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New dental sealer could improve root canal healing

NCT ID NCT03732170

Disease control Sponsor: National University Hospital, Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two types of dental sealers used during root canal treatment: TotalFill (a bioceramic sealer) and AH Plus. The goal is to see which one leads to better healing of infections at the tooth root tip. 170 teeth from adults at a dental clinic in Singapore are being studied, with X-rays and pain scores used to track outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
TotalFill® Bioceramic sealer and AH plus® sealer (dental sealers used during root canal treatment)
What this could lead to
If TotalFill works better, it could improve healing of tooth infections after root canals, reducing the need for retreatment.
What could go wrong
This is a single-center trial with 170 teeth, so results may not apply to everyone. The study is not yet complete, and the difference between sealers may be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

170 people

The number who actually took part.

Started

Aug 2018

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 95 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * A preoperative periapical radiograph will be required for diagnosis. * Subjects at least 21 years old. * Medically healthy * In a patient with multiple teeth requiring root canal treatment, only 1 tooth from each side will be included and selected at random. Exclusion Criteria: * Patient below 21 years old * Pregnant women. * Patients with autoimmune diseases and uncontrolled diabetes. * Teeth with periodontal probing depths of 5mm or more. * Incomplete root formation that is detected radiographically. * Cracked teeth * Teeth are deemed to have poor restorative prognosis. * Teeth with adjacent teeth on the same side that require root canal treatment

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Conditions

The condition(s) this trial relates to.

periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Root canal obturation

Contacts and locations

Locations

  • National University Hospital, Singapore

    Singapore, 119085, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.