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Root canal showdown: which sealer causes less pain?

NCT ID NCT07307807

Symptom relief Sponsor: Ankara Yildirim Beyazıt University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two different materials used to fill root canals after infection. 64 adults with infected but painless teeth will get one of the two sealers. Researchers will track pain for a week and check healing with X-rays over time to see which works better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 64 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Jan 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy individuals aged between 18 and 60 years with no systemic diseases 2. Teeth with periapical lesions (apical periodontitis) that have not undergone previous root canal treatment 3. Single-rooted maxillary and mandibular teeth 4. Teeth with PAI scores of 2, 3, and 4 according to the PAI classification 5. Teeth without a sinus tract or acute apical abscess 6. Patients who voluntarily agree to participate in the study and attend follow-up visits 7. Teeth with sufficient remaining tooth structure to allow restoration with a direct restoration after root canal treatment - Exclusion Criteria: Patients who have used antibiotics, analgesics, or anti-inflammatory drugs within the last 7 days Pregnant or breastfeeding patients Patients with traumatic malocclusion Patients without occlusal contact Teeth with root resorption, open apices, or calcification Teeth presenting gingival recession greater than 3 mm, deep periodontal pockets, or mobility Teeth with root fractures or cracks Presence of an adjacent tooth requiring endodontic treatment that may cause referred pain Multirooted teeth Teeth with a PAI score of 5 Teeth requiring restorations such as endocrowns, onlays, overlays, or full crowns due to excessive loss of tooth structure after root canal treatment Teeth with structural loss severe enough to require post-core application Cases in which adequate anesthesia cannot be achieved with local anesthesia alone (requiring additional intrapulpal or intraligamentary anesthesia) Teeth requiring active periodontal treatment Individuals with severe systemic diseases \-

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Root canal obturation

Contacts and locations

Locations

  • Ankara Yıldırım Beyazıt University

    Ankara, Keçiören, 06490, Turkey (Türkiye)

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