Triple threat: new drug combo aims to shrink advanced breast cancer
NCT ID NCT02778685
First seen Feb 28, 2026 · Last updated May 24, 2026 · Updated 8 times
Summary
This study tested whether adding an immunotherapy drug (pembrolizumab) to standard hormone therapy (letrozole or fulvestrant) and a targeted drug (palbociclib) could shrink tumors in postmenopausal women with newly diagnosed stage IV estrogen receptor positive (ER+) breast cancer. 47 participants received the combination. The goal was to see how many had their tumors shrink significantly. This is not a cure, as patients continue on maintenance therapy, but it aims to better control the cancer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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City of Hope Antelope Valley
Lancaster, California, 93534, United States
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City of Hope Corona
Corona, California, 92879, United States
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City of Hope Medical Center
Duarte, California, 91010, United States
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City of Hope Mission Hills
Mission Hills, California, 91345, United States
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City of Hope South Pasadena
South Pasadena, California, 91030, United States
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City of Hope Upland
Upland, California, 91786, United States
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City of Hope West Covina
West Covina, California, 91790, United States
Conditions
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