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Could antidepressants soothe your gums? new study investigates

NCT ID NCT03553095

Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether taking antidepressants can reduce gum inflammation in people with chronic periodontitis (gum disease) and depression. Researchers will collect gum fluid and plaque samples from 92 patients during routine dental procedures. The goal is to see if depression medication lowers inflammatory markers in the mouth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could point toward using antidepressants to help treat gum disease in people with depression.
What could go wrong
This is a small observational study, not a treatment trial. It may not prove that antidepressants directly reduce inflammation, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

92 people

The number who actually took part.

Started

Jul 2018

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * At least 18 years old * Must be a patient of the UAB Dental School * Able to read and understand informed consent document * Good general health as evidenced by medical history * Minimum of 18 teeth, excluding third molars * Having moderate to severe periodontal disease according to AAP definition (teeth ≥5 mm PD and ≥3 mm CAL) * Having \>30 percent bleeding sites upon probing * Patients taking depression medication with chronic periodontitis * Patients without depression with chronic periodontitis * Patients who have not had a dental cleaning in the past 3 months prior to procedure * Patients scheduled for surgical procedures (i.e. gum surgery, tooth extraction, or dental implants) Exclusion Criteria: * Non-English speaking * Less than 18 years old * Smokers/tobacco users (\>10 cigarettes/day) * Any dental condition that requires immediate treatment, such as emergency care * Chronic use (≥3 times/week) of anti-inflammatory medications (e.g., non-steroidal anti-inflammatory drugs, steroids). Low-dose aspirin (less than 325 mg daily) * Immunocompromised subjects * Any medical history or any concomitant medication that might affect the assessment of the study treatment or periodontal tissues, such as uncontrolled diabetes, nifedipine, phenytoin (Dilantin), subjects with arthritis and morbidly obese (BMI ≥ 40)

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Conditions

The condition(s) this trial relates to.

chronic periodontitis Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic periodontitis Depression

Contacts and locations

Locations

  • Unversity of Alabama at Birmingham, School of Dentistry

    Birmingham, Alabama, 35294-0007, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.