City Of Hope Medical Center

This study tests a vaccine designed to protect children from cytomegalovirus (CMV) after a stem cell transplant. CMV can cause serious complications in these patients. The trial will find the best dose and check if the vaccine safely reduces CMV infections. About 80 children will…

This study tests a new, shorter radiation treatment for women with stage I-III breast cancer who have had a lumpectomy. Instead of weeks of daily radiation, patients receive 5 ultra-high-dose treatments to the whole breast and surgical area at once. The goal is to see if this app…

This study tests giving radiation therapy to all active cancer spots before CAR T-cell infusion in people with large B-cell lymphoma that has returned or not responded to treatment. The goal is to control the disease and symptoms during the wait for CAR T-cells, potentially impro…

This early-phase study tests whether combining a targeted radiation drug (177Lu-PSMA-617) with an immune cell therapy (Sipuleucel-T) works better than the radiation drug alone for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. About 3…

This study tests a combination of three treatments for Richter's transformation, an aggressive form of blood cancer. The approach uses the patient's own immune cells (liso-cel) plus two drugs (nivolumab and ibrutinib) to boost the immune system and block cancer growth. About 20 a…

This early-stage study tests a stem cell transplant using a partially matched donor for people with severe aplastic anemia that did not get better or came back after standard treatment. The approach uses a milder chemotherapy and immune-suppressing drugs before the transplant to …

This study tests whether a combination of three drugs—acalabrutinib, obinutuzumab, and glofitamab—is safe and effective for people with mantle cell lymphoma that has come back or stopped responding to prior treatments. About 40 adults will receive the drugs, which work by blockin…

This early-stage trial tests two oral drugs, zanubrutinib and sonrotoclax, for people with B-cell non-Hodgkin lymphoma that has returned or not responded to prior treatment. The study focuses on Black, Hispanic, and other underrepresented groups to improve access and outcomes. Ab…

This early-phase study tests the safety and effectiveness of combining two drugs—zanubrutinib and odronextamab—in 23 adults with Richter's transformation, a fast-growing lymphoma that arises from chronic lymphocytic leukemia. Zanubrutinib blocks a protein that helps cancer grow, …

This study looks at whether metformin, a common diabetes medicine, can help prevent or reverse insulin resistance (a step toward diabetes) in women who finished chemotherapy for early-stage breast cancer. About 200 women will either get metformin plus standard diet and exercise a…

This study tests whether adding the drug ruxolitinib to the usual two-drug regimen (tacrolimus and methotrexate) can better prevent graft-versus-host disease (GVHD) in children and young adults (ages 2-22) undergoing bone marrow transplant for leukemia or myelodysplastic syndrome…

This early-phase trial is testing a procedure called PIPAC, which turns liquid chemotherapy into a fine mist and sprays it directly into the abdomen during a keyhole surgery. It is for people with ovarian, uterine, appendix, colorectal, or stomach cancer that has spread to the li…

This study tests a type of radiation therapy (craniospinal irradiation) for people with breast or lung cancer that has spread to the fluid and lining around the brain and spinal cord. The goal is to see if this treatment can help control the disease in the central nervous system.…

This early-stage trial tests a new treatment for multiple myeloma that has come back or stopped responding to standard therapies. The treatment combines a cancer-targeting antibody (daratumumab) with a radioactive payload to deliver radiation directly to cancer cells. The study a…

This early-stage trial tests whether adding a live bacteria product (EXL01) to standard immunotherapy drugs (nivolumab and ipilimumab) is safe and helps control metastatic kidney cancer. About 33 adults with advanced kidney cancer that has spread will receive either the standard …

This study looks at whether a special health check-up for older adults (geriatric assessment) can help people aged 60 and older recover faster after CAR-T therapy for B-cell non-Hodgkin lymphoma or multiple myeloma. The check-up identifies weaknesses in physical function, thinkin…

This study tests whether adding a gut hormone called gastrin to an islet cell transplant can help people with hard-to-control type 1 diabetes produce their own insulin and improve blood sugar. About 20 adults aged 18-68 with unstable blood sugar will receive donor islet cells plu…

This study tests whether combining two targeted drugs, loncastuximab tesirine and mosunetuzumab, can safely and effectively treat adults with diffuse large B-cell lymphoma that has come back or stopped responding to prior therapy. The drugs work by attaching to cancer cells and e…

This study tests whether using a PET scan to guide radiation therapy can better control lung cancer, melanoma, or kidney cancer that has started growing again in up to 5 spots. About 32 adults will receive either standard radiation or a PET-adapted version that delivers a higher …

This study tests whether giving fecal transplants from healthy donors can repair gut damage caused by antibiotics and chemotherapy in lymphoma patients receiving CAR T-cell therapy. About 56 adults with relapsed or hard-to-treat lymphoma will be randomly assigned to receive eithe…

This early-phase study tests the safety of combining targeted radiation (SBRT) with the immunotherapy drug atezolizumab for people with advanced skin squamous cell carcinoma that can or cannot be removed by surgery. The goal is to see if this combination can better control the ca…

This early-phase study tests a new way to deliver total body radiation before a stem cell transplant for people with severe systemic sclerosis (scleroderma). The goal is to see if using a precise radiation technique (IMRT) along with chemotherapy can reduce damage to the lungs an…

This study tests a new drug combination (epcoritamab plus chemotherapy) given before a stem cell transplant for people with a type of aggressive lymphoma (DLBCL) that has come back or not responded to prior treatments. The goal is to see if this approach can completely eliminate …

This early-phase study tests whether adding venetoclax (a drug that blocks a protein cancer cells need to survive) to a standard chemotherapy regimen is safe for adults aged 18–54 with a specific, hard-to-treat type of B-cell acute lymphoblastic leukemia (Ph-like ALL). About 24 p…

This early-phase study tests whether combining a patient's own modified immune cells (CAR T-cells) with a special vaccine is safe and possible for people with B-cell non-Hodgkin lymphoma that has returned or not responded to treatment. The CAR T-cells are designed to find and kil…

This early-phase trial tests whether combining two drugs—tagraxofusp and azacitidine—can safely prevent cancer from returning after a donor stem cell transplant in people with CD123-positive acute myeloid leukemia or myelodysplastic syndrome. About 43 adults aged 18 to 75 will re…

This early-phase trial tests whether adding emapalumab to standard medications can safely prevent graft-versus-host disease (GVHD) in 15 adults with leukemia or myelodysplastic syndrome receiving a reduced-intensity donor stem cell transplant. Emapalumab blocks a protein that dri…

This early-phase study tests whether giving specially engineered immune cells (CAR T-cells) along with a vaccine can safely prevent B-cell lymphoma from coming back after a stem cell transplant. About 15 adults with aggressive or returning lymphoma will receive the treatment. The…

This early-phase trial is testing whether combining two targeted drugs (pacritinib and a BTK inhibitor) is safe and effective for people with mantle cell lymphoma that has come back or stopped responding to prior therapy. The study will enroll 10 adults and monitor side effects a…

This study tests whether a low dose of anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil can help young people (ages 9 to under 21) with newly diagnosed type 1 diabetes keep making their own insulin for longer. About 120 participants will be randomly assign…

This early-phase trial is testing whether the drug olutasidenib can safely prevent blood cancers (AML, MDS, or CMML) from coming back after a donor stem cell transplant. The study includes 15 adults whose cancers have a specific IDH1 gene change. Participants will take olutasiden…

This early-phase trial tests a new treatment for men with a type of advanced prostate cancer that no longer responds to hormone therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. Some participants will als…

This early-phase study tests a new treatment for children whose brain tumors have returned or not responded to standard care. The treatment uses the child's own immune cells, which are modified in a lab to better recognize and attack tumor cells. These cells are given along with …

This early study tests whether giving special immune cells (CAR T cells) along with a vaccine can safely help prevent leukemia from coming back after a stem cell transplant. The CAR T cells are made from the donor's immune cells and are designed to attack a protein called CD19 fo…

This early-phase trial tests whether adding bosentan (a drug for blood pressure) to standard chemotherapy can help treat pancreatic cancer that can't be removed by surgery. About 21 adults will take part to find the best dose and check for side effects. The goal is to see if this…

This study tests a new treatment for people with HIV that uses their own immune cells, modified to recognize and attack HIV. The goal is to see if these special cells can stay active in the body and help control the virus, possibly allowing participants to stop daily antiretrovir…

This study tests a new treatment for mantle cell lymphoma that has returned or stopped responding to standard care. It combines a patient's own genetically modified immune cells (CAR-T cells) with a targeted drug (acalabrutinib) to attack cancer cells. The goal is to see if this …

This early-stage study tests a new drug, AOH1996, in 12 adults whose acute myeloid leukemia (AML) has returned or not responded to standard treatments. The main goals are to find a safe dose and check for side effects. AOH1996 works by blocking a protein that cancer cells need to…

This study tests a procedure called chemoembolization for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor, then block that artery with tiny beads. This traps the chem…

This study tests whether adding the immunotherapy drug pembrolizumab to a gentler chemotherapy regimen can safely treat frail patients newly diagnosed with classical Hodgkin lymphoma who cannot receive standard strong chemo. About 23 participants will receive the combination and …

This study tests a new combination treatment for a rare type of skin lymphoma called erythrodermic cutaneous T-cell lymphoma (CTCL). The treatment combines a light-based blood therapy (ECP) with a targeted antibody drug (mogamulizumab) to kill cancer cells and boost the immune sy…

This early-phase study tests the safety and best dose of a new drug, miRisten, in 12 adults with acute myeloid leukemia (AML) that has come back or not improved after standard treatments. The drug works by blocking certain molecules that help cancer cells grow. The main goal is t…

This early-phase study tests a new treatment for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack leukemia cells. The main goals…

This early-phase study tests whether adding a radioactive antibody (225Ac-DOTA-daratumumab) to standard chemotherapy and radiation before a donor stem cell transplant is safe and effective for people with high-risk acute myeloid leukemia, acute lymphoblastic leukemia, or myelodys…

This early-stage trial tests whether adding two targeted drugs (dabrafenib and trametinib) to standard radiation therapy can better treat a rare and fast-growing thyroid cancer called anaplastic thyroid cancer that has a specific gene change (BRAF mutation). The study involves 6 …

This study tests whether adding the drug talazoparib to standard hormone therapy can better control prostate cancer that still responds to hormone treatment. About 70 men with metastatic prostate cancer will receive the combination. The goal is to see if this approach lowers PSA …

This study tests whether two targeted drugs, vemurafenib and cobimetinib, can make thyroid cancer cells more responsive to radioactive iodine therapy. About 21 adults with a specific gene mutation (BRAF V600E) and high-risk thyroid cancer will receive the drug combo before their …

This early-phase study tests whether combining two drugs, carfilzomib and sotorasib, is safe and effective for people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation. About 15 adults who have already tried a KRAS inhibitor will receive the combinat…

This early-phase trial tests a combination of three drugs (pembrolizumab, decitabine, and venetoclax) in adults with acute myeloid leukemia or myelodysplastic syndrome that has returned or not responded to prior treatment. The goal is to find the safest dose and see how well the …

This early-stage trial is testing a combination of three drugs (asparaginase, venetoclax, and blinatumomab) in adults whose B-cell acute lymphoblastic leukemia has returned or not responded to prior treatment. The study aims to find the safest dose and see how well the combinatio…

This study tests a new form of the drug asparaginase (made from a different bacterium) combined with standard chemotherapy in 53 high-risk adults aged 18–54 with newly diagnosed acute lymphoblastic leukemia or lymphoblastic lymphoma. The goal is to see if the combination is safe …

This early-phase study tests whether adding the drug mezigdomide after CAR T-cell therapy can help keep multiple myeloma from coming back. It involves 15 adults whose cancer returned after at least four prior treatments. The goal is to find the safest dose and see if it extends t…

This early-stage trial tests whether adding leflunomide (an arthritis drug) to standard chemotherapy (gemcitabine) is safe and effective for people with advanced pancreatic cancer that cannot be removed by surgery. About 19 adults will take part. The goal is to find the best dose…

This study tests whether combining an immunotherapy drug (cemiplimab) with a procedure that delivers tiny radioactive beads directly to liver tumors (Y90 radioembolization) can help people with breast cancer that has spread to the liver. The goal is to boost the immune system's a…

This study tests a combination of three drugs (glofitamab, venetoclax, and lenalidomide) in people newly diagnosed with a fast-growing type of mantle cell lymphoma. The goal is to see if this mix is safe and works better than current treatments. About 50 adults aged 18 to 80 with…

This study looks at whether time-restricted eating (intermittent fasting) or GLP-1 medications (semaglutide, tirzepatide) can reduce heart risks in prostate cancer patients receiving hormone therapy. About 60 men will be randomly assigned to one of these approaches or a standard …

This early-phase trial tests whether a specially engineered immune cell therapy (huCD19-CAR T cells) is safe and effective for adults with B-cell acute lymphoblastic leukemia that has returned or not responded to standard treatments. Up to 24 participants will receive their own m…

This study tests whether adding a drug called epcoritamab to the usual two-drug treatment (venetoclax and obinutuzumab) can make cancer disappear more completely in people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 33 adults will …

This early-stage trial tests a new treatment for adults with high-grade gliomas that have returned or worsened. The therapy uses the patient's own immune cells, modified in a lab to recognize and attack tumor cells, and delivers them directly into the brain. The main goals are to…

This study tests a drug called enasidenib given after a donor stem cell transplant to people with a specific genetic form of acute myeloid leukemia (IDH2 mutation). The goal is to see if it safely helps prevent the cancer from coming back. About 35 participants will take enasiden…

This study tests whether two drugs—brentuximab vedotin and nivolumab—can control Hodgkin lymphoma that has returned or not responded to initial treatment. About 31 adults will receive the drug combination, aiming to avoid the need for a stem cell transplant. The main goal is to s…

This study tests whether a precise type of radiation (SBRT) can control limited cancer growth in people with ER+ metastatic breast cancer, allowing them to continue their current medication instead of switching. It also evaluates a special PET scan (FES) to better detect where th…

This early-phase trial tests a new method of delivering chemotherapy directly into the abdomen as a fine mist under pressure (PIPAC) for stomach cancer that has spread to the lining of the belly. About 30 adults who have already tried one standard treatment will receive this mist…

This study tests a combination of two drugs, nemtabrutinib and rituximab, for people with untreated mantle cell lymphoma, a rare blood cancer. The goal is to see if this combo can kill more cancer cells. About 27 adults will take part in this phase 2 trial.

This study tests whether a digital health app with remote monitoring can help 190 patients and their caregivers better manage symptoms and distress during and after CAR-T therapy for blood cancers. Patients use the app to report symptoms, and caregivers track their own stress lev…

This phase 2 trial tests a combination of two targeted drugs, mosunetuzumab and polatuzumab vedotin, in 41 adults with follicular lymphoma that has come back or not responded to prior therapy. The goal is to see if the combo can shrink or eliminate cancer cells while monitoring s…

This study tests whether adding leflunomide to two standard drugs (pomalidomide and dexamethasone) can better control multiple myeloma that has come back or is resistant to treatment. About 29 adults with this type of blood cancer will receive the three-drug combination. The goal…

This early-phase trial tests the safety of a new drug called glofitamab, given after a pre-treatment with obinutuzumab, for people with central nervous system (CNS) lymphoma. The drugs work by helping the immune system attack cancer cells. The study involves 20 participants and a…

This study is for people with solid tumors (like lung, ovarian, or pancreatic cancer) that have stopped responding to standard treatments. It tests a new drug called AOH1996, which works by blocking certain enzymes that cancer cells need to grow. The main goals are to find the be…

This study tests a new approach for Hodgkin lymphoma that has returned or not responded to treatment. It combines a radioactive antibody (yttrium-90 anti-CD25) with standard chemotherapy (BEAM) before a stem cell transplant. The goal is to kill cancer cells more effectively and i…

This study is for people with untreated mantle cell lymphoma, a type of blood cancer. It tests whether adding an experimental drug called venetoclax to two standard drugs (lenalidomide and rituximab) is safe and works well. About 28 adults will take part to find the best dose and…

This study tests whether adding two types of focused radiation (BgRT and SBRT) to the standard drug osimertinib can better control EGFR-positive non-small cell lung cancer that has started to grow in a few new spots. About 32 adults with advanced lung cancer will receive the comb…

This study tests whether adding targeted radiation to the drug talquetamab can safely and effectively treat multiple myeloma that has spread to organs or soft tissues (extramedullary disease). About 20 adults with this difficult-to-treat condition will receive radiation to one tu…

This early-phase study tests a new treatment for adults with a type of blood cancer called multiple myeloma that has returned or stopped responding to standard therapies. The treatment involves taking a patient's own immune cells, modifying them in a lab to recognize and attack m…

This early-phase study tests the safety and best dose of revumenib, a drug that blocks a protein fueling leukemia growth, in 27 adults and children with specific genetic types of acute leukemia. Participants take revumenib after a stem cell transplant to help keep the cancer from…

This early-phase study tests a new stem cell treatment called Orca-T, combined with targeted radiation and chemotherapy, for people aged 60-75 with acute leukemias or myelodysplastic syndrome (MDS). The goal is to find the safest dose and see how well the body tolerates the treat…

This study looks at whether a home-based blood test (liquid biopsy) can make lung cancer screening easier for high-risk smokers aged 50-80. Instead of going to a clinic for a CT scan, participants collect a blood sample at home to check for cancer DNA. If the test finds signs of …

This study aims to develop a simple blood test that can detect whether colorectal cancer has spread beyond the liver to other parts of the body. Current imaging methods often miss small or hidden metastases, which can affect treatment choices. Researchers will analyze tiny partic…

This study is testing a new DNA-based method to determine whether thyroid nodules are cancerous or benign. Researchers will analyze tissue samples from 1,450 adults undergoing needle biopsies. The goal is to create a more accurate test that reduces unnecessary surgeries for harml…

This early-phase study tests a special PET scan using a substance called 64Cu-M5A to see how well it shows tumor activity in people with advanced rectal cancer. About 15 participants will get the scan before and after standard chemotherapy and radiation, and the results will be c…

This study is developing a blood test that looks for tiny molecules called miRNAs to detect several types of digestive system cancers (like liver, pancreatic, and colon cancer) early. The goal is to create a simple, noninvasive screening tool that can be used for large population…

This study is testing a special PET/MRI scan that uses a radioactive tracer to find HER2-positive breast cancer that has spread to the brain. The goal is to see if the scan can show which brain tumors will respond to a standard chemotherapy drug. About 10 women with metastatic br…

This study aims to create a simple blood test to find esophageal cancer early, when it's easier to treat. Researchers will look at tiny particles in the blood from 600 adults with and without the disease. The goal is to replace invasive scopes with a quick, non-invasive screening…

This study is testing a new blood test that looks for tiny particles called exosomes to find pancreatic cancer early. The goal is to see if this test can accurately detect the disease in 2000 adults, including those with and without cancer. If successful, it could lead to a simpl…

This study aims to develop a blood test that can accurately distinguish between two common types of liver cancer—hepatocellular carcinoma and cholangiocarcinoma—before surgery. Researchers will analyze tiny particles called exosomes in the blood using machine learning. The goal i…

This study is developing a blood test to detect colorectal cancer in people under 50, a group where cases are rising. The test looks at tiny particles called exosomes and uses machine learning to find cancer signals. Researchers will test blood samples from 400 participants, incl…

This study aims to develop a blood test that can detect liver cancer (hepatocellular carcinoma) at an early stage, when treatment is more likely to work. Researchers will analyze tiny genetic particles in the blood of 600 people already diagnosed with liver cancer to see if these…

This study is testing a new blood test that looks for tiny particles called exosomal microRNAs to find leftover stomach cancer cells after surgery. The goal is to catch a recurrence earlier than standard scans. The study will involve 500 people who had their stomach cancer remove…

This study is testing a new blood test that looks for circular RNA to find colorectal cancer early. Researchers will collect blood samples from 600 adults with stage I-III colorectal cancer to see how accurate the test is. If successful, this could offer a non-invasive way to det…

This study looks at whether a DNA-based test can accurately detect thyroid cancer in people with thyroid nodules. Researchers will compare the test results to the final diagnosis to see how well it works. The goal is to find a less invasive way to check for thyroid cancer.

This study tests whether giving a CMV vaccine to stem cell donors can protect transplant recipients from CMV infection. Donors receive the vaccine before donating stem cells, and the immunity is passed to the patient. The trial involves 216 people with blood cancers and aims to r…

This early-phase trial tests a vaccine (CMV-MVA Triplex) given to both stem cell donors and recipients to boost immunity against cytomegalovirus (CMV) and prevent active infection after transplant. About 46 people with various blood cancers or disorders will take part. The goal i…

This early-phase trial tests whether the drug ruxolitinib can prevent chronic graft-versus-host disease (cGVHD) in 42 patients who are at high risk after a stem cell transplant for blood cancer. Doctors use a blood test to find patients with high levels of cGVHD biomarkers, then …

This study looks at whether a lower dose of the chemotherapy drugs docetaxel and cyclophosphamide can effectively treat early-stage breast cancer in women aged 65 and older. Standard doses often cause harsh side effects in older patients. The goal is to find a dose that works wel…

This study tests whether telehealth self-management coaching sessions can improve quality of life for people with metastatic pancreatic cancer and their family caregivers. Participants will receive coaching on managing physical symptoms, emotional well-being, and social and spiri…

This early-stage trial is testing whether giving chemotherapy as a fine mist directly into the abdomen (PIPAC) can reduce side effects for people with biliary tract cancer that has spread to the lining of the belly. About 12 participants will receive this mist along with standard…

This study looks at whether a special geriatric assessment (a thorough check of physical, mental, and emotional health) can help manage side effects and improve quality of life for adults aged 60 and older undergoing radiation for head and neck cancer, as well as their family car…

This study tests a robotic system that performs abdominal and pelvic surgeries through just one small cut. The goal is to see if it causes less pain, fewer complications, and quicker recovery than traditional methods. About 33 adults who need these surgeries will take part.

This study tests whether using virtual reality (VR) can help reduce depression, anxiety, pain, and stress in people with head and neck cancer who are getting radiation therapy, as well as their caregivers. About 40 patients and their caregivers will try either a 3D VR mindfulness…

This study tests whether CBD, THC, or a mix of both can reduce nerve pain, tingling, and numbness caused by chemotherapy in breast and colon cancer survivors. About 120 people will take one of these cannabis-based compounds for 12 weeks. The goal is to see if they improve symptom…

This study tests if different types of massage can help lower anxiety in cancer patients during chemotherapy. About 50 adults who have already had at least one chemo session and feel anxious will receive massage during their infusions. Researchers will check if patients can compl…

This early-stage trial tests whether adding Pedmark to standard cisplatin chemotherapy can prevent hearing loss in men with testicular cancer that has spread. About 80% of patients currently develop hearing damage from cisplatin. Pedmark works by neutralizing harmful molecules ca…

This early-stage study tests a new radiation method called BgRT for people whose cancer has spread to the bone and causes pain. The treatment uses live imaging to precisely target the tumor during a single session. Researchers want to see if it is safe and can reduce pain and the…

This study tests a telehealth program that teaches cancer survivors with an ostomy how to manage their care before and after surgery. The program includes seven group sessions online. Researchers want to see if it helps patients feel more confident and improves their quality of l…

This study tests whether L-theanine, a natural substance found in green tea, can help cancer patients who have finished treatment feel more relaxed and improve their mood. About 50 adults who are at least 6 months past cancer treatment will take L-theanine and report their stress…

This study tests whether telephone-based physical activity coaching helps older adults (65+) recovering from lung cancer surgery and their caregivers improve physical function compared to self-monitored activity. Participants will wear a pedometer and complete surveys and tests l…

This study tests if sucking on popsicles during chemotherapy can reduce taste changes in prostate cancer patients. Taste changes are a common side effect of taxane chemotherapy. The idea is that the cold from the popsicles narrows blood vessels in the mouth, which may limit how m…

This study tests whether using bright white light therapy glasses can reduce fatigue and improve mood in men with advanced prostate cancer who are on hormone therapy. About 210 men will either start light therapy right away or wait a few months. The goal is to help patients feel …

This study looks at how well older adults (70+) with hormone receptor positive metastatic breast cancer tolerate the drug abemaciclib after other treatments have stopped working. The main goal is to track side effects and see if the drug can be safely combined with hormone therap…

This study tests a high-CBD plant extract (BRC-001) to see if it can reduce joint pain and stiffness in women with breast cancer who take aromatase inhibitors (AIs). AIs lower estrogen to prevent cancer return but often cause arthritis-like side effects, leading some women to sto…

This study tests whether light therapy and occupational therapy can help reduce cancer-related fatigue in people with bladder, kidney, or prostate cancer. About 224 participants who are on active treatment will be assigned to receive light therapy, occupational therapy, both, or …

This study looks at a common skin rash caused by the cancer drug mogamulizumab in people with mycosis fungoides or Sezary syndrome (types of blood cancer). The rash can look like the cancer itself, leading doctors to stop treatment too early. Researchers want to learn how to tell…

This study aims to develop a blood test that can tell doctors which patients with advanced colorectal cancer will respond well to certain targeted therapies. Researchers will analyze DNA fragments in the blood of 500 patients to find patterns linked to treatment success or failur…

This study tests whether a telemedicine program can help older adults (65+) with cancer get care that matches their needs and goals. Researchers will use a special health assessment to find areas of weakness and connect patients with a team of experts. The goal is to see if this …

This study aims to develop a machine learning tool that analyzes tiny particles called exosomes in the blood to better determine how aggressive a person's colon cancer is before surgery. By combining this molecular information with standard clinical assessments, doctors hope to m…

This study is developing a computer model that uses genetic information from tumors to predict which colorectal cancer patients will benefit from chemotherapy after surgery. Researchers will analyze tumor samples from 200 patients to find patterns linked to treatment success or c…

This study looks at how cutaneous lymphoma (a rare skin cancer) affects patients' quality of life. Researchers will ask 1,250 participants to fill out a questionnaire called Skindex29, which measures symptoms, emotions, and daily function. The goal is to better understand patient…

This study looks at whether a special type of PET scan (PSMA-PET) and a blood test for tumor DNA can detect prostate cancer progression earlier than the standard PSA test. About 50 men with prostate cancer that has spread to a few spots will receive targeted radiation. Researcher…

This study looks at whether eating white button mushrooms can lower chronic inflammation and improve immune function in obese postmenopausal women who have a high risk of breast cancer. Researchers will measure changes in immune cells and inflammation markers in the blood. The go…

This study looks at how radiation and chemotherapy change the bone marrow in people with acute leukemia. Researchers will use special scans and collect blood and bone marrow samples to track these changes over time. The goal is to learn more, not to test a new treatment. About 74…

This study looks at stored tumor samples from 400 people with appendiceal cancer to find patterns in DNA and RNA that may help predict how the disease will progress. Researchers hope these molecular clues will improve risk assessment beyond standard lab tests. No new treatments a…

This study tests whether a wearable wristband can accurately measure medication levels in sweat and saliva, compared to standard blood tests. Researchers will enroll 100 people with chronic or infectious diseases who are already taking certain medications. The goal is to see if s…

This study looks at a new way to help family members of people with inherited cancer get tested for the same gene changes. About 15% of cancers are inherited, but many people don't know they carry a risky gene. The study will test if having a doctor reach out to at-risk relatives…

This study aims to find out if a simple blood test can predict which patients with metastatic colorectal cancer will respond well to standard chemotherapy. Researchers will analyze blood samples from 600 patients before they start treatment. The goal is to develop a test that hel…

This study follows 700 people with multiple myeloma to see how cannabis use affects their quality of life and symptoms during chemotherapy. Researchers will compare cannabis users and non-users using surveys and medical reports. The goal is to understand potential benefits and ha…

This study looks at how biomarkers (like DNA in the blood) can help predict whether immunotherapy will work for people with advanced non-small cell lung cancer. Researchers will collect blood and tissue samples from about 535 participants to understand treatment response and find…

This study looks at how the bacteria, fungi, and viruses living in the gut and urine change in 30 prostate cancer patients during hormone therapy and radiation. Researchers want to see if these tiny organisms affect healing from radiation side effects. The goal is to find new way…

This study aims to find biological markers in blood or other fluids that show when insulin-making beta cells are damaged or dying. Researchers will compare people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The goal is to better understand how diab…

This study looks at genetic information from stomach cancer tumors to predict how well a patient will respond to chemotherapy after surgery. Researchers will use machine learning to analyze these genetic patterns and create a model that helps doctors decide who is most likely to …

This study tests whether a combination of breath tests for H. pylori bacteria, questionnaires, and endoscopies can identify people at high risk for stomach cancer. It involves 240 adults aged 40 to 80 who are Asian, Hispanic, or Black American. The goal is to see if this screenin…

This study is developing a blood test that looks at tiny particles called exosomes to predict how well pancreatic cancer will respond to chemotherapy given before surgery. Researchers will analyze blood samples from 200 patients who have already had chemotherapy and surgery. The …

This study tests a new PET scan that tracks immune cells called CD8+ T cells, which help fight cancer. Ten adults with lymphoma or metastatic solid tumors will get the scan before and after radiation therapy. The goal is to see if radiation brings more immune cells to tumors, not…