University Hospital, Bordeaux

This Phase III trial tests whether combining baricitinib with an anti-TNF drug (adalimumab or etanercept) works better than baricitinib alone for people with rheumatoid arthritis who haven't responded to prior treatments. The study involves 160 adults aged 18-65 with active disea…

This study tests whether adding metformin, a diabetes drug, to standard methotrexate therapy helps more people with rheumatoid arthritis achieve disease control. About 128 adults with active RA who have not recently taken methotrexate will receive either methotrexate plus metform…

This study tests a combination of two drugs (spartalizumab and low-dose pazopanib) in 80 children and adults whose solid tumors have not responded to standard treatments. The goal is to see if the combo can shrink or stabilize the cancer for at least 6 months. The pediatric part …

This study tests whether virtual reality exposure therapy can help people who had bariatric surgery feel better about their body image. It includes 11 participants who are 18 to 30 months post-surgery and unhappy with their appearance. The approach uses VR sessions to address bod…

This study looks at whether health mediation can help people living in informal housing (like streets, shanties, squats, or caravans) in France use healthcare services more, especially for cancer screening. Over 1,000 participants are involved, along with health mediators and soc…

This study follows 66 people with primary progressive multiple sclerosis (PPMS) and healthy volunteers for two years to understand how thinking and memory change over time. Participants take cognitive tests and undergo MRI scans to see how brain tissue damage relates to mental de…

This study looks at 500 adults with lupus to see if certain immune markers can better predict who will develop heart disease. Participants give blood samples, have ultrasound scans of their neck arteries, and fill out diet and exercise questionnaires. The goal is to improve how d…

This study looks at whether routine screening for heart disease is a good use of healthcare money for people with type 2 diabetes who are at very high risk but have no known heart problems. Researchers will analyze data from 90,000 patients in French health databases to compare c…

This study is for adults receiving a kidney, lung, liver, or heart transplant. It will collect blood and tissue samples to learn how the body responds to CMV, a common virus that can cause serious problems after transplant. The goal is to better understand the virus and improve f…

This study looks back at 46 adults with non-small-cell lung cancer that has spread only to the brain (fewer than 5 spots). Researchers want to see which treatment strategies worked best by tracking how long patients stayed free of cancer growth. The goal is to find a standard app…