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New immune duo shows promise in preventing Post-Transplant infection

NCT ID NCT04934527

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new way to prevent CMV infection in 42 CMV-positive kidney transplant patients. Researchers combined an antibody infusion with a specific type of immune cell (gamma delta T cells) to see if it could stop the virus from reactivating. The goal was to find a safer alternative to standard antiviral drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

42 people

The number who actually took part.

Started

Nov 2021

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female over 18 years of age, 2. Patient candidate for a first transplant or a re-transplantation, registered on the national waiting list of the Biomedicine Agency. 3. CMV seropositive patients (positive serology at pre-transplant assessment or at D0 of transplantation) 4. Patients receiving a kidney transplant from a deceased or living donor. 5. Women of childbearing age with a negative pregnancy test at inclusion and agreeing to the use of effective contraception throughout the study period and two months after the end of the follow-up period. 6. Patient affiliated to or benefiting from a social security scheme. Exclusion Criteria: 1. CMV negative (R-) patients. 2. Historical or current Graft Incompatible Rate (GIR) \> 85%. 3. Patients who have received anti-CMV therapy within 28 days prior to transplantation. 4. Indication for induction therapy with anti-lymphocyte globulin, rituximab, polyvalent intravenous immunoglobulin or any other immunomodulatory molecule, and mTOR inhibitor therapy, which have been described to be associated with a decreased incidence of CMV infection 5. Patients who have received or are receiving a solid organ transplant other than a kidney transplant. 6. Patients known to be seropositive for human immunodeficiency virus (HIV), hepatitis B virus (HBV; HbS Ag positive) or hepatitis C virus (HCV; HCV antibody positive), 7. Known allergy, contraindication or intolerance to specific anti-HCV Ig, mycophenolic acid, basiliximab, corticosteroids, cyclosporine A, tacrolimus or to excipients of these products. 8. Any form of substance abuse, psychiatric disorder or condition that, in the opinion of the investigator, may complicate communication during follow-up. 9. Foreseeable inability to comply with planned protocol visits/reviews. 10. Patients under guardianship/guardianship 11. Pregnant or breastfeeding woman 12. Patients with a contraindication to receiving Cytotect

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hopital Pellegrin

    Bordeaux, 33000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.