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Baking soda in epidural may reduce need for general anesthesia in urgent C-Sections

NCT ID NCT05313256

Symptom relief Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study tested whether adding sodium bicarbonate (baking soda) to the standard epidural painkiller (lidocaine with epinephrine) could provide better pain relief for women needing an extremely urgent C-section during labor. 65 women were randomly assigned to receive either the buffered or standard version. The main goal was to see if fewer women would need general anesthesia due to inadequate pain control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine with epinephrine, with or without sodium bicarbonate (baking soda)
What this could lead to
If it works, this could offer faster, more reliable pain relief for emergency C-sections, lowering the need for general anesthesia.
What could go wrong
This is a small, completed Phase 2/3 trial with only 65 participants, so results may not apply widely. The intervention only targets pain during a specific procedure, not the underlying condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

65 people

The number who actually took part.

Started

Jul 2022

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients, affiliated to social security * Informed consent signed by the participant and the investigating physician at the latest after the therapeutic intervention * Initial indication for vaginal delivery * Benefiting from emergency caesarean section during labour for fetal extraction with a maximum 15-minute decision-to-delivery delay (i.e. extremely urgent caesarean section) Exclusion Criteria: * Opposition to participation in research before delivery * Refusal or impossibility of informed consent * Lack of understanding or significant language barrier * Initial indication for general anaesthesia defined by the following situations: non-functional epidural analgesia, altered consciousness, eclampsia, suspicion of amniotic embolism, confirmed or suspected severe haemorrhage occurring before birth * Contraindication to the use of the products defined in the protocol : adrenalized lidocaine ; sodium bicarbonate. * Persons placed under judicial protection

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Conditions

The condition(s) this trial relates to.

Obstetric Labor Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obstetric labor complications

Contacts and locations

Locations

  • CH de la Côte Basque

    Bayonne, France

  • CHU de Bordeaux

    Bordeaux, France

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