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Spit test may reveal if root canal worked

NCT ID NCT07468643

Knowledge-focused Sponsor: Faculty of Dental Medicine for Girls Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 60 adults with infected teeth who receive standard root canal treatment. Researchers collect fluid from around the tooth before and after treatment to see if certain proteins can predict whether the infection heals on X-rays after one year. The goal is to find a simple way to monitor healing without extra radiation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help dentists predict which root canals are healing properly without relying only on X-rays.
What could go wrong
This is a small observational study, not a treatment trial. The biomarkers may not reliably predict healing in real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adult patients presenting to a university endodontic clinic who require primary nonsurgical root canal treatment for permanent teeth diagnosed with asymptomatic apical periodontitis. Participants will be recruited from patients seeking routine endodontic care. Eligible teeth will present with pulp necrosis and a radiographically detectable periapical radiolucency on standardized digital periapical radiographs. Gingival crevicular fluid samples will be collected from the affected tooth before treatment and during follow-up visits to evaluate biomarker levels and their association with radiographic healing after root canal treatment.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adults 18 -40 years . Presence of one permanent tooth diagnosed with asymptomatic apical periodontitis. Diagnosis confirmed by pulp necrosis or non-vital pulp and presence of a periapical radiolucency on digital periapical radiograph. Tooth indicated for primary nonsurgical root canal treatment. Tooth must be restorable and periodontally healthy. Periapical lesion detectable radiographically and suitable for follow-up evaluation. Participant able and willing to provide written informed consent. Participant willing to attend follow-up visits during the study period. Exclusion Criteria Participants will be excluded if any of the following conditions are present: Teeth previously treated with root canal treatment (retreatment cases). Teeth with acute apical abscess, swelling, or sinus tract. Teeth with combined endodontic-periodontal lesions. Periodontal pockets \>3 mm or evidence of active periodontal disease around the study tooth. Teeth with vertical root fracture, root perforation, or severe root resorption. Teeth with hopeless restorative or periodontal prognosis. Patients with systemic diseases that may affect healing (e.g., uncontrolled diabetes, immunosuppression). Pregnant or breastfeeding women. Patients currently taking systemic antibiotics, corticosteroids, or anti-inflammatory medications within the last 2 weeks. Current smokers or tobacco users. Inability to attend scheduled follow-up visits.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulp and periapical tissue disease

Contacts and locations

Locations

  • ALazhar university - faculty of dental medicine for girls

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.