City Of Hope Medical Center

This study tests a combination of two drugs—nemtabrutinib and rituximab—for people with marginal zone lymphoma, a slow-growing blood cancer. The goal is to see if the combo can shrink or eliminate tumors. About 35 adults will take part. The approach aims to control the disease, n…

This study tests a new method called PIPAC, which delivers chemotherapy as a pressurized mist directly into the abdomen during a small surgery. It is for people with appendix or colorectal cancer that has spread to the lining of the belly and cannot be removed surgically. About 1…

This study tests a new drug, golcadomide, combined with rituximab for people with mantle cell lymphoma that has come back or stopped responding to treatment. The goal is to find the safest dose and see how well the combination works. About 58 adults will take part in this early-s…

This study tests whether giving two immunotherapy drugs (botensilimab and balstilimab) before surgery can shrink tumors and improve outcomes for people with advanced colon or rectal cancer that can be removed. About 100 adults with stage IIB to IIIC colorectal cancer will receive…

This early-phase study tests whether specially modified immune cells (called CD6-CAR Tregs) can safely control type 1 diabetes. The cells are designed to stop the immune system from attacking insulin-producing cells. Six adults with stage 3 type 1 diabetes will receive their own …

This study tests whether the drug duvelisib can help prevent peripheral T-cell lymphoma from returning after initial treatment. About 25 adults whose cancer has disappeared after first-line therapy will take duvelisib as maintenance. The goal is to see if it extends the time befo…

This early-phase study tests a new treatment called BSB-2002 for adults with a specific type of acute myeloid leukemia (AML) that has returned or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and att…

This study tests a new combination treatment for people with advanced kidney cancer that has spread and worsened after immunotherapy. The treatment pairs a drug called zanzalintinib, which blocks cancer cell growth, with a capsule (MO-03) that helps good gut bacteria thrive, pote…

This study tests a new way to prepare older patients (50 and older) with leukemia or MDS that has not responded to treatment for a stem cell transplant. Instead of full-body radiation, they receive targeted radiation to the bone marrow and lymph nodes, plus two chemotherapy drugs…

This study tests a new treatment for advanced kidney cancer that has spread and worsened after immunotherapy. The treatment combines a modified cold sore virus (RP2) that attacks tumor cells and activates the immune system, with a targeted drug (tivozanib) that blocks tumor growt…

This study tests a combination of three drugs (acalabrutinib, venetoclax, and tafasitamab) in 35 adults with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal is to see if the combo is safe and can achieve a complete response with undetecta…

This early-phase trial tests whether adding the targeted drug ruxolitinib to standard chemotherapy (CHOP) is safe and effective for people with untreated nodal T-follicular helper (TFH) cell lymphoma, a rare blood cancer. About 20 adults will take part to find the best dose and w…

This study tests a drug called ivonescimab given before surgery for high-risk kidney cancer that hasn't spread. The drug helps the immune system attack cancer and may also block blood vessel growth to tumors. About 31 people will take part to see if the drug shrinks tumors and ho…

This early-phase study tests two experimental immunotherapy drugs (ivonescimab and ADG126) alone or with chemotherapy in 30 adults with advanced or metastatic microsatellite stable (MSS) colorectal cancer. The main goal is to find safe doses and check for side effects. This type …

This study is testing if adding a specific probiotic (CBM588) to a standard immunotherapy drug (pembrolizumab) can better prevent kidney cancer from coming back after surgery. The trial will enroll 62 patients who have had surgery for high-risk kidney cancer. Researchers believe …

This study will examine if exercise lowers the risk of death in healthy adults aged 55-74. Researchers will analyze data from 19,000 participants in a past cancer screening trial. They will compare those who exercise with those who do not to see if exercise is linked to living lo…

This study looks at why some people develop chronic graft-versus-host disease (GVHD) after a stem cell transplant. Researchers will analyze immune cells in blood and affected tissues from 75 participants. The goal is to better understand the disease, not to test a new treatment.

This early-stage study tests whether a special report, created from a patient's tumor tissue, can help doctors choose the most effective treatments for advanced hormone receptor-positive breast cancer. The report looks at the cancer's biology to suggest which drugs might work and…