Periodontal disorder

Researchers test whether intentionally removing, treating, and replanting a severely loose lower front tooth works better than splinting alone. Fifty adults with advanced periodontitis and at least 50% bone loss around the tooth join the study. Half receive replantation plus spli…

This study compares two ways to remove infection at the tip of a tooth root: using a rotary bur (a small drill) or a piezoelectric unit (a vibrating tool). 124 adults with root infections will have surgery and then be followed for 12 months to see which method leads to better bon…

This study looks at whether a toothpaste with a special gum-health ingredient can improve gum health in people with gingivitis. 150 adults will use the test toothpaste for 13 weeks, then switch to a regular fluoride toothpaste for 4 weeks. Researchers will measure gum inflammatio…

This trial tests whether a toothpaste containing arginine can alter the bacteria living below the gumline in people with gum disease who are already receiving ongoing dental care. Participants will brush twice daily for six months with either an arginine toothpaste or a standard …

This study tests whether simple text messages and online activities can encourage people with Type 2 Diabetes to get more preventive dental care, like cleanings, instead of waiting for expensive treatments. Researchers will track dental insurance claims from 10,000 adults over 18…

This study compares a new cleaning solution made from ferumoxytol nanozymes to the standard treatment for root canal infections. About 72 adults with infected teeth will receive either the new solution or the usual one during their root canal procedure. Researchers will measure h…

This trial evaluates a modified surgical technique called the vertically coronally advanced flap (V-CAF) combined with a connective tissue graft and tissue regeneration materials to treat gum recession. It focuses on people with Miller Class III recession, a more severe form wher…

This study tested two approaches for placing dental implants in people with thin jawbones. In one group, the bone was built up first, and the implant was placed six months later. In the other group, both steps were done at the same time. The goal was to see if the one-step method…

This trial is testing two ways of performing a deep dental cleaning, called scaling and root planing, in people with advanced gum disease (Stage III periodontitis). One method cleans the entire mouth in a single session, while the other cleans one quadrant of the mouth at a time …

This study tests whether a special wipe containing xylitol, a natural sweetener, can reduce dangerous bloodstream infections in children and young adults undergoing stem cell transplants. These infections often start from bacteria in the mouth and can be life-threatening. Partici…

This study tests whether adding concentrated platelet-rich fibrin (C-PRF), a gel made from a patient's own blood, to a minimally invasive non-surgical gum treatment can improve healing in people with advanced periodontitis. Thirty adults with severe gum disease and deep bone defe…

This pilot study tests whether using a videoscope—a small camera that gives surgeons a magnified, clearer view—during minimally invasive gum surgery improves outcomes for people with severe chronic periodontitis. Participants are randomly assigned to receive surgery with the vide…

This trial compares two surgical techniques for treating receding gums, a condition where the gum tissue pulls away from the teeth, exposing the roots. One technique is the standard coronally advanced flap, and the other is a newer vertical variation. Both are performed along wit…

This study looks at how the part of a dental crown that sits under the gums is shaped and whether that shape helps keep gums and bone healthy. Thirty people with gum disease who already have a dental implant will get a custom crown. Researchers will measure bone loss, gum thickne…

This study tests a special drilling technique called osseodensification to widen narrow jawbone so dental implants can be placed without extra bone grafting. Thirty adults with healed tooth sockets and narrow ridges will have their bone width measured before and after the procedu…

This trial tests whether applying a gel containing hyaluronic acid and chlorhexidine after a minimally invasive deep cleaning can improve gum healing in people with advanced periodontitis (stage III or IV). Participants receive either the deep cleaning alone or the cleaning plus …

This study looks at whether a special dental sealer (bioceramic) helps heal infections and reduces pain after a repeat root canal done in one visit. About 70 adults with failed root canals and silent infections in their back teeth will take part. They will get the new sealer or a…

This trial tests whether placing a temporary crown immediately after a dental implant helps keep gum tissue stable compared to placing the implant alone. About 44 adults with a non-restorable front tooth will be randomly assigned to one of the two approaches. Researchers will mea…

This study tests a surgical procedure to cover exposed tooth roots on the tongue side of lower teeth. Twenty adults with gum recession will receive the surgery and be followed for up to 24 months. The main goal is to see how much root coverage is achieved at 6 months, along with …

This trial tests whether a thin, strong fiber splint glued to the back of loose front teeth can keep them stable for a year. The splint is made of ultra-high molecular weight polyethylene and is placed after standard gum treatment. Researchers will track how many teeth survive, h…

This study compares a new calcium silicate-based sealer to the standard resin-based sealer for root canals in molar teeth. About 136 adults aged 18-65 with infected molars will receive one of the two sealers. The goal is to see which material leads to better healing and fewer sym…

This study investigates whether injecting Botox a few days before modified lip repositioning surgery helps prevent the return of a gummy smile (excessive gum display when smiling) within one year. Twenty adults with a gummy smile and hyperactive upper lip will be enrolled. The tr…

This completed trial tested a new bone substitute called ALBO-OS in 20 people with periodontitis (severe gum disease) or needing jawbone preservation after tooth extraction. The material was placed into deep gum pockets or empty tooth sockets to help new bone grow. Early results …

This study looks at whether the timing of follow-up exams after non-surgical gum treatment affects how well the gums heal. Researchers will compare re-evaluations done at 3-4 months, 6-8 months, and 12 months after treatment. The goal is to see which timing leads to the most clos…

This study tests a new heat-resistant calcium silicate-based sealer used during root canals in people with infected tooth roots (apical periodontitis). The sealer is applied with different filling techniques to see if it improves bone healing and reduces pain after treatment. Par…

This study tests whether adding hyaluronic acid to a platelet-rich fibrin membrane improves the treatment of receding gums. Thirty adults with a specific type of gum recession will receive either the PRF membrane alone or with hyaluronic acid, alongside a surgical flap procedure.…

When a tooth is removed, the bone and gum often shrink, making it harder to place a dental implant later. This study tests a new magnesium membrane that is placed over a bone graft in the socket. Unlike standard membranes, it is rigid enough to protect the graft but dissolves on …

This study looks at whether placing a calcium hydroxide paste inside a tooth between root canal appointments helps infected teeth heal better. About 110 adults with painful tooth infections will receive standard root canal treatment over multiple visits. One group gets the extra …

This study tests a minimally-invasive non-surgical therapy (MINST) for treating gum disease-related bone defects. The approach uses small instruments and magnification to clean deep gum pockets with less tissue damage than traditional surgery. Researchers will measure bone healin…

This study compares two types of dental crowns for baby molars in 100 children aged 3-7. Each child gets a zirconia crown on one molar and a stainless steel crown on the opposite molar. Researchers will check gum health, plaque buildup, and parent satisfaction over 3 years to see…

This trial tests whether adding a healing material made from the patient's own blood (Advanced Platelet-Rich Fibrin, or A-PRF) to standard gum surgery helps cover exposed tooth roots better than surgery alone. Eleven adults with gum recession will receive either the combined trea…

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This study tests whether adding a special nano-gel (nano-hydroxyapatite) to a deep-cleaning gum treatment helps heal deep gum pockets better than cleaning alone. About 28 adults with advanced gum disease will be randomly assigned to get either the cleaning plus gel or just the cl…

This study tests whether a toothpaste with stannous fluoride works better than regular fluoride toothpaste at reducing dental plaque and gum inflammation (gingivitis). About 85 adults with mild to moderate gum disease will brush twice daily for 6 months. Dentists will measure pla…

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This study tests whether adding nano-hyaluronic acid gel to a non-surgical deep cleaning procedure helps heal gum pockets better than cleaning alone. About 28 adults with moderate to severe gum disease will be randomly assigned to receive either the gel plus cleaning or just clea…

This trial tests four methods of activating the cleaning liquid during root canal treatment in adults aged 20 to 40 with an infected lower first molar. The goal is to see which method helps the infection at the root tip heal best after 12 months. Participants receive one-visit ro…

This study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…

This study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…

This study looked at whether adding a diode laser to standard deep-cleaning treatment helps people with gum disease (periodontitis). Twenty-one adults in Yemen received the combined treatment, and researchers measured plaque, gum bleeding, pocket depth, and immune markers in gum …

This study tests whether adding a diode laser to standard deep cleaning helps people with gum disease. Forty adults with periodontitis will receive either standard cleaning alone or cleaning plus laser. Researchers will measure gum pocket depth and inflammatory markers in saliva …

This study tests whether personalized oral hygiene advice, delivered through an AI-powered mobile health app by trained volunteers, can improve gum health in older adults. Eighty-eight participants aged 60 and over from daycare centers in Hong Kong will receive bi-weekly advice b…

This study tests whether using a patient's own extracted tooth as a bone graft works as well as a traditional bone graft to repair bone damage from severe gum disease. Sixty adults with chronic periodontitis will receive one of the two graft types, both combined with a healing ge…

This study tests whether a new mouthwash that repairs enamel and fights bacteria works better than a standard chlorhexidine mouthwash for treating gum disease. About 40 adults with mild to moderate gum disease will use one of the mouthwashes along with deep cleaning. The goal is …

This study tests whether a blackberry extract mouthwash works as well as a standard antiseptic mouthwash (chlorhexidine) for treating gum disease. 48 adults with periodontitis will receive standard deep cleaning and then rinse with one of the mouthwashes or just plain water. Rese…

This study aimed to compare two surgical techniques for covering exposed tooth roots caused by gum recession, using a porcine (pig) collagen matrix as a graft material. The trial planned to enroll 20 non-smoking adults with multiple gum recessions. However, the study was withdraw…

This study tests whether oleanolic acid, a natural plant compound, works better than standard medicines (calcium hydroxide and Ledermix) when placed inside a root canal. The goal is to reduce bacteria and inflammation in teeth with infection. Thirty-six adults with infected singl…

This study tests whether adding aspirin and omega-3 fatty acids to standard deep-cleaning gum treatment helps people with advanced gum disease (periodontitis). About 120 adults will be randomly assigned to get either standard cleaning alone, cleaning plus omega-3, or cleaning plu…

This study tested two methods for preparing gum grafts to treat receding gums. One method uses a scalpel outside the mouth, the other uses a radiofrequency device inside the mouth. Forty-eight patients received one of these grafts along with a surgical gum lift. Researchers check…

This study tests a modified pinhole surgical technique for treating localized gum recession. It compares using a bi-layer collagen membrane versus a connective tissue graft to cover exposed tooth roots. The trial involves 18 healthy adults with gum recession and will measure chan…

This program provides early access to an experimental drug called CNM-Au8 for people with amyotrophic lateral sclerosis (ALS), a progressive nerve disease. Participants must be 18 or older and have a confirmed ALS diagnosis. The goal is to offer treatment to those who cannot join…

This study tests whether a probiotic tablet (Lactobacillus reuteri) can reduce harmful mouth bacteria as well as a standard chlorhexidine mouthwash in people with gum disease and type 2 diabetes. Twenty participants will use either the mouthwash or the probiotic for 30 days. The …

This study in Malawi tests whether chewing xylitol gum three times a day during pregnancy can improve gum health and change the bacteria in the mouth and vagina. Researchers will also check if it reduces pregnancy complications and affects babies' brain development. 80 pregnant w…

This early-phase study tests whether a new biomaterial (REGENFAST) works better than a standard platelet-based treatment (L-PRF) for repairing gum and bone damage caused by gum disease. Fifteen adults with matching defects on both sides of the mouth will receive one treatment on …

This study compares two different incision methods for gum graft surgery to treat receding gums. Twenty-two adults with gum recession and thin gum tissue will receive a graft made from donated skin. The goal is to see which method covers more exposed tooth root and causes less pa…

This study tests whether a magnetic mallet—a tool that uses controlled electromagnetic pulses—can place dental implants more stably and with less trauma than conventional drilling in people with soft jawbone (type D4 bone). Thirty participants with missing teeth in the upper back…

This early-phase trial tests whether calcium silicate and pectin, placed inside the tooth, can kill bacteria better than standard calcium hydroxide in root canals of dead teeth with abscesses. 63 adults with a single infected premolar will receive one of the three medications. Th…

This study looks at whether deep cleaning for gum disease can lower a key heart failure marker in the blood. About 80 adults with or without heart failure will receive dental scaling and root planing. Researchers will track changes in NT-proBNP levels and gum health over 6 months…

This study tests whether a protein from camel milk, made into tiny nanoparticles, can help repair bone damage caused by severe gum disease. About 44 adults with deep gum pockets and bone loss will receive the treatment during surgery. The goal is to see if the camel protein helps…

This study tests whether a gel made from ferulic acid, a natural antioxidant, can improve the results of deep cleaning for gum disease. Researchers will compare three groups: cleaning plus the gel, cleaning plus a placebo gel, and cleaning alone. The goal is to see if the gel hel…

This early-stage trial tests whether injecting resveratrol nanoparticles into the gums can improve treatment for stage III periodontitis. 48 adults will receive either the resveratrol gel, a placebo, or standard deep cleaning alone. Researchers will measure gum attachment levels …

This study tests whether motivational interviewing, a supportive counseling method, can help teenagers aged 14-19 with braces improve their oral hygiene. Participants receive short, non-judgmental conversations to set their own goals for brushing and flossing. The goal is to redu…

This study compares two methods to clean infected root canals during a single dental visit: laser-activated irrigation and sonic-activated irrigation. Sixty adults with chronic apical periodontitis (a tooth infection) will receive one of the two treatments. Researchers will measu…

This study tested whether adding injectable Platelet-Rich Fibrin (i-PRF), a natural concentrate from a patient's own blood, to standard deep cleaning improves gum disease outcomes. In 13 adults with moderate to severe periodontitis, one side of the mouth received the combined tre…

This study tests whether a substance made from a patient's own blood, called Horizontal Platelet Rich Fibrin (H-PRF), can help the jawbone heal better after a tooth is pulled. The goal is to create stronger bone for a future dental implant. Thirty adults aged 18-40 who need a too…

This study compares two types of minimally invasive gum surgery for treating deep pockets caused by periodontitis. Fifty adults with advanced gum disease will be randomly assigned to receive either a single-flap or double-flap procedure. Researchers will measure how well each tec…

This study tests whether a melatonin-loaded gel, made from your own blood, can improve gum health in people with stage II periodontitis. About 60 adults with mild to moderate gum disease will receive the treatment. The main goal is to see if it helps reattach gums to teeth.

This study tests whether microneedling, with or without a growth factor injection, can thicken the gum tissue around dental implants. Twenty people with thin gums will receive either the growth factor alone or microneedling plus the growth factor. The goal is to see if this simpl…

This study reviews past dental records to see how effective scaling and root planing (a deep cleaning procedure) is for treating gum pockets that are 5 to 8 millimeters deep. Researchers will analyze data from 110 patients treated by dental students over two years. The goal is to…

This study tests whether adding a concentrate from the patient's own blood (injectable platelet rich fibrin, or I-PRF) to a standard bone graft helps repair bone defects caused by advanced gum disease. Twenty adults with stage III periodontitis and deep gum pockets will receive e…

This study tests two types of donated human tissue grafts for treating gum recession. Twenty adults who need a gum graft will receive either a standard graft or a new micro-surfaced version. Researchers will compare how well the gum covers the tooth root, how the site heals, and …

This study compares two types of dental sealers used during root canal treatment: TotalFill (a bioceramic sealer) and AH Plus. The goal is to see which one leads to better healing of infections at the tooth root tip. 170 teeth from adults at a dental clinic in Singapore are being…

This study tests whether treating severe gum disease can slow down Alzheimer's disease. Researchers will give 26 people with both conditions deep dental cleaning, extractions if needed, and oral hygiene training. Over 24 months, they will track memory, thinking skills, and brain …

This study aimed to compare different surgical techniques for treating receding gums, including a flap procedure and a tunnel approach, with or without a platelet concentrate. It was designed for 100 adults with multiple gum recessions. However, the trial was withdrawn before enr…

This study tested two surgical techniques to fix receding gums on the lower front teeth. 26 adults with gum recession received either a modified laterally stretched technique or a tunneling method with a connective tissue graft. The goal was to see which approach better covers ex…

This study looks at two ways to treat severe gum disease that has reached the area where the roots of back teeth split. One approach uses non-surgical cleaning and maintenance, while the other involves surgery to reshape or rebuild bone. The goal is to see which method helps keep…

This study provides an experimental stem cell treatment (HB-adMSCs) to an 83-year-old man with Primary Lateral Sclerosis, a rare nerve disease that causes progressive muscle weakness. The patient's own banked stem cells are used, aiming to slow the disease. This is a single-patie…

This study is checking how safe and effective a new membrane made from pig tissue is for dental surgery. It involves 50 adults who need gum tissue regeneration around teeth or implants. Researchers will monitor for complications and measure gum thickness and width over 24 months.

This study tests whether brushing with stannous fluoride toothpaste twice a day for three months reduces gum bleeding and inflammation better than a standard fluoride toothpaste. 120 adults with mild to moderate gingivitis will be randomly assigned to one of three toothpastes. Th…

This trial tests whether an artificial intelligence model can accurately diagnose gingivitis — early gum disease — by analyzing digital photographs and X-rays. Researchers will compare the AI's assessments to those of dental experts. If it works, this approach could make gum dise…

This study is testing whether artificial intelligence (AI) can accurately diagnose periodontitis (severe gum disease) and monitor gum inflammation using dental records and X-rays. Researchers will develop and validate AI models using data from 900 patients across multiple hospita…

This study tests whether a topical 10% povidone-iodine solution can prevent white spot lesions on the front teeth of teens undergoing fixed orthodontic treatment. Healthy participants aged 10 to 17 will receive either the iodine solution or a placebo applied to all tooth surfaces…

Researchers compare whether adding omega-3 or resveratrol supplements to standard non-surgical gum treatment improves periodontal health in healthy non-smokers with periodontitis. The study looks back at records from 60 patients split into three groups: those who took resveratrol…

This study looks at three different methods to activate cleaning fluids during root canal retreatment: ultrasonic, sonic, and laser. The goal is to see which one causes the least pain and helps the infection heal best. Seventy-five adults with previously treated teeth that still …

This study tested two ways to teach people with gingivitis (early gum disease) how to clean their teeth better. One group watched a video, the other practiced on a dental model. After one month, both groups showed improved gum health and awareness, with no major difference betwee…

This study tests two standard methods—manual scraping with a hand tool or using a small rotating bur—to clean out unhealthy tissue from a tooth socket after extraction. About 60 adults with long-term tooth infections will be randomly assigned to one method, then all receive a bon…

This trial compares five different motion patterns used in root canal treatment to see which one causes the least pain afterward. Adults aged 18 to 65 with asymptomatic root canal needs will be randomly assigned to one of the five motion types. Pain levels and inflammatory marker…

This study compares four different rinsing tools used after root canal treatment to see which one reduces pain the most. Fifty-two adults with an infected lower back tooth will be randomly assigned to one of four groups. They will rate their pain at several times over two days an…

This small pilot study tests two different stitching techniques during gum surgery to cover exposed tooth roots caused by gum recession. Seven healthy adults with multiple areas of gum recession will receive both techniques in different parts of their mouth. The goal is to see wh…

This study tests a numbing method called intraseptal anesthesia for gum surgery. Sixty adults with gum disease will receive a small amount of articaine to see if it effectively blocks pain during the procedure. The goal is to find a less painful alternative to standard numbing te…

This study compares two treatments for severe tooth pain: vital pulp therapy, which tries to save the tooth's nerve, and standard root canal treatment, which removes it. Researchers will measure pain after 24 hours and one week, and check healing at 6 and 12 months using AI to re…

This study tested how well different home oral hygiene devices (like interdental brushes and picks) reduce plaque and gum bleeding in 40 adults with gingivitis. Participants used the tools at home and were checked monthly. The goal was to see which device works best for everyday …

This study looks at two ways to clean root canals (rotary vs. reciprocating files) and whether rinsing with very cold saline (cryotherapy) reduces pain after the procedure. Sixty adults with infected but painless teeth will be randomly assigned to one of four groups. Patients wil…

This study looks at whether sonic electric toothbrushes or manual toothbrushes are better at reducing gum inflammation in pregnant women. Gum problems are common during pregnancy due to hormone changes. The trial will follow 120 pregnant women aged 18-40 to see which toothbrush t…

This study tests two ways to clean a tooth during a root canal: laser-activated irrigation and passive ultrasonic irrigation. Researchers want to see which method leads to less pain and better quality of life afterward. 90 adults with infected or damaged permanent teeth are takin…

This study looks at two different cleaning solutions used during root canal treatment for teeth with long-term infection. The goal is to see which method helps the infection heal better and causes less pain afterward. 63 healthy adults with infected front or premolar teeth will b…

This study tests a less invasive surgical approach for treating persistent tooth infections. Instead of removing all infected tissue and using stitches, surgeons remove only part of the tissue and seal the area with a medical glue. The goal is to see if this method reduces pain, …

This study tests whether adding N-acetylcysteine (NAC) to standard root canal treatment can reduce pain and improve healing in people with infected, dead teeth. Forty adults with mature teeth and signs of infection around the root tip will receive either NAC or standard medicatio…

This study looks at two different materials used to fill root canals after infection. 64 adults with infected but painless teeth will get one of the two sealers. Researchers will track pain for a week and check healing with X-rays over time to see which works better.

This study tests whether adding a common mouthwash ingredient (chlorhexidine) to a standard root canal medicine (calcium hydroxide) helps reduce pain after treatment. 80 adults with infected front teeth will receive one of two mixtures. Pain levels are checked at 12, 24, and 48 h…

This study looks at whether applying a hyaluronic acid gel (Gingigel) and using a special light therapy (photobiomodulation) can help gums heal better and with less pain after a common gum surgery called gingivectomy. About 38 adults with enlarged gums will be split into three gr…

This study tests two different pastes placed inside the tooth between root canal visits to see which one reduces pain and helps the bone heal better. Eighty adults with infected but painless front teeth will receive either Bio-C Temp or Metapaste. Pain is tracked for a week, and …

Researchers at Semmelweis University are studying whether bacteria that cause gum disease also show up in damaged blood vessels. They will compare samples from the mouth and from diseased artery sites in 100 people who need surgery for aortic aneurysm or carotid artery narrowing.…

This study at the University of Michigan is testing whether ultrasound can monitor bone graft healing after tooth extraction, potentially replacing more invasive scans. About 140 adults needing a tooth extraction and bone graft for a future dental implant will have their healing …

This study gathers mouth pictures from 150 adults with different gum conditions to teach an AI system how to spot gum disease. Participants simply have their teeth and gums photographed with a special probe. No treatment or medication is involved—just data collection to improve f…

This study looks at whether the Parkinson's drug Levodopa-Benserazide affects gum health and inflammation. Researchers will measure gum health and saliva markers in 136 people, including Parkinson's patients with and without gum disease, and healthy controls. The goal is to under…

This observational study measures three proteins, PTHrP, RANKL, and OPG, in the fluid that seeps from the gums. Researchers will compare levels in 81 adults split into three groups: healthy gums, gingivitis, and periodontitis. During a routine dental exam, they collect fluid samp…

This study investigates whether chronic gum disease (periodontitis) is linked to changes in the autonomic nervous system — the body's automatic 'wiring' that controls heart rate, digestion, and stress responses. Researchers will measure heart rate variability, a marker of nervous…

This study follows 100 people who already have short, 3D-printed dental implants in the back of the upper or lower jaw. Researchers measure bone loss and other dental health markers over three years to see how well these implants hold up. The goal is to learn whether these specia…

This study investigates whether severe gum disease (periodontitis) changes the quality and quantity of a blood-derived material called leukocyte- and platelet-rich fibrin (L-PRF), which is used to help heal gums and bone after dental procedures. Researchers will compare L-PRF sam…

This study explores whether a health app and follow-up digital meetings can motivate teenagers to improve their oral hygiene. Researchers will interview 25 adolescents aged 16-17 who have gum disease (gingivitis) to see if the app helps them build better brushing habits. The goal…

This study follows 200 adults with high blood pressure and gum disease to see how gum health affects blood pressure and cholesterol levels over 6 to 12 months. Researchers will measure triglycerides and LDL cholesterol to understand the link. The goal is to learn whether treating…

This study looks at tissue samples taken from deep gum pockets in people with periodontitis who have already completed initial treatment. Researchers want to describe the tissue features and see if they relate to how well the gums heal. The goal is to better understand healing pa…

This study compares the levels of two bacteria, E. saphenum and P. gingivalis, in 148 adults over age 30—111 with gum disease (periodontitis) and 37 with healthy gums. Researchers collect plaque samples and use advanced lab tests to measure bacterial levels. The goal is to better…

This study looks at whether routine blood sugar testing during dental checkups can help find hidden high blood sugar in people with advanced gum disease. About 300 adults with severe gum disease will get a simple finger-prick blood test during their dental visit. The goal is to s…

This study checks how many teeth remain functional 10 years after root canal treatment using a sealer called Endomethasone N. Researchers will review records from 179 adults who had the treatment at least 5 years ago. The goal is to understand the long-term success and safety of …

This study looks at how smoking changes the body's immune response in gum disease. Researchers compared smokers and non-smokers with healthy gums, gingivitis, or periodontitis. They measured specific proteins and genes in gum tissue to understand the link between smoking and infl…

This study looks at how a standard deep-cleaning procedure called scaling and root planing affects certain proteins in the blood and gum fluid of people with advanced gum disease. Researchers will compare 28 patients with stage 3 periodontitis to 28 healthy individuals, measuring…

This study looks at whether a person's genetic makeup influences how well a tooth infection heals after root canal treatment. Researchers will collect saliva samples from 96 adults with chronic apical periodontitis and analyze specific genes related to inflammation and bone repai…

This study examines how nicotine buildup in gum tissue influences the results of non-surgical periodontitis treatment. Researchers will measure nicotine and cotinine levels in the gums of 56 smokers and non-smokers with periodontitis. The goal is to understand if nicotine intoxic…

This study looks at how the severity of gum disease (periodontitis) impacts people's daily lives. Researchers examined 300 adults aged 18 to 65, measuring gum health through clinical exams and using two short questionnaires (OHIP-14 and OShip-14) to capture how oral health affect…

This study looks at whether offering dental exams and cleanings to people with cirrhosis can improve their oral health and overall well-being. Researchers will also ask participants about barriers to getting dental care. About 100 adults with confirmed cirrhosis will take part, a…

This study looks at how an acute tooth infection (apical periodontitis) affects the masseter muscle, a key jaw muscle used for chewing. Researchers will use ultrasound to measure muscle thickness and stiffness before and after dental treatment with calcium hydroxide. The goal is …

This study follows 60 adults with infected teeth who receive standard root canal treatment. Researchers collect fluid from around the tooth before and after treatment to see if certain proteins can predict whether the infection heals on X-rays after one year. The goal is to find …

This study looks at how different root canal cleaning methods—laser and ultrasound—affect the immune response in people with and without type 2 diabetes who have a tooth infection called apical periodontitis. Researchers will measure certain immune markers in fluid from around th…

This study follows 100 head and neck cancer patients receiving standard radiotherapy to see how their teeth, gums, and saliva change over time. Researchers measure gum health, tooth condition, and quality of life before and after treatment. The goal is to better understand these …

This study looks at how metal and ceramic braces change the bacteria in dental plaque (biofilm) and affect gum health in 80 people with crooked teeth. Researchers will measure the types and amounts of bacteria, plaque buildup, and gum swelling. The goal is to understand how diffe…

This study looks at 50 people with gum disease—25 smokers and 25 non-smokers—to see if a protein in saliva called histatin-1 is linked to healing after standard non-surgical gum treatment. Researchers measure the protein and gum health at the start, one month, and three months af…

This study looks at two genetic markers (Cofilin-2 and Lactoferrin) in 84 adults with gum disease, some of whom also have coronary heart disease. Researchers measure changes in these markers and gum health after a standard deep-cleaning dental treatment. The goal is to better und…

This study tests four different methods for removing the surface layer of gum tissue during dental grafting surgery. The methods include a surgical blade, a special drill (mucotome), a diamond bur, and a laser. Researchers will measure how much tissue remains, how long the proced…

This study follows 30 adults who had surgery for advanced gum disease (periodontitis). Researchers want to see if the surgery keeps teeth healthy and how long the benefits last. Participants are checked at regular visits with exams and X-rays. This is an observational study, mean…

This study looks at whether taking antidepressants can reduce gum inflammation in people with chronic periodontitis (gum disease) and depression. Researchers will collect gum fluid and plaque samples from 92 patients during routine dental procedures. The goal is to see if depress…

This early-phase study tests whether strawberry gummies can improve oral health in 36 adults, including smokers and non-smokers. Participants eat two types of gummies (real strawberry or placebo) four times daily for a week. Researchers measure how the body absorbs strawberry com…

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that can quickly tell if someone has a bloodstream infection, which could help diagnose sepsis faster. About 100 adults with gum disease ar…

This study tests whether using ozone water during root canal treatment can reduce oxidative stress (a sign of inflammation) in the jawbone. Sixty adults with a single-rooted tooth and a silent infection will be randomly assigned to receive either ozone water or salt water as a fi…