City Of Hope Medical Center

This study tests whether a new COVID-19 booster vaccine (GEO-CM04S1) works better than the standard mRNA booster for people with chronic lymphocytic leukemia (CLL). About 80 adults with CLL who have already had at least two mRNA COVID shots will receive either the new vaccine or …

This study tests a vaccine designed to protect people who have had a stem cell transplant from a common virus called CMV. The virus can cause serious illness in those with weak immune systems. The vaccine uses a harmless virus to teach the body to fight CMV, aiming to reduce infe…

This early-stage study tests a combination of two drugs, copanlisib and venetoclax, in adults with mantle cell lymphoma that has come back or no longer responds to standard treatments. The goal is to find the safest dose and see how well the drugs work together to shrink or contr…

This study tests a vaccine called Triplex to see if it can prevent cytomegalovirus (CMV) infection in adults who have received a stem cell transplant. CMV is usually harmless but can be dangerous for people with weakened immune systems. The vaccine uses harmless pieces of CMV DNA…

This study tested a chemotherapy combination (carboplatin and nab-paclitaxel) given before surgery to people with a fast-growing type of breast cancer called triple negative. The goal was to shrink tumors enough so that no cancer remains at the time of surgery. The study included…

This study tested a modified approach to prevent and treat cytomegalovirus (CMV) infection in 153 people with blood cancers who had a donor stem cell transplant. The goal was to see if delaying or adjusting anti-CMV therapy could still keep patients safe while reducing unnecessar…

This study is for people with high-risk acute leukemia or myelodysplastic syndrome (MDS). It tests a new way to prepare the body for a donor stem cell transplant by combining targeted radiation (TMLI) with two chemotherapy drugs. The goal is to find the safest dose that can kill …

This study tested two different chemotherapy regimens, given before surgery, to see which works better for stage II-III breast cancer. Some participants also received trastuzumab, a targeted therapy. The main goal was to see if the tumor disappeared completely by the time of surg…

This study tests a combination of two drugs, tafasitamab and zanubrutinib, in people newly diagnosed with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to see if the combo can kill more cancer cells than either drug alone. About 26 adults wil…

This early-stage study tests whether giving gene therapy after chemotherapy is safe for people with AIDS-related lymphoma. Ten participants will receive stem cells modified with anti-HIV genes to help their bodies fight the virus. The goal is to see if this approach can control b…

This early-stage study tests a new cancer vaccine (p53MVA) combined with the immunotherapy drug pembrolizumab in people with advanced solid tumors that have not responded to other treatments. The vaccine helps the immune system recognize and attack cancer cells, while pembrolizum…

This early-stage trial tested whether adding regorafenib to the standard venetoclax and azacitidine regimen is safe and effective for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatment. The study aimed to find the best dose and check fo…

This study tests a new radiation technique called total marrow and lymphoid irradiation (TMLI) given before a stem cell transplant from a half-matched donor. The goal is to deliver higher radiation to cancer cells while protecting healthy organs, potentially reducing serious side…

This early-phase trial tests a new vaccine made from a person's own immune cells. The goal is to teach the immune system to stop attacking the pancreas, so the body can keep making some insulin. Six adults with type 1 diabetes who use insulin and have no other diabetes complicati…

This study tests a new combination of drugs (PolaR-ICE) for people with diffuse large B-cell lymphoma that has come back or hasn't responded to initial treatment. The goal is to see if adding a targeted drug (polatuzumab vedotin) to standard chemotherapy can improve the chance of…

This early-phase study tests a new combination of two drugs, minnelide and osimertinib, for people with advanced non-small cell lung cancer that has a specific gene change (EGFR mutation). The main goal is to find the safest dose and see how the body responds. Only 8 participants…

This early-phase study looks at whether adding a probiotic called CBM588 to the usual two-drug treatment (cabozantinib and nivolumab) can improve outcomes for people with advanced kidney cancer that has spread. The probiotic is meant to increase helpful gut bacteria, which may he…

This early-phase trial tests a new drug combination (IRX-2, cyclophosphamide, and nivolumab) in 8 adults with advanced liver cancer that has returned or spread and no longer responds to standard treatments. The goal is to find the safest dose and check for side effects. The appro…

This study tested a combination of a targeted drug (brentuximab vedotin) and chemotherapy in 48 adults with a rare, aggressive lymphoma called CD30-positive peripheral T-cell lymphoma. The goal was to see how well the treatment shrinks tumors and what side effects occur. Particip…

This early-phase study tests a combination of two drugs, copanlisib and nivolumab, in people with certain types of blood cancer that have changed into a more aggressive form (Richter's transformation or transformed non-Hodgkin lymphoma). The goal is to find the best dose and see …

This early-phase trial studies the safety and effectiveness of two immunotherapy drugs (durvalumab and tremelimumab) given after a targeted radiation procedure for patients with advanced liver cancer that cannot be removed by surgery. The treatment aims to help the immune system …

This early-phase study tests whether giving gene therapy after standard chemotherapy is safe for people with AIDS-related non-Hodgkin lymphoma. The treatment uses a virus to insert anti-HIV genes into the patient's own blood stem cells, potentially making them resistant to HIV. O…

This study tests whether giving two chemotherapy drugs (clofarabine and melphalan) before a donor stem cell transplant can help prevent leukemia from returning in patients whose cancer is in remission. The approach aims to kill any remaining cancer cells and stop the immune syste…

This study tests whether a white button mushroom supplement can lower PSA levels in men with prostate cancer that has returned after treatment or is low-risk and being watched. About 133 men will take the supplement or be monitored as usual. The goal is to see if the mushroom aff…

This study tested a treatment for prostate cancer that has spread to a few other places in the body (up to 5 spots). It combined hormone therapy (which lowers male hormones that fuel cancer) with a precise type of radiation aimed directly at the cancer spots. The goal was to see …

This early-phase study tests a new drug (LB-100) added to standard chemotherapy and immunotherapy for people with untreated extensive-stage small cell lung cancer. The goal is to find the safest dose and see if the combination helps shrink tumors. Only 3 participants were enrolle…

This early-phase study is for people with a specific kind of advanced lung cancer (ALK-positive non-small cell lung cancer) that has gotten worse despite prior ALK-targeted therapy. Researchers are testing a combination of two drugs—brigatinib and bevacizumab—to see what dose is …

This study tests a combination of three treatments for prostate cancer that has spread to a few spots in the body. The treatments are a radioactive drug (radium-223), hormone therapy to lower testosterone, and precise radiation to tumors. The goal is to see if this triple approac…

This study tests whether a structured exercise program can slow or stop the progression of localized prostate cancer in men who are not yet receiving active treatment (active surveillance). Researchers will compare molecular and imaging markers of tumor aggressiveness between men…

This study tests a new approach for people with leukemia or myelodysplastic syndromes (MDS) who need a donor stem cell transplant. Before the transplant, patients receive a special type of radiation (helical tomotherapy) along with two chemotherapy drugs (fludarabine and melphala…

This study tests whether giving duvelisib on an irregular schedule can still control chronic lymphocytic leukemia or small lymphocytic lymphoma while causing fewer severe side effects. Fifteen adults with cancer that has come back or not responded to treatment will take part. The…

This early-stage trial tests a new treatment called CD6-CAR Tregs for people with chronic graft-versus-host disease (cGVHD), a complication after stem cell transplants. The treatment uses specially engineered immune cells from a donor to help control the immune attack on the pati…

This study tested whether adding an immunotherapy drug (pembrolizumab) to standard hormone therapy (letrozole or fulvestrant) and a targeted drug (palbociclib) could shrink tumors in postmenopausal women with newly diagnosed stage IV estrogen receptor positive (ER+) breast cancer…

This study tests whether two immunotherapy drugs, nivolumab and brentuximab vedotin, can help prevent Hodgkin lymphoma from coming back after a stem cell transplant. It includes 62 people with high-risk lymphoma that returned or didn't respond to earlier treatments. The goal is t…

This early-stage study tests a new drug that delivers radiation directly to cancer cells that make a protein called CEA. The drug, Ac225-DOTA-M5A, is designed to find and kill these cancer cells while sparing healthy tissue. The study includes up to 20 people with advanced or met…

This early-stage trial tests a new drug (8-chloro-adenosine) combined with an existing drug (venetoclax) in 30 adults whose acute myeloid leukemia has come back or stopped responding to standard treatments. The main goal is to find the safest dose and check for side effects. The …

This early-phase trial tests a new way to prepare adults with acute myeloid leukemia (AML) for a donor stem cell transplant. Instead of full-body radiation, it uses targeted radiation to the bone marrow and lymph nodes, followed by a drug called cyclophosphamide to prevent graft-…

This early-stage trial tests whether adding camu camu, a prebiotic berry, to standard immunotherapy (nivolumab and ipilimumab) can improve treatment for advanced kidney cancer. About 31 people with metastatic clear-cell or sarcomatoid kidney cancer will receive the combination. T…

This very early trial tested leflunomide, an anti-inflammatory drug, in just one person with high-risk smoldering multiple myeloma. The goal was to see if the drug could delay the disease from becoming active myeloma. The study focused on safety and whether the drug slows progres…

This early-stage study tests a new treatment for people with malignant glioma that has returned or not responded to standard therapy. Doctors take a patient's own immune cells (T cells), add a special gene to help them recognize and attack the tumor, and infuse them back. The mai…

This study tests whether adding pterostilbene (an antioxidant from blueberries) to the hormone drug megestrol acetate works better than megestrol acetate alone in shrinking or slowing endometrial cancer. About 44 women scheduled for hysterectomy will receive one of the two treatm…

This study tests a new type of stem cell transplant for people with severe sickle cell disease who don't have a fully matched donor. It uses a half-matched relative as a donor and a milder chemotherapy to prepare the body, along with removing certain immune cells from the donated…

This early-phase trial tests whether specially engineered immune cells (T cells) can safely target and kill recurrent malignant glioma, an aggressive brain cancer. About 29 patients will receive these cells to find the best dose and check for side effects. The goal is to control …

This early study tests a new way to prepare the body for a stem cell transplant in people with sickle cell disease. Instead of full-body radiation, doctors use targeted radiation to the bone marrow and lymph nodes, plus a drug called alemtuzumab, to reduce damage to healthy organ…

This early-stage study tests a new type of immunotherapy for people with certain leukemias that have come back or not responded to standard treatment. The therapy uses a patient's own or donor's immune cells that are genetically modified to recognize and attack cancer cells carry…

This early-phase study tests a new treatment for adults with B-cell cancers (like lymphoma or leukemia) that returned after prior therapy. Doctors take a patient's own white blood cells, add a gene to help them find and kill cancer cells, and give them back after chemotherapy. Th…

This study tests leflunomide, a drug that lowers immune activity, in 27 African-American and European-American adults with high-risk smoldering multiple myeloma. The goal is to see if it can delay the disease from turning into active multiple myeloma. Participants take the drug a…

This early-phase study tests a new type of immunotherapy for people with high-risk B-cell non-Hodgkin lymphoma that has come back after initial treatment. Participants first receive a stem cell transplant, then get an infusion of their own immune cells that have been genetically …

This early-phase study tests a probiotic called CBM588 in 36 people who have had a donor stem cell transplant for blood cancers. The goal is to see if it is safe and can help restore healthy gut bacteria, which may reduce severe diarrhea and other gut problems. Participants take …

This study tests a new gene therapy for people with HIV. Doctors take the patient's own blood stem cells, modify them to resist HIV, and give them back after a mild chemotherapy. The goal is to see if this approach is safe and can help control HIV without needing daily medication…

This early-phase trial tests a new treatment for people with metastatic triple-negative breast cancer, a type that has spread and is hard to treat. The treatment uses a specially designed virus that is injected directly into tumors to infect and break them down. The main goal is …

This study tests whether transplanting insulin-producing cells from donors can help people with type 1 diabetes control blood sugar better and possibly stop taking insulin. Participants receive anti-rejection drugs to protect the transplanted cells and are followed for five years…

This study tests a drug called durvalumab, given alone or with lenalidomide, in people with T-cell lymphoma that returned or didn't respond to prior treatments. The goal is to find the best dose and see how well the combination works. About 38 adults with certain types of T-cell …

This early-phase study tests a new treatment for glioblastoma, a serious brain cancer that has returned or not responded to standard therapy. The approach uses specially engineered immune cells (CAR T cells) designed to target and attack the tumor, combined with drugs that boost …

This early-stage trial aimed to test the safety and effectiveness of STIL101, a personalized cell therapy made from a patient's own tumor-fighting T cells, for several advanced cancers including pancreatic, colorectal, kidney, cervical, and melanoma. The treatment involved collec…

This study tests a drug called acalabrutinib in people with chronic lymphocytic leukemia (CLL) who also have a type of anemia (AIHA) that came back or didn't get better with standard treatment. The drug works by blocking certain enzymes that help cancer cells grow. The main goal …

This early-phase study tests a new type of immune cell therapy (CAR T cells) designed to target a protein called MMP2 found on glioblastoma brain tumors that have returned or worsened. The main goals are to find the safest dose and understand side effects. About 19 participants w…

This study tests a combination of two drugs, epcoritamab and lenalidomide, in 29 adults with untreated follicular lymphoma, a slow-growing blood cancer that is not currently curable. The goal is to see if the pair works better than either drug alone to shrink tumors and improve r…

This study tests whether a combination of two drugs, lenvatinib and pembrolizumab, can help control advanced pancreatic cancer that cannot be removed by surgery. About 28 adults whose cancer has not worsened after initial treatment will receive these drugs as maintenance therapy.…

This early-stage study tested a combination of two drugs—pembrolizumab (an immunotherapy) and vorinostat (a targeted therapy)—in 52 adults with certain types of lymphoma that had returned or stopped responding to standard treatments. The main goals were to find the safest dose of…

This early-stage study tests a new three-drug combination for people with acute myeloid leukemia (AML) that has returned or stopped responding to standard treatments, including the drug venetoclax. The main goal is to find the safest dose and understand side effects. About 17 adu…

This early-stage trial tests a combination of chemotherapy (FOLFOX), a blood vessel blocker (bevacizumab), and two immunotherapy drugs (botensilimab and balstilimab) in 20 people with a type of advanced colorectal cancer (MSS) that has spread. The goal is to find the safest dose …

This early-phase trial tests whether specially engineered immune cells (IL13Rα2-CAR T cells) can safely target and destroy brain tumor cells that have spread to the lining of the brain and spinal cord. Ten adults with glioblastoma, ependymoma, or medulloblastoma will receive thes…

This study tests a combination of two drugs, epcoritamab and tazemetostat, in people with a type of blood cancer called follicular lymphoma that has come back or not responded to prior treatments. The goal is to see if the combination is safe and effective at shrinking or elimina…

This study tests a combination of three drugs (botensilimab, balstilimab, and regorafenib) in people with a type of colorectal cancer that has spread and stopped responding to chemotherapy. The goal is to see if this mix can shrink tumors or slow the disease. About 28 adults with…

This early-phase study tests a new approach for people with high-grade gliomas (aggressive brain tumors) that have come back after previous treatment. Researchers place genetically modified neural stem cells directly into the brain tumor to make it more sensitive to the chemother…

This study tests whether combining cabozantinib (a targeted drug) with temozolomide (chemotherapy) can slow or stop tumor growth in people with advanced leiomyosarcoma or other soft tissue sarcomas that cannot be surgically removed or have spread. About 96 participants receive bo…

This early-stage study tests a new immune cell therapy for adults with a high-risk form of acute lymphoblastic leukemia (ALL) that has come back or not responded to treatment. Doctors take a patient's own white blood cells, add a special gene to help them recognize and attack can…

This study tests a more precise radiation method (IMRT) for total body irradiation before stem cell transplant in 20 adults with acute leukemia or myelodysplastic syndrome. The goal is to reduce radiation to the lungs, lowering the risk of lung side effects while still preparing …

This early-stage study tests whether a drug called plerixafor can safely collect enough stem cells from people with sickle cell disease for a future gene therapy. Five participants will receive up to two injections of plerixafor. The goal is to see if this method is safe and work…

This early-stage trial tests whether drinking milk from goats genetically modified to produce a human enzyme (lysozyme) can help prevent graft-versus-host disease (GVHD) in people with blood cancer receiving a donor stem cell transplant. About 53 participants will drink a daily a…

This early-phase trial tests the safety and best dose of specially modified T-cells (immune cells) given after a stem cell transplant for people with high-risk or returning non-Hodgkin lymphoma. The modified T-cells are designed to recognize and attack cancer cells. The study inv…

This study tests whether giving the drug daratumumab after a stem cell transplant can help keep multiple myeloma from coming back. About 31 adults with myeloma (including those with related amyloidosis) will receive daratumumab as a follow-up treatment. The goal is to see if this…

This early-phase study tests whether giving a dose of heated chemotherapy directly into the abdomen during surgery can help lower the risk of cancer returning in people with advanced ovarian, fallopian tube, uterine, or peritoneal cancer. About 40 participants with stage III or I…

This study tested a combination of the immunotherapy drug nivolumab and chemotherapy (ICE) in 78 people with Hodgkin lymphoma that returned or didn't respond to initial treatment. The goal was to see if this approach could shrink tumors enough to allow a stem cell transplant. The…

This early-stage study tests a high-precision radiation technique called stereotactic body radiation therapy (SBRT) in 26 men whose prostate cancer has returned after surgery. The main goal is to find the safest and most effective dose by monitoring side effects. The approach tar…

This study tests a treatment plan for people with esophageal cancer that hasn't spread. Before surgery, patients receive chemotherapy, radiation, and two immunotherapy drugs (pembrolizumab and lenvatinib) to shrink tumors and boost the immune system's attack on cancer. The goal i…

This early-stage trial tests the safety of giving multiple doses of neural stem cells that carry a cancer-killing virus directly into the brain of people with recurrent glioblastoma, a severe brain cancer. The stem cells are designed to seek out tumor cells and release the virus …

This early-phase study tests whether adding the diabetes drug metformin and a specific dietary supplement mix to standard chemotherapy is safe and feasible for people with pancreatic cancer that cannot be removed by surgery. The supplement includes ingredients like curcumin, vita…

This study tests whether transplanting insulin-making cells (islets) can help people with type 1 diabetes who struggle with dangerous blood sugar swings. About 17 participants will receive the transplant along with immune-suppressing drugs to prevent rejection. The goal is to red…

This early-phase study tests a new treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The treatment involves taking the patient's own immune cells, modifying them to recognize and attack HER2-positive cancer cells,…

This early-phase trial tests a new approach for people with aggressive B-cell non-Hodgkin lymphoma that has come back after treatment. After a standard stem cell transplant, patients receive their own immune cells (T cells) that have been genetically modified in a lab to better r…

This early-stage trial tests whether a personalized cell therapy (CAR T-cells) can safely prevent relapse in older adults with B-cell acute lymphoblastic leukemia who are already in first remission. About 18 participants will receive their own immune cells, modified in a lab to t…

This study tests a new way to do stem cell transplants for people with sickle cell disease. Instead of needing a perfectly matched donor, it uses a half-matched family donor (haploidentical). Before the transplant, patients get two rounds of immune-suppressing therapy to help the…

This early-phase study tests two drugs, pevonedistat and ibrutinib, together in people with chronic lymphocytic leukemia (CLL) or non-Hodgkin lymphoma that has returned or no longer responds to standard therapy. The main goal is to find the safest dose and understand side effects…

This study tests whether a special PET scan using copper Cu64-DOTA-trastuzumab can predict how well HER2-positive breast cancer responds to targeted drugs (trastuzumab and pertuzumab) before surgery. About 18 women with locally advanced breast cancer will receive the scan and the…

This pilot study tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with breast, colon, lung, or other CEA-positi…

This study tests whether a special PET scan can predict if the drug T-DM1 will work in people with advanced HER2-positive breast cancer that has spread. Ten women with metastatic breast cancer received a radioactive tracer to see where the drug goes in the body. The goal is to he…

This study aims to develop a blood test that can find colorectal cancer early, even before symptoms start. Researchers will analyze blood samples from 500 people—some with cancer and some without—to look for specific chemical markers on DNA. The goal is to create a simple, noninv…

This study tested a special PET scan that uses a radioactive tracer (64Cu-DOTA-trastuzumab) to find HER2-positive breast cancer tumors in women with advanced stage IV disease. The goal was to see if the scan could tell the difference between HER2-positive and HER2-negative tumors…

This study looks at whether portable, easy-to-use devices can detect early signs of heart damage in childhood cancer survivors. These devices can be used at home or in a clinic, potentially catching problems sooner than standard tests. The study involves 149 participants and comp…

This study tests a free, culturally tailored program called Eat, Move, Live (EML) to help reduce the risk of cancer and chronic diseases like diabetes in underserved communities. About 347 adults will attend 12 weeks of nutrition and physical activity sessions. The program teache…

This early-phase trial tests whether giving a CMV vaccine to stem cell donors can boost the recipient's immunity after transplant. About 34 blood cancer patients receiving donor stem cells are involved. The goal is to prevent CMV viremia, a common and serious viral infection, wit…

This study looks at whether taking omega-3 fatty acids (like fish oil) can lower the chance of breast cancer returning in women who have already been treated for a certain type of breast cancer. 80 women will take either a low or high dose of omega-3s for 12 months. Researchers w…

This study tests an online program called Day by Day to help women with stage III or IV gynecologic cancer manage their fear of the cancer growing or coming back. About 23 women will use the program and answer questionnaires to see if it is easy to use and helps reduce anxiety. T…

This study tests a special recovery plan for people with stomach cancer who need surgery. The plan focuses on reducing pain and nausea, helping the bowels work sooner, and shortening hospital stays. About 52 patients with early to advanced stomach cancer will take part to see if …

This study tests a once-daily radiation schedule for women with low-risk, hormone-sensitive breast cancer. The goal is to see if this shorter treatment (5 days in a row) leads to better breast appearance compared to the standard every-other-day schedule. About 48 women aged 40 an…

This study tests whether smelling lavender oil can help cancer patients feel less pain and anxiety during a bone marrow biopsy. About 45 adults with cancer who are nervous about the procedure will try the aromatherapy. The goal is to find a safe, non-drug way to make the experien…

This study looks at whether curcumin, the ingredient in turmeric, can reduce joint pain in breast cancer survivors caused by aromatase inhibitor drugs. About 42 postmenopausal women will take either curcumin or placebo capsules for 3 months. The goal is to see if curcumin improve…

This study compares two skin creams, Aquaphor and Miaderm, to see which one better treats the painful skin rash caused by radiation therapy in breast cancer patients. About 208 women getting radiation after breast cancer surgery will use one of the creams and report their skin re…

This study tests a nurse-led multimedia program that helps family caregivers and lung cancer patients get ready for surgery. The program includes videos and guides to reduce caregiver stress, improve patient recovery, and boost quality of life. About 380 people with stage I-III l…

This study tests a nurse-led program designed to help people with advanced lung or gynecologic cancer cope with fears about the future. About 42 participants will try the program to see if it is practical and helpful in medical centers and clinics. The goal is to learn if this ap…

This study tests whether a smartphone app that teaches mindfulness can help people with metastatic kidney cancer feel better emotionally and improve their quality of life. About 21 adults with advanced kidney cancer who are on immunotherapy and have moderate to high fear of their…

This study looks at whether a special light treatment (photobiomodulation) can help reduce mouth sores, pain, taste changes, and dry mouth in patients getting a stem cell transplant. Six adult patients are being observed, some who received the light therapy and some who did not. …

This study tests whether a telehealth program that provides diet support can help improve nutrition and quality of life for people who have had surgery for stomach or esophagus cancer. About 53 adults who recently started eating again after surgery will take part in online sessio…

This study tests whether listening to music during a bone marrow biopsy or aspiration can lower anxiety. About 113 adults with blood cancers will be randomly assigned to either receive standard care or also listen to music during the procedure. Researchers will measure anxiety le…

This study looks at whether training parents in specific skills can improve learning and school functioning for Latino children with acute leukemia or lymphoma. About 214 families will take part, with some parents receiving a high-intensity program and others getting standard sup…

This study tests whether a social media campaign called 'End Stigma End Fear, End Cervical Cancer' can reduce stigma and encourage Pap tests among underserved women in Southern California and Trinidad and Tobago. About 336 women who need a Pap test will be followed for 3 months t…

This study tests whether a high-intensity digital health program—including video coaching and a special website—can help children aged 6 to 12 who were treated for leukemia or lymphoma improve their learning and school performance. Many children with these cancers are cured, but …

This study looks at a blood test that finds tiny bits of tumor DNA in the blood of people with early-stage breast cancer. The goal is to see if this test can tell who still has cancer cells after treatment and might need more therapy. About 350 adults with stage I-III breast canc…

This study looks at whether a program of exercise and a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and insulin resistance in adult survivors of childhood cancer who have prediabetes. About 20 participants will follow a 6-week…

This study looks at whether a peer navigator program can help African-American women who have finished breast cancer treatment better understand and follow their survivorship care plans. About 145 women who are 1-12 months past treatment will be randomly assigned to receive peer …

This study looks at whether older adults with cancer (age 65+) can use computer surveys to report their health and daily living needs. Researchers tested two different computer methods to see if they are reliable and easy to use. The goal is to make it simpler for doctors to asse…

This study follows 500 people who had early-stage breast cancer (stage 0 to IIIC) to learn about their long-term health, quality of life, and any late side effects from treatment. Researchers will also study blood and tumor samples to understand how the immune system fights breas…

This study looks at whether whole body MRI scans and liquid biopsies (blood tests) are acceptable to people with a strong family history of cancer. Researchers want to see if these tools can help find early-stage cancers. About 100 participants aged 50 or older (or younger if clo…

This study looks at whether a special PET scan using Posluma can help doctors better plan radiation therapy for prostate cancer. About 20 adults with prostate cancer will get an extra scan on the RefleXion X1 machine to compare with their standard scan. The goal is to improve how…

This study tests a new PET-CT scanner (RefleXion) in 20 cancer patients to see if it can produce images as good as the standard scan. The goal is to use the same scan for both imaging and planning radiation therapy, potentially reducing the number of scans needed. Participants wi…

This study tests whether a new imaging system (RefleXion RMRS) can produce clear PET-CT scans of prostate cancer tumors, similar to standard scans. About 34 adults with prostate cancer will get both types of scans. If the new system works well, it may allow doctors to plan radiat…

This study was designed to check if getting an IV in the arm of breast cancer patients who had lymph node surgery increases their risk of lymphedema (arm swelling). Researchers planned to use a safe dye called indocyanine green and a special camera to see how the lymph system wor…

This study compares two types of urine samples—expressed prostatic secretion (EPS) and post massage urine (PMU)—to see which one more accurately predicts whether a prostate biopsy will find cancer. About 243 men scheduled for a prostate biopsy will provide both samples. The goal …

This study tests a 12-month program to help stem cell transplant survivors detect skin cancer early. Survivors are at high risk for skin cancer years after their transplant. The program teaches people how to check their own skin and encourages them to tell their doctors about any…

This study looks at normal breast tissue changes and breast MRI images to find early signs that might lead to cancer. Researchers want to see if combining these tools can better predict a woman's risk of developing breast cancer. About 344 women already getting high-risk breast M…

This study tests a web-based education tool called HOPE-Genomics that teaches cancer patients about their genetic test results. About 465 adults with lung, breast, colorectal, pancreatic, ovarian, or prostate cancer are taking part. The goal is to see if the tool helps patients r…

This study tests a telehealth self-management program for people who have finished treatment for early-stage lung or colorectal cancer. The program coaches survivors on follow-up care, communication with doctors, and managing their health. Researchers want to see if it improves c…

This study uses advanced MRI scans to see how chemotherapy changes the brain in women aged 65 and older with early-stage breast cancer. Researchers will compare brain images and thinking tests taken before and after treatment. The goal is to better understand why some older patie…

This study looks at whether a special health check-up (geriatric assessment) for older adults with solid tumors can help predict serious side effects from chemotherapy. About 600 participants will be evaluated for things like daily function, other health problems, mood, social su…

This study tests a telephone-based counseling program designed for Latinas at high risk for hereditary breast or ovarian cancer. The goal is to see if culturally-informed support helps women better understand their cancer risk and feel more in control. About 493 women with or wit…

This study tested whether having patients use simple devices at home (like a thermometer, pulse oximeter, scale, and activity watch) after cancer surgery can improve recovery. The goal was to see if collecting health data in real-time helps catch problems early and makes care bet…

This study tests a mobile app called Oncpatient designed to help cancer patients navigate radiation therapy. Radiation treatment involves daily visits and managing side effects, which can be overwhelming. The app aims to provide easy-to-access information and guidance. Twenty adu…

This study looks at whether a team of healthcare professionals can help older adults (65 and older) stay healthy and recover better after a stem cell transplant for blood cancer. About 40 participants will see multiple providers to improve their fitness before and after the trans…

This study follows 2,500 men who had surgery for prostate cancer at City of Hope, at least one year after their operation. Researchers collect data on quality of life, sexual health, and long-term complications to better understand survivors' health. The goal is to use this infor…

This study was designed to see if an online mental health program could help women with advanced gynecologic or breast cancer cope with the fear of their cancer coming back. It planned to compare the program to standard educational materials. However, the study was withdrawn befo…

This study looks at whether a personalized survivorship care plan can improve quality of life for breast cancer survivors. About 100 women in Southern California who have finished active treatment will take part. Researchers want to see if having a care plan reduces stress and he…

This study aims to create a model that predicts which older adults (65+) with early-stage breast cancer are more likely to experience serious side effects from chemotherapy. Researchers will look at clinical factors and blood markers to understand why some patients have more toxi…

This study looks at whether a special assessment tool can help doctors predict how older patients with cancer will handle chemotherapy. Over 1,000 participants will be evaluated on their thinking, memory, and daily living skills. The goal is to see if this tool can forecast serio…

This study follows 350 stem cell transplant survivors to see how their heart, lungs, and muscles work together over two years. Researchers measure exercise capacity and other health markers to learn why transplant survivors have a higher risk of heart disease. Participants includ…

This study follows 238 breast cancer patients to see how chemotherapy impacts their physical function, health, and quality of life over time. Researchers compare women aged 65 and older with those under 65, tracking changes from before treatment to six months after. The goal is t…

This study collects blood plasma from people who have recovered from COVID-19 to build a bank and analyze the antibodies it contains. Researchers will give this plasma to current COVID-19 patients and track their recovery to see if certain antibody profiles lead to better outcome…