University Hospital, Bordeaux

This study tests whether giving oxybutynin syrup early to boys aged 3-6 months with posterior urethral valves can improve bladder function. The trial includes 50 boys who have already had valve surgery. Researchers will measure bladder pressure, capacity, and compliance after 9 m…

This study compares two treatments for men with intermediate-risk prostate cancer: focal HIFU (a targeted ultrasound that destroys only the tumor) and radical prostatectomy (complete removal of the prostate). The goal is to see which approach offers better value for money and qua…

This study looks at two different blood thinner plans after a procedure to close a small heart pouch in people with atrial fibrillation. About 60 adults will get either aspirin alone or aspirin plus clopidogrel for 3 months. The goal is to see which plan better prevents small bra…

This study tests a combined approach to make emergency breathing tube placement safer for adults in life-threatening situations outside hospitals. The strategy includes using a specific muscle relaxant, mask ventilation before the tube, and a special guide. Researchers will track…

This study looks at two less invasive options—radiofrequency ablation (RFA) and uterine artery embolization (UAE)—for women with heavy bleeding due to adenomyosis who are eligible for hysterectomy. The goal is to see if these treatments can reduce bleeding and pain as well as hys…

This study tests whether special MRI and CT scans can accurately measure the stiffness of kidney tumors. Researchers will compare these scans to standard methods in 50 adults scheduled for kidney tumor surgery. The goal is to improve 3D-printed models that help surgeons plan oper…

This study aims to create a new diagnostic score to help doctors identify adrenal adenomas that produce moderate amounts of cortisol, a condition called MACS. Researchers will measure 19 steroid hormones in the blood and combine them with basic health info like BMI, blood sugar, …

This study is testing whether a special PET/CT scan using gallium-68 citrate can more accurately diagnose infections in artificial heart valves. Researchers will compare the scan results with the standard diagnosis after 3 months. The study involves 40 adults with suspected valve…

About 13 in 1,000 children are born with heart disease, but current tools struggle to measure how well the heart fills with blood. This study tests a new, ultrafast ultrasound technique that captures images at a very high rate to measure heart stiffness and blood flow. Researcher…

This study is testing two new ways to predict gestational diabetes and large babies (macrosomia) in pregnant women. Researchers will measure skin autofluorescence and glycated albumin in 800 pregnant women and compare them to the standard HbA1c test. The goal is to see if these m…

This study is testing whether measuring a specific protein (P2X4) on blood cells can help diagnose ALS, a serious nerve disease that causes muscle weakness and paralysis. Researchers will compare P2X4 levels in 50 people with ALS to those without the disease. If successful, this …

This study aims to validate a heart ultrasound test that helps doctors decide if a critically ill child on a low-volume breathing machine needs more fluids. Giving unnecessary fluids can be harmful, so this test could prevent fluid overload. The study will include 60 children in …

This study looks at a new, noninvasive test to quickly tell if a critically ill child needs more IV fluids. The test uses a gentle belly press and a simple heart monitor to measure blood flow. It aims to help doctors avoid giving unnecessary fluids, which can be harmful. The stud…

This study is developing a blood test that can determine the father of a fetus without any risk to the pregnancy. It is designed for victims of sexual assault who become pregnant and need to know paternity for legal reasons. The test analyzes fetal DNA found naturally in the moth…

This study aims to see if a protein test on bile fluid can accurately diagnose cholangiocarcinoma (bile duct cancer). Researchers will collect bile samples from 200 adults with bile duct narrowing during a routine scope procedure. They will compare the protein test results with s…

This study is testing whether a new type of PET scan (68Ga-FAPI-46) can better detect the spread of pancreatic and bile duct cancers compared to standard CT and MRI scans. About 120 adults with newly diagnosed, potentially curable cancer will receive the new scan. If it proves mo…

This study tests whether using a computer-aided detection (CAD) system during screening colonoscopy can lower the chance of developing advanced polyps or cancer within 3 years. About 592 adults at risk for colorectal cancer will be randomly assigned to standard colonoscopy or CAD…

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This study looks at how hormone replacement therapy (HRT) changes sexual quality of life in women with premature ovarian failure (early menopause). About 135 women will fill out a questionnaire before and 6 months after starting HRT. The goal is to see if HRT helps with desire, a…

This study looks at whether a short hypnosis session before a cardiac MRI can improve the quality of the images in patients who feel anxious. Researchers will compare scans from 90 anxious and non-anxious adults. The goal is to see if hypnosis reduces movement or stress, leading …

This study tests a modified surgery that aims to preserve ejaculation in men over 40 with an enlarged prostate, compared to the standard complete removal of prostate tissue. The goal is to see if the new method can relieve urinary symptoms just as well while avoiding the common s…

This study looks at people with cerebral small vessel disease, a common condition in older adults that can lead to stroke and dementia. Researchers will measure brain activity using EEG and test whether home-based cognitive training or mild brain stimulation can improve thinking …

This study tracks 253 cystic fibrosis patients starting a new drug combination (elexacaftor/tezacaftor/ivacaftor). Researchers collect sputum, stool, and blood samples at the start, 6 months, and 1 year to see how the drug changes bacteria and inflammation in the lungs and gut. T…

This study is looking at how cortisol and other steroid hormones are produced over 24 hours in people with adrenal tumors. Some of these tumors cause mild excess cortisol, which can be hard to diagnose with current tests. Researchers will use a special device called U-RHYTHM to c…

This study tracks 300 adults who developed a surgical site infection after orthopedic surgery on their limbs or spine. Researchers will use questionnaires to measure how often depression and malnutrition occur over one year. The goal is to better understand these complications so…

This study looks at whether a specific blood test (MAIPA) can identify anti-platelet antibodies to confirm autoimmune thrombocytopenia (ITP) at diagnosis. Researchers will enroll 225 adults with low platelet counts and compare antibody results with final diagnoses. The goal is to…

This study looks at 20 adults with severe acute respiratory distress syndrome (ARDS) who are on a ventilator and placed face-down (prone position). Researchers will use electrical impedance tomography (EIT), a non-invasive imaging tool, to measure lung overdistension and collapse…

This study looks at how a type of cell death called ferroptosis, which is linked to iron, plays a role in lupus. Researchers will measure certain markers in immune cells from 120 people with lupus, as well as from people with other inflammatory diseases. The goal is to better und…

This study aims to find unique substances in the blood (biomarkers) that are only present in people with atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from 400 patients with AF to those without, and track changes over time. The goal is…

This study follows 1,000 adults with diabetic foot ulcers for up to 5 years to learn why some have worse outcomes, including death. Researchers will track health events and build a risk score to identify those most at risk. The goal is to better understand the disease and improve…

This study looks at specific immune cells (B and CD4 T cells) in the blood and spinal fluid of 150 people with multiple sclerosis or early symptoms. The goal is to find which cell types cause damage in different forms of MS, especially progressive MS. This research does not test …

This study checks how consistent the Maintenance of Wakefulness Test (MWT) is when repeated in people who feel very sleepy during the day. About 100 participants will take the test twice to see if results stay the same. The goal is to find out if the MWT is a trustworthy tool for…

This study follows 250 adults who need surgery to repair large bone defects in their lower leg. Doctors will compare two techniques: the Masquelet method and using electromagnetic transport nails. The main goal is to see which approach leads to faster bone healing, and researcher…

This study aims to translate and validate a French version of the Sleep Regularity Questionnaire (SRQ), a tool that measures how consistent a person's sleep schedule is. Researchers will enroll 50 adults with chronic insomnia or circadian rhythm disorders, who will fill out the q…

This study checks if using specially controlled water in reusable bottles during colonoscopy stays free of bacteria from the patient's gut. Researchers will test water samples after each procedure in 40 adults. If the water remains clean, it could lead to a more eco-friendly and …

This study surveys 500 transgender adults in France to find out how much they know about gynaecological care and cancer screening. Participants fill out an online questionnaire. The goal is to understand current awareness and improve future healthcare recommendations.

This study is testing new MRI sequences to improve image quality, reduce scan time, and better handle motion from breathing or heartbeat. Two hundred healthy adults will undergo MRI scans without any injections or invasive procedures. The goal is to develop better tools for diagn…

This study tests whether using a smartphone to answer quick surveys several times a day is a practical way to track restless legs syndrome (RLS) symptoms in real time. Researchers will enroll 62 adults with RLS to use a study phone for 14 days. The goal is to see if patients find…

This study uses brain scans (PET and MRI) to see how two brain chemicals, dopamine and acetylcholine, are linked to apathy after a stroke. Researchers will compare 15 apathetic and 15 non-apathetic stroke survivors. The goal is to better understand what causes apathy, which could…

This study examines gynecological problems and infertility in women who received a stem cell transplant for acute leukemia as adults. Researchers will review medical records of 80 women to see how common issues like early menopause, vaginal graft-versus-host disease, and cervical…

This study looks at how the brain handles internal body signals in people with Restless Legs Syndrome (RLS). Researchers will compare brain scans from 30 adults (15 with RLS and 15 healthy) taken in the morning and evening. They aim to see if differences in brain connectivity rel…

This study will follow 150 people with systemic granulomatosis, a rare inflammatory condition, for up to 10 years. Researchers will track how the disease changes over time and collect blood, urine, and DNA samples. The goal is to better understand the disease and find factors tha…

This study is building a large French database of up to 30,000 kidney cancer patients. Researchers will collect detailed medical information and biological samples over time to better understand the disease and improve care. The goal is to create a powerful research tool, not to …

This study is creating and testing a new tool to assess the mouth condition of intensive care patients who have a breathing tube. Currently, there is no specific tool for these patients, who often develop mouth sores that can affect recovery. Researchers will test the tool on 500…

This study looks at whether adding a simple microscope test of the tiny blood vessels at the base of your fingernails (capillaroscopy) can help doctors diagnose a type of lung disease called interstitial lung disease (PID) that is linked to connective tissue diseases (like lupus …

This study looks at whether multiple sclerosis (MS) affects a woman's egg supply (ovarian reserve). Researchers will compare blood hormone levels and ultrasound results between 160 women with MS and healthy women aged 25 to 35. The goal is to understand if MS itself impacts ferti…

This study is looking for better ways to predict blood clots in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will measure specific markers in the blood of 300 participants to see if they can tell who is at higher risk for clots. The goal …

This study looks at 800 adults in the ICU who have tumor lysis syndrome (a complication from cancer treatment) and sudden kidney injury. Researchers want to see if starting dialysis early or waiting helps kidney function better after 30 days. The goal is to find the best timing t…

This study looks at a blood test that may help doctors decide which children need extra fluids after heart surgery. Giving fluids when not needed can be harmful. The researchers will check if a certain blood marker can predict which children will benefit from fluids. About 110 ch…

This study looks at how mitochondrial diseases affect the immune system. Researchers will measure immune cells and antibodies in 60 people with confirmed mitochondrial disease. The goal is to better understand these immune problems, which could lead to better diagnosis and new tr…

This study looks at how a special filter (OXIRIS membrane) used for kidney dialysis affects blood clotting and immune cells in intensive care patients with septic shock. Researchers will measure markers of clotting and immune activation before and after using the filter. The goal…

This study looks at how the immune system ages faster in people with lupus. Researchers will measure specific immune cells and telomeres in 75 adults with lupus. The goal is to understand the aging process better, not to test a new treatment.

This study follows 500 adults with systemic sclerosis (a rare autoimmune disease causing skin and organ hardening) for up to 5 years. Researchers will track how the disease naturally progresses, including complications like lung or kidney problems, and collect blood samples to be…

This study follows 15,000 people with spinal problems (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Researchers will track which treatments are used and how patients feel. No new treatment is being tested—this is a…

This study looks at whether giving extra nutrition through a feeding tube before surgery can lower the chance of complications in malnourished people with esophageal or stomach cancer. About 670 participants will be followed to compare those who get nutritional support with those…