National University Hospital, Singapore

This study tests a new drug called ivonescimab in 42 adults with advanced nasopharyngeal cancer that has stopped responding to standard treatments like immunotherapy and chemotherapy. The goal is to see if the drug can shrink tumors or slow the cancer's growth. Participants will …

This study tests whether combining trastuzumab (a targeted antibody) with a patient's own modified immune cells (CAR T cells) is safe and can control HER2-positive advanced breast cancer and other solid tumors. About 36 adults aged 21 and older will take part. The goal is to see …

This study tests whether a mouthpiece worn during sleep can improve heart health and quality of life in people with both heart failure and obstructive sleep apnea. The device, called a mandibular advancement device (MAD), keeps the airway open. 328 adults in Singapore will use ei…

This study tests whether combining two types of nerve stimulation—one on the brain and one on the spine—can improve arm and hand strength in adults with chronic incomplete spinal cord injury. 24 participants will receive either the combined stimulation plus rehabilitation, or spi…

This study tests whether adding brain stimulation to spinal cord stimulation can improve leg strength and walking more than spinal stimulation alone in people with chronic incomplete spinal cord injury. Twenty-four adults will receive 32 treatment sessions over 16 weeks. Research…

This study tests whether letting patients report their symptoms online can help schedule follow-up visits more flexibly. About 250 adults with chronic skin conditions like eczema or psoriasis will be assigned to either standard fixed appointments or a system that adjusts visits b…

This study tests an online educational program designed to help people with darker skin tones learn to tell the difference between harmless and potentially cancerous skin growths. About 280 adults in Singapore will take part. The goal is to see if the program improves their abili…