City Of Hope Medical Center

This early-phase study tested a combination of three drugs—regorafenib, nivolumab, and ipilimumab—in 39 people with advanced colorectal cancer that had spread and was no longer responding to chemotherapy. The goal was to find the safest dose and see if the combination could slow …

This study tested a new way to prepare people with hard-to-treat acute leukemia for a donor stem cell transplant. It combined a precise type of radiation (IMRT) with two chemotherapy drugs (etoposide and cyclophosphamide) to kill cancer cells and help the donor cells take hold. T…

This early-phase study tested a combination of two drugs, pevonedistat and decitabine, in 12 people with high-risk acute myeloid leukemia (AML). The goal was to find the safest dose and see how well the drugs work together to stop cancer cell growth. Participants had AML that was…

This study tested a strong chemotherapy combination followed by a stem cell transplant in 25 people with HIV and lymphoma. The goal was to see if the treatment is safe and possible. Participants had to be on HIV medications to keep the virus under control. The study focused on si…

This early-stage trial tested a combination of two targeted drugs, enasidenib and cobimetinib, in 3 adults with a specific genetic form of acute myeloid leukemia (AML) that had returned or not responded to prior treatment. The main goals were to find the safest dose and identify …

This study tested whether adding the drug itacitinib to the usual two-drug regimen (tacrolimus and sirolimus) could better prevent graft-versus-host disease (GVHD) in 59 adults with blood cancers (acute leukemia, myelodysplastic syndrome, or myelofibrosis) undergoing a donor stem…

This early-stage trial tested a drug called flotetuzumab in 13 people with advanced blood cancers that had returned or stopped responding to treatment. The goal was to find the best dose and check for side effects. Flotetuzumab is a lab-made antibody that may stop cancer cells fr…

This early-phase study tested whether transplanting insulin-making cells (islets) into people with type 1 diabetes who already had a kidney transplant could help them stop using insulin. Only 3 participants were enrolled, and they stayed on lifelong anti-rejection drugs. The goal…

This study tested a treatment for adults with acute myeloid leukemia (AML) who were in their first remission. Patients received high-dose chemotherapy and radiation, followed by a transplant of their own previously collected stem cells, plus an immune-boosting drug after transpla…

This study tested a strong chemotherapy regimen followed by a stem cell transplant for people with stage IIIB inflammatory breast cancer. The goal was to see if this approach could improve how long patients live without the cancer coming back. 41 patients took part in this phase …

This small pilot study tested whether an 8-week home exercise program guided by a trainer over video calls is practical and helpful for lymphoma survivors. The goal was to see if this approach could improve heart health in survivors who face a higher risk of cardiovascular proble…

This study tested a new blood test that looks for tiny particles (exosomes) released by cancer cells to find early signs of liver spread in people with pancreatic cancer. The goal was to identify patients at high risk before surgery, so doctors can choose the best treatment plan.…

This study tested a new blood test to detect intrahepatic cholangiocarcinoma, a rare and aggressive liver cancer. Researchers looked for tiny particles called exosomal miRNAs in the blood of 535 adults. The goal was to see if this non-invasive test could accurately identify cance…

This study looked at whether a blood test can tell if bile duct cancer has spread to nearby lymph nodes before surgery. Researchers analyzed blood samples from 230 patients with intrahepatic cholangiocarcinoma. The goal is to help doctors choose the best treatment without needing…

This study tested a new blood test that looks at tiny particles called exosomes to find hidden cancer spread in people with a type of bile duct cancer (intrahepatic cholangiocarcinoma). The goal was to see if the test could predict which patients already have cancer cells that ha…

This study tested whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. The goal was to see if patients could use the equipment and if the da…

This study looked at 109 people to understand how genetics and social factors like income, education, and environment might increase the risk of lung cancer. Researchers compared lung cancer patients and never-smokers to find clues that could help catch the disease earlier. The s…

This study tested a new blood test that looks for tiny bits of cancer DNA left behind after surgery in people with stage II or III colorectal cancer. The goal was to see if the test could find patients at high risk of the cancer coming back, so they could get the right follow-up …

This study looked at how the relationship, or 'therapeutic alliance,' between Latino patients with advanced cancer and their oncologists affects care. Researchers interviewed doctors and held group discussions with patients to understand what helps or hurts this bond, and how bei…