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Tooth infection study tests if extra dressing boosts root canal success

NCT ID NCT06447519

Disease control Sponsor: Aristotle University Of Thessaloniki Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether placing a calcium hydroxide paste inside a tooth between root canal appointments helps infected teeth heal better. About 110 adults with painful tooth infections will receive standard root canal treatment over multiple visits. One group gets the extra paste, the other does not. Researchers will check pain and X-ray healing for up to 2 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 110 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA grade: I or II * Age: ≥18 years * Permanent teeth * Pulp diagnosis: necrosis or previously treated * Diagnosis of periapical tissues: symptomatic apical periodontitis * Teeth sensitive to percussion and/or palpation * Initial PAI: 3-5 * Signed Patient Consent Statement for participation in clinical research Exclusion Criteria: * Subjects that do not meet the inclusion criteria * Pregnant women * Patients who receive corticosteroids and/or have received antibiotics within the previous three months * Patients who report pain in a different area than that of the tooth under investigation * Teeth that cannot be isolated with a rubber dam * Teeth with extensive hard tissue destruction that is not restorable * Teeth with an anatomic peculiarity of the root canal (internal resorption, perforation, displacement of root canal course due to previous endodontic treatment) * Teeth in which the formation of the apex has not been completed * Fractured teeth with periodontal involvement * Teeth with periodontal pocket depth ≥ 4mm or teeth with bone loss at the bifurcation of the roots due to periodontitis * Teeth with loss of periodontal attachment ≥ 5 mm * Teeth with embedded exudate in the session planned for root canal obturation. * Teeth that after completion of the endodontic treatment show underocclusion \>2mm or hyperobstruction \>1mm from the radiographic apex. * Teeth in which permanent restoration has not been completed over time less than one month after endodontic treatment.

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Conditions

The condition(s) this trial relates to.

periapical periodontitis Tooth, Nonvital

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Calcium hydroxide Endodontically treated teeth

Contacts and locations

Locations

  • School of Dentitry, Aristotle University of Thessaloniki

    Thessaloniki, Central Macedonia, 54124, Greece

More trials for these conditions

Other studies related to the condition(s) this trial covers.