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Diet change may soothe stubborn heartburn when pills fail

NCT ID NCT02471989

Symptom relief Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a low-FODMAP diet could help people with gastro-esophageal reflux disease (GERD) whose symptoms persist despite taking standard acid-reducing drugs (PPIs). Thirty-one adults with confirmed reflux were randomly assigned to either a low-FODMAP diet or a standard GERD diet for several weeks. The main goal was to see if the low-FODMAP diet led to more people achieving symptom remission, measured by a reflux symptom questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Low-FODMAP diet
What this could lead to
If it works, this could offer a dietary approach to ease reflux symptoms for people whose GERD doesn't respond to standard acid-reducing medications.
What could go wrong
This was a small, early study with only 31 participants. Dietary changes can be hard to maintain, and results may not apply to everyone with GERD.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

31 people

The number who actually took part.

Started

Jan 2016

Finished

Nov 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 * Affiliation to French Social Security * Informed written consent * RDQ score \> 3 * Abnormal pH-impedance monitoring on PPI twice daily (since 3 months) according to normal values published by Zerbib et al (CGH 2013) Exclusion Criteria: * Pregnancy or breast feeding * Women of childbearing potential without an effective method of contraception * Person under guardianship * History of thoracic of abdominal surgery (excepted appendectomy and cholecystectomy)

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Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gastro-esophageal reflux disease (GERD)

Contacts and locations

Locations

  • Explorations fonctionnelles

    Lyon, 69437, France

  • Explorations fonctionnelles Digestives

    Rennes, 35033, France

  • Gastroentérologie

    Colombes, 92700, France

  • Gastroentérologie

    Nantes, 44093, France

  • Gastroentérologie

    Rouen, 76031, France

  • Hépato-Gastroentérologie et oncologie digestive,

    Bordeaux, 33075, France