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Grape seed mouthrinse takes on plaque in new trial

NCT ID NCT00838266

First seen Jun 07, 2026 · Last updated Jun 20, 2026 · Updated 2 times

Summary

This study tested whether a mouthrinse made with red grape seed extract and a fluoride compound can reduce dental plaque. Fifty healthy volunteers used the rinse three times a day for four days without brushing. The trial was double-blind and cross-over, meaning each person tried both the active rinse and a placebo. Researchers measured plaque buildup and checked for side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • CHU de Bordeaux - Hôpital ST André - 1 rue Jean Burguet

    Bordeaux, 33075, France

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

mouthrinse containing red grape seed extract and nicomethanol fluorhydrate

What this could lead to

If it works, this could offer a new option for controlling dental plaque between brushings.

What could go wrong

This is a small, short-term trial (4 days) and may not reflect real-world use. The effect may be small or not better than a placebo.

Conditions

The condition(s) this trial relates to.

Dental Plaque

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.