AI vs. dentists: can chatbots diagnose tooth infections?
NCT ID NCT07732985
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This trial tests whether three AI chatbots — ChatGPT, Gemini, and Claude — can accurately diagnose infections of the tooth pulp and surrounding tissues, and assess case difficulty, using patient data and dental X-rays. Their answers will be compared against a panel of dental experts. The goal is to see if AI could serve as a reliable decision-support tool in endodontics.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Large language models (ChatGPT, Gemini, Claude) used to analyze clinical data and dental X-rays for diagnosis
- What this could lead to
- If AI can diagnose tooth infections as accurately as experts, it could become a quick, low-cost decision-support tool for dentists.
- What could go wrong
- This is an early-stage diagnostic study, not a treatment trial. The AI models may not perform well enough in real-world settings, and they cannot replace clinical judgment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 342 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Systemically healthy adult patients (≥16 years) requiring primary endodontic treatment or retreatment at the Endodontic Department, Faculty of Dentistry, Cairo University, who provide informed consent.
- Ages
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16 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age above 16 years old. 2. Systemically healthy patient (ASA I or II). 3. Requiring endodontic treatment or retreatment 4. Patient's acceptance to participate in the study Exclusion Criteria: 1. Medically compromised patients. 2. Pregnant women. 3. Traumatic dental injuries 4. Low quality periapical radiograph
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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