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Enzyme-HPV link in cervical disease explored

NCT ID NCT04072913

Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how certain enzymes called matrix metalloproteinases (MMPs) and their inhibitors relate to human papillomavirus (HPV) in cervical dysplasia and cancer. Researchers collected tissue and cell samples from 216 women with different stages of cervical lesions. The goal was to compare enzyme activity across groups to better understand disease progression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

216 people

The number who actually took part.

Started

Oct 2007

Finished

Jan 2011

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For control group: * Age between 20 and 65 years * Patients hospitalized for partial or total removal of the cervix * Absence of cervical lesion observed on biopsy or hysterectomy * Free, informed and written consent, dated and signed by the patient and the investigator (at the latest before any examination required by the study) * Affiliate or beneficiary of a social security scheme For dysplasia and cancer group: * Age between 20 and 65 years * Cervical Intraepithelial Neoplasia or previously untreated cervical cancer * Free, informed and written consent, dated and signed by the patient and the investigator (at the latest before any examination required by the study) * Affiliate or beneficiary of a social security scheme Exclusion Criteria: For control group: * History of laser or conisation * Known antecedent of HIV infection * Congenital or acquired immunodepression * Long-term treatment with corticosteroids or immunosuppressants * Persons placed under the protection of justice For dysplasia and cancer group: * History of laser or conisation * Pre-treatment of invasive cancers by radiotherapy or chemotherapy * Known antecedent of HIV infection * Congenital or acquired immunodepression * Long-term treatment with corticosteroids or immunosuppressants * Persons placed under the protection of justice

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Conditions

The condition(s) this trial relates to.

cervical cancer cervical carcinoma cervical intraepithelial neoplasia human papilloma virus infection Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervix cancer Dysplasia Papillomavirus infections

Contacts and locations

Locations

  • CHU de Bordeaux

    Bordeaux, France

More trials for these conditions

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