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Could pectin and calcium silicate beat root canal infections?

NCT ID NCT07423663

Disease control Sponsor: Suez Canal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests whether calcium silicate and pectin, placed inside the tooth, can kill bacteria better than standard calcium hydroxide in root canals of dead teeth with abscesses. 63 adults with a single infected premolar will receive one of the three medications. The study measures changes in the types of bacteria present before and after treatment to see which works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Calcium silicate, pectin, and calcium hydroxide (as intracanal medications)
What this could lead to
If successful, this could point toward better, less resistance-prone disinfectants for root canal treatments.
What could go wrong
This is a very early, small trial (63 people) testing only one type of tooth. Results may not apply broadly, and the medications may not outperform standard treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

63 people

The number who actually took part.

Started

Sep 2024

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 49 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Patients presenting with a single rooted mandibular premolar tooth with a closed apex and a single patent canal type I in Vertucci's classification (Vertucci et al., 1974). * Having a necrotic pulp. * A pocket depth measurement of \< 3 mm. * Teeth with no previous history of endodontic treatment. * Teeth with periapical lesions of endodontic origin having a periapical index score of 4 or 5 (Orstavik et al., 1986) * Patients who took antibiotics within the period of three months before the study. * Non-restorable teeth. * Teeth with periodontal pockets deeper than 4mm, with or without concomitant or combined endo-perio communication * Multirooted teeth. * Previously initiated or treated teeth. * Teeth with root canal calcifications or resorption. * Teeth with internal/external root resorption or root fracture. * Immune-compromised patients or patients with systemic diseases i.e. (diabetes mellitus, human immunodeficiency virus, leukemia, neutropenia, undergoing chemo- or systemic corticosteroid therapy) * Teeth with root curvature of more than 15 degrees. * Pregnant women * Patients with known sensitivity to the medicaments used in this study.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asymptomatic apical periodontitis

Contacts and locations

Locations

  • Suez Canal University

    Ismailia, Ismailia Governorate, 41511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.