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Grape seed mouthrinse takes on plaque in new trial

NCT ID NCT00838266

Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a mouthrinse made with red grape seed extract and a fluoride compound can reduce dental plaque. Fifty healthy volunteers used the rinse three times a day for four days without brushing. The trial was double-blind and cross-over, meaning each person tried both the active rinse and a placebo. Researchers measured plaque buildup and checked for side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mouthrinse containing red grape seed extract and nicomethanol fluorhydrate
What this could lead to
If it works, this could offer a new option for controlling dental plaque between brushings.
What could go wrong
This is a small, short-term trial (4 days) and may not reflect real-world use. The effect may be small or not better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

50 people

The number who actually took part.

Start date

Feb 2009

Finished

Mar 2009

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy volunteer * without caries * with at least 20 natural teeth excluding third molars * Women using contraceptives for at least twelve weeks and while on study * Protected by French social security system * Written informed consent Exclusion Criteria: * Pregnancy or breast feeding * Volunteers with partial denture or orthodontic appliance * Person protected by the law who * Person unable to give their consent to participate to the study. * Under aged * Current participation in another clinical trial * Oral pathologies * Systemic diseases * Volunteers allergic to of the componentst of the tested products * Volunteers with hyposalivation or xerostomia * Treatment with antibiotics o intestinal antiseptics within 3 month before inclusion * Treatment with oral antiseptics within 1 month before inclusion * Alcoholic consumption more than 20 g/day (or 2 glasses) * Heavy smokers * Volunteers drinking a lot of tea or coffee

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Conditions

The condition(s) this trial relates to.

Dental Plaque

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental plaque

Contacts and locations

Locations

  • CHU de Bordeaux - Hôpital ST André - 1 rue Jean Burguet

    Bordeaux, 33075, France

More trials for these conditions

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