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Probiotic tablets vs. mouthwash: a new way to fight gum disease?

NCT ID NCT07489924

Disease control Sponsor: Universidad de Colima Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a probiotic tablet (Lactobacillus reuteri) can reduce harmful mouth bacteria as well as a standard chlorhexidine mouthwash in people with gum disease and type 2 diabetes. Twenty participants will use either the mouthwash or the probiotic for 30 days. The main goal is to see how much the bacteria Porphyromonas gingivalis decreases.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chlorhexidine mouthwash and probiotic (Lactobacillus reuteri) tablets
What this could lead to
If successful, this could show that a simple probiotic tablet is as good as a mouthwash for controlling gum-disease bacteria in people with diabetes.
What could go wrong
This is a very small, early-phase trial with only 20 participants, so results may not apply to everyone. The probiotic might not work as well as the mouthwash.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

20 people

The number who actually took part.

Started

Jan 2023

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Previous diagnosis of controlled type 2 diabetes mellitus. * Periodontal disease (≥2 quadrants affected; probing depth ≥4 mm; bleeding on probing \>10%). * Patients affiliated with the Unidad de Salud Zona Oriente (IMSS-BIENESTAR). * Signed informed consent. Exclusion Criteria: * Inability to cooperate. * Antibiotic treatment within the last 3 months. * Soft tissue pathologies not related to periodontal disease. Elimination Criteria: * Failure to complete the study. * Insufficient or non-extracted DNA sample. * Indication of antibiotics/fluoxetine during the intervention.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus periodontal disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus type 2 Periodontal diseases

Contacts and locations

Locations

  • University of Colima

    Colima, 28040, Mexico

More trials for these conditions

Other studies related to the condition(s) this trial covers.