctors used either a transversal or longitudinal ultrasound view to guide the needle. The goal was to see which method was quicker and had fewer c…

This study tested a new way to monitor vision during brain surgery near the optic nerve. Researchers used special goggles and anesthesia to track brain signals (visual evoked potentials) in 40 patients. The goal was to see if this method could help surgeons avoid damaging eyesigh…

This study looked at how the skeleton lines up with gravity in adults who have posture problems. Researchers used special 3D X-ray images to measure bone positions in 26 people. The goal was to better understand what causes poor balance, not to test a treatment.

This study looked at 36 adults with pulsatile tinnitus (a rhythmic noise in the ear) to see if a special ear test called multifrequency impedancemetry could detect changes related to the condition. Researchers measured how the ear responds to different sound frequencies and check…

This study measured levels of a hormone called pregnenolone and related compounds in the blood of 25 men—some with obesity and some at a healthy weight. Researchers wanted to see if a breakdown in the body's natural feedback loop might lead to overactivity of the endocannabinoid …

This study checked if people with long-term pain of unknown cause might have Fabry disease, a rare genetic disorder. Researchers tested 776 patients aged 6 to 80 from pain clinics across France. The goal was to see how often Fabry disease appears in this group, not to provide tre…

This study tested a new way to monitor breathing at home in 120 adults with severe asthma. The goal was to see if a special analysis of resting breath patterns could predict when an asthma attack might occur. The approach is observational and aims to improve early warning, not to…

This study looked at 13 adults who had been on a breathing tube for at least 2 days and were at risk for breathing trouble after the tube was removed. Researchers compared two types of noninvasive breathing support: one that senses the patient's own breathing signals (NAVA) and o…

This study looked at 27 people with advanced basal cell skin cancer who were taking the drug vismodegib. The goal was to see if the amount of drug in their blood was linked to side effects like muscle cramps, hair loss, and taste changes. Researchers monitored patients for 6 mont…

This study looked at whether regular physical activity can slow down memory and thinking problems in healthy older adults and people with early-stage Alzheimer's disease. Researchers measured brain function, fitness, and daily activity in 139 people aged 60-80. The goal was to se…

This study looked at whether radiation therapy for certain brain tumors (cavernous sinus meningioma or pituitary adenoma) can harm autobiographical memory—the memory of personal life events. Researchers recruited 17 patients aged 35 to 65 who were scheduled for radiotherapy. They…

This study looked at 38 people who had a first stroke in the cerebellum, a brain area involved in mood. Researchers used interviews and smartphone tracking to measure depression, anxiety, and apathy in daily life. The goal was to better understand how these mood problems develop …