University Hospital, Bordeaux

This study compares a focused ultrasound treatment (HIFU) that targets only the cancerous part of the prostate to complete surgical removal of the prostate in men with intermediate-risk prostate cancer. The goal is to see which approach provides better quality of life and value f…

This study compares two less invasive treatments—radiofrequency ablation (RFA) and uterine artery embolization (UAE)—to hysterectomy for women with heavy bleeding caused by adenomyosis. About 230 women aged 30-50 who are eligible for hysterectomy will be randomly assigned to one …

This study is testing a new way to diagnose cholangiocarcinoma, a type of bile duct cancer, by analyzing proteins in bile fluid instead of taking a tissue sample. Researchers will collect bile from 200 adults with bile duct narrowing during a routine endoscopic procedure. They wi…

This study aims to create a new diagnostic tool that uses a panel of 19 steroid hormones plus basic health measures (BMI, blood sugar, blood pressure) to tell apart adrenal tumors that mildly overproduce cortisol from those that don't. Researchers will enroll 291 adults with adre…

This study aims to develop a blood test that uses fetal DNA found in the mother's blood to determine paternity early in pregnancy (6 to 22 weeks). It is designed for cases of sexual assault where the father is unknown, helping to reduce uncertainty and trauma. The test will be us…

This study tests whether using artificial intelligence (AI) during screening colonoscopy can reduce the chance of developing advanced polyps or colorectal cancer within three years. About 592 adults who need a screening colonoscopy will be randomly assigned to have the procedure …

This study tests a modified prostate surgery that aims to preserve ejaculation while still relieving urinary problems caused by an enlarged prostate. About 336 men over 40 with moderate to severe symptoms will be randomly assigned to either the new partial surgery or the standard…

This study looks at how hormone replacement therapy (HRT) changes sexual quality of life in women with premature ovarian failure (early menopause). About 135 women will fill out a questionnaire before and 6 months after starting HRT. The goal is to see if HRT helps improve sexual…

This study looks at how the immune system ages in people with lupus. Researchers will measure specific immune cells and telomeres in 75 adults aged 18 to 60. The goal is to understand the aging process, not to test a treatment.

This study will follow 150 adults with systemic granulomatosis (like sarcoidosis) for up to 10 years. Researchers will track how the disease changes over time and collect blood, urine, and DNA samples. The goal is to better understand the disease and find factors that predict its…

This study follows 1000 adults with diabetic foot ulcers for up to 5 years to learn why they face higher risks of death and complications. Researchers will track health events like infections, amputations, and deaths to build a risk score. No new treatments are tested—the goal is…

This study checks if using specially cleaned water in reusable bottles for colonoscopy is safe and practical. Researchers will test if the water gets contaminated with bacteria from the patient during the procedure. If safe, this could reduce medical waste and make colonoscopy mo…

This study looks at how consistent the Maintenance of Wakefulness Test (MWT) is when repeated in people who have trouble staying awake. Researchers will test 100 participants twice to see if the results are reliable. If the test proves trustworthy, it could help decide if it's sa…

This study looks at a blood marker to help doctors decide which children in the ICU after heart surgery will benefit from extra fluids. Giving fluids when not needed can cause harm, so the goal is to identify the right patients. About 110 children under 15 will be enrolled, and t…

This study examines gynecological problems and infertility in women who had a stem cell transplant for leukemia as adults. Researchers will review medical records of 80 women to see how common issues like early menopause, vaginal graft-versus-host disease, and cervical problems a…

This study looks at how a special filter (OXIRIS membrane) used for kidney support affects blood clotting and immune cells in intensive care patients with septic shock. Researchers will measure markers of clotting and immune activity before and after using the filter. The goal is…

This study looks at whether multiple sclerosis (MS) affects a woman's egg supply (ovarian reserve). Researchers will compare blood hormone levels and ultrasound results between 160 women with MS and healthy women aged 25-35. The goal is to understand if MS itself impacts fertilit…

This study aims to translate and validate a French version of the Sleep Regularity Questionnaire, a tool that measures how consistent a person's sleep patterns are. Researchers will enroll 50 adults with chronic insomnia or circadian rhythm disorders to test the questionnaire's a…

This study looks at how often people become depressed after getting a surgical site infection following orthopedic surgery (like hip, knee, or spine procedures). Researchers will follow 300 adults for one year to track depression and related problems like malnutrition. The goal i…

This study aims to develop and test new MRI sequences to make scans faster, clearer, and more detailed. Researchers will enroll 200 healthy volunteers to compare new imaging methods against standard ones. The goal is to improve diagnosis and treatment monitoring by enhancing imag…

About 13 in 1,000 children are born with heart disease, but current tools struggle to assess how well the heart fills with blood. This study will test a new ultrafast ultrasound method to measure heart stiffness and blood flow in 300 children with congenital heart disease. The go…

This study follows 500 adults with systemic sclerosis (a rare autoimmune disease causing skin thickening and organ damage) over 5 years. Researchers will track how the disease naturally progresses by monitoring key complications like lung and kidney problems. They will also colle…

This study looks at whether adding a capillaroscopy test (a painless exam of tiny blood vessels at the nail base) to standard care helps doctors diagnose connective tissue disease faster in people newly diagnosed with interstitial lung disease. About 48 adults will participate. T…

This study looks at whether starting dialysis earlier or later helps patients with tumor lysis syndrome (a complication from cancer treatment) who also have sudden kidney injury. Researchers will compare kidney function 30 days after treatment in 800 adults. The goal is to find t…

This study involves 20 adults with severe lung failure (ARDS) who are on a breathing machine. Researchers will use a special imaging tool called electrical impedance tomography (EIT) to measure how much the lungs are overstretched or collapsed when changing ventilator pressure. T…

This study is testing two new markers—skin autofluorescence and glycated albumin—to see if they can predict gestational diabetes and large babies (macrosomia) better than the standard HbA1c test. Researchers will follow 800 pregnant women to compare these markers. The goal is to …

This study looks at how small vessel disease in the brain affects thinking skills like memory and attention. Researchers will measure brain activity using EEG in 80 older adults and test whether personalized computer-based brain training or gentle electrical stimulation can help.…

This study aims to learn how much transgender people in France know about gynecological care and cancer screening. Researchers will survey 500 transgender adults to understand their awareness of health recommendations. The goal is to improve care for this community.

This study looks at how mitochondrial diseases can weaken the immune system. Researchers will measure immune cells and antibodies in 60 people with confirmed mitochondrial disease. The goal is to better understand these immune problems, which could lead to better diagnosis and ne…

This study aims to understand how cortisol and other steroid hormones are produced over 24 hours in people with adrenal gland tumors. Researchers will use a special device to take fluid samples every 20 minutes for 1-2 days from 40 participants. The goal is to compare hormone pat…