National University Hospital, Singapore

This study tests a lower dose of the targeted therapy osimertinib in people with advanced EGFR-positive non-small cell lung cancer. The goal is to see if the lower dose can still control the cancer while causing fewer side effects. About 58 adults with specific EGFR mutations wil…

This study tests if dupilumab can help children aged 6-18 with severe nephrotic syndrome, a kidney disease that causes swelling and protein in urine. Participants get injections of dupilumab or a placebo every 2-4 weeks for 6 months, while slowly reducing their steroid dose. The …

This study tests whether adding the antibiotic doxycycline to standard tuberculosis (TB) treatment can reduce lung damage and improve heart health. About 150 adults with active TB and lung cavities will receive either doxycycline or a placebo for 8 weeks. Researchers will measure…

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's. Researchers think these drugs might slow memory decline by blocking a process linked to Alzheimer's. About …

This study compares two treatments for very deep cavities that reach the tooth's nerve: a partial nerve removal (pulpotomy) versus a full root canal. About 93 people aged 12 and older with a single affected tooth will be randomly assigned to one of the two procedures. The goal is…

This study compares ready-to-eat very low calorie meals to standard liquid meal replacements for people preparing for bariatric surgery. The goal is to see if the ready-to-eat option helps patients stick to their diet better. About 140 adults scheduled for surgery will participat…

This small pilot study tests whether adding transcutaneous spinal cord stimulation (tSCS) to robotic gait training helps people with chronic spinal cord injury improve trunk control and walking. Twelve adults with incomplete injury will first receive robotic training alone, then …

This study tests whether a supplement called myo-inositol can help pregnant women with type 2 diabetes have healthier babies. About 182 women will take the supplement alongside their usual diabetes care. The goal is to see if it reduces complications like early delivery or low bi…

This study tests a new type of CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to other treatments. The therapy uses a patient's own immune cells, modified to attack cancer cells. The goal is to find the best dose and see if it is safe and e…

This study tests whether adding two extra drugs (pembrolizumab and bevacizumab) to standard chemotherapy can improve outcomes for people with advanced nasopharyngeal cancer. About 50 adults with stage III or IVA disease will receive either standard chemo or the four-drug combo. T…

This study is testing whether a blood test can be used as a first step to screen for lung cancer in people at high risk. If the blood test is negative, those individuals might not need a CT scan, reducing radiation exposure and healthcare costs. The study involves 140 participant…

This study tests a small, smart sensor that listens to chest sounds to help doctors screen for pneumonia in people who are at high risk—specifically stroke patients and those with kidney failure on dialysis. The sensor detects abnormal sounds that might mean fluid or infection in…

This study tests a special cooling sleeve worn on the arms and legs during chemotherapy to prevent nerve damage, a common side effect. About 80 cancer patients receiving weekly paclitaxel will try the device. Researchers will check for side effects and ask patients about numbness…

This study tests whether early and intensive occupational therapy (like motivating activities and sleep routines) can reduce delirium—a state of confusion—in patients after coronary artery bypass surgery. About 300 adults in Singapore will be split into two groups: one receiving …

This study tests whether a non-invasive brain stimulation technique called TMS can reduce the severity of chronic tinnitus (ringing in the ears). Fifty adults with tinnitus will receive both real and sham (placebo) TMS sessions, with an MRI scan used to guide the stimulation. The…

This study looks at whether a dental mouthpiece works as well as a CPAP machine to improve thinking and memory in people with sleep apnea who also have mild memory problems. About 260 adults aged 45 and older with moderate-to-severe sleep apnea will be randomly assigned to use ei…

This pilot study tests whether adding a gentle electrical stimulation to the spinal cord (tSCS) can make robotic arm training work better for people with chronic spinal cord injuries. Six to eight adults with neck-level injuries will first do robotic training alone, then robotic …

This study aims to see if a lab-grown model of a patient's brain tumor can help doctors choose the most effective drug combination when the tumor returns. Ten adults with recurrent high-grade glioma will have a tumor sample taken to create a mini-tumor in the lab, which is then t…

This study compares a new type of hospital care, called an Acute Medical Unit, to standard hospital care for older adults with sudden medical illnesses like infections or falls. Researchers want to see if this model reduces time spent in the hospital, improves quality of life, an…

This study aims to help adults aged 60 and older in Singapore stay healthy and independent for as long as possible. Researchers will screen participants in community settings for early signs of decline in areas like memory, mobility, and mood. Those who show early decline will be…

This early-phase study tests whether artificial intelligence can help doctors choose and dose the right combination of cancer drugs for each person with a solid tumor (like breast or gastrointestinal cancer). Researchers will use a patient's own tumor sample in the lab to find th…