National University Hospital, Singapore

Researchers are testing whether a personalized form of brain stimulation can ease symptoms in people with anxiety disorders that have not improved with standard treatments. The approach uses a device to deliver rapid magnetic pulses to specific brain circuits, guided by each pers…

This trial tests a personalized approach to maintaining improvement in people with treatment-resistant depression. Participants who previously responded to a type of brain stimulation called iTBS will receive maintenance stimulation scheduled by a symptom-based algorithm, along w…

This trial tests whether a brain-computer interface called Lifescapes can help stroke survivors with severe hand paralysis improve arm and hand function. The system reads brain signals during imagined movements and pairs them with electrical stimulation and robotic assistance to …

This pilot trial tests whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve arm movement in people who had a stroke at least nine months ago. Participants receive either real or sham stimulation three times a we…

This trial is testing whether a personalized form of brain stimulation, called accelerated intermittent theta-burst stimulation (iTBS), can improve symptoms of depression and anxiety in people with treatment-resistant depression. The approach uses brain imaging to target specific…

This study tests a combination of three drugs—tislelizumab, bevacizumab, and capecitabine—in people with advanced solid tumors. The trial focuses on two challenging groups: those whose cancers have stopped responding to immunotherapy and those with tumors that have spread to the …

This phase 2 trial is testing a drug called ivonescimab in 42 people with a type of head and neck cancer (nasopharyngeal carcinoma) that has stopped responding to standard immunotherapy and chemotherapy. The drug is given every 3 weeks by IV. Researchers will measure how many pat…

This study tests if a mouthpiece worn during sleep can help people with both heart failure and obstructive sleep apnea. The device keeps the airway open, which may reduce stress on the heart and improve quality of life. 328 participants will use either the real device or a sham o…

This early-stage trial tests whether combining trastuzumab (a targeted antibody) with specially engineered immune cells (CAR T-cells) can safely control HER2-positive advanced breast cancer and other solid tumors. About 36 adults will receive the combination after a short chemoth…

This trial tests whether low-energy laser light applied to the skin, called photobiomodulation, can speed up recovery of sensation in the lower lip, chin, and cheek after jaw surgery. Numbness in these areas is a common side effect, affecting about one third of patients a year af…

This pilot trial tests whether a non-invasive nerve stimulation technique, called transcutaneous tibial nerve stimulation (TTNS), can help people with spinal cord injuries who have overactive bladder muscles. Participants will use a small device to deliver mild electrical pulses …

This trial compares early versus delayed acupuncture to reduce dry mouth caused by chemoradiation in head and neck cancer patients. Participants receive acupuncture either during chemoradiation or after, and their dry mouth symptoms are tracked for a year. The goal is to find the…

This study tests whether adding brain stimulation to spinal cord stimulation can improve leg strength and walking in adults with chronic incomplete spinal cord injury. 24 participants will receive either combined therapy or spinal stimulation alone over 16 weeks. The goal is to s…

This pilot study tests whether combining two types of non-invasive stimulation—one on the brain and one on the spine—can improve arm and hand function in people with chronic incomplete cervical spinal cord injury. 24 adults will receive either both stimulations plus rehabilitatio…

This study tests whether letting patients report their symptoms online can help doctors schedule follow-up visits only when needed. About 250 adults with chronic skin conditions like eczema or psoriasis will either get standard fixed appointments or flexible scheduling based on m…